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Now showing items 65 - 80 of 114

  • Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes

    Liu, Zhiqiang   Xu, Yi   Zhang, Xiaofan   Miao, Jinfeng   Han, Jing   Zhu, Zhou  

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  • Early haemoperfusion with continuous venovenous haemofiltration improves survival of acute paraquat-poisoned patients.

    Gao, Yanxia   Zhang, Xiaofan   Yang, Yanjie   Li, Wenlu  

    OBJECTIVE: To determine whether haemoperfusion (HP) with continuous venovenous haemofiltration (CVVH) improves the survival of patients with acute paraquat poisoning, compared with those treated using HP alone.; METHODS: Medical records of patients with acute paraquat poisoning were analysed. Patients were randomised to undergo HP or HP + CVVH within 24 h of paraquat ingestion. Mortality rate, survival duration and cause of death were recorded.; RESULTS: There were no significant differences in mortality rate between the HP group (n =3D 458) and the HP + CVVH group (n =3D 226) (57.4% and 58.4%, respectively). The mean survival duration was significantly longer in the HP + CVVH group than the HP group (8.6 =C2=B1 3.1 and 5.1 =C2=B1 2.3 days, respectively). Early circulatory collapse was a major cause of death in the HP group. The major cause of death in the HP + CVVH group was late respiratory failure.; CONCLUSION: Combined therapy with HP and CVVH can prevent early death and prolong survival duration following acute paraquat poisoning, providing the opportunity for further treatment. =C2=A9 The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
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  • Genetic Variations in the Sonic Hedgehog Pathway Affect Clinical Outcomes in Non-Muscle-Invasive Bladder Cancer

    Chen, Meng   Hildebrandt, Michelle A. T.   Clague, Jessica   Kamat, Ashish M.   Picornell, Antoni   Chang, Joshua   Zhang, Xiaofan   Izzo, Julie   Yang, Hushan   Lin, Jie   Gu, Jian   Chanock, Stephen   Kogevinas, Manolis   Rothman, Nathaniel   Silverman, Debra T.   Garcia-Closas, Montserrat   Grossman, H. Barton   Dinney, Colin P.   Malats, Nuria   Wu, Xifeng  

    Sonic hedgehog (Shh) pathway genetic variations may affect bladder cancer risk and clinical outcomes. Therefore, we genotyped 177 single-nucleotide polymorphisms (SNP) in 11 Shh pathway genes in a study including 803 bladder cancer cases and 803 controls. We assessed SNP associations with cancer risk and clinical outcomes in 419 cases of non-muscle-invasive bladder cancer (NMIBC) and 318 cases of muscle-invasive and metastatic bladder cancer (MiMBC). Only three SNPs (GLI3 rs3823720, rs3735361, and rs10951671) reached nominal significance in association with risk (P <= 0.05), which became nonsignificant after adjusting for multiple comparisons. Nine SNPs reached a nominally significant individual association with recurrence of NMIBC in patients who received transurethral resection (TUR) only (P <= 0.05), of which two (SHH rs1233560 and GLI2 rs11685068) were replicated independently in 356 TUR-only NMIBC patients, with P values of 1.0 x 10(-3) (SHH rs1233560) and 1.3 x 10(-3) (GLI2 rs11685068). Nine SNPs also reached a nominally significant individual association with clinical outcome of NMIBC patients who received Bacillus Calmette-Guerin (BCG; P <= 0.05), of which two, the independent GLI3 variants rs6463089 and rs3801192, remained significant after adjusting for multiple comparisons (P = 2 x 10(-4) and 9 x 10(-4), respectively). The wildtype genotype of either of these SNPs was associated with a lower recurrence rate and longer recurrence-free survival (versus the variants). Although three SNPs (GLI2 rs735557, GLI2 rs4848632, and SHH rs208684) showed nominal significance in association with overall survival in MiMBC patients (P <= 0.05), none remained significant after multiple-comparison adjustments. Germ-line genetic variations in the Shh pathway predicted clinical outcomes of TUR and BCG for NMIBC patients. Cancer Prev Res; 3(10); 1235-45. (c) 2010 AACR.
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  • Photophysical/Chemistry Properties of Distyryl-BODIPY Derivatives:An Experimental and Density Functional Theoretical Study

