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Now showing items 113 - 128 of 133

  • A J-shaped association between soy food intake and depressive symptoms in Chinese adults

    Yu, Bin   Yu, Fei   Su, Qian   Zhang, Qing   Liu, Li   Meng, Ge   Wu, Hongmei   Xia, Yang   Bao, Xue   Shi, Hongbin   Gu, Yeqing   Fang, Liyun   Yang, Huijun   Sun, Shaomei   Wang, Xing   Zhou, Ming   Jia, Qiyu   Guo, Qi   Liu, Huijun   Song, Kun   Niu, Kaijun  

    Background & aims: Soy food has been proven to have multiple positive effects on human health, however, no study has yet investigated the association between habitual intake of soy food and depressive symptoms in general population. The objective of this study was to examine this association. Methods: In a cross-sectional analysis, we studied a sample of 13,760 adults (mean age 43.5 years) in Tianjin, China. The Self-Rating Depression Scale (SDS) was used to assess depressive symptoms, with four cut-off points (SDS >=3D 40, 45, 48 or 50) indicating increased level of depressive symptoms. Food Frequency Questionnaire (FFQ) was used to assess dietary intake. Results: In the total population, the prevalence of increased depressive symptoms was 7.2% (SDS >=3D 50). Comparing to the group with lowest intake frequency of soy food (=3D twice/day. Associations remained when other cut-off points (SDS >=3D 40, 45 or 48) were used as a definition of increased depressive symptoms. Conclusion: Findings from this study suggested a J-shaped association between intake frequency of soy food and incidence of depressive symptoms among adults. For the first time, the study provides evidence that light-to-moderate intake of soy food may reduce the incidence of depressive symptoms, while relatively high (>=3D twice/day) intake may generate the opposite effect. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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  • Structures,formation mechanisms,and ion exchange properties of alpha-,beta-,and gamma-Na2TiO3

    Meng, Fancheng   Liu, Yahui   Xue, Tianyan   Su, Qian   Wang, Weijing   Qi, Tao  

    alpha-, beta-, and gamma-Na2TiO3 were prepared from rutile TiO2 and molten NaOH. Three models of beta-Na2TiO3 with space groups of R (3) over bar, P (1) over bar, and P (3) over bar were proposed, and the R (3) over bar model was refined from the experimental data by using the Rietveld method. The structure of beta-Na2TiO3 is a superstructure of alpha-Na2TiO3 and supposedly contains Ti6O19 clusters. The structures of Na2TiO3 were mainly determined by the particle sizes of rutile and the reaction temperatures. alpha-Na2TiO3 could be prepared from fine rutile particles (D(50) < 25.8 mu m) and molten NaOH at 500 degrees C or quenching the melt of Na2TiO3 at 1000 degrees C quickly. gamma- and beta-Na2TiO3 were the thermodynamically stable phases of Na2TiO3 at around 500 degrees C and above 800 degrees C, respectively. alpha-Na2TiO3 was formed far beyond the thermodynamically stable state. The Na+ in alpha-Na2TiO3 was easier to exchange with H+ in water than that in beta or gamma phases. They all converted to amorphous phases after the 2nd, 6th, and 4th water washings at 25 degrees C, respectively. beta-Na2TiO3 followed similar paths of ion exchange as alpha-Na2TiO3, which was different from that of gamma-Na2TiO3.
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  • Mechanism modeling for phase fraction measurement with ultrasound attenuation in oil-water two-phase flow

    Su, Qian   Tan, Chao   Dong, Feng  

    When measuring the phase fraction of oil-water two-phase flow with the ultrasound attenuation, the phase distribution and fraction have direct influence on the attenuation coefficient. Therefore, the ultrasound propagation at various phase fractions and distributions were investigated. Mechanism models describing phase fraction with the ultrasound attenuation coefficient were established by analyzing the interaction between ultrasound and two-phase flow by considering the scattering, absorption and diffusion effect. Experiments were performed to verify the theoretical analysis, and the test results gave good agreement with the theoretical analysis. When the dispersed phase fraction is low, the relationship between ultrasound attenuation coefficient and phase fraction is of monotonic linearity; at higher dispersed phase fraction, ultrasound attenuation coefficient presents an irregular response to the dispersed phase fraction. The presented mechanism models give reasonable explanations about the trend of ultrasound attenuation.
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  • Experimental and numerical analyses of lightweight foamed concrete as filler for widening embankment

    Shi, Xiaona   Huang, Junjie   Su, Qian  

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  • Evaluation of Prebiotic Potential of Three Marine Algae Oligosaccharides from Enzymatic Hydrolysis

    Han, Zhen-Lian   Yang, Min   Fu, Xiao-Dan   Chen, Meng   Su, Qian   Zhao, Yuan-Hui   Mou, Hai-Jin  

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  • Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer

    Liu, Yan   Li, Jian   Ma, Zhifang   Zhang, Jun   Wang, Yuzhi   Yu, Zhenghong   Lin, Xue   Xu, Zhi   Su, Qian   An, Li   Zhou, Yehui   Ma, Xinxing   Yang, Yiwen   Wang, Feifei   Chen, Qingfei   Zhang, Yunchao   Wang, Jilinlin   Zheng, Huilin   Shi, Aihua   Yu, Shuang   Zhang, Jingzhong   Zhao, Weiyong   Chen, Liming  

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  • Experimental Study on the Effect of Water on the Properties of Cast In Situ Foamed Concrete

    Zhao, Wenhui   Su, Qian   Wang, Wubin   Niu, Lele   Liu, Ting  

    This study aims to investigate the effect of water on the properties of cast in situ foamed concrete with a dry density of 300-800 kg/m(3) (100 kg/m(3) is a gradient). Firstly, the shrinkage deformation with the curing time and the volumetric moisture content is studied by the drying shrinkage test and improved drying shrinkage test. Secondly, the influence of volumetric moisture content on mechanical properties is assessed. At last, the effects of immersion time and immersion type on the mechanical properties of foamed concrete are studied by considering the water-level conditions. The achieved results show that the shrinkage deformations increase with the curing time for the drying shrinkage test and the improved drying shrinkage test, while the variations are different. The shrinkage deformation increases with the decrease of volumetric moisture content for six dry densities of foamed concrete. Besides, it gradually changes in the early stage, while it changes fast in the later stage. The compressive strength and elastic modulus decrease with the increase of volumetric moisture content for each density. For the water-level unchanged condition, the compressive strength and elastic modulus initially decrease and then slowly increase with the increase of the immersion time. For the water-level changed condition, the compressive strength and elastic modulus of foamed concrete decrease with the increase of immersion time for each dry density, and the rate of early attenuation is high, whereas the rate of later attenuation is limited.
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  • The Paradox of Dopamine and Angiotensin II-Mediated Na+, K+-ATPase Regulation in Renal Proximal Tubules

    Guo, Fang   Guo, Huicai   Wang, Haiyan   Zhang, Zhe   Liu, Xu   Shi, Xiaolu   Gou, Xiangbo   Su, Qian   Yin, Jian  

    Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na+ and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na+,K+-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA alpha(1)-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-beta, PKC-zeta), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.
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  • The Relationship Between Thyroid Function and the Prevalence of Type 2 Diabetes Mellitus in Euthyroid Subjects

    Gu, Yeqing   Li, Huihui   Bao, Xue   Zhang, Qing   Liu, Li   Meng, Ge   Wu, Hongmei   Du, Huanmin   Shi, Hongbin   Xia, Yang   Su, Qian   Fang, Liyun   Yu, Fei   Yang, Huijun   Yu, Bin   Sun, Shaomei   Wang, Xing   Zhou, Ming   Jia, Qiyu   Guo, Qi   Chang, Hong   Wang, Guolin   Huang, Guowei   Song, Kun   Niu, Kaijun  

    Purpose: Thyroid hormones (THs) are primarily responsible for the regulation of energy balance and metabolism, suggesting that TH levels may contribute to the development of type 2 diabetes mellitus (T2DM). However, few studies have investigated the relationship between TH and T2DM in a general population. The aim of this study was to evaluate whether serum TH levels within the reference range are related to T2DM. Methods: A cross-sectional study (n =3D 15,296) was performed in Tianjin, China. Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) levels were measured by chemiluminescence immunoassay, and T2DM was defined according to the American Diabetes Association criteria. Multiple logistic regression models were used to assess the sexspecific relationships between FT3, FT4, FT3/FT4 ratios, and TSH quintiles and T2DM. Results: The prevalence of T2DM was 16.2% in males and 7.7% in females. In males, the multivariable-adjusted odds ratios (95% confidence interval) of T2DM for increasing quintiles of FT3, FT4, and FT3/FT4 ratios were 1.00, 0.75(0.63 to 0.89), 0.70(0.58 to 0.84), 0.63(0.52 to 0.76), 0.56 (0.46 to 0.68; P for trend, 0.0001); 1.00, 1.05(0.87 to 1.27), 1.16(0.96 to 1.40), 1.09(0.90 to 1.31), 1.29 (1.07 to 1.56; P for trend =3D 0.01); and 1.00, 0.69(0.58 to 0.83), 0.72(0.60 to 0.86), 0.59(0.48 to 0.71), and 0.55(0.46 to 0.66; P for trend, 0.0001), respectively. Similar results also were observed in females. In contrast, a strong negative correlation between TSHand T2DMwas observed inmales, but not in females. Conclusions: This study demonstrated that decreased FT3, FT3/FT4 ratios, and increased FT4 levels are independently related to a higher prevalence of T2DM in both males and females, and TSH is inversely related to T2DM in males only.
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  • Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues

    Yu, Miaorong   Wang, Jiuling   Yang, Yiwei   Zhu, Chunliu   Su, Qian   Guo, Shiyan   Sun, Jiashu   Gan, Yong   Shi, Xinghua   Gao, Huajian  

    Mucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles. (NPs), such as mesoporous silica nanorods and calcium phosphate nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.
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  • Vibration and Long-Term Performance Analysis of Pile-Plank-Supported Low Subgrade of Ballastless Track under Excitation Loads

    Huang, Junjie   Su, Qian   Liu, Ting   Wang, Xun  

    Pile-plank structures are widely applied for high-speed railway built in soft ground in China. It can be used as a reinforcement to improve the behavior of subgrade by providing vertical confinement to increase their stiffness and strength and reduce the subgrade settlement of ballastless track. However, the use of pile-board structure for soft ground reinforcement of high-speed railway is hindered by the existing gap between applications and theories. To verify vibration characteristics and long-term performance of pile-plank-supported low subgrade of ballastless track and the benefit of pile-board structure, an experimental study was conducted on low subgrade of pile-board under excitation loads using both in situ frequency sweeping and cyclic loading experiments. The frequency sweeping experimental results show that the pile-plank-supported low subgrade has smooth stiffness along the longitudinal subgrade and can effectively control the progressive effects of train speed on dynamic stiffness of the subgrade, which ensures driving safety and comfort. The cycle loading experimental results show that the pile-plank-supported low subgrade has favorable long-term dynamic stability, and its dynamic response is uniform along the longitudinal subgrade.
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  • Assessment of the use of fiberglass-reinforced foam concrete in high-speed railway bridge approach involving foundation cost comparison

    Liu, Kai-Wen   Yue, Fei   Su, Qian   Zhou, Chuanbin   Xiong, Zhipeng   He, Yi  

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  • Study on the Heat of Hydration and Strength Development of Cast-In-Situ Foamed Concrete

    Zhao, Wenhui   Su, Qian   Han, Feng   Wang, Wubin  

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  • Impact of COMT haplotypes on functional connectivity density and its association with the gene expression of dopamine receptors

    Tang, Jie   Li, Yanjun   Xu, Jiayuan   Qin, Wen   Su, Qian   Xu, Qiang   Liu, Bing   Jiang, Tianzi   Yu, Chunshui  

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  • Tailoring Molecular Weight of Bioderived Polycarbonates via Bifunctional Ionic Liquids Catalysts under Metal-Free Conditions

    Ma, Congkai   Xu, Fei   Cheng, Weiguo   Tan, Xin   Su, Qian   Zhang, Suojiang  

    Synthesis of bioderived high-molecular-weight polycarbonates over metal-free catalysts is of great importance but also challenging. In this work, a series of 1-butyl-3-methylimidazolium (Bmim) ionic liquids (ILs) were prepared as catalysts for a melt polycondensation reaction of isosorbide and diphenyl carbonate. By modifying the structures of ILs' anions, the number-average molecular weight (M-n) of poly(isosorbide carbonate) (PIC) was effectively tailored. In the presence of a trace amount (0.05 mol % based on isosorbide) of bifunctional [Bmim][CH3CHOHCOO], the synthesized PIC possessed high M-n of 61,700 g/mol and a glass transition temperature of 174 degrees C, both the highest so far to the best of our knowledge. Besides, it was found that the anions with stronger electronegativity and hydrogen bond formation ability were more efficient for the formation of PIC with higher M-n. To modify the flexibility of PIC, poly(aliphatic diol-co-isosorbide carbonate)s with M-n ranging from 34,000 to 75,700 g/mol were also formulated by incorporating with various aliphatic diols. Additionally, based on the experimental results and nuclear magnetic resonance spectroscopy, a possible mechanism of cooperative nucleophilic-electrophilic activation through hydrogen bond formation and electrostatic interactions by the ILs catalyst was proposed.
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  • Overexpression of a bifunctional enzyme, CrtS, enhances astaxanthin synthesis through two pathways in Phaffia rhodozyma.

    Chi, Shuang   He, Yanfeng   Ren, Jie   Su, Qian   Liu, Xingchao   Chen, Zhi   Wang, Mingan   Li, Ying   Li, Jilun  

    BACKGROUND: A moderate-temperature, astaxanthin-overproducing mutant strain (termed MK19) of Phaffia rhodozyma was generated in our laboratory. The intracellular astaxanthin content of MK19 was 17-fold higher than that of wild-type. The TLC profile of MK19 showed a band for an unknown carotenoid pigment between those of beta-carotene and astaxanthin. In the present study, we attempted to identify the unknown pigment and to enhance astaxanthin synthesis in MK19 by overexpression of the crtS gene that encodes astaxanthin synthase (CrtS).; RESULTS: A crtS-overexpressing strain was constructed without antibiotic marker. A recombinant plasmid with lower copy numbers was shown to be stable in MK19. In the positive recombinant strain (termed CSR19), maximal astaxanthin yield was 33.5% higher than MK19, and the proportion of astaxanthin as a percentage of total carotenoids was 84%. The unknown carotenoid was identified as 3-hydroxy-3',4'-didehydro-beta,Psi-carotene-4-one (HDCO) by HPLC, mass spectrometry, and NMR spectroscopy. CrtS was found to be a bifunctional enzyme that helped convert HDCO to astaxanthin. Enhancement of crtS transcriptional level increased transcription levels of related genes (crtE, crtYB, crtI) in the astaxanthin synthesis pathway. A scheme of carotenoid biosynthesis in P. rhodozyma involving alternative bicyclic and monocyclic pathways is proposed.; CONCLUSIONS: CrtS overexpression leads to up-regulation of synthesis-related genes and increased astaxanthin production. The transformant CSR19 is a stable, secure strain suitable for feed additive production. The present findings help clarify the regulatory mechanisms that underlie metabolic fluxes in P. rhodozyma carotenoid biosynthesis pathways.=20
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