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    Disclosed are a binary translation execution method and apparatus for shared libraries. The binary translation execution method for shared libraries may comprise: when a first function in a second shared library is called, a host executes the first function to call a translation function in a first shared library; the host translates a second function, having the same function interface as that of the first function, in a third shared library by using the called translation function in the first shared library, so as to obtain a third function supported by the host, a function interface of the third function being the same as the function interface of the second function; and the host executes the third function. The solution provided in embodiments of the present invention helps to reduce the amount of relevant code translation in shared library translation, and thus increases execution efficiency of binary translation and improves user experience.
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  • Genetic diversity among mulberry genotypes from seven countries

    Wang, Zhenjiang   Zhang, Yufei   Dai, Fanwei   Luo, Guoqing   Xiao, Gengsheng   Tang, Cuiming  

    Mulberry (Morus alba) is an economically and ecologically important, widespread woody plant. It has served human beings for over hundreds of years, and it is still widely used in pharmaceuticals, food industry and farming nowadays. Using modern techniques, deeper understanding in classification and conservation resources of mulberry leads to higher-efficiency hybrids among populations. Genetic polymorphisms among 42 mulberry genotypes from seven countries over Asia and South America were detected using 17 inter simple sequence repeat (ISSR) primers. A dendrogram was constructed using the similarity matrix among genotypes and a principal component analysis (PCA) was carried out to further identify and cluster the mulberry genotypes. In the 42 genotypes, 175 distinct bands were displayed, among which 169 were polymorphic bands (96.57%). The polymorphic information content of 17 ISSR primers ranged from 0.2921 to 0.3746 with the mean of 0.3494. And Nei's index and Shanon's information index averaged 0.116 and 0.174, respectively, indicating low diversity of mulberry. For further study, cluster analysis and PCA were carried out and the results were similar. 42 genotypes were grouped, showing some hybridized combinations. Additionally, a connection between mulberry diseases and their genotypes was noted, which indicates possible application for ISSR in studying disease resistance of mulberry.
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  • Genetic diversity among mulberry genotypes from seven countries

    Wang, Zhenjiang   Zhang, Yufei   Dai, Fanwei   Luo, Guoqing   Xiao, Gengsheng   Tang, Cuiming  

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  • On-the-fly structure splitting for heap objects

    Wang, Zhenjiang   Wu, Chenggang   Yew, Pen-Chung   Li, Jianjun   Xu, Di  

    With the advent of multicore systems, the gap between processor speed and memory latency has grown worse because of their complex interconnect. Sophisticated techniques are needed more than ever to improve an application's spatial and temporal locality. This paper describes an optimization that aims to improve heap data layout by structure-splitting. It also provides runtime address checking by piggybacking on the existing page protection mechanism to guarantee the correctness of such optimization that has eluded many previous attempts due to safety concerns. The technique can be applied to both sequential and parallel programs at either compile time or runtime. However, we focus primarily on sequential programs (i.e., single-threaded programs) at runtime in this paper. Experimental results show that some benchmarks in SPEC 2000 and 2006 can achieve a speedup of up to 142.8%.
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  • Transcriptional analysis of different mulberry cultivars in response to Ralstonia solanacearum

    Dai, Fanwei   Wang, Zhenjiang   Luo, Guoqing   Tang, Cuiming  

    Bacterial wilt caused by Ralstonia solanacearum is a major disease of the mulberry (Morus atropurpurea Roxb.), resulting in severe yield and quality losses. However, little is known about the molecular mechanisms of resistance. Using the RNA sequencing technique, we identified early transcriptional changes in resistant (KQ10 and YS283) and susceptible (YSD10) mulberry cultivars in response to R. solanacearum infection. We observed that 798 genes were differentially and specifically regulated in both resistant cultivars but not in the susceptible cultivar after infection with R. solanacearum, including 502 upregulated and 296 downregulated genes. Among the differentially expressed genes, 31 encode transcription factors and 48 encode protein kinases. Interestingly, we found that a large number of genes (61) associated with cell-wall modification were differentially and specifically regulated in the resistant cultivars. These genes could be divided into 10 major groups. The largest group is the glucosyltransferase family, followed by the pectinesterase inhibitor, glucanase, and glycoprotein families, suggesting that cell-wall modifications may play an important role in resistance levels in mulberry. This transcriptional analysis paves the way for elucidating the molecular mechanisms of the resistance response to R. solanacearum in mulberry.
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  • Phenotypic and Transcriptomic Analyses of Autotetraploid and Diploid Mulberry (Morus alba L.).

