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Now showing items 81 - 96 of 109

  • Role of immune checkpoint inhibitor-based therapies for metastatic renal cell carcinoma in the first-line setting: A Bayesian network analysis

    Wang, Junpeng   Li, Xin   Wu, Xiaoqiang   Wang, Zhiwei   Zhang, Chan   Cao, Guanghui   Zhang, Xiaofan   Peng, Feng   Yan, Tianzhong  

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  • High-resolution morphological identification and characterization of living neuroblastoma SK-N-SH cells by hopping probe ion conductance microscopy

    Liu, Xiao   Yang, Xi   Zhang, Bin   Zhang, Xiaofan   Lu, Hujie  

    It is well known that heterogeneous neuroblastoma (NB) has three different phenotypic variants; the differentiation and transdifferentiation among them increase the complexity of this cancer. However, high-resolution characterization of their morphology has not been addressed by conventional microscopy. Under the help of high-resolution hopping probe ion conductance microscopy, we demonstrated that three morphologically distinct cell populations exist in live NB SK-N-SH cell line. Among these three types cells, N-type cells had the smallest cell volume and the biggest height, S-type owned the biggest cell volume and the smallest height, and I-type was intermediate between N- and S-type. The difference of microvilli morphology rendered I- and N-type cells with a higher RMS than S-type cells. These high-resolution morphologic criteria can provide more direct information to distinguish (Efferent cell types in NB tumor, and may give a hand to the development of new therapies and diagnosis. (C) 2011 Elsevier B.V. All rights reserved.
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  • A Multiple Structure-Design Strategy towards Ultrathin Niobate Perovskite Nanosheets with Thickness-Dependent Photocatalytic Hydrogen-Evolution Performance

    Zhou, Yannan   Wen, Ting   Zhang, Xiaofan   Chang, Binbin   Kong, Weiqian   Guo, Yanzhen   Yang, Baocheng   Wang, Yonggang  

    Hydrogen production by catalytic water splitting using sunlight holds great promise for clean and sustainable energy source. Despite the efforts made in the past decades, challenges still exist in pursuing solid catalysts with light-harvesting capacity, large surface areas and efficient utilities of the photogenerated carrier, at the same time. Here, a multiple structure design strategy leading to highly enhanced photocatalytic performance on hydrogen production from water splitting in Dion-Jacobson perovskites KCa2Nan-3NbnO3n+1 is described. Specifically, chemical doping (N/Nb4+) of the parent oxides via ammoniation improved the ability of sunlight harvesting efficiently; subsequent liquid exfoliation of the doped perovskites yielded ultrathin [Ca2Nan-3NbnO3n+1](-) nanosheets with greatly increased surface areas. Significantly, the maximum hydrogen evolution appears in the n=3D4 nanosheets, which suggests the most favorable thickness for charge separation in such perovskite-type catalysts. The optimized black N/Nb4+-[Ca2NaNb4O13](-) nanosheets show greatly enhanced photocatalytic performance, as high as 973 mu molh(-1) with Pt loading, on hydrogen evolution from water splitting. As a proof-of-concept, this work highlights the feasibility of combining various chemical strategies towards better catalysts and precise thickness control of two-dimensional materials.
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  • TiO 2 Nanorods Co‐decorated with Metal‐Free Carbon Materials for Boosted Photoelectrochemical Water Oxidation

    Kong, Weiqian   Zhang, Xiaofan   Chang, Binbin   Guo, Yanzhen   Li, Yipeng   Zhang, Shouren   Yang, Baocheng  

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  • Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning

    Zhou, Mingmin   Chen, Nannan   Tian, Jingsong   Zeng, Jianzhi   Zhang, Yunpeng   Zhang, Xiaofan   Guo, Jing   Sun, Jinghan   Li, Yulong   Guo, Aike   Li, Yan  

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  • High-performance electrospinning-phase inversion composite PDMS membrane for extractive membrane bioreactor: Fabrication, characterization, optimization and application

