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Now showing items 17 - 32 of 58

  • Spectroscopic studies on binding of 1-phenyl-3-(coumarin-6-yl)sulfonylurea to bovine serum albumin

    Xiao-Hui Liu   Pin-Xian Xi   Feng-Juan Chen   Zhi-Hong Xu   Zheng-Zhi Zeng  

    The interaction of 1-phenyl-3-(coumarin-6-yl)sulfonylurea (SU22) with bovine serum albumin (BSA) has been investigated by fluorescence quenching spectroscopy combined with UV-absorption, circular dichroism (CD), Fourier transform infrared (FT-IR) spectroscopy techniques under simulative physiological conditions for the first time. Fluorescence data and UV-absorption spectra revealed that the quenching mechanism of fluorescence of BSA by SU22 was a static quenching process and the number of binding sites was about 0.8858; the thermodynamic parameters (ΔG = −29.23 kJ mol−1, ΔH = −47.48 kJ mol−1, and ΔS = −61.24 J mol−1 K−1) explained that hydrogen bond and Van der Waals interaction were the main binding force stabilizing the complex. The binding average distance between SU22 and BSA was obtained (3.20 nm) on the basis of the Förster’s theory. In addition, The CD spectra and FT-IR spectra have proved that BSA secondary structure changed in the presence of SU22 in aqueous solution.
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  • Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same

    The present invention relates to pharmaceutical formulations comprising the protein kinase inhibitor, MP470, and methods of using same in treating conditions involving undesirable cell proliferation, such as cancer.
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  • Characterization of 0.7Bi(Fe0.9Cr0.1)O3–0.2PbTiO3–0.1BaTiO3 Multiferroic Ceramics Derived from Sol–Gel

    Xiao-Hui Liu   Zhuo Xu   Xiao-Yong Wei   Xi Yao  

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  • Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase

    Xiao-hui Liu   Glenn D. Prestwich  

    Didehydrofarnesyl diphosphate (DELTADELTAFPP), a fluorescent pentaene analogue of farnesyl diphosphate (FPP), was synthesized using stereoselective Wittig reactions. Although DELTADELTAFPP was not an alternative substrate for yeast protein farnesyltransferase (FTase), the fluorescent analogue was a potent competitive inhibitor with a Ki value of 8.8 muM (Km (FPP) = 27 muM). Copyright 2004 Elsevier Ltd. All rights reserved.
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  • Ferroelectric and Ferromagnetic Properties of 0.7BiFe1?xCrxO3–0.3BaTiO3 Solid Solutions

    Xiao-Hui Liu   Zhuo Xu   Xiao-Yong Wei   Xi Yao  

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  • Homocysteine is Associated with Exaggerated Morning Blood Pressure Surge in Patients with Acute Ischemic Stroke

    Jun-Chao Xie   Ying-Ying Lin   Xiao-Hui Liu   Yi-Chen Zhao   Xiao-Ye Ma   Jia Yu   Xue-Yuan Liu   Yan-Xin Zhao  

    Abstract Background Considerable researches suggest that high level of homocysteine (Hcy) is associated with the risk of ischemic stroke. Ambulatory blood pressure monitoring (ABPM) parameters have also been confirmed associated with cardio-cerebrovascular events. However, the relationship between Hcy and ABPM parameters remains unclear in patients with acute ischemic stroke. In this study, we aim to investigate the association between Hcy level and ABPM parameters in patients with acute ischemic stroke. Methods We enrolled 60 patients with acute ischemic stroke who received ABPM. We calculated ABPM parameters like morning blood pressure surge (MBPS), ambulatory arterial stiffness index, blood pressure variability, and night dipping patterns. Results Multivariate logistic regression analysis indicated that patients in the top quartile of Hcy level tended to have a higher level of prewaking and sleep-trough MBPS compared with patients in the lower 3 quartiles after adjusted for age and gender ( P  = .028 and P  = .030, respectively). When treating Hcy as a continuous variable, the linear regression showed the association between Hcy level and both MBPS parameters remained significant (prewaking MBPS, r = .356, P  = .022; sleep-trough MBPS, r = .365, P  = .017, respectively). However, there is no association between Hcy level and ambulatory arterial stiffness index, blood pressure variability or night dipping patterns ( P  = .635, P  = .348 and P  = .127 respectively). Conclusions There is a relationship between the 2 major cerebrovascular risk factors: MBPS and Hcy.
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  • Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors

    The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.
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  • The effects of Gekko sulfated glycopeptide and basic fibroblast growth factor on human fibrosarcoma HT1080 cells

    Xiao-Hui Liu   Cui-Hong Zhu   Xiong-Zhi Wu  

    Background:Fibrosarcoma is a malignant soft tissue tumor of mesenchymal origin.Gekko sulfated glycopeptide(GSPP),an anticancer drug in traditional Chinese medicine,could inhibited the tumor angiogenesis by targeting basic fibroblast growth factor(bFGF).bFGF promoted the proliferation of fibroblasts.Both fibrosarcoma and fibroblasts derived from fibrous connective tissue.This study investigated whether GSPP has the inhibitory effects on human fibrosarcoma HT1080 cells.Materials and methods:The trypan blue exclusion assay was used to determine cell viability and cell numbers.Cells migration was observed by wound-healing and transwell.Results:From the first day to seventh day,HT1080 cells number of GSPP,bFGF,GSPP combined bFGF groups had not change compared with control.HT1080 cells migration distance and the number of migrating cells of GSPP,bFGF,GSPP combined bFGF groups were not significantly reduced.Conclusions:GSPP did not have inhibitory effects on the proliferation and migration of human fibrosarcoma HT1080 cells.Thus further research should be carried out in order to study the mechanism of GSPP and bFGF acting on the tumor stroma.
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  • Ambient temperature copper-mediated living radical polymerization of acrylonitrile with Me6TREN as the reducing agent

    Yun-Hai Yu   Xiao-Hui Liu   Di Jia   Bo-Wen Cheng   Yuan-Lin Ren   Fei-Jun Zhang   Hui-Na Li   Peng Chen and Shan Xie  

    A universal high reactive ligand, Me6TREN, was successfully explored as the reducing agent for the ambient temperature copper-mediated LRP of AN. The key to success is ascribed to the optimized Me6TREN amount and reaction conditions employed, producing ideal living free radical polymerization characteristics. The very high chain-end functionality of the resultant polymer has been confirmed by GPC and 1H NMR analyses as well as the chain-extension reaction.
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  • Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors

    The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II):
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  • Copper-mediated initiators for continuous activator regeneration atom transfer radical polymerization of acrylonitrile

    Xiao-hui Liu   Jin Wang   Fei-jun Zhang   Shu-lin An   Yuan-lin Ren   Yun-hai Yu   Peng Chen   Shan Xie  

    Initiators for continuous activator regeneration atom transfer radical polymerization technique was first accessed to acrylonitrile by using CuBr 2/2,2'-bipyridine as the catalyst, ethyl 2-bromoisobutyrate as the halogen initiator, and azobis(isobutyronitrile) as the free radical initiator. The key to success is ascribed to the facile achievement of the rapid equilibrium between active species and dormant species. Effects of ligand, catalyst concentration, free radical initiator concentration, and reaction temperature on the polymerization reaction and molecular weight (MW) as well as polydispersity index (PDI) were investigated in detail. The polymerization proceeded in a controlled/living fashion even though the concentration of copper catalyst decreased to 50 ppm, which is evident in pseudo first-order kinetics of polymerization, linear increase of molecular weight, low PDI, and high chain-end functionality of the generated polymer. copy 2012 Wiley Periodicals, Inc.
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  • Copper-mediated initiators for continuous activator regeneration atom transfer radical polymerization of acrylonitrile

    Xiao-hui Liu   Jin Wang   Fei-jun Zhang   Shu-lin An   Yuan-lin Ren   Yun-hai Yu   Peng Chen and Shan Xie  

