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Now showing items 1 - 12 of 12

  • Information representation and retrieval in the digital age. 2nd ed

    Lin, Yongtao  

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  • Featuring: Yongtao Lin

    Lin, Yongtao  

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  • PubMed Health

    Lin, Yongtao  

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  • Enantioselective separation of ketoconazole enantiomers by membrane extraction

    Wang, Zhao   Cai, Changqun   Lin, Yongtao   Bian, Yongru   Guo, Hongqin   Chen, Xiaoming  

    A new process has been developed to separate ketoconazole (KTZ) enantiomers by membrane extraction. with the oppositely preferential recognition of hydrophobic and hydrophilic chiral selectors in organic and aqueous phases, respectively. This system is established by adding hydrophobic L-isopentyl tartrate (L-IPT) in organic strip phase (shell side) and hydrophilic sulfobutylether-beta-cyclodextrin (SBE-beta-CD) in aqueous feed phase (lumen side), which preferentially recognizes (+)-2R,4S-ketoconazole and (-)-2S,4R-ketoconazole, respectively. The studies performed involve two enantioselective extractions in a biphasic system, where KTZ enantiomers form four complexes with SBE-beta-CD in aqueous phase and L-IPT in organic phase, respectively. The membrane is permeable to the KTZ enantiomers but non-permeable to the chiral selector molecules. Fractional chiral extraction theory, mass transfer performance of hollow fiber membrane, enantioselectivity and some experimental conditions are investigated to optimize the separation system. Mathematical model of I/II = 0.893e(0.039NTU) for racemic KTZ separation by hollow fiber extraction, is established. The optical purity for KTZ enantiomers is up to 90% when 9 hollow fiber membrane modules of 30 cm in length in series are used. (C) 2011 Elsevier B.V. All rights reserved.
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  • Renoprotective effect and mechanism of polysaccharide from Polyporus umbellatus sclerotia on renal fibrosis

    Li, Hailun   Yan, Zhuan   Xiong, Qingping   Chen, Xiaoling   Lin, Yongtao   Xu, Yong   Bai, Lin   Jiang, Wei   Zheng, Donghui   Xing, Changying  

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  • Analysis of Auto-Fluorescence Distribution on Teeth Surface Based on Finite Element Method

    Lin, Yongtao   Lu, Yingfei   Hao, Lifang   Wu, Qiong   Lin, Bin   Chen, Qingguang  

    Based on solution of diffusion equation using finite element numerical method; the excitation light intensity field inside the teeth tissue and the auto-fluorescence distribution on the surface of simplified 3D teeth model excited by uniform light are both presented. The influence of optical parameters such as scattering coefficient; anisotropy coefficient etc. on the fluorescence distribution of teeth surface is analyzed quantitatively. The results indicate that the fluorescence intensity increases with the increment of scattering coefficient of dental enamel and dentine; while decreases with the increment of anisotropy coefficient. Based on the definition of optical parameters; the possible reason is given. The results provide a possible method using fluorescence intensity to detect the early dental caries. Finally; the solution of diffusion equation based on finite element method is verified by Monte Carlo random simulation.
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  • Meta-analytic comparison of randomized and nonrandomized studies of breast cancer surgery

    Edwards, Janet P.   Kelly, Elizabeth J.   Lin, Yongtao   Lenders, Taryn   Ghali, William A.   Graham, Andrew J.  

    Background: Randomized controlled trials (RCTs) are thought to provide the most accurate estimation of "true" treatment effect. The relative quality of effect estimates derived from nonrandomized studies (nRCTs) remains unclear, particularly in surgery, where the obstacles to performing high-quality RCTs are compounded. We performed a meta-analysis of effect estimates of RCTs comparing surgical procedures for breast cancer relative to those of corresponding nRCTs. Methods: English-language RCTs of breast cancer treatment in human patients published from 2003 to 2008 were identified in MEDLINE, EMBASE and Cochrane databases. We identified nRCTs using the National Library of Medicine's "related articles" function and reference lists. Two reviewers conducted all steps of study selection. We included studies comparing 2 surgical arms for the treatment of breast cancer. Information on treatment efficacy estimates, expressed as relative risk (RR) for outcomes of interest in both the RCTs and nRCTs was extracted. Results: We identified 12 RCTs representing 10 topic/outcome combinations with comparable nRCTs. On visual inspection, 4 of 10 outcomes showed substantial differences in summary RR. The pooled RR estimates for RCTs versus nRCTs differed more than 2-fold in 2 of 10 outcomes and failed to demonstrate consistency of statistical differences in 3 of 10 cases. A statistically significant difference, as assessed by the z score, was not detected for any of the outcomes. Conclusion: Randomized controlled trials comparing surgical procedures for breast cancer may demonstrate clinically relevant differences in effect estimates in 20%-40% of cases relative to those generated by nRCTs, depending on which metric is used.
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  • Featuring: Yongtao Lin

    Lin, Yongtao  

    Download Collect
  • Information representation and retrieval in the digital age. 2nd ed

    Lin, Yongtao  

    Download Collect
  • PubMed Health

    Lin, Yongtao  

    Download Collect
  • Making literature reviews more ethical:a researcher and health sciences librarian collaborative process

    Thomas, Bejoy   Tachble, Admasu   Peiris, Delshani   Malhi, Rebecca   Godlovitch, Glenys   Lin, Yongtao  

    Background: With emphasis on evidence-based medical care, 'evidence' is often the result of literature reviews. Hence, the critical question, " are literature reviews comprehensive?" Aim: This study compares the literature generated by a researcher and a health sciences librarian (HSL). Methods: The Research Associate and the HSL conducted a parallel, segregated literature search on 'patient-centered care'. Results: The Research Associate identified 215 manuscripts, and the HSL 129 manuscripts. Overlap was only 55 manuscripts. Differences in process and blind spots are discussed. Conclusion: To improve the quality of research outcomes, it seems prudent and ethical to have a synergistic collaboration between researchers and HSLs. Given that this is just one case study that has looked into the issue, further research is strongly encouraged. Literature reviews are not just compilations of easily accessible research and should not be taken lightly. Literature reviews are critical to decision-making in clinical trials, medical care and directions of health systems. We wanted to see if researchers and health science librarians working in isolation would create a robust and balanced literature review. This case study showed that both approaches have shortcomings. We recommend that researcher and health science librarian must work together for the success of improving medical care.
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  • Curcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury

    Chen, Xiaoling   Sun, Jian   Li, Hailun   Wang, Hongwu   Lin, Yongtao   Hu, Yu   Zheng, Donghui  

    Background/Aims: Rhabdomyolysis (RM) is a potentially life-threatening condition that results from the breakdown of muscle and consequent release of toxic compounds into circulation. The most common and severe complication of RM is acute kidney injury (AKI). This study aimed to evaluate the efficacy and mechanisms of action of curcumin-loaded nanoparticles (Cur-NP) for treatment of RM-induced AKI. Methods: Curcumin-NP was synthesized using the nanocarrier distearoylphosphatidylethanolamine-polyethylene glycol (DSPE-PEG) to achieve a prolonged and constant drug release profile compared with the curcumin-free group. The anti-AKI effects of Curcumin-NP were examined both in vitro (myoglobin-treated renal tubular epithelial HK-2 cells) and in vivo (glycerol-induced AKI model). Results