    Ren, Long-Fei   Liu, Changqing   Xu, Yunfan   Zhang, Xiaofan   Shao, Jiahui   He, Yiliang  

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  • MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer

    Zhang, Xiaofan   Yang, Hushan   Lee, J. Jack   Kim, Edward   Lippman, Scott M.   Khuri, Fadlo R.   Spitz, Margaret R.   Lotan, Reuben   Hong, Waun K.   Wu, Xifeng  

    Second primary tumor (SPT) and/or recurrence negatively impact the prognosis of patients with curatively treated early-stage head and neck cancer. MicroRNAs (miRNAs) play important roles in cancer development. We explored whether the variations of miRNA-related pathway were associated with the risk of SPT/recurrence in patients with early-stage head and neck cancer. This study includes 150 early-stage head and neck cancer patients with SPT/recurrence and 300 patients without SPT/recurrence. Two hundred and thirty-five tagging and potentially functional single-nucleotide polymorphisms (SNPs) were genotyped from eight miRNA biogenesis pathway genes and 135 miRNA-targeted genes. Eighteen miRNA-related SNPs were significantly associated with the risk of SPT/recurrence. The most significant SNP was rs3747238, a miRNA-binding site SNP in SMC1B. The variant homozygous genotype of this SNP was associated with a 1.74-fold increased risk [95% confidence interval (CI) 1.19-2.54; P =3D 0.004]. Cumulative effect analysis showed joint effects for the number of unfavorable genotype in patients. Survival tree analysis further identified the high-order gene-gene interactions and categorized the study subjects into low-, medium- and high-risk groups. Patients in the high-risk group had a 4.84-fold increased risk (95% CI: 3.11-7.51; P =3D 2.45 x 10(-12)) and a shorter event-free median survival time of 37.9 months (log rank P =3D 2.28 x 10(-13)). Our results suggested that miRNA-related genetic polymorphisms may be used individually and jointly to predict the risk of SPT/recurrence of early-stage head and neck cancer patients.
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  • Design, synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives as cytotoxic and antitumor agents with fluorescent properties.

    Sun, Jufeng   Zhang, Shuping   Yu, Chen   Hou, Guige   Zhang, Xiaofan   Li, Keke   Zhao, Feng  

    Ten new N-substituted-3,5-bis(arylidene)-4-piperidone derivatives (series 1 and 2) were synthesized and subsequently evaluated against human carcinoma cell lines SW1990, MIA PaCa-2, PG-BE1, NCI-H460, and SK-BR-3 for cytotoxic activity by the CCK-8 method, and their fluorescent properties were investigated as well. The compounds were confirmed to display greater cytotoxic activity to the neoplastic cells, and approximately 50% of the IC50 values were lower than 5 mum. In particular, compounds 1a, 1c, 1d, and 1e bearing 3-bromophenyl groups were revealed as the most active antitumor drug candidates and had the average IC50 values of 1.94, 1.11, 1.16, and 0.817 mum, respectively. Furthermore, their fluorescent properties were interesting and might contribute to the visualization of their distribution in tumor cells. Some possible reasons for the disparity between cytotoxic activity and fluorescent properties in the two series of compounds were explored. This study revealed high potential of these molecules for further development as fluorescent cytotoxic and antitumor agents. =C2=A9 2013 John Wiley & Sons A/S.
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  • Experimental investigation of the effect of electrospinning parameters on properties of superhydrophobic PDMS/PMMA membrane and its application in membrane distillation