    Dai, Fanwei   Wang, Zhenjiang   Luo, Guoqing   Tang, Cuiming  

    Autopolyploid plants and their organs are often larger than their diploid counterparts, which makes them attractive to plant breeders. Mulberry (Morus alba L.) is an important commercial woody plant in many tropical and subtropical areas. In this study, we obtained a series of autotetraploid mulberry plants resulting from a colchicine treatment. To evaluate the effects of genome duplications in mulberry, we compared the phenotypes and transcriptomes of autotetraploid and diploid mulberry trees. In the autotetraploids, the height, breast-height diameter, leaf size, and fruit size were larger than those of diploids. Transcriptome data revealed that of 21,229 expressed genes only 609 (2.87%) were differentially expressed between diploids and autotetraploids. Among them, 30 genes were associated with the biosynthesis and signal transduction of plant hormones, including cytokinin, gibberellins, ethylene, and auxin. In addition, 41 differentially expressed genes were involved in photosynthesis. These results enhance our understanding of the variations that occur in mulberry autotetraploids and will benefit future breeding work. =20
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  • Identification and validation of reference genes for qRT-PCR analysis in mulberry (Morus alba L.).

    Dai, Fanwei   Zhao, Xiting   Tang, Cuiming   Wang, Zhenjiang   Kuang, Zheshi   Li, Zhiyi   Huang, Jing   Luo, Guoqing  

    Mulberry (Morus alba L.) is an important economic tree species in many countries. Quantitative real time PCR (qRT-PCR) has become a widely used method for gene expression studies in plants. A suitable reference gene is essential to ensure accurate and reliable results for qRT-PCR analyses. However, no reports describing the selection of reference genes have been published for mulberry. In this work, we evaluated the stability of twenty candidate reference genes in different plant tissues and under different stress conditions by qRT-PCR in mulberry using algorithms in two programs-geNorm and NormFinder. The results revealed that TUB2, UBI4, ACTIN3 and RPL4 were ranked as the most stable reference genes in the samples subsets, whereas EF1alpha4 and TUB3showed the least stability with both algorithms. To further validate the stability of the reference genes, the expression patterns of six genes of mulberry were analyzed by normalization with the selected reference genes. Our study will benefit future analyses of gene expression in mulberry.=20
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  • Transcriptomic and proteomic analyses of mulberry (Morus atropurpurea) fruit response to Ciboria carunculoides

    Dai, Fanwei   Wang, Zhenjiang   Li, Zhiyi   Luo, Guoqing   Wang, Yi   Tang, Cuiming  

    The aim of this work was to gain insights into the molecular mechanisms and dynamics of the mulberry (Morus atropurpurea) fruit response to Ciboria carunculoides infection. A transcriptomic and proteomic study was carried out based on RNA sequencing and isobaric tags for relative and absolute quantification analysis, respectively. These data were then validated using quantitative real-time PCR and multiple reaction monitoring assays. Comparative analyses revealed that 9.0% of the transcriptome and 20.8% of the proteome were differentially regulated after C. carunculoides infection at the early stage (stage 1) and middle stage (stage 2), but correlation analysis revealed that only 145 genes were differentially regulated at both the transcriptome and proteome levels. The combined transcriptome and proteome analysis showed that plant hormone signal transduction, calcium-mediated defense signaling, transcription factors, and secondary metabolites were stimulated, whereas photosynthesis and cellular growth related metabolism were suppressed after C. carunculoides infection. These finding provide theoretical foundation for disease resistance breeding of C. carunculoides. Biological significance: Ciboria carunculoides is a major fungal pathogen that infects mulberry fruit, leading to extensive damage and productivity loss. Despite this major impact, the mulberry fruit response to C. carunculoides infection has yet to be characterized. This study provides the first system-wide datasets with which to examine changes in the transcriptome and proteome after C. carunculoides infection in mulberry fruit. The results showed that plant hormone signal transduction, calcium-mediated defense signaling, and other pathways were stimulated, whereas photosynthesis and cellular growth related metabolism were suppressed by C. carunculoides. These results will lead to a better understanding of the molecular mechanisms triggered in mulberry fruit in response to C. carunculoides infection and will provide new molecular targets for regulating defense responses to fungal pathogens in berry fruits.
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  • Impact of Evidence-Based Stroke Care on Patient Outcomes:A Multilevel Analysis of an International Study

