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Now showing items 1 - 16 of 65709

  • Acute cardiac failure after sunitinib RID B-8002-2008

    Machiels, J. -P.   Bletard, N.   Pirenne, P.   Jacquet, L.   Bonbled, F.   Duck, L.  

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  • A proof of concept trial of the anti-EGFR antibody mixture Sym004 in patients with squamous cell carcinoma of the head and neck

    Machiels, J. -P.   Specenier, P.   Krauss, J.   Dietz, A.   Kaminsky, M. -C.   Lalami, Y.   Henke, M.   Keilholz, U.   Knecht, R.   Skartved, N. J.   Horak, I. D.   Pamperin, P.   Braun, S.   Gauler, T. C.  

    The purpose of the trial was to assess the efficacy and tolerability of Sym004, a novel 1:1 mixture of two chimeric monoclonal antibodies (992 and 1024) targeting non-overlapping epitopes of the anti-epidermal growth factor receptor (EGFR), in patients with squamous cell carcinoma of the head and neck (SCCHN). Incurable, recurrent and/or metastatic SCCHN patients with acquired resistance to anti-EGFR monoclonal antibody-containing treatment received weekly infusions of 12 mg/kg Sym004 until disease progression or unacceptable toxicity. Among the 26 patients treated with Sym004, the proportion of patients alive without disease progression at 6 months was 12 % (95 % CI 1-39 %). The median duration of progression-free survival was 82 days (95 % CI 41-140 days). Of 19 patients evaluable for response, eight showed a decrease in the sum of the largest diameter in their target lesions (median 11 %; range 7-27 %). The best overall response was stable disease in 13 patients (50 %). Paired biopsies showed a significant down-regulation of EGFR in both skin and tumors following exposure to Sym004. All patients had EGFR-related adverse events, including grade 3 skin toxicities and grade a parts per thousand yen3 hypomagnesemia reported in 13 (50 %) and 10 (38 %) of 26 patients, respectively. One event fulfilling the protocol-defined criteria for infusion-related reactions (grade 2) was reported. No anti-drug antibodies were detected. The marked EGFR down-regulation shown in target tissues supports the proposed mechanism of action of Sym004. This trial revealed modest anti-tumor activity of Sym004 in extensively pretreated advanced SCCHN patients.
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  • J P support system

    A multi-workstation for use in a work area of a garage having a vertically oriented pole with an upper end and a lower end and a light fixture mounted between the upper end and the lower end of the vertically oriented pole. The light fixture is capable of sliding up and down along the pole, rotating about an axis that is perpendicular to the axis of the pole, moving horizontally toward and away from the pole, and rotating about an axis that is perpendicular to the axis of the pole. Locking means is provided to lock the light fixture at a desired height and angle relative to the pole and mounting means is provided to hold the pole in a vertical position.
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  • , by P. J. Philipson & J. M. Gary, Lanham

    Anna Nosko  

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  • Photoproduction of J/psi in non-single-diffractive p plus p collisions

    Cao, Ze-Hua   Ruan, Li-Juan   Tang, Ze-Bo   Xu, Zhang-Bu   Yang, Chi   Yang, Shuai   Zha, Wang-Mei  

    Significant enhancements of J/psi production at very low transverse momenta were recently observed by the ALICE and STAR collaborations in peripheral hadronic A+A collisions. The anomalous excess points to coherent photon-nucleus interactions in violent hadronic heavy-ion collisions, which were conventionally studied only in ultra-peripheral collisions. Assuming that the coherent photoproduction is the underlying mechanism responsible for the excess observed in peripheral A+A collisions, its contribution in p+p collisions with nuclear overlap, i.e. nonsingle-diffractive collisions, is of particular interest. In this paper, we perform a calculation of exclusive J/psi photoproduction in non-single-diffractive p+p collisions at the RHIC and LHC energies based on the pQCD motivated parametrization using the world-wide experimental data, which could be further employed to improve the precision of the phenomenological calculations for photoproduction in A+A collisions. The differential rapidity and transverse momentum distributions of J/psi from photoproduction are presented. In comparison with the J/psi production from hadronic interactions, we find that the contribution of photoproduction is negligible.
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  • Floris P. J. T. Rutjes

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  • Floris P. J. T. Rutjes

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  • Robert J. P. Williams (1926-2015).

    Mann, Stephen   Thomson, Andrew J  

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  • Inertia of the matrix [(p(i) + p(j)](r)]

    Bhatial, Rajendra   Jain, Tanvi  

    Let p(1),..., p(n) be positive real numbers. It is well known that for every r < 0 the matrix [(p(i) + p(j))(r)] is positive definite. Our main theorem gives a count of the number of positive and negative eigenvalues of this matrix when r > 0. Connections with some other matrices that arise in Loewner's theory of operator monotone functions and in the theory of spline interpolation are discussed.
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  • 50 Years Ago in T J P

    Rowe, Jared H.  

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  • 50 Years Ago in T J P

    Sanchez-Espino, Luis F.; Salinas-Silva, Cynthia A.  

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  • 50 Years Ago in T J P

    Mittal, Hema Gupta; Gupta, Piyush  

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  • 50 Years Ago in T J P

    Dhir, Shashi Kant; Gupta, Piyush  

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  • 50 Years Ago in T J P

    Ta, Allison D.  

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  • 50 Years Ago in T J P

    Andresen, Jannicke H.; Saugstad, Ola Didrik  

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  • On Sequences of J. P. King-Type Operators

    Acar, Tuncer   Cappelletti Montano, Mirella   Garrancho, Pedro   Leonessa, Vita  

    This survey is devoted to a series of investigations developed in the last fifteen years, starting from the introduction of a sequence of positive linear operators which modify the classical Bernstein operators in order to reproduce constant functions and x2 on [0,1]. Nowadays, these operators are known as King operators, in honor of J. P. King who defined them, and they have been a source of inspiration for many scholars. In this paper we try to take stock of the situation and highlight the state of the art, hoping that this will be a useful tool for all people who intend to extend King's approach to some new contents within Approximation Theory. In particular, we recall the main results concerning certain King-type modifications of two well known sequences of positive linear operators, the Bernstein operators and the Szasz-Mirakyan operators.
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