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Now showing items 33 - 48 of 2626

  • Revascularization in Patients with Diabetes: PCI or CABG or None at All

    Mavromatis, Kreton   Samady, Habib   King, Spencer B.  

    Patients with diabetes have a high incidence of coronary artery disease, with particularly high rates of acute coronary syndromes and mortality. Revascularization by coronary artery bypass grafting was found to be effective in reducing angina and mortality in patients with extensive coronary artery disease over 30 years ago. Percutaneous coronary intervention, particularly with drug-eluting stents, has more recently been demonstrated to reduce recurrent angina and improve quality of life in diabetic patients with less extensive coronary artery disease. Most recently, coronary artery bypass grafting has been shown to be superior to percutaneous coronary intervention in improving mortality in patients with diabetes and three-vessel coronary artery disease who are not at high surgical risk. The role of coronary artery bypass grafting vs. percutaneous coronary intervention in patients who have less extensive coronary artery disease and/or higher surgical risk has not been fully elucidated. Newer treatment strategies, such as percutaneous coronary intervention with second-generation drug-eluting stents, use of fractional flow reserve guidance, or hybrid revascularization combining minimally invasive coronary artery bypass grafting with percutaneous coronary intervention, may result in further improvements in outcomes in patients with diabetes and coronary artery disease.
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  • Then there were none

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  • “There Are None So Blind as Those Who Will Not See”

    O\"Toole   Mary Ellen  

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  • One index fits none: the conundrum of euro area inflation-linked bonds

    Arnold   Ivo J.M.  

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  • Rule Over None I: What Justifies Democracy?


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  • “Half a loaf is better than none

    Roberts   Simon Gwyn  

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  • None shall pass...without answering the call bell

    Colancecco, Elise M.   Moriarty, Susan   Litak, Lisa  

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  • Will too much kidney function kill you: just as none at all?

    Emrich, I. E.   Heine, G. H.  

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  • Caution: There Is No “All or None” with Ebstein’s Anomaly

    Dearani   Joseph A.  

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  • None So Blind

    Mirsky   Steve  

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  • None more black

    Paul-Choudhury   Sumit  

    Can you paint nothing? Sumit Paul-Choudhury stares into the void
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  • Neocytolysis: none, one or many? A reappraisal and future perspectives

    Risso, Angela   Ciana, Annarita   Achilli, Cesare   Antonutto, Guglielmo   Minetti, Giampaolo  

    Neocytolysis is the hypothesis formulated to explain experimental evidence of selective lysis of young red blood cells (RBCs) (neocytes) associated with decreased plasma levels of erythropoietin (EPO). In humans, it appears to take place whenever a fast RBC mass reduction is required, i.e., in astronauts during the first days of spaceflight under weightlessness, where a fast reduction in plasma volume and increase in haematocrit occur. EPO plasma levels then decline and a decrease in RBC mass takes place, apparently because of the selective lysis of the youngest, recently generated RBCs (neocytes). The same process seems to occur in people descending to sea level after acclimatization at high altitude. After descent, the polycythaemia developed at high altitude must be abrogated, and a rapid reduction in the number of circulating RBCs is obtained by a decrease in EPO synthesis and the lysis of what seem to be young RBCs. In vivo, neocytolysis seems to be abolished by EPO administration. More recent research has ascribed to neocytolysis the RBC destruction that occurs under such disparate pathophysiologic conditions as nephropathy, severe obstructive pulmonary disease, blood doping, and even malaria anaemia. According to the theory, EPO's central role would be not only to stimulate the production of new RBCs in conditions of anaemia, as maintained by the orthodox view, but also that of a cytoprotective factor for circulating young RBCs. Why neocytes are specifically destroyed and how is this related to decreased EPO levels has not yet been elucidated. Changes in membrane molecules of young RBCs isolated from astronauts or mountain climbers upon return to normal conditions seem to indicate a higher susceptibility of neocytes to ingestion by macrophages. By limiting the context to space missions and high altitude expeditions, this review will address unresolved and critical issues that in our opinion have not been sufficiently highlighted in previous works.
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  • Physical activity in diabetes: Is any better than none?

    Carson, April P.   Williams, Lovoria B.   Hill, Alethea N.  

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  • Reply: Air Leak Test, Two Hands Are Better Than None

    Aloia, Thomas A.   Vauthey, Jean-Nicolas  

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  • And then there were none

    Bacon, David F.   Cheng, Perry   Shukla, Sunil  

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  • Flow injection analysis: An approach via linear none equilibrium thermodynamics

    Kuznetsov   Vladimir V.  

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