    Venturelli, Paula Munoz   Li, Xian   Middleton, Sandy   Watkins, Caroline   Lavados, Pablo M.   Olavarria, Veronica V.   Brunser, Alejandro   Pontes-Neto, Octavio   Santos, Taiza E. G.   Arima, Hisatomi   Billot, Laurent   Hackett, Maree L.   Song, Lily   Robinson, Thompson   Anderson, Craig S.   Mead, Gillian   Hackett, Maree   Anderson, Craig S.   Billot, Laurent   Lavados, Pablo M.   Middleton, Sandy   Watkins, Caroline L.   Robinson, Thompson G.   Arima, Hisatomi   De Silva, H. Asita   Pandian, Jeyaraj D.   Lin, Ruey-Tay   Lee, Tsong-Hai   Cui, Liying   Peng, Bin   Pontes-Neto, Octavio M.   Heritier, Stephane   Lindley, Richard   Jan, Stephen   Boaden, Elizabeth   Brunser, Alejandro   Herbert, Robert   Chen, Christopher P. L. H.   Forster, Anne   Billot, Laurent   Woodward, Mark   Rogers, Kris   Scaria, Anish   Lim, Joyce Y.   Espinosa, Natalie   McEvoy, Lucy   Blackburn, Lee   Richtering, Sarah S.   You, Shoujiang   Ladwig, Simon   Merritt, Gabrielle P.   Thomsen, Bryce   Jenson, Kerry   Gordon, Penelope   Nguyen, Dennis Ryan   Quan, Wei Wei   Lo, Tessa Pei-Yi   Lim, Jonathan   Goh, Selena   Ivanova, Elizaveta   Liu, Leibo   Ahmad, Mirza   Singh, Ravider   Donnelly, Paul   Armenis, Manuela   Van Zyl, Marna   Monaghan, Helen   Smith, Phillipa   Glass., Parisa   Zhou, Fanli   Shen, Yun   Lei, Li   Li, Di   Zhang, Ting   Song, Lili   Zhang, Xiaoyan   Peng, Yun   Feng, Lingling   Ye, Zhiping   Gregory., Philip   Pandain, Jeyaraj D.   Arora, Deepti   Lavados, Pablo M.   Munoz-Venturelli, Paula   Gonzalez, Francisca   Portales, Bernardita   Pontes-Neto, Octavio   Santos-Pontelli, Taiza   Rimoli, Brunna   Braga, Monica   Hoffmeister, Lorena   Vidal, Carolina   Benadof, Dafna   Rivas, Rodrigo J.   Carvallo, Laura   Carvallo, Pamela   Miranda, Rubia   Pileggi., Brunna   de Silva, H. Asita   Weerawardena, Shalomi   Jeevarajah, Thanushanthan   Dharmawardena, Devaki   Ranasinghe, Dumindi   Dharshana, Matheesha   Shafras, M. M. M.   Nandadeva, Nilesh   Nawarathna, Savithri   Lin, Ruey-Tay   Lee, Tsong-Hai   Yin, Jiu-Haw   Yeh, Shoou-Jeng   Ma, Ruei-Jen   Watkins, Caroline L.   Whiteley, Gemma   Forshaw, Denise   Lightbody, Catherine Elizabeth   Cox, Joanna   Fitzgerald, Jane   Heney, John F.   Byfield, Helen   Finley, Simone   Tyrer, Hayley E.   Bruce, Carole   Gibbon, Alison   Jones, Brett   Siracusa, Emma   Gowda, Koushik   Cowans, Shahla   Forman, Briana   Jacob, Sherin   Caprecho, Kristine   Khatri, Roshan   Wan, Po Yi   Lopez, Maria   Vanika, Sifiso   Bleeker, Wilhelmina   Ireland, Marinka   Jala, Sheila   Day, Susan   Ha, Eric   Krause, Martin   Passer, Melissa   Giaccari, Sarah   Burkolter, Nadia   Braithwaite, Michael   Tastula, Kylie   Ghia, Darshan   Musuka, Tapuwa   Alvaro, Anthony   Edmonds, Gillian   O'Loughin, Nicole   Phair, Rebecca   Kaoutal, Joanne   Blacker, David J.   Saint, Belinda L.   Parrey, Kim   Coad, Michelle   Kinchington, Matthew   Senanayake, Nishantha   Alabban, Johanna   Kuehne, Irma   Santos-Pontelli, Taiza   Braga, Monica   Rimoli, Brunna   Camilo, Millene   Libardi, Milena   Martins, Sheila   Carlos, Batista   Martins, Magda   Carbonera, Leonardo   Almeida, Andrea   Kelin, Martin   Kelin, Martin   Martins, Gladys   Pauli, Carla   Lunardi, Mariana   Silveira, Luciane   Chagas, Olga   Souza, Daily   Bazan, Rodrigo   Braga, Gabriel   Ribeiro, Priscila   Luvizutto, Gustavo   Polin, Marcia   Winckler, Fernanda   Liu, Jinfeng   Wang, Zhenjiang   Wang, Huibing   Lin, Suying   Dong, Jing   Zhou, Junshan   Qin, Suping   Zhan, Hui   Xue, Yongquan   Tian, Dong   Yang, Dan   Yin, Yan   Li, He   Geng, Changming   Liu, Jieyi   Jiang, Xiaolin   Wu, Yujun   Sun, Wei   Yu, Bingqi   Guan, Yanmei   Wang, Qin   Wei, Bo   Wang, Huirong   Wang, Yan   Tai, Liwen   Zhang, Wenchao   Zhao, Weili   Wang, Xueying   Li, Guoli   Ni, Zhiming   Guo, Fudong   Cen, Lan   Lu, Jun   Chen, Zheng   Yin, Guoming   Wang, Yingchun   Zheng, Jiping   Zhou, Zhimin   Wang, Hongquan   Zou, Renlin   Xue, Bin   Li, Airu   Guo, Jing   Guo, Ying   Jiang, Xingguo   Tan, Xiuge   Zhang, Chunpeng   Shao, Bei   Niu, Xiaoting   Liu, Chunfeng   Chen, Dongqin   Liang, Ping   Zhang, Xia   Zhang, Chunqing   Gong, Wenjie   Huang, Zhichao   Liu, Huihui   You, Shoujiang   Huang, Junying   Shi, Rongfang   Wang, Cuilan   Liu, Ying   Wang, Jinchao   Wu, Guojun   Gao, Zhihong   Lin, Qunli   Xu, Cong   Zheng, Huile   Ye, Xinghai   Jin, Xiaoqiong   Liu, Junyan   Cao, Xiaoyun   Zhang, Yan   Wang, Jinyang   Xu, Yuzhu   Li, Yan   Ma, Xin   Kong, Qi   Hao, Yanlei   Qiao, Baojun   Yan, Hui   Huang, Zhiyong   Chang, Baoqiang   Yan, Jinjin   Liao, Pinjun   Zhang, Wei   Liu, Ling   Zhu, Tingting   Liu, Xuehui   Li, Yongping   Dong, Ruifang   Chen, Miao   Ge, Xiaoli   Wang, Hairong   Dai, Lihua   Liu, Jiafu   Wang, Shixia   Du, Jihui   Song, Aixiu   Li, Yunhai   Feng, Jie   Yu, Cheng   Feng, Honglin   Sun, Xiaojia   Sun, Ruihong   Liu, Weisong   Liu, Jianfeng   Lu, Xuesheng   Chen, Enzhuo   Gao, Wei   Liu, Hui   Wang, Heping   Wang, Yanxia   Song, Juan   Liu, Dongqi   Du, Wenhui   Li, Guixia   Li, Cuiling   Liang, Yanling   Cai, Xuekun   Zhang, Jinli   Tao, Xiaowei   An, Pingshun   Tang, Ranran   Qin, Xu   Wang, Yingling   Zhang, Wenjun   Ma, Rong   Huang, Xiaoqiong   Liu, Yonglin   Wang, Yazhi   Fan, Ping   Yang, Hailan   Feng, Lianyuan   Zhi, Jianxia   Xin, XiangYa   Zhang, Jiewen   Wu, Danhong   He, Haiyan   Chen, Xiaohong   Hou, Yongge   Su, Xiaohui   Cui, Liying   Peng, Bin   Fan, Siyuan   Suarez, Luis   Sotomayor, Patricio   Urzua, Ricardo   Conejan, Nathalie   Escobar, Arturo   Gonzalez, Monica   Vargas, Danisa   Constante, Angel   Godoy, Elizabeth   Figueroa, Christian   Martin, Vanesa San   Vidal, Nataly   Munoz, Madeleyn   Brunser, Alejandro   Almeida, Juan   Acosta, Ignacio   Guerrero, Rodrigo   Lozano, Prudencio   Aguayo, Camila   Pizarro, Jimena   Soto, Alvaro   Bonilla, Flor   Del Castillo, Carolina   Grandjean, Marcela   Von Johnn, Alexis   Gutierrez, Ignacio   Rivero, Francisca   Kate, Mahesh   Akhtar, Naushad   Narang, Gibbsdeep S.   Deepak, Ashish   Huded, Vikram   De Sowza, Romnesh   Sigamani, Alben   Rajendran, Karthikeyan   Vishwanath, Anisha   Kumaravelu, Somasundaram   Rahamath, Syed   Kannneganti, Sandeep   Khurana, Dheeraj   Katoch, Cheena   Kaur, Taranpreet   Karadan, Ummer   Kuriakose, Anu   John, Jaison   Basheer, Mumthaz   Padmavathy, Sylaja   Sreedharan., Sapna Erat   Gunasekara, Harsha Hemal   De Silva, Gamlath Chandima Udeni   Ubeywickrama, Peetagam Harshi Lakmali   Silva, Kavisha Chathumali   De Silva, Eshani Anuradha   Ranawaka, Udaya   Mettananda, Chamila   Nanayakkara, Yamuna   Mendis, Tharini   Fernando, Gayathri   Imthikab, Ahamed   Pieris, Kandula   Gunatilake, Saman B.   Madanayake, Pamuditha M. W.   Paranavitane, Shiran A.   Senanayake, Bimsara   Vishwanathan, Vaidhehi   Sivapalan, Maathury   Murage, Ruwangi U.   Chandradeva., Uthpala   Lin, Ruey-Tay   Liu, Yao-Hua   Lin, Chih-Lung   Lin, Hsiu-Fen   Liu, Kuan-Ting   Chen, Chien-Fu   Wu, Meng-Ni   Tsai, Su-Hua   Chen, Chi-Ching   Chen, Lan-Yi   Lee, Tsong-Hai   Chang, Chien-Hung   Chang, Yeu-Jhy   Huang, Kuo-Lun   Chang, Ting-Yu   Liu, Chi-Hung   Seak, Chen-June   Lin, Yu-Li   Luo, Jia-Yi   Yang, Hsiao-Ying   Wang, Ching-Yi   Chan, Lung   Hu, Chaur-Jong   Chi, Nai-Fang   Wu, Dean   Yao   Kuan, Yi-Chun   Hong, Chien-Tai   Chen, Yi-Chun   Sun, Yu   Lin, Cheng-Huai   Lu, Chien-Jung   Chu, Hai-Jui   Lo, Yi-Chia   Chang, Wen-Hui   Lin, Wan-Jung   Lin, Tien-Yu   Cho, Chi-Hsuan   Lu, Shu-Lan   Hsueh, Ya-Fang   Lai, Ching-Yi   Jarrett, David   James, Claire   Valentine, Stacey   Whistler, Clare   Butler, Rebecca   Browning, Simone   Watchurst, Caroline   Erande, Renuka   Elliott, Emma   Patel, Krishna   Brezitski, Maria   Hogan, Caroline   Banaras, Asra   Crook, Lucinda   Ahmed, Rashidat   Potter, Lindsay   Laird, Rosie   Clarke, Natasha   Loosemore, Alison   Godber, J.   