    Kang, Hongwei   Si, Yubing   Liu, Yuxiu   Zhang, Xiaofan   Zhang, Weiwei   Zhao, Yi   Yang, Baocheng   Liu, Yaxuan   Liu, Zhongyi  

    Singlet oxygen is the key element for photodynamic therapy. In this paper, six novel distyryl-BODIPY compounds were synthesized and investigated in detail to fully evaluate their photophysical/chemistry characteristics. Specially, the singlet oxygen (O-1(2)) quantum yield of compounds 2 and 4 each bearing two bromine atoms in their skeleton revealed the position effect of heavy atom for O-1(2) production. The O-1(2) quantum yield of 4, which was brominated at 2/6 position of BODIPY skeleton, was much higher than that of compound 2, brominated at styryl group with a long distance toward BODIPY core. Importantly, theoretical calculations were carried out to elaborate the essential reason for the difference of 2 and 4 by investigating intersystem crossing rate.
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  • The Effect of Oxytocin on Social and Non-Social Behaviour and Striatal Protein Expression in C57BL/6N Mice

    Zhang, Xiaofan   Li, Qi   Zhang, Min   Lam, Sylvia   Sham, Pak Chung   Bu, Bitao   Chua, Siew Eng   Wang, Wei   McAlonan, Grainne Mary  

    Oxytocin has been suggested as a promising new treatment for neurodevelopmental disorders. However, important gaps remain in our understanding of its mode of action, in particular, to what extent oxytocin modulates social and non-social behaviours and whether its effects are generalizable across both sexes. Here we investigated the effects of a range of oxytocin doses on social and non-social behaviours in C57BL/6N mice of both sexes. As the striatum modulates social and non-social behaviours, and is implicated in neurodevelopmental disorders, we also conducted a pilot exploration of changes in striatal protein expression elicited by oxytocin. Oxytocin increased prepulse inhibition of startle but attenuated the recognition memory in male C57BL/6N mice. It increased social interaction time and suppressed the amphetamine locomotor response in both sexes. The striatum proteome following oxytocin exposure could be clearly discriminated from saline controls. With the caveat that these results are preliminary, oxytocin appeared to alter individual protein expression in directions similar to conventional anti-psychotics. The proteins affected by oxytocin could be broadly categorized as those that modulate glutamatergic, GABAergic or dopaminergic signalling and those that mediate cytoskeleton dynamics. Our results here encourage further research into the clinical application of this peptide hormone, which may potentially extend treatment options across a spectrum of neurodevelopmental conditions.
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  • Photoelectrochemical Water Splitting System-A Study of Interfacial Charge Transfer with Scanning Electrochemical Microscopy

    Zhang, Bingyan   Zhang, Xiaofan   Xiao, Xin   Shen, Yan  

    Fast charge transfer kinetics at the photoelectrode/electrolyte interface is critical for efficient photoelectrochemical (PEC) water splitting system. Thus, far, a measurement of kinetics constants for such processes is limited. In this study, scanning electrochemical microscopy (SECM) is employed to investigate the charge transfer kinetics at the photoelectrode/electrolyte interface in the feedback mode in order to simulate the oxygen evolution process in PEC system. The popular photocatalysts BiVO4 and Mo doped BiVO4 (labeled as Mo:BiVO4) are selected as photoanodes and the common redox couple [Fe(CN)(6)](3-)/[Fe(CN)(6)](4-) as molecular probe. SECM characterization can directly reveal the surface catalytic reaction kinetics constant of 9.30 x 10(7) mol(-1) cm(3) s(-1) for the BiVO4. Furthermore, we find that after excitation, the ratio of rate constant for photogenerated hole to electron via Mo:BiVO4 reacting with mediator at the electrode/electrolyte interface is about 30 times larger than that of BiVO4. This suggests that introduction of Mo6+ ion into BiVO4 can possibly facilitate solar to oxygen evolution (hole involved process) and suppress the interfacial back reaction (electron involved process) at photoanode/electrolyte interface. Therefore, the SECM measurement allows us to make a comprehensive analysis of interfacial charge transfer kinetics in PEC system.
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  • Near-circularly polarized single attosecond pulse generation from nitrogen molecules in spatially inhomogeneous laser fields

