A micro speaker is disclosed. The micro speaker includes a vibration system including a diaphragm and a voice coil for driving the diaphragm, the diaphragm including a conductive dome and a suspension surrounding the conductive dome; a magnetic circuit system including a lower plate, a first magnetic part on the lower plate, a second magnetic part on the lower plate, a pole plate attached to the first magnetic part, one of the first and second magnetic part being a permanent magnet for forming a magnetic gap. The conductive dome includes a number of units for forming capacitors together with the pole plate for outputting electrical signals according to vibrations of the diaphragm and for detecting real-time replacement of the diaphragm.
A micro speaker is disclosed. The micro speaker includes a vibration system including a diaphragm and a voice coil for driving the diaphragm, the diaphragm including a conductive dome a suspension surrounding the conductive dome; a magnetic circuit system including a lower plate, a first magnetic part on the lower plate, a second magnetic part on the lower plate, a pole plate attached to the first magnetic part and including a plurality of units, one of the first and second magnetic part being a permanent magnet for forming a magnetic gap; capacitors formed by the conductive dome and the units of the pole plate for outputting electrical signals according to vibrations of the diaphragm and for detecting real-time replacement of the diaphragm.
A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.
A touch sensor interface includes one or more touch detection electrodes whose capacitance increases when touched. A processor converts the increase in capacitance into a change in a counter value. A detector compares the change in the counter value with one or more count thresholds to detect faults in the touch sensor interface.
Iris Dror
Shula Shazman
Srayanta Mukherjee
Yang Zhang
Fabian Glaser and Yael Mandel-Gutfreund
The function of DNA- and RNA-binding proteins can be inferred from the characterization and accurate prediction of their binding interfaces. However, the main pitfall of various structure-based methods for predicting nucleic acid binding function is that they are all limited to a relatively small number of proteins for which high-resolution three-dimensional structures are available. In this study, we developed a pipeline for extracting functional electrostatic patches from surfaces of protein structural models, obtained using the I-TASSER protein structure predictor. The largest positive patches are extracted from the protein surface using the patchfinder algorithm. We show that functional electrostatic patches extracted from an ensemble of structural models highly overlap the patches extracted from high-resolution structures. Furthermore, by testing our pipeline on a set of 55 known nucleic acid binding proteins for which I-TASSER produces high-quality models, we show that the method accurately identifies the nucleic acids binding interface on structural models of proteins. Employing a combined patch approach we show that patches extracted from an ensemble of models better predicts the real nucleic acid binding interfaces compared with patches extracted from independent models. Overall, these results suggest that combining information from a collection of low-resolution structural models could be a valuable approach for functional annotation. We suggest that our method will be further applicable for predicting other functional surfaces of proteins with unknown structure. Proteins 2012.
The present invention discloses an implementation method of user interface for a mobile device and a mobile device. Herein, the method comprises: detecting a trigger action on the mobile device; in response to the trigger action, displaying n layers of response region, wherein the n layers of response region are transparent rectangle, and overlap at one of their corners or edges, calculating display position(s) of one or more UI element(s), and presenting the UI element(s) in the valid region of each layer of response region. In the present invention, the sector UI may provide the user with a convenient access to opening an application corresponding to the UI element.
Xue Chen
Yang Zhang
Fang Wang
Mangju Wang
Wen Teng
Yuehui Lin
Xiangping Han
Fangyuan Jin
Yuanli Xu
Panxiang Cao
Jiancheng Fang
Ping Zhu
Chunrong Tong
Hongxing Liu
Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the development of lymphoma in Chinese patients are limited to date. In the present study, 90 patients with lymphoma were analyzed for UNC13D, PRF1, STXBP2, STX11, SH2D1A and X-linked inhibitor of apoptosis. Mutations were observed in 24 (26.67%) patients; 16 patients exhibited mutations in UNC13D, 7 exhibited PRF1 mutations, and 1 exhibited monoallelic mutation in STX11. UNC13D c.2588G>A/p.G863D mutation was detected in 9 patients (10.00%) and in 4/210 controls (1.90%). This mutation was predicted to be pathogenic and it predominantly existed in the Chinese population. These findings suggest that impaired cytotoxic machinery may represent a predisposing factor for the development of lymphoma. Furthermore, these data describe a distinct mutation spectrum in Chinese patients with lymphoma, whereby UNC13D is the most frequently mutated gene. In addition, these findings suggest UNC13D c.2588G>A mutation is a founder mutation in Chinese patients.
Yang ZHANG
Shi-li ZHENG
Hao DU
Hong-bin XU
Yi ZHANG
Mechanical activation was used to improve the extraction of chromium in molten NaOH. It is observed that the extraction ratio reaches 97%after leaching for 200 min when chromite ore is mechanically activated for 10 min, but only 34%if not activated. Mechanical activation can decrease the particle size, increase the surface area, and enhance the lattice distortion. Further, the mechanisms for mechanical activation were exposed. The results show that the mechanical activation mainly focuses on chromite ore particle size decrease and the lattice distortion. The formation of aggregation weakens the strengthening effect of mechanical activation for releasing high surface energy.
The invention provides a compound of Formula (I)
pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
A method and apparatus for imaging a biologic fluid sample quiescently residing within a chamber is provided. The method includes the steps of: a) positioning the chamber at a Z-axis position relative to an objective lens having a lens axis, wherein the Z-axis is parallel to the lens axis; b) moving one or both of the chamber and the objective lens relative to one another at a velocity along the Z-axis; and c) creating one or more images of the biologic fluid sample as one or both of the chamber and the objective lens are moving at a velocity relative to one another within a focus search range along the Z-axis.
A dynamic voltage scaling system based on on-chip monitoring and voltage prediction is disclosed, comprising a main circuit that has integrated on-chip monitoring circuits, a supply voltage scaling module, and voltage converters, wherein, the supply voltage scaling module comprises a sampling and statistics module designed to calculate the error rate of the main circuit in the current time slice, a state recording module designed to record the error rate and the corresponding supply voltage, an error prediction module, and a state transition probability generation module; the error prediction module predicts the error trend of the main circuit in a future time slice according to the state recording module and the state transition probability generation module, and generates regulation signals and sends to the corresponding voltage converters, so as to generate the voltage required for operation of the entire main circuit.
Magnetically actuated micro-electro-mechanical capacitor switches in laminate are disclosed. According to one embodiment, an apparatus comprises a first layer comprising a coil and magnetic element, the magnetic element made from one of nickel and iron; a second layer comprising a flexible member, wherein a permanent magnet is attached to the flexible member; a conductive plate having an insulating dielectric coating, the conductive plate attached to one of the flexible member or a magnet; and a third layer comprising a transmission line and magnetic material, wherein the transmission line comprises one or more of a signal conductor and one or more ground conductors in near proximity.
The high mobility of vehicles and the unreliable wireless communication significantly degrade the performance of data access in vehicular ad hoc networks (VANETs). To address this problem, we propose a novel vehicle-platoon-aware data access solution called V-PADA. In V-PADA, vehicles contribute part of their buffers to replicate data for others in the same platoon and share data with them. When a vehicle leaves the platoon, it prefetches interested data and transfers its buffered data to other vehicles in advance so that they can still access the data after it leaves. To achieve this goal, V-PADA consists of two components: First, a vehicle-platooning protocol is designed to identify platoon formation and predict platoon splits. We use stochastic time series analysis to detect platoon and mobility anomalies and further introduce a two-step split prediction method to reduce the false alarm rate due to road curves. Second, a data management component is designed to guide platoon members to replicate and prefetch the most suitable data so that both high data availability and low data access overhead can be achieved. Extensive simulation results show that V-PADA can effectively improve the data access performance in VANETs.
The relationship-focused and credential-focused identity managements are both user-centric notions in Service-oriented architecture (SOA). For composite services, pure user-centric identity management is inefficient because each subservice may authenticate and authorize users and users need participate in every identity provisioning transaction. If the above two paradigms are unified into the universal identity management where identity information and privileges are delegatable, user centricity will be more feasible in SOA. The credential-focused system is a good starting point for constructing a universal identity management system. However, how to implement a practical delegation scheme is still a challenge although there are some delegatable anonymous credential schemes that were theoretically constructed. This paper aims to propose a practical delegation solution for universal identity management. For this, a pseudonym-based signature scheme is first designed where pseudonyms are self-generated and unlinkable for realizing user's privacy. Next, a proxy signature is presented with the pseudonyms as public keys where delegation can be achieved through certificate chains. Finally, the security of our scheme is analyzed and proved in the random oracle model.