Gawned, Sara   Hamilton, K. A.   Jones, Rachael   Guyler, Paul   Tysoe, Sharon   Prabakaran, Raji   Shah, Sweni   Calver, Joanne   Sztriha, Laszlo K.   Fitzpatrick, Maria   Drysdale, Stephanie   McKenzie, Emma   Chitando, Belinda   Willcoxson, Paul   Iveson, Elizabeth   Wanklyn, Peter   Dyer, Natasha   Keeling, Michael   Rodriguez, Romina   Elliott, Kerry   Porteous, Mia   O'Neill, Mark   Orme, Sheridan   Richardson, Carla   Tomlinson, Janet   Hawkins, Suzanne   Bester, Delia   Jeffs, Carol   Howard, Joanne   Brown, Pauline   Ward, Deborah   Turfrey, Jennifer   Raybould, Leanne   Bates, Allison   O'Connell, Sue   O'Connor, Margaret   Williams, Samantha   Emsley, Hedley C. A.   McLoughlin, Alison   Raj, Sonia   Gregary, Bindu   Doyle, Donna   Courtauld, G. M.   Schofield, C.   Lucas, L.   Lydon, A.   James, A.   Saastamoinen, Kari   Howaniec, Laura   Daboo, Premchand   Ali, N. Ali   Richards, Emma   Howe, Joanne   Kamara, Christine   Stocks, Kathy   Lindert, Ralf   Day, Diana J.   Finlay, Sarah   Mcgee, Joanne   Mitchell, Jennifer   Amis, Elaine   Macey, Rosemary   Tauro, Suzanne   Henry, Lauren   Cuddy, Sarah   Steele, Andrew   Mullen, Kerry   Kirker, Sarah   Bhattad, Murudappa   Carpenter, Michael   Datta, Prabal   Needle, Ann   Jackson, Linda   Ball, Julie   Beckitt, Rosie   Chivers, Nicola   Bowring, Angela   Eddy, Sara   Thorpe, Kevin   Keenan, Samantha   Griffin, Alison   Maguire, Stuart   Patterson, Chris   Ramadan, Hawraman   Bellfield, Ruth   Hooley, Michaela   Stewart, Kelvin   Williams, Lucy   Gurney, Cara   Oliver, Deborah   Gardiner, Maria   Grayland, Sarah   Bhandari, Mohit   Collas, David M.   Adesina, Tolu   Sundayi, Saul   Harvey, Ruth   Pope, Emma   Lam, Audrey   Walker, Elaine   Merrill, Colin   Banerjee, Soma   Harvey, Kirsten Hannah   Mashate, Sheila   Wilding, Peter   Johnson, Linda   Namushi, Robert   Jacob, Patricia   Andole, Sreeman   Dunne, Karen   Gadapa, Naveen   King, Sam   Siliuzaite, Sonata   Dealing, Sharon   Attwood, Karen   Sanmuganathan, Samuel   Woods, Annette   Sandhu, Banher   Mamun, Maam   Mahmood, Afzal   Jones, June   Ojo, Abimbola   Carter-Evans, Denise   Fitzsimmons, Paul   Manoj, Aravind   Fletcher, Glyn   Lopez, Paula   Rana, Pretap Singh   Greig, Jill   Robinson, Matthew   Jones, Phil   Jones, Sarah   Jones, Lorinda   West, Claire   Tench, Helen   Potter, Sue   Gascoyne, Rachel   Whileman, Amanda   Hall, Emily   Wright, Stephanie   Toms, Julie   Tomlinson, Janet   Sekaran, Lakshmanan   Phiri, Duke   Sethuraman, Sakthivel   Mohammed, Niaz   Justin, Frances   Tate, Margaret Louise   Chauhan, Meena   Chatterjee, Kausik   Haider, Syed I.   Nallasivan, Arumugam   Webster, Tim   Leason, Sandra   Seagrave, Samantha   Owksu-Agyei, Peter   Temple, Natalie   Butterworth-Cowin, Nicola   Magezi, Frederick   Turner, Eleanor   Khan, Shagufta   Stephens, Claire   Mistri, Amit   Murphy, Aidan   Lam, Manda   Underwood, Paul   Thompson, Catherine   Smith, Caroline   Buckley, Clare   Wood, Diane   Board, Sarah   Howard, Linda   Johnson, Sharon   Ahmed, Ashraf   Oates, Bethany   Jenkinson, Damian F.   Leonard, Sara   Jupp, Becky J.   Thavanesan, Kamy   Dharmasiri, Michelle   Logianathan, Sathyabama   Ovington, Catherine   Hann, Gail   Cox, Chantel   McCormick, Michael T.   Douglas, Catherine   Goggin, Michael   Fearon, Patricia   Gilpin, Sara   O'Hagan, Margaret   Mangion, David M.   Hardwick, Anne   Netherton, Kimberley   Ni, H.   Quinn, Judith   Bozkaplan, Tulu   Jose, Josin  

    Background-The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence-based processes of care for acute ischemic stroke (AIS) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up, head positioning in acute stroke. Methods and Results-Use of 8 AIS processes of care were considered: reperfusion therapy in eligible patients; acute stroke unit care; antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation; dysphagia assessment; and physiotherapist review. Hierarchical, mixed, logistic regression models were performed to determine associations with good outcome (modified Rankin Scale scores 0-2) at 90 days, adjusted for patient and hospital variables. Among 9485 patients with AIS, implementation of all processes of care in eligible patients, or "defect-free" care, was associated with improved outcome (odds ratio, 1.40; 95% CI, 1.18-1.65) and better survival (odds ratio, 2.23; 95% CI, 1.62-3.09). Defect-free stroke care was also significantly associated with excellent outcome (modified Rankin Scale score 0-1) (odds ratio, 1.22; 95% CI, 1.04-1.43). No hospital characteristic was independently predictive of outcome. Only 1445 (15%) of eligible patients with AIS received all processes of care, with significant regional variations in overall and individual rates. Conclusions-Use of evidence-based care is associated with improved clinical outcome in AIS. Strategies are required to address regional variation in the use of proven AIS treatments.
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  • Phenolic profiles and antioxidant capacities of mulberry (Morus atropurpurea Roxb.) juices from different cultivars