    Initiators for continuous activator regeneration atom transfer radical polymerization technique was first accessed to acrylonitrile by using CuBr2/2,2′-bipyridine as the catalyst, ethyl 2-bromoisobutyrate as the halogen initiator, and azobis(isobutyronitrile) as the free radical initiator. The key to success is ascribed to the facile achievement of the rapid equilibrium between active species and dormant species. Effects of ligand, catalyst concentration, free radical initiator concentration, and reaction temperature on the polymerization reaction and molecular weight (MW) as well as polydispersity index (PDI) were investigated in detail. The polymerization proceeded in a controlled/living fashion even though the concentration of copper catalyst decreased to 50 ppm, which is evident in pseudo first-order kinetics of polymerization, linear increase of molecular weight, low PDI, and high chain-end functionality of the generated polymer.
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  • Dibenzyl trithiocarbonate mediated reversible addition–fragmentation chain transfer polymerization of acrylonitrile

    Xiao-Hui Liu   Gui-Bao Zhang   Xian-Feng Lu   Jing-Yu Liu   Ding Pan   Yue-Sheng Li  

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  • In situ Cu(0)-mediated single electron transfer living radical polymerization of methyl methacrylate using nickel powder

    Xiao-Hui Liu   Yun-Hai Yu   Di Jia   Bo-Wen Cheng   Fei-Jun Zhang   Hui-Na Li   Peng Chen and Shan Xie  

    Single electron transfer living radical polymerization of methyl methacrylate catalyzed by the in situ prepared Cu(0) at ambient temperature was first examined using various metallic powders, including Zn(0), Ni(0), Mg(0), and Fe(0). Importantly, the polymerization initiated with Ni(0)/EBiB/CuBr2/PMDETA system exhibited optimal living/controlled nature and generated polymers with polydispersity index as low as 1.04 for 75.27% conversion and controlled molecular weights close to theoretical ones. A wide of range of Cu(II) salts were also investigated as catalyst sources instead of CuBr2. The recycling of Ni(0) was very convenient due to its magnetic property, which enables its extensive application.
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  • Ferroelectric and ferromagnetic properties of Mn-doped 0.7BiFeO3–0.3BaTiO3 solid solution

    Xiao-Hui Liu   Zhuo Xu   Shao-Bo Qu   Xiao-Yong Wei   Jiang-Li Chen  

    Binary solid solutions 0.7BiFeO3–0.3BaTiO3–x wt.%MnO2 (x = 0, 0.2, 0.3, and 0.5) were prepared by a traditional ceramic process. All ceramic samples show single perovskite phase. The effect of manganese doping on structure, dielectric, ferroelectric and ferromagnetic properties, and resistivity was investigated. Results show that Mn-dopant can improve the sintering ability of the materials when MnO2 content is below 0.3 wt.%. When MnO2 content exceeds 0.3 wt.%, the sintering ability is weakened and the phase structure of 0.7BiFeO3–0.3BaTiO3 solid solution changes from rhombohedral into tetragonal phase. With increasing concentration of MnO2, the resistivity increases at first and then decreases. Whereas the coercive electric field decreases at first and then increases, the remanent magnetization Mr increases and the coercive magnetic field decreases.
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  • Fast copper catalyzed living radical polymerization of acrylonitrile utilizing a high concentration of radical initiator

    Xiao-hui Liu   Jin Wang   Jian-shi Yang   Shu-lin An   Yuan-lin Ren   Yun-hai Yu   Peng Chen  

    This article first reports a fast and controlled living radical polymerization (LRP) of acrylonitrile, evidenced by 81.3% monomer conversion within 40 min and well-defined the polymers with a narrow polydispersity index (PDI) range of 1.14−1.38. This was achieved by utilizing azobis(isobutyronitrile) as radical initiator with a high concentration up to 190 mM and CuBr2 as catalyst with a very low concentration down to 50 ppm. The polymerization displayed typical LRP characteristics, including pseudo first-order kinetics of polymerization, the linear increase of number-average molecular weights (MWs), low PDI values. The influence of various experimental components, radical initiator concentration, catalyst concentration, and reaction temperature, on the polymerization reaction and MW as well as PDI has been investigated in detail. 1H NMR and gel permeation chromatography analyses as well as chain extension reaction confirmed the very high chain-end functionality of the resultant polymer.
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