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Now showing items 177 - 192 of 7380

  • Spectral distribution for the decay tau -> v(tau)K pi RID A-1219-2007

    Jamin, Matthias   Pich, Antonio   Portoles, Jorge  

    With the newly available data sets on hadronic tau decays from the B-factories BaBar and BELLE, and future data from BESIII, precise information on the decay distributions will soon become available. This calls for an improvement of the decay spectra also on the theoretical side. In this work, the distribution function for the decay tau -> v(tau)K pi will be presented with the relevant K pi vector and scalar forth factors being calculated in the framework of the resonance chiral theory, also taking into account additional constraints from dispersion relations and short-distances. As a by-product the slope and curvature of the vector form factor F-+(K pi)(s) are determined to be lambda'(+) = 25.6 x 10(-3) and lambda"(+) = 1.31 x 10(-3) respectively. From our approach it appears that it should be possible to obtain information on the low lying scalar K*(800) as well as the sec0 ond vector K*(1410) resonances from the tau decay data. In particular, the exclusive branching fraction of the scalar component is found to be B[tau -> vT (K pi)(S-wave)] = (3.88 +/- 0.19) x 10(-4). (c) 2006 Elsevier B.V. All rights reserved.
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  • A Ligand-Based Approach to the Discovery of Lead-Like Potassium Channel K(V)1.3 Inhibitors

    Pereira, Gilberto   Szwarc, Beatriz   Mondragao, Miguel A.   Lima, Pedro A.   Pereira, Florbela  

    Voltage-gated ion channels are key molecular targets for autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and psoriasis. In silico models, using 340 molecules whose IC50 towards Kv1.3 was determined by reported assays, were developed through exploration of four machine learning (ML) techniques. ML techniques explored included Random Forest, Support Vector Machine, Multilayer Perceptron, and K-Nearest Neighbors. Two QSAR classification approaches were developed. In the first approach, the compounds were classified into either moderate-active-to-very-active or inactive-to-moderate-active categories. Only the compounds predicted to be moderate-active-to-very-active in the first classification model were submitted to the second model, a classification model that predicted two more categories, very-active and not-very-active. The performances of the models were successfully evaluated by internal validation and external test set validation, with an overall predictability (Q) of 0.83 and 0.69 for the test set in the first and second approaches of the best models, respectively. The best models for the two approaches were employed for the virtual screening of K(V)1.3 inhibitors from ZINC natural products and approved drugs databases. A list of the most promising lead-like K(V)1.3 inhibitors was proposed, from which an approved drug and a natural product were experimentally evaluated with whole-cell voltage-clamp assays at 1000 nM.
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  • Anmerkung zu FG Düsseldorf, Urt. v. 19.9.2013 – 11 K 3968/11 F (nicht rechtskräftig)

    Ketteler-Eising, Thomas  

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  • The isothermal section of the Gd–Ni–V ternary system at 773 K

    Yan Zhong   Huaiying Zhou   Qingrong Yao   Chengying Tang   R.P. Zou  

    The phase equilibria of the Gd–Ni–V system at 773 K were investigated by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), and electron probe microanalysis (EPMA). The experimental results show no existence of ternary compounds at 773 K. The existence of 14 single-phase regions, 25 two-phase regions and 12 three-phase regions was determined. The maximum solubility of V in (Ni), Gd2Ni17, GdNi5 and GdNi2 was measured to be about 16 at.%, 2 at.%, 3 at.%and 2.5 at.%, respectively, while that of Gd in (Ni), Ni3V, Ni2V, Ni2V3, NiV3 and (V) was less than 1 at.%. An isothermal section of the Gd–Ni–V system at 773 K has been presented according to the present work.
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  • Poznámky k sémantické typologii predikát? v latině

    ILONA GRUBEROVá  

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  • PROFILES IN TOXICOLOGY: V. K. Rowe (1914-2004)

    Kociba   R. J.  

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  • PROFILES IN TOXICOLOGY: V. K. Rowe (1914-2004)

    Kociba, R. J.  

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  • Systematic construction of q-analogs of t-(v,k,lambda)-designs

    Braun, M   Kerber, A   Laue, R  

    In the present paper we consider a q-analog of t - (v, k, lambda)-designs. It is canonic since it arises by replacing sets by vector spaces over GF(q), and their orders by dimensions. These generalizations were introduced by Thomas [Geom.Dedicata vol. 63, pp. 247-253 (1996)] they are called t-(v,k,lambda;q)-designs. A few of such q-analogs are known today, they were constructed using sophisticated geometric arguments and case-by-case methods. It is our aim now to present a general method that allows systematically to construct such designs, and to give complete catalogs (for small parameters, of course) using an implemented software package. In order to attack the (highly complex) construction, we prepare them for an enormous data reduction by embedding their definition into the theory of group actions on posets, so that we can derive and use a generalization of the Kramer-Mesner matrix for their definition, together with an improved version of the LLL-algorithm. By doing so we generalize the methods developed in a research project on t - (v, k, lambda)-designs on sets, obtaining this way new results on the existence of t - (v, k, lambda; q)-designs on spaces for further quintuples (t, v, k, lambda; q) of parameters. We present several 2 - (6, 3, lambda; 2)-designs, 2-(7, 3, lambda; 2)-designs and, as far as we know, the very first 3-designs over GF(q).
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  • PPTX, a Pentraxin Domain-Containing Protein, Interacts With the T1 Domain of K(v)4

    Harvey, Margaret   Karolat, Joerg   Sakai, Yoshihisa   Sokolowski, Bernd  

    Voltage-gated K(+) (K(v)) channels reside as tetramers in the membrane. The events that coordinate folding, trafficking, and tetramerization are mediated by an array of associated proteins and phospholipids whose identification is vital to understanding the dynamic nature of channel expression and activity. An interaction between an A-type K(+) channel, K(v)4.2, and a protein containing a pentraxin domain (PPTX) was demonstrated in the cochlea (Duzhyy et al. [2005] J. Biol. Chem. 280:15165-15172). Here, we present results based on fold recognition and homology modeling that revealed the tetramerization (T1) domain of K(v)4.2 as a potential docking site for interacting proteins such as PPTX. By using this model, putative sites were experimentally tested with the yeast two-hybrid system to assay interactions between PPTX and the T1 domain of K(v)4.2 wild type (wt) and mutants (mut). Results showed that amino acid residues 86 and 118 in the T1 domain are essential for interaction, because replacing these negatively charged with neutrally charged amino acids inhibits interactions. Cotransfections of Chinese hamster ovary cells with PPTX and K(v)4.2wt further revealed that PPTX increases K(v)4.2wt expression in vitro when analyzing total lysates, whereas interactions with K(v)4.2mut resulted in a decrease. These studies suggest that portions of the T1 domain can act as docking sites for proteins such as PPTX, further underscoring the significance of this domain. (C) 2009 Wiley-Liss, Inc.
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  • L - Z, Addendum A - K || V

    Vollkommer, Rainer  

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  • A K(V)4.2 truncation mutation in a patient with temporal lobe epilepsy

    Singh, Baljinder   Ogiwara, Ikuo   Kaneda, Makoto   Tokonami, Natsuko   Mazaki, Emi   Baba, Koichi   Matsuda, Kazumi   Inoue, Yushi   Yamakawa, Kazuhiro  

    Temporal lobe epilepsy (TLE) has a multifactorial etiology involving developmental, environmental, and genetic components. Here, we report a voltage-gated potassium channel gene mutation found in a TLE patient, namely a K(v)4.2 truncation mutation. K(v)4.2 channels, encoded by the A'CND2 gene, mediate A currents in the brain. The identified mutation corresponds to an N587fsX1 amino acid change, predicted to produce a truncated K(v)4.2 protein lacking the last 44 amino acids in the carboxyl terminal. Electrophysiological analysis indicates attenuated K+ current density in cells expressing this K(v)4.2-N587fsX1 mutantchannel, which is consistent with a model ofaberrant neuronal excitabilit, * v characteristic of TLE. Our observations, together with other lines ofevidence, raise the intriguing possibility of a role for KCjVD2 in the etiology of TLE. (c) 2006 Elsevier Inc. All rights reserved.
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  • Book Review: RNA and the Regulation of Gene Expression. By K. V. Morris (Ed.).

    Kathleen Schleinitz  

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  • Book Review: RNA and the Regulation of Gene Expression. By K. V. Morris (Ed.).

    Kathleen Schleinitz  

    No abstract is available for this article.
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  • A 0.18-μm 3.3 V 16 k Bits 1R1T Phase Change Random Access Memory (PCRAM) Chip

    Sheng, Ding; Zhi-Tang, Song; Bo, Liu; Min, Zhu; Xiao-Gang, Chen; Yi-Feng, Chen; Ju, Shen; Cong, Fu; Song-Lin, Feng  

    Using standard 0.18-mum CMOS process and the special platform for 8-inch phase change random access memory (PCRAM), the first Chinese 16 k bits PCRAM chip has been successfully achieved. A 1R1T structure has been designed for low voltage drop and low cost compared to the 1R1D structure and the BJT-switch structure. Full integration of the 16 k bits PCRAM chip, including memory cell, array structure, critical circuit module, and physical layout, has been designed and verified. The critical integration technology of the phase change material (PCM) fabrication and the standard CMOS process has been solved. Test results about PCM in a large-scale array have been generated for the next research of PCRAM chip.
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  • V. K. Wellington Koo and the Emergence of Modern Chinaby Stephen G. Craft

    Review by: Stephen R. MacKinnon  

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  • V. K. Wellington Koo and the Emergence of Modern Chinaby Stephen G. Craft

    Review by: Stephen R. MacKinnon  

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