    Wang, Zhenjiang   Lin, Yimin   Li, Tingting   Dai, Fanwei   Luo, Guoqing   Xiao, Gengsheng   Tang, Cuiming  

    Two hundred and seventy six mulberry juice samples were analyzed by high-performance liquid chromatography with diode-array detection quadrupole time-of-flight tandem mass spectrometry to identify the major polyphenols in the representative mulberry fruit cultivar Da10. Using FRAP, ABTS, and DPPH assays, total phenolic contents and antioxidant capacities of 276 mulberry juice samples from four provinces in China were found to be within the following ranges: 412.55-1471.86 mg/L gallic acid equivalent, 37.90-361.75 mmol/mL ferrous sulfate equivalent, 46.12-342.13 mmol/mL Trolox equivalent, and 7.30-216.41 mmol/mL ascorbic acid equivalent. Cluster analysis separated the cultivars into two groups. One group consisted of samples from Guangdong, Guangxi, and Hainan Provinces, which had high phenolic contents and antioxidant capacities. The other group consisted of samples from Xinjiang Province, which had low phenolic contents and antioxidant capacities. Antioxidant activity and phenolic content were correlated. Flavonoids were the main polyphenols of "Da10". In addition to free phenolic compounds, various bound phenolic compounds were identified. This work provides a large dataset characterizing different mulberry cultivars for deeper research. "45-7", "qianshan3" and "guoxuan04-129" were superior cultivars based on their high phenolic contents and antioxidant capacities. The results of this study support further research into mulberry use in human food and healthcare industries.
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  • The occurrences and geochemical characteristics of thorium in iron ore in the Bayan Obo deposit, Northern China

    Hou, Xiaozhi   Yang, Zhanfeng   Wang, Zhenjiang   Wang, Wencai  

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  • Dislocation Density-Based Modeling of Dynamic Recrystallized Microstructure and Process in Friction Stir Spot Welding of AA6082

    Gao, Zeng   Feng, Jianguang   Wang, Zhenjiang   Niu, Jitai   Sommitsch, Christof  

    This work mainly focuses on a series of microstructural analysis and predictions regarding dynamic recrystallization behavior, change in grain size, and dislocation density. Additionally, this study includes the shape prediction of the stir zone formed during friction stir spot welding. Microstructure analysis of the joint reveals that the mechanism of dynamic recrystallization in the stir zone is geometric dynamic recrystallization. A set of constitutive equations based on dislocation density is established and implemented in DEFORM-3D software to predict dynamic recrystallization during friction stir spot welding of AA6082. From the experimental and model predictions, it is observed that the original microstructure in the stir zone is completely replaced by a recrystallized fine grained microstructure. There is satisfactory agreement between the experimental grain size and the simulated results. In addition, the predicted shape of the stir zone fits quite well with the experimental shape as well.
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  • Expression of IL-17A, E, and F and their receptors in human prostatic cancer: Comparison with benign prostatic hyperplasia.

    Liu, Yanbo   Zhao, Xiaohui   Sun, Xuemei   Li, Yongmei   Wang, Zhenjiang   Jiang, Jing   Han, Huiming   Shen, Weigao   Corrigan, Chris J   Sun, Ying  

    BACKGROUND: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are the most common urological diseases in elderly men. Although studies suggest the cytokine family might be associated with BPH and PCa, there has been no systematic comparisons of expression of IL-17A, E, F and their receptors, infiltration of inflammatory cells, and changes in structural cells in PCa and BPH.; METHODS: Immunohistochemistry was employed to evaluate immunoreactivity for IL-17A, E, F and their receptors IL-17RA, IL-17BR, and IL-17CR, infiltration of inflammatory cells, and changes in structural cells including endothelial cells, fibroblasts, and smooth muscle cells in prostate tissues from subjects with PCa or BPH as well as controls.; RESULTS: Immunostaining showed that expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from BPH and PCa compared with that in controls, which was accompanied by increased numbers of infiltrating inflammatory cells and CD31(+) blood vessels. Compared with BPH, PCa was characterized by reduced immunoreactivity for IL-17BR and reduced numbers of CD68(+) macrophages, fibroblasts, and smooth muscle cells, although there was a trend for these changes to correlate with disease severity in both PCa and BPH.; CONCLUSION: Our data are compatible with hypothesis that IL-17A acting through IL-17RA, but not IL-17CR contribute to the pathogenesis of BPH and PCa. In contrast, IL-17E interacting with the IL-17BR might have an anti-tumor effect. =C2=A9 2015 Wiley Periodicals, Inc.
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  • Synthesis and properties of poly(p-phenylene vinylene) derivatives with hyperbranched structure and containing a nitro substituent

    Li, Ruyu   Mo, Yanjiao   Shi, Rong   Li, Peng   Li, Chengyu   Wang, Zhenjiang   Wang, Xun   Li, Shengbiao  

    In order to improve efficiency, processability, and stability, two groups of novel poly(p-phenylene vinylene) (PPV) derivatives (P-1-P-3 and P-4-P-6) with hyperbranched structure and containing a nitro substituent were synthesized via a Gilch reaction in different monomer ratios. The properties of the polymers were investigated by using UV-Vis absorption, fluorescence spectroscopy, cyclic voltammetry, and thermogravimetric analysis. The result shows that the band gaps of the PPV derivatives with a nitro substituent were decreased and the polymers had higher molecular weights (10(6)), excellent solubility in common organic solvents, good film-forming ability, and better thermal stability. The polymers can be used as an efficient acceptor material in polymeric solar cells.
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  • Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer:comparison with polyp and cystitis

    Liu, Yanbo   Yang, Wanguo   Zhao, Lijing   Liang, Zuowen   Shen, Weigao   Hou, Qinlong   Wang, Zhenjiang   Jiang, Jing   Ying, Sun  

    Background: Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign prostatic hyperplasia (BPH) and prostate cancer (Pca) while IL-17E interacting with IL-17RB might have an anti-tumor effect. Results: Using imunohistochemistry, we systemically compared immunoreactivity of ligands (IL-17A, E and F) and receptors (IL-17RA, IL-17RB and IL-17RC) of IL-17 family, infiltration of inflammatory cells and changes of structural cells (fibroblast cells, smooth muscle and vascular endothelial cells) in sections of bladder tissues from subjects with bladder cancer, cystitis and bladder polyp. Compared with subjects with cystitis, immunoreactivity for IL-17A, IL-17 F and IL-17RC was significantly elevated in the group of bladder cancer (p < 0.01), while immunoreactivity of IL-17E, IL-17RA and IL-17RB, and the infiltrating neutrophils were decreased (p < 0.05). The numbers of infiltrating lymphocytes and phagocytes and CD31(+) blood vessels and immunoreactivity of CD90(+) fibroblasts were also elevated in patients with bladder cancer compared with those of cystitis. The patterns of IL-17 ligands and receptors, and inflammatory cells and structural cells varied in cystitis, bladder polyp and bladder cancer. In bladder cancer, immunoreactivity of IL-17E and IL-17 F was positively correlated with smooth muscles and lymphocytes, respectively. In addition, immunoreactivity of IL-17A and IL-17E was positively correlated with their receptors IL-17RA and IL-17RB respectively. Conclusions: The data suggest that changed patterns of expression of the IL-17 cytokine family ligands and receptors might be associated with infiltration of inflammatory cells and structural cells (CD90(+) fibroblasts and CD31(+) blood vessels), which might also contribute to occurrence and development in bladder cancer.
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  • [IEEE 2017 13th IEEE Conference on Automation Science and Engineering (CASE 2017) - Xi\"an (2017.8.20-2017.8.23)] 2017 13th IEEE Conference on Automation Science and Engineering (CASE) - A study on attribute selection for job shop scheduling problem

    Wang, Zhenjiang   Cao, Zhengcai   Huang, Ran   Zhang, Jiaqi  

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