    Ren, Long-Fei   Xia, Fan   Shao, Jiahui   Zhang, Xiaofan   Li, Jun  

    Considerable efforts have been devoted to finding economic and simple preparation methods for polydimethylsiloxane (PDMS) superhydrophobic membrane in past decades. This study provides a simple method to electrospin PDMS membrane using poly (methyl methacrylate) (PMMA) as carrier polymer. Effects of PMMA concentration, PDMS/PMMA mass ratio and main parameters of electrospinning process (voltage and injection rate) were investigated to obtain superhydrophobic membrane with high water contact angle (WCA). A highest WCA of 1630 could be obtained on the membrane surface fabricated by electrospinning solution containing PDMS: PMMA: tetrahydrofuran (THF): N,N-dimethylformamide (DMF) (mass ratio 1: 1: 8.88: 9.48) under applied voltage of 11 kV and injection rate of 0.1 mm/min. The superhydrophobic PDMS/PMMA membrane was further applied in membrane distillation process for desalination, and a high permeation flux of 39.61 L/m(2) h and an excellent salt rejection of 99.96% were achieved during long-term MD process (24 h). (C) 2016 Elsevier B.V. All rights reserved.
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  • Quantification of alcohols, diols and glycerol in fermentation with an instantaneous derivatization using trichloroacetyl isocyanante via liquid chromatography-massspectrometry.

    Chen, Jun   Chen, Dayu   Zhang, Xiaofan   Wang, Meng   Chen, Biqiang   An, Dongge   Xu, Li   Lyu, Qiang  

    A sensitive LC-MS/MS method was established to quantify diols and glycerol in fermentation broth using trichloroacetyl isocyanate as instantaneous derivatization reagent for monitoring the production of 1,3-propanediol and 2,3-butanediol from the biodiesel biorefinery process. Due to the derivatization reaction was very quickly at room temperature, only 1=E2=80=AFmin was needed for the reaction process. In addition, both extraction of analytes and evaporation of water were not employed in the analytical procedure. Furthermore, the isotope of chlorine was beneficial for understanding of the secondary mass spectrum and avoiding false positive results. Therefore, much more accurate results of diols and glycerol concentration in fermentation could be obtained even at very low levels for the evaluation of microbial metabolism pathway modification. Copyright =C2=A9 2018 Elsevier B.V. All rights reserved.
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  • Electrochemical sensing of H 2 O 2 released from living cells based on AuPd alloy-modified PDA nanotubes

    He, Guangli   Gao, Fengli   Li, Wei   Li, Pengwei   Zhang, Xiaofan   Yin, Hang   Yang, Baocheng   Liu, Yibiao   Zhang, Shouren  

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  • Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis

    Gong, Wenci   Huang, Fengjuan   Sun, Lei   Yu, Aiping   Zhang, Xiaofan   Xu, Yuxin   Shen, Yujuan   Cao, Jianping   McSorley, Henry John  

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  • Phenol separation from phenol-laden saline wastewater by membrane aromatic recovery system-like membrane contactor using superhydrophobic/organophilic electrospun PDMS/PMMA membrane.

    Ren, Long-Fei   Adeel, Mister   Li, Jun   Xu, Cong   Xu, Zheng   Zhang, Xiaofan   Shao, Jiahui   He, Yiliang  

    Phenol recovery from phenol-laden saline wastewater plays an important role in the waste reclamation and pollution control. A membrane aromatic recovery system-like membrane contactor (MARS-like membrane contactor) was set up in this study using electrospun polydimethylsiloxane/polymethyl methacrylate (PDMS/PMMA) membrane with 0.0048=E2=80=AFm2 effective area to separate phenol from saline wastewater. Phenol and water contact angles of 0=C2=B0 and 162=C2=B0 were achieved on this membrane surface simultaneously, indicating its potential in the separation of phenol and water-soluble salt. Feed solution (500=E2=80=AFmL) of 0.90=E2=80=AFL/h and receiving solution (500=E2=80=AFmL) of 1.26=E2=80=AFL/h were investigated to be the optimum conditions for phenol separation, which corresponds to the employed Reynolds number of 14.6 and 20.5. During 108-h continuous separation for feed solution (2.0=E2=80=AFg/L phenol, 10.0=E2=80=AFg/L NaCl) under room temperature (20=E2=80=AF=C2=B0C), 42.6% of phenol was recycled in receiving solution with a salt rejection of 99.95%. Meanwhile, the mean phenol mass transfer coefficient (Kov) was 6.7=E2=80=AF*=E2=80=AF10-7=E2=80=AFm=E2=80=AFs-1. As a membrane-based process, though the permeated phenol increased with the increase of phenol concentration in feed solution, the phenol recovery ratio was determined by the membrane properties rather than the pollutant concentrations. Phenol was found to permeate this membrane via adsorption, diffusion and desorption, and therefore, the membrane fouling generated from pore blockage in other membrane separation processes was totally avoided. Copyright =C2=A9 2018 Elsevier Ltd. All rights reserved.
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  • Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis.