    Zhang, Xiaofan   Li, Yang   Zhu, Xiaosong   Zhang, Qingbin   Lan, Pengfei   Lu, Peixiang  

    The generation of an attosecond pulse in nitrogen molecules using spatially inhomogeneous laser fields is investigated by numerically solving the time-dependent Schrodinger equation. It is found that an isolated attosecond pulse with elliptical polarization can be generated using linearly polarized laser fields. By changing polarization direction with respect to the molecular axis, the ellipticity of the attosecond pulse can be easily controlled. At some specific angles, the intensities of the two mutually vertical harmonic components, parallel and perpendicular to the driving laser polarization direction, are comparable. Additionally, the relative phase between the two components is about pi/2. As a result, it supports the generation of the isolated near-circularly polarized attosecond pulse with a duration of 155 as.
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  • Near-circularly polarized single attosecond pulse generation from nitrogen molecules in spatially inhomogeneous laser fields

    Zhang, Xiaofan   Li, Yang   Zhu, Xiaosong   Zhang, Qingbin   Lan, Pengfei   Lu, Peixiang  

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  • Independent Contributions of Discrete Dopaminergic Circuits to Cellular Plasticity, Memory Strength, and Valence in Drosophila

    Boto, Tamara   Stahl, Aaron   Zhang, Xiaofan   Louis, Thierry   Tomchik, Seth M.  

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  • Helicity reversion in high-order-harmonic generation driven by bichromatic counter-rotating circularly polarized laser fields

    Zhang, Xiaofan   Li, Liang   Zhu, Xiaosong   Liu, Xi   Zhang, Qingbin   Lan, Pengfei   Lu, Peixiang  

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  • Local strain hardening behavior in a dissimilar metal welded joint with buttering layer of ultra-supercritical turbine rotor

    Wang, Wenke   Dong, Zhiqiang   Xu, Zhenzhen   Zhu, Bo   Zhang, Xiaofan   Zhong, Jie   Zhang, Jianxun  

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  • Molecular and clinical relationship between live-attenuated Japanese encephalitis vaccination and childhood onset myasthenia gravis

    He, Dan   Zhang, Han   Xiao, Jun   Zhang, Xiaofan   Xie, Minjie   Pan, Dengji   Wang, Minghuan   Luo, Xiang   Bu, Bitao   Zhang, Min   Wang, Wei  

    ObjectiveThe incidence of childhood onset myasthenia gravis (CMG) in China is higher than that in other countries; however, the reasons for this are unclear. MethodsWe investigated the clinical and immunological profiles of CMG, and assessed the potential precipitating factors. For the mouse studies, the possible implication of vaccination in the pathogenesis was explored. ResultsIn our retrospective study, 51.22% of the 4,219 cases of myasthenia gravis (MG) were of the childhood onset type. The cohort study uncovered that the pathophysiology of CMG was mediated by immune deviation, rather than through gene mutations or virus infections. The administration of the live-attenuated Japanese encephalitis vaccine (LA-JEV), but not the inactivated vaccine or other vaccines, in mice induced serum acetylcholine receptor (AChR) antibody production, reduced the AChR density at the endplates, and decreased both muscle strength and response to repetitive nerve stimulation. We found a peptide (containing 7 amino acids) of LA-JEV similar to the AChR- subunit, and immunization with a synthesized protein containing this peptide reproduced the MG-like phenotype in mice. InterpretationOur results describe the immunological profile of CMG. Immunization with LA-JEV induced an autoimmune reaction against the AChR through molecular mimicry. These findings might explain the higher occurrence rate of CMG in China, where children are routinely vaccinated with LA-JEV, compared with that in countries, where this vaccination is not as common. Efforts should be made to optimize immunization strategies and reduce the risk for developing autoimmune disorders among children. Ann Neurol 2018;84:386-400
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  • Changes in degrading ability,populations and metabolism of microbes in activated sludge in the treatment of phenol wastewater

    Chen, Rui   Ren, Long-Fei   Shao, Jiahui   He, Yiliang   Zhang, Xiaofan  

    Herein, changes in the degrading ability, populations and metabolism of microbes in activated sludge exposed to 60-350 mg L-1 phenol are thoroughly investigated. A phenol degradation experiment is conducted using activated sludge as inoculum over 140 days. The results suggest that the sludge efficiently degrades 250 mg L-1 phenol; however, it is unable to remove 350 mg L-1 phenol completely in two days, which might be caused by the decreased activities of catechol 1,2 dioxygenase (C12O) and catechol 2,3 dioxygenase (C23O). The specific oxygen uptake rate (SOUR) of the sludge and extracellular polymeric substances (EPS) generation are inhibited at the beginning of phenol degradation and then increase with phenol loading. A large amount of humic acid (HA) is produced during the degradation of 350 mg L-1 phenol due to cell decomposition. Illumina-MiSeq sequencing indicates that denitrifiers are competitive clusters at high phenol concentrations. The present study provides a comprehensive understanding of mechanisms of microbial responses to toxic compounds.
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  • N Doped Carbon Dot Modified WO 3 Nanoflakes for Efficient Photoelectrochemical Water Oxidation

    Kong, Weiqian   Zhang, Xiaofan   Liu, Shuangshuang   Zhou, Yannan   Chang, Binbin   Zhang, Shouren   Fan, Hongbo   Yang, Baocheng  

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  • A Novel Dietary Source of EPA and DHA: Metabolic Engineering of an Important Freshwater Species—Common Carp by fat1-Transgenesis

    Zhang, Xiaofan   Pang, Shaochen   Liu, Chengjie   Wang, Houpeng   Ye, Ding   Zhu, Zuoyan   Sun, Yonghua  

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  • Intranasal immunization with recombinant Toxoplasma gondii actin depolymerizing factor confers protective efficacy against toxoplasmosis in mice

    Liu, Zhuanzhuan   Yin, Litian   Li, Yaqing   Yuan, Fei   Zhang, Xiaofan   Ma, Jiazhi   Liu, Hongmei   Wang, Yanjuan   Zheng, Kuiyang   Cao, Jianping  

    Background: Toxoplasma gondii is an opportunistic protozoan closely associated with AIDS and vertical transmission. T. gondii actin depolymerizing factor (TgADF) plays an important role in actin cytoskeleton remodeling, and it is required to invade host cells. TgADF was a promising vaccine candidate. To observe the immunological changes and protective efficacy of recombinant TgADF protein (rTgADF) against T. gondii infection, we optimized the intranasal immunization dose of rTgADF and analyzed the survival rate and tachyzoite loads in mouse tissues after oral challenge with T. gondii tachyzoites. Results: rTgADF was prepared, purified, and combined with mouse anti-His antibody and rabbit anti T. gondii serum. After intranasal immunization with 10 mu g, 20 mu g, 30 mu g, or 40 mu g of rTgADF, the 30-mu g group elicited high levels of secretory IgA (sIgA) in nasal, intestinal, and vesical washes, raised IgG titres in the sera, strong proliferation of splenocytes, and increased secretion of IL-2 and IFN-gamma when compared with the control group. When the mice were orally challenged with T. gondii, an increase in the survival rate (36.36 %) and a decrease in the tachyzoite loads in the liver (67.77 %) and brain (51.01 %) were observed. Conclusions: Our findings demonstrate that intranasal immunization with rTgADF can simultaneously trigger mucosal and systemic immune responses and protect the mice against T. gondii infection.
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