The present invention relates to 4-methyl-1H-diaryl pyrazole derivatives, and specifically relates to the compounds represented by formula (I) and stereoisomers, solvates or pharmaceutically acceptable salts thereof. The present invention also relates to a preparation method of the compounds, a pharmaceutical composition containing them, and use of said compounds as cannabine type I (CB1) receptor inhibitor in brain in preparing drugs for preventing, treating or alleviating diseases or symptoms relating to excessive activity of CBI receptor, such as obesity, memory or cognition impairment and smoke addiction, etc..
A dual vector expression system is provided for delivery of CRISPR/Cas9, sgRNA and donor templates for supplying corrected genes or gene sequences to neonatal subjects. An AAV8 system for delivery to proliferating cells such as hepatocytes is described, as are other dual AAV vector systems for targeting to other cells.
A membrane separation production method and device for edible raw sugar comprises the following steps: step 1, extracting sucrose juice from a plant containing sucrose, pre-filtering the sucrose, and then feeding the pre-filtered sucrose to a ceramic membrane for filtering, so as to obtain a ceramic membrane concentrated solution and a ceramic membrane clear solution; and step 2, concentrating the ceramic membrane clear solution, and then performing crystallization and sugar separation to obtain raw sugar. A membrane separation technology is used in the raw sugar preparation method, and raw sugar having good quality can be obtained after sucrose juice is processed by using a membrane filtering technology, and the raw sugar satisfies edible level standards, thereby avoiding the problems of great consumption of medicaments and the poor effect of impurity removal and long operation time in the traditional method in which deposition is carried by using lime and clarification is carried out.
The present invention belongs to the field of pharmaceuticals and chemicals, and relates to thiazole inner salt compounds, and a preparation method and use thereof. In particular, the present invention relates to compounds as shown by formula I, and hydrates or pharmaceutically acceptable salts thereof. The compounds of formula I of the present invention are potent crosslinking protein cleavage agent, and have a stable structure, good physical and chemical properties, and good pharmacological action; large-scale production can obtain samples with stable, controllable and reliable quality, and are suitable for developing into a drug.
The present invention relates to homoserine lactone derivatives represented by formula I, a preparation method therefor and a use. The present compounds have a bacterial quorum sensing regulatory effect, and may be used for preventing and/or treating related diseases caused by bacterial infection.
Disclosed are a derivative of homoserine lactone shown in formula I, and a preparation method and use thereof. The compound has a function of sensing and regulating a bacterial colony, and can be used for prevention and/or treatment of related diseases caused by bacterial infection.
Graphene-wrapped Fe2O3 nanorings (RGO/Fe2O3) were synthesized by a facile approach, which assembled with graphene and the Fe2O3 nanorings precursor through the colloidal coagulation effect at room temperature. The uniform Fe2O3 nanorings prepared by hydrothermal routes were homogeneously distributed and well wrapped by graphene. When tested as anode for lithium ion batteries, RGO/Fe2O3 exhibits a high capacity and good cycling stability. This could be attributed to the interaction of ring-shaped structure and graphene sheets, which inherit the good kinetic property of Fe2O3 nanorings and enhance the structural integrity with graphene sheets' support.
Embodiments of the present invention relate to the field of communications and disclose a method and device for determining the next hop and distributing routing information for reducing the operation complexity of forwarding devices and lowering the work load of network maintenance. The method for determining the next hop provided in the embodiments of the present invention comprises: a control device receives a first routing information transmitted by a first forwarding device; the first routing information comprises: the identifier of the first forwarding device; a first routing path is determined according to the identifier of the first forwarding device, the identifier of a second forwarding device, and a routing path group; the next hop of the second routing information of the second routing device is determined according to the first routing path; the second forwarding device is the receiving end of the second routing information distributed by the control device.
Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.