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Now showing items 65 - 80 of 94

  • The Two-Good-Neighbor Connectivity and Diagnosability of the Augmented Three-Ary n -Cubes

    Wang, Shiying   Zhao, Nan  

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  • Effects of HfB2 and HfN Additions on the Microstructures and Mechanical Properties of TiB2-Based Ceramic Tool Materials

    An, Jing   Song, Jinpeng   Liang, Guoxing   Gao, Jiaojiao   Xie, Juncai   Cao, Lei   Wang, Shiying   Lv, Ming  

    The effects of HfB2 and HfN additions on the microstructures and mechanical properties of TiB2-based ceramic tool materials were investigated. The results showed that the HfB2 additive not only can inhibit the TiB2 grain growth but can also change the morphology of some TiB2 grains from bigger polygons to smaller polygons or longer ovals that are advantageous for forming a relatively fine microstructure, and that the HfN additive had a tendency toward agglomeration. The improvement of flexural strength and Vickers hardness of the TiB2-HfB2 ceramics was due to the relatively fine microstructure; the decrease of fracture toughness was ascribed to the formation of a weaker grain boundary strength due to the brittle rim phase and the poor wettability between HfB2 and Ni. The decrease of the flexural strength and Vickers hardness of the TiB2-HfN ceramics was due to the increase of defects such as TiB2 coarse grains and HfN agglomeration; the enhancement of fracture toughness was mainly attributed to the decrease of the pore number and the increase of the rim phase and TiB2 coarse grains. The toughening mechanisms of TiB2-HfB2 ceramics mainly included crack bridging and transgranular fracture, while the toughening mechanisms of TiB2-HfN ceramics mainly included crack deflection, crack bridging, transgranular fracture, and the core-rim structure.
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  • Effect of HfN,HfC and HfB2 additives on phase transformation,microstructure and mechanical properties of ZrO2-based ceramics

    Song, Jinpeng   Cao, Lei   Jiang, Longkai   Liang, Guoxing   Gao, Jiaojiao   Li, Dongxu   Wang, Shiying   Lv, Ming  

    ZrO2-based ceramics were fabricated by the hot pressing sintering technology at 1550 degrees C. Effect of HfN, HfC and HfB2 additives on their phase transformation, microstructure and mechanical properties were investigated. The m-ZrO2 was not discovered in ZrO2-HfC ceramics but discovered in ZrO2-HfN and ZrO2-HfB2 ceramics, which indicated that HfC potentiated the effect of Y2O3 stabilizer on inhibiting phase transformation and that to some extend HEN and HfB2 undermined this effect. Meanwhile, HfC can inhibit the ZrO2 grain growth or amalgamation to form fine ZrO2 grains in ZrO2-HfC ceramics, whereas HfN and HfB2 probably induced the ZrO2 grain growth or amalgamation to form big ZrO2 grains in their ceramics. And the bonding strength between HfB2 and ZrO2 higher than the other two was approximately inferred from the observed grain boundary-interface dihedral angles between the ZrO2 grain and these particles (HfC, HfN and HfB2). Fracture model of these ceramics was the mixed inter/transgranular fracture model. When the additive content - HfN, HfC and HfB2 content - increased from 5 wt% to 15 wt%, the pinning effect of HfN particle in ZrO2-HfN ceramics as well as fine ZrO2 grains in ZrO2-HfC ceramics and the high bonding strength between the ZrO2 grain and HfB2 particle in ZrO2-HfB2 ceramics played a dominant role in improving the flexural strength and fracture toughness; meanwhile, the improved Vickers hardness of these ceramics was mainly attributed to the increase of hard additive content. However, when these additives content increased to 20 wt%, many big micro-voids in ZrO2-HfN and ZrO2-HfC ceramics and big ZrO2 grains in ZrO2-HfB2 ceramic produced negative effect on mechanical properties. In these ceramics, ZrO2-15 wt%HfB2 ceramic showed the optimum mechanical properties: flexural strength of 1093.06 +/- 24 MPa, fracture toughness of 8.17 +/- 0.18 MPa m(1/2) and Vickers hardness of 14.37 +/- 0.21 GPa.
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  • Stress-induced heat-shock protein synthesis in peripheral leukocytes of turkeys, Meleagris gallopavo

    Wang, Shiying   Edens, F. W.  

    1. Thermal stress, in vitro and in vivo, induced the synthesis of heat-shock proteins, HSP90, HSP70, and HSP23 in turkey leukocytes. 2. HSP induction was both temperature- and time-dependent. 3. Salinity-specific stress proteins were expressed with elevated osmolality in culture medium.
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  • Serum IFN-gamma Predicts the Therapeutic Effect of Mesenchymal Stem Cells Transplantation in Systemic Lupus Erythematosus Patients

    Wang, Dandan   Wang, Shiying   Huang, Saisai   Zhang, Zhuoya   Yuan, Xinran   Feng, Xuebing   Lu, Liwei  

    Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) show immunoregulatory properties on various immune cells and display therapeutic effects on various autoimmune diseases such as systemic lupus erythematosus (SLE). The aim of this study was to investigate the effect of the SLE environment on UC MSCs and to identify a potential serum biomarker to predict the therapeutic effect. UC MSCs were cocultured with peripheral blood mononuclear cells (PBMCs) from active lupus patients, and the proliferation, apoptosis and surface markers of UC MSCs were observed. UC MSC functional molecules were assessed by real-time polymerase chain reaction, and the signaling pathways were analyzed by Western blot. The clinical effect of MSC transplantation (MSCT) for lupus patients was followed-up, whereas baseline serum cytokines were analyzed by enzyme-linked immunosorbent assay. The coculture of PBMC f(r)om lupus patients promoted MSC proliferation. Lupus PBMCs were more potent in stimulating UC MSCs to secrete vascular endothelial growth factor (VEGF) and CXCL-12. Furthermore, lupus PBMCs activated Akt, I kappa B, and Stat5 signaling pathways in UC MSCs but did not affect Erk1/2 and Smad1/5/8 pathways. Moreover, our clinical study showed that higher baseline levels of IFN-gamma might predict a good response to MSCT in active lupus patients. Baseline IFN-gamma levels may predict clinical response to MSC therapy for active lupus patients, which will help to choose suitable patients for clinical transplantation.
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  • Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism

    Li, Yuanmin   Wang, Linlin   Dong, Zhihui   Wang, Shiying   Qi, Lili   Cho, Kenka   Zhang, Zhou   Li, Na   Hu, Yurong   Jiang, Baohong  

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  • Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K/Akt signaling pathway

    Jing, Xiaoping   Cheng, Weiwei   Wang, Shiying   Li, Pin   He, Li  

    Resveratrol is a polyphenolic compound that is extracted from Polygonum cuspidatum and is used in traditional Chinese medicine. Previous data have shown that resveratrol inhibits the growth of human gastric cancer. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and trypan blue assays showed that resveratrol significantly decreased the survival rate of MGC803 cells in a concentration- and time-dependentmanner. Our flow cytometric analysis showed that resveratrol treatment arrested the cells at the G0/G1 phase of the cell cycle. Furthermore, western blotting demonstrated that resveratrol decreased the protein expression of phospho-glycogen synthase kinase 3 beta (p-GSK3 beta), cyclin D1, phospho-phosphatase and tensin homologue (p-PTEN), phospho-phosphatidylinositol 3'-OH kinase (p-PI3K), and phospho-protein kinase B (p-PKB/Akt). We also found that resveratrol inhibited the progression of the cell cycle in MGC803 cells by repressing p-PI3K and p-Akt expression. Meanwhile, resveratrol did not decrease the phosphorylation level of Akt when the PTEN gene expression was knocked down by an siRNA in the MGC803 cells. Taken together, these results suggest that resveratrol induced cell cycle arrest in human gastric cancer MGC803 cells by regulating the PTEN/PI3K/Akt signaling pathway.
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  • Difference in pH value and nutrient and bacterial diversity in the Carya cathayensis forest soil under different management models

    Zhang, Mei   Lin, Mashui   Cao, Xiuxiu   Zhao, Shumin   Jiang, Daqing   Wang, Bingxuan   Wang, Shiying   Fan, Yandi   Guo, Ming  

    To optimize management of the Carya cathayensis forest through the diversity and function of soil bacteria, disease index, soil pH, and nutrient and soil bacterial diversity were investigated under ecological management and excessive management during the Botryosphaeria dothidea infected period using 16S rRNA gene high-throughput sequencing technology. The correlations between each interrelationship factors were also analyzed. Results showed that the disease index of the ecologically managed forest was 3.3 +/- 3.35, which was significantly lower than that of the excessively managed forest with 81.9 +/- 1.27. Moreover, ecological management significantly improved the ability of hickory forest resistant to B. dothidea. The soil pH value of the ecologically managed forest was near neutral with a reading of 6.64 +/- 0.06, which was significantly higher than that of excessively managed forest soil with 5.80 +/- 0.04. The contents of available phosphorus, available potassium, and available nitrogen in the excessively managed forest soil were 18.10 +/- 0.58 mg/kg, 698.63 +/- 11.24 mg/kg and 227.13 +/- 3.81 mg/kg, which were significantly higher than those in the ecologically managed forest respectively, with 14.94 +/- 0.27 mg/kg, 497.13 +/- 6.19 mg/kg and 195.28 +/- 6.01 mg/kg. There were 14 and 21 major bacterial genera found in the ecologically and excessively managed forest soil samples, respectively. In ecologically managed forest soils, the dominant genera were Sphingomonas, Gaiella and Lysobacter, and the relative abundance of these was significantly higher than excessively managed forest soils. Bryobacter, Candidatus Solibacter, and Bradyrhizobium were the dominant genera in the excessively managed forest soils, and their relative abundance was significantly higher than the ecologically managed forest soils. There was no significant difference of OTUs or Ace, Chao, Shannon and Simpson indices between ecologically and excessively managed forest soils. Redundancy analysis (RDA) and Monte Carlo testing showed that pH value, available phosphorous and available nitrogen had significant effects on the bacterial flora of the dominant bacterial species in the soil (P < 0.05). Our results can provide valuable references for the sustainable management of hickory forests.
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  • Studies on the interaction mechanism of 1,10-phenanthroline cobalt(II) complex with DNA and preparation of electrochemical DNA biosensor

    Niu, Shuyan   Li, Feng   Zhang, Shusheng   Wang, Long   Li, Xuemei   Wang, Shiying  

    Fluorescence spectroscopy and ultraviolet (UV) spectroscopy techniques coupled with cyclic voltammetry ( C) were used to study the interaction between salmon sperm DNA and 1,10-Phenanthroline cobalt(II) complex, [Co(phen)(2)(Cl)(H2O)] Cl center dot H2O, where phen = 1,10-phenanthroline. The interaction between [Co(phen)(2)(Cl)(H2O)](+) and doublestrand DNA (dsDNA) was identified to be intercalative mode. An electrochemical DNA biosensor was developed by covalent immobilization of probe single-strand DNA (ssDNA) related to human immunodeficiency virus(HIV) on the activated glassy carbon electrode (GCE). With [Co(phen)(2)(Cl)(H2O)](+) being the novel electrochemical hybridization indicator, the selectivity of ssDNA-modified electrode was investigated and selective detection of complementary ssDNA was achieved using differential pulse voltammetry (DPV).
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  • An increase in new Sargassum (Phaeophyceae) blooms along the coast of the East China Sea and Yellow Sea

    Zhang, Jianheng   Ding, Xiaowei   Zhuang, Minmin   Wang, Shiying   Chen, Li   Shen, Hui   He, Peimin  

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  • Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model How Little Can We See?

    Wang, Shiying   Herbst, Elizabeth B.   Mauldin, F. William, Jr.   Diakova, Galina B.   Klibanov, Alexander L.   Hossack, John A.  

    Objectives: The objective of this study was to evaluate the minimum microbubble dose for ultrasound molecular imaging to achieve statistically significant detection of angiogenesis in a mouse model. Materials and Methods: The preburst minus postburst method was implemented on a Verasonics ultrasound research scanner using a multiframe compounding pulse inversion imaging sequence. Biotinylated lipid (distearoyl phosphatidylcholine-based) microbubbles that were conjugated with antivascular endothelial growth factor 2 (VEGFR2) antibody (MBVEGFR2) or isotype control antibody (MBControl) were injected into mice carrying adenocarcinoma xeno-grafts. Different injection doses ranging from 5 x 10(4) to 1 x 10(7) microbubbles per mouse were evaluated to determine the minimum diagnostically effective dose. Results: The proposed imaging sequence was able to achieve statistically significant detection (P < 0.05, n = 5) of VEGFR2 in tumors with a minimum MBVEGFR2 injection dose of only 5 x 10(4) microbubbles per mouse (distearoyl phosphatidylcholine at 0.053 ng/g mouse body mass). Nonspecific adhesion of MBControl at the same injection dose was negligible. In addition, the targeted contrast ultrasound signal of MBVEGFR2 decreased with lower microbubble doses, whereas nonspecific adhesion of MBControl increased with higher microbubble doses. Conclusions: The dose of 5 x 10(4) microbubbles per animal is now the lowest injection dose on record for ultrasound molecular imaging to achieve statistically significant detection of molecular targets in vivo. Findings in this study provide us with further guidance for future developments of clinically translatable ultrasound molecular imaging applications using a lower dose of microbubbles.
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  • Effects of Renal Denervation on Cardiac Structural and Functional Abnormalities in Patients with Resistant Hypertension or Diastolic Dysfunction

    Wang, Shiying   Yang, Suxia   Zhao, Xinxin   Shi, Jun  

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  • Production rate and diameter analysis of spherical monodisperse microbubbles from two-dimensional, expanding-nozzle flow-focusing microfluidic devices

    Wang, Shiying   Dhanaliwala, Ali H.   Chen, Johnny L.   Hossack, John A.  

    Flow-focusing microfluidic devices (FFMDs) can produce microbubbles (MBs) with precisely controlled diameters and a narrow size distribution. In this paper, poly-dimethyl-siloxane based, rectangular-nozzle, two-dimensional (2-D) planar, expanding-nozzle FFMDs were characterized using a high speed camera to determine the production rate and diameter of Tween 20 (2% v/v) stabilized MBs. The effect of gas pressure and liquid flow rate on MB production rate and diameter was analyzed in order to develop a relationship between FFMD input parameters and MB production. MB generation was observed to transition through five regimes at a constant gas pressure and increasing liquid flow rate. Each MB generation event (i.e., break-off to break-off) was further separated into two characteristic phases: bubbling and waiting. The duration of the bubbling phase was linearly related to the liquid flow rate, while the duration of the waiting phase was related to both liquid flow rate and gas pressure. The MB production rate was found to be inversely proportional to the sum of the bubbling and waiting times, while the diameter was found to be proportional to the product of the gas pressure and bubbling time. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774069]
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  • Indoxacarb-Loaded Anionic Polyurethane Blend with Sodium Alginate Improves pH Sensitivity and Ecological Security for Potential Application in Agriculture

    Wang, Shiying   Zhang, Yi   Yang, Liupeng   Zhu, Qizhan   Ma, Qianli   Wang, Ruifei   Zhang, Chaoqun   Zhang, Zhixiang  

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  • Study on nanomagnets supported TiO(2) photocatalysts prepared by a sol-gel process in reverse microemulsion combining with solvent-thermal technique

    Li, Hansheng   Zhang, Yaping   Wang, Shiying   Wu, Qin   Liu, Changhao  

    A sol-gel process in reverse microemulsion combined with solvent-thermal technique was developed for synthesizing a series of nanomagnets supported TiO(2) (TiO(2)/NMs) photocatalysts in this study. The structure of TiO(2)/NMs photocatalysts was characterized by Fourier transform infrared (FTIR),TG-DSC, Xray diffraction (XRD), Raman spectrometry, TEM, BET, and VSM. The influence of CoFe(2)O(4) dosage on the photocatalytic activity and magnetism of TiO(2)/NMs photocatalysts was investigated. The results showed that nanosized anatase TiO(2) were uniformly coated on spinel CoFe(2)O(4) in the prepared TiO(2)/NMs photocatalysts. They possessed typical ferromagnetic hysteresis and performed better photocatalytic activity in degradation of methylene blue than TiO(2) prepared by the same method. The existence of CoFe(2)O(4) nanomagnets played an important role on the crystalline grain size of TiO(2) and the specific surface area of the prepared TiO(2)/NMs photocatalysts, thus had an important influence on its photocatalytic performance and magnetism. The photocatalytic performance of TiO(2)/NMs photocatalysts is related to their specific surface area, crystalline grain sizes of TiO(2) and particle size, as well as the doping effect of Fe(3+). The highest photocatalytic activity in degradation of methylene blue for TiO(2)/NMs photocatalysts at the CoFe(2)O(4) content of 20 wt.% was achieved, with k(p) 28.32% higher than that of pure TiO(2) photocatalyst. Moreover, the experiments on recycled use of TiO(2)/NMs photocatalyst demonstrated a good repeatability of the photocatalytic activity. (c) 2009 Elsevier B.V. All rights reserved.
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  • Outcome of surgical treatment for carotid body tumors in different Shambling type without preoperative embolization: A single-center retrospective study.

    Han, Tonglei   Wang, Shiying   Wei, Xiaolong   Xie, Yongfu   Sun, Yudong   Sun, Huiying   Zhu, Jiang   Wu, Yani   Zhou, Jian   Zhao, Zhiqing   Jing, Zaiping  

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