    Gong, Wenci   Huang, Fengjuan   Sun, Lei   Yu, Aiping   Zhang, Xiaofan   Xu, Yuxin   Shen, Yujuan   Cao, Jianping  

    Schistosomiasis is endemic to many regions of the world and affects approximately 200 million people. Conventional adaptive T cell responses are considered to be the primary contributors to the pathogenesis of Schistosoma japonicum infection, leading to liver granuloma and fibrosis. However, the functional polarization of macrophages and the associated underlying molecular mechanisms during the pathogenesis of schistosomiasis remains unknown. In the present study, we found that excretory-secretory (ES) antigens derived from S. japonicum eggs can activate macrophages, which exhibit an M2b polarization. Furthermore, ES antigen-induced M2b polarization was found to be dependent on enhanced NF-kappaB signaling mediated by the MyD88/MAPK pathway in a TLR2-dependent manner. In addition, the cytokine profile of the liver macrophages from wild-type-infected mice are quite distinct from those found in TLR2 knockout-infected mice by quantitative PCR analysis. More importantly, the size of granuloma and the severity of the fibrosis in the livers of TLR2-/- mice were significantly reduced compared to that in WT mice. Our findings reveal a novel role for M2b polarization in the pathogenesis of schistosome infection.=20
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  • Investigation of morphological and functional changes during neuronal differentiation of PC12 cells by combined Hopping Probe Ion Conductance Microscopy and patch-clamp technique

    Yang, Xi   Liu, Xiao   Zhang, Xiaofan   Lu, Hujie   Zhang, Jianning   Zhang, Yanjun  

    PC12 cells derived from rat pheochromocytoma can differentiate into sympathetic-neuron-like cells in response to nerve growth factor (NGF). These cells have been proved to be a useful cell model to study neuronal differentiation. NGF induces rapid changes in membrane morphology, neurite outgrowth, and electrical excitability. However, the relationship between the 3D morphological changes of NGF-differentiated PC12 cells and their electrophysiological functions remains poorly understood. In this study, we combined a recently developed Hopping Probe Ion Conductance Microscopy (HPICM) with patch-clamp technique to investigate the high-resolution morphological changes and functional ion-channel development during the NGF-induced neuronal differentiation of PC12 cells. NGF enlarged TTX-sensitive sodium currents of PC12 cells, which associated with cell volume, membrane surface area, surface roughness of the membrane, and neurite outgrowth. These results demonstrate that the combination of HPICM and patch-clamp technique can provide detailed information of membrane microstructures and ion-channel functions during the differentiation of PC12 cells, and has the potential to become a powerful tool for neuronal research. (c) 2011 Elsevier B.V. All rights reserved.
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  • Novel “Bird-Nest” Structured Co 3 O 4 /Acidified Multiwall Carbon Nanotube (ACNT) Hosting Materials for Lithium–Sulfur Batteries

    Liu, Ruiping   Guo, Fei   Zhang, Xiaofan   Yang, Jinlin   Li, Mingyang   Miaomiao, Wu   Liu, Hang   Feng, Ming   Zhang, Lei  

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