Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 49 - 57 of 57

  • Data envelopment analysis based on maximin relative efficiency criterion

    Parkan, Celik   Wang, Jiamin   Wu, Desheng   Wei, Guiwu  

    While gauging the performances of operating entities using imprecise information on the input and output importance weights, an entity is considered Farrell efficient as long as it outperforms its peers for at least one feasible combination of the weights for inputs and outputs. This paper argues that Farrell efficiency computations are based on an optimistic perspective and a Farrell-efficient entity may perform rather poorly when weights corresponding to realistic considerations are assigned to inputs and outputs. An entity is defined as robust efficient if its relative efficiency score reaches 1 in all feasible combinations of the input and output weights. A linear programming based approach is proposed to perform what is referred to as robust efficiency analysis to identify robust efficient entities. In contrast to Farrell efficiency analysis, robust efficiency analysis involves the computation of the lowest efficiency score that can be assigned to an entity relative to the highest score among all the entities where an identical combination of weights for inputs and outputs is applied. The production possibility set underlying the proposed approach is also defined and interpreted. An experimental study illustrates that when compared with Farrell efficiency analysis robust efficiency analysis has sharper discrimination capability and the entity it identifies as efficient has superior average performance. (C) 2011 Elsevier Ltd. All rights reserved.
    Download Collect
  • An investigation of methyl tert=E2=80=91butyl ether=E2=80=91induced cytotoxicity and protein profile in Chinese hamster ovary cells.

    Xie, Guangshan   Hong, Wen-Xu   Zhou, Li   Yang, Xifei   Huang, Haiyan   Wu, Desheng   Huang, Xinfeng   Zhu, Weiguo   Liu, Jianjun  

    Methyl tert-butyl ether (MTBE) is widely used as an oxygenating agent in gasoline to reduce harmful emissions. However, previous studies have demonstrated that MTBE is a cytotoxic substance that has harmful effects invivo and invitro. Although remarkable progress has been made in elucidating the mechanisms underlying the MTBE=E2=80=91induced reproductive toxicological effect in different cell lines, the precise mechanisms remain far from understood. The present study aimed to evaluate whether mammalian ovary cells were sensitive to MTBE exposure invitro by assessing cell viability, lactate dehydrogenase (LDH) leakage, malondialdehyde (MDA) content and antioxidant enzyme activities. In addition, the effect of MTBE exposure on differential protein expression profiles was examined by two=E2=80=91dimensional electrophoresis and matrix=E2=80=91assisted laser desorption/ionization=E2=80=91time of flight mass spectrometry. MTBE exposure induced significant effects on cell viability, LDH leakage, plasma membrane damage and the activity of antioxidant enzymes. In the proteomic analysis, 24 proteins were demonstrated to be significantly affected by MTBE exposure. Functional analysis indicated that these proteins were involved in catalytic activity, binding, structural molecule activity, metabolic processes, cellular processes and localization, highlighting the fact that the cytotoxic mechanisms resulting from MTBE exposure are complex and diverse. The altered expression levels of two representative proteins, heat shock protein family A (Hsp70) members 8 and 9, were further confirmed by western blot analysis. The results revealed that MTBE exposure affects protein expression in Chinese hamster ovary cells and that oxidative stress and altered protein levels constitute the mechanisms underlying MTBE=E2=80=91induced cytotoxicity. These findings provided novel insights into the biochemical mechanisms involved in MTBE=E2=80=91induced cytotoxicity in the reproductive system.=20
    Download Collect
  • Emerging Issues in Multi-Channel Operations Management in the O2O Era

    Wu, Desheng   Choi, Tsan-Ming   Yue, Xiaohang  

    Download Collect
  • The Design and Research of Activity Instruction Based on LAMS

    Gao, Ming   Wu, Desheng   Wang, Lin   Zhao, Chengling  

    Guided by the theory of activity instruction and based on the instruction platform of LAMS; this paper studies the application of the theory of activity the learning in teaching practice and puts it into practice. Firstly; there is a brief introduction of LAMS and its characteristics and correlative applications; bringing up the principles of activity instruction and its correlative teaching strategy. In the instructional design dissertation for the public class of education technology; the students can study by themselves and get personal experience while combining the activity theory with LAMS; This performance reaches a good result. Therefore; the readers will be expected to develop the instructional design in the theory of activity instruction and enrich ideas and methods in teaching practice.
    Download Collect
  • A deep learning approach for credit scoring using credit default swaps

    Luo, Cuicui   Wu, Desheng   Wu, Dexiang  

    After 2007-2008 crisis, it is clear that corporate credit scoring is becoming a key role in credit risk management. In this paper, we investigate the performances of credit scoring models applied to CDS data sets. The classification performance of deep learning algorithm such as deep belief networks with Restricted Boltzmann Machines are evaluated and compared with some popular credit scoring models such as logistic regression, multi-layer perceptron and support vector machine. The performance is assessed using the classification accuracy and the area under the receiver operating characteristic curve. It is found that DBN yields the best performance. (C) 2016 Elsevier Ltd. All rights reserved.
    Download Collect
  • Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency

    Li, Xinhua   Liu, Xiaoming   Wang, Yiru   Cao, Fuming   Chen, Zhaoxiong   Hu, Zhouyang   Yu, Bin   Feng, Hang   Ba, Zhaoyu   Liu, Tao   Li, Haoxi   Jiang, Bei   Huang, Yufeng   Li, Lijun   Wu, Desheng  

    Download Collect
  • Simulation of fuzzy multiattribute models for grey relationships

    Olson, David L.   Wu, Desheng  

    Multiattribute decision making involves tradeoffs among alternative performances over multiple attributes. The accuracy of performance measures are usually assumed to be accurate. Most multiattribute models also assume given values for the relative importance of weights for attributes. However, there is usually some uncertainty involved in both of these model inputs. Outranking multiattribute methods have always provided fuzzy input for performance scores. Many analysts have also recognized that weight estimates also involve some imprecision, either through individual decision maker uncertainty, or through aggregation of diverging group member preferences. Many fuzzy multiattribute models have been proposed, but they have focused on identifying the expected value solution (or extreme solutions). This paper demonstrates how simulation can be used to reflect fuzzy inputs, which allows more complete probabilistic interpretation of model results. (c) 2005 Elsevier B.V. All rights reserved.
    Download Collect
  • Possible involvement of the oxLDL/LOX-1 system in the pathogenesis and progression of human intervertebral disc degeneration or herniation

    Li, Xinhua   Wang, Xuejun   Hu, Zhouyang   Chen, Zhaoxiong   Li, Haoxi   Liu, Xiaoming   Yong, Zhi Yao   Wang, Shanjing   Wei, Zhanying   Han, Yingchao   Tan, Jun   Li, Cong   He, Xiao Bo   Sun, Guixin   Wu, Desheng   Li, Lijun  

    Epidemiological studies have concluded that hyperlipidemia and atherosclerosis were related to intervertebral disc degeneration (IVDD). The presence of oxidized low density lipoprotein (ox-LDL) and the expression of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) have not been explored in this tissue. In this study, we investigated the presence of ox-LDL and the expression of its receptor LOX-1 in non-degenerated, degenerated or herniated human intervertebral discs (IVDs). The expression of LOX-1 and matrix metalloproteinase 3 (MMP3) were studied after incubating nucleus pulposus cells (NPCs) with ox-LDL. The presence of ox-LDL and LOX-1 was positively related with the extent of IVDD in nucleus pulposus (NP), end-plate cartilage and outer annulus fibrous, but not with the extent of degeneration of inter annulus fibrous. Ox-LDL significantly reduced the viability of human NPCs in a dose and time-dependent manner, and increased the expression of MMP3 induced by LOX-1. Pretreatment with anti-human LOX-1 monoclonal antibody reversed these effects. Ox-LDL, principally mediated by LOX-1, enhanced MMP3 production in NPCs through the NF-kappa B signaling pathway. In conclusion, increased accumulation of ox-LDL and LOX-1 in IVDs indicates a specific role of the receptor-ligand interaction in degeneration or herniation of IVDs.
    Download Collect
  • Finance-Operations Interface Mechanism and Models

    Wu, Desheng   Olson, David L.   Wang, Shouyang  

    Download Collect
1 2 3 4

Contact

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback