Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 1 - 16 of 36

  • Family Portraits: The Life and Art of Alice Mary Chambers

    McLean, Thomas  

    Download Collect
  • Romantic Feuds: Transcending the ‘Age of Personality’

    McLean, Thomas  

    Download Collect
  • Mutations in the transcriptional repressor REST predispose to Wilms tumor.

    Mahamdallie, Shazia S   Hanks, Sandra   Karlin, Kristen L   Zachariou, Anna   Perdeaux, Elizabeth R   Ruark, Elise   Shaw, Chad A   Renwick, Alexander   Ramsay, Emma   Yost, Shawn   Elliott, Anna   Birch, Jillian   Capra, Michael   Gray, Juliet   Hale, Juliet   Kingston, Judith   Levitt, Gill   McLean, Thomas   Sheridan, Eamonn   Renwick, Anthony   Seal, Sheila   Stiller, Charles   Sebire, Neil   Westbrook, Thomas F   Rahman, Nazneen  

    Wilms tumor is the most common childhood renal cancer. To identify mutations that predispose to Wilms tumor, we are conducting exome sequencing studies. Here we describe 11 different inactivating mutations in the REST gene (encoding RE1-silencing transcription factor) in four familial Wilms tumor pedigrees and nine non-familial cases. Notably, no similar mutations were identified in the ICR1000 control series (13/558 versus 0/993; P < 0.0001) or in the ExAC series (13/558 versus 0/61,312; P < 0.0001). We identified a second mutational event in two tumors, suggesting that REST may act as a tumor-suppressor gene in Wilms tumor pathogenesis. REST is a zinc-finger transcription factor that functions in cellular differentiation and embryonic development. Notably, ten of 11 mutations clustered within the portion of REST encoding the DNA-binding domain, and functional analyses showed that these mutations compromise REST transcriptional repression. These data establish REST as a Wilms tumor predisposition gene accounting for 2% of Wilms tumor. =20
    Download Collect
  • Poland in the Irish Nationalist Imagination,1772-1922:Anti-Colonialism within Europe

    McLean, Thomas  

    Download Collect
  • A 9-year-old girl with ankle, knee, and shoulder pain

    Shiner, Erin K.   McLean, Thomas   Pang, Changlee S.   Rouster-Stevens, Kelly  

    Download Collect
  • Offstage Dramas: Jane Porter, Edmund Kean, and the Tragedy of Switzerland

    McLean, Thomas  

    Biographies of Edmund Kean occasionally mention his disastrous one-night performance in Jane Porter's play Switzerland in February 1819. While several commentators have blamed the work's failure on its inferior quality, Porter's unpublished letters tell a more complicated story. Using Porter's correspondence with Mary Kean, the Drury Lane committee, and various friends, this essay sheds light on her experiences in the London theatrical world and suggests interesting parallels between the careers of Porter and John Keats. Porter read Endymion with interest and hoped to meet the author, but she probably did not know that they shared a dangerous fascination with Edmund Kean.
    Download Collect
  • Will reputational incentives stimulate a reversal of the physician brain drain?

    McLean, Thomas  

    An increased supply of physicians in high income countries both from domestic production and from immigration from low and middle income countries has made medical employment increasingly competitive. This has been heightened by the introduction of reputational incentives, such as public reporting of physicians' outcomes, and the use of other health care professionals, such as nurses. An unanticipated consequence might be a reversal of the 'brain drain', with physicians migrating to low and middle income countries.
    Download Collect
  • Thymic carcinoma in a child with HIV infection

    McDonald, Morgan   McLean, Thomas   Belhorn, Thomas   Smith, Scott Victor   Fordham, Lynn Ansley   Woods, Charles   Blatt, Julie  

    Download Collect
  • Commoditization of the international teleradiology market.

    McLean, Thomas  

    Telemedicine improves access to medical care. However, telemedicine will also increase market volatility because of its ability to stimulate price competition and the insidious way it shifts liability for providing medical services. To cope with increased volatility, other economic sectors have evolved commodities markets by making greater use of standardized forward/future contracts. In the past, the need for medical services to be produced and consumed locally and a lack of an objective definition for medical quality, prohibited the use of forward contracts for health-care services. However, telemedicine, and the increasing use of statistical definitions of medical quality now make standardized forward contracts for health-care services conceivable. Commoditization of teleradiology would offer several advantages including increasing market transparency, a mechanism for ensuring medical quality, and a means for bringing capital into the health-care sector. To reap the benefits of a commodities market in teleradiology, the key will be for market stakeholders to overcome their fear of the unknown in order to organize a central exchange.
    Download Collect
  • Nobody's Argument: Jane Porter and the Historical Novel

    McLean, Thomas  

    Download Collect
  • Mutations in the transcriptional repressor REST predispose to Wilms tumor (vol 47,pg 1471,2015)

    Mahamdallie, Shazia S.   Hanks, Sandra   Karlin, Kristen L.   Zachariou, Anna   Perdeaux, Elizabeth R.   Ruark, Elise   Shaw, Chad A.   Renwick, Alexander   Ramsay, Emma   Yost, Shawn   Elliott, Anna   Birch, Jillian   Capra, Michael   Gray, Juliet   Hale, Juliet   Kingston, Judith   Levitt, Gill   McLean, Thomas   Sheridan, Eamonn   Renwick, Anthony   Seal, Sheila   Stiller, Charles   Sebire, Neil   Westbrook, Thomas F.   Rahman, Nazneen  

    Download Collect
  • FIBRE GYROSCOPE WITH BUFFER LAYERS AND POTTING MATERIAL FOR THE FIBRE COIL

    An apparatus (100) in one example comprises a buffer layer (110, 112) located on a face (106) that serves as a primary support for an optical fiber winding (208) along a first general direction (172). The face is coupled with a body (104) that serves as a primary support for the optical fiber winding along a second general direction (170). The optical fiber winding comprises an optical fiber (111) wound about the body. The buffer layer serves to promote a decrease of one or more strain gradients among a plurality of portions (146, 148, 150) of the optical fiber winding.
    Download Collect
  • MULTI-LEVEL OPTICAL FIBER AND COMPONENT STORAGE TRAY

    Single and multi-level structures provide neatly organized, secure and easily repairable optical fiber connections between a pump source laser diode (54) and optical fiber coils represented by x-axis coil (22), y-axis coil (24) and z-axis coil (26). The structures employ specially organized trays (60, 62) for supporting such components as a 1x3 fiber optic coupler (46), an optical isolator (ISO) (48), a wavelength division multiplexer (WDM) (50), a doped fiber coil (52) and a tap coupler (56), and for holding and routing the optical fibers coupled to and between the components. Routing and secure holding of the fibers are facilitated by a built-in optical fiber holder (120), integral with tray (60), and individual optical fiber holders (140), which are stackable upon the built-in holder or upon each other. Each tray includes internal guides, such as a guide post (118), and segmented internal and external walls which provide optical fiber routing paths (96, 100, 160) and wall separations and/or openings (102, 104, 106, 132, 162) to permit ingress and/or egress of fibers or attachment points, similar to wall separations (145) in the stackable holders. Special resilient clam-shell holders (168, 172) safely hold the fragile components, and are incorporated within the trays to facilitate inter-structural and exterior coupling.
    Download Collect
  • L'Arbre de Cracovie: Le mythe polonais dans la litterature francaise

    McLean, Thomas  

    Download Collect
  • “OCCUPATIONAL STRESS” Edited by Alan McLean, M.D. Thomas Publisher

    No abstract is available for this article.
    Download Collect
  • “OCCUPATIONAL STRESS” Edited by Alan McLean, M.D. Thomas Publisher

    Download Collect
1 2 3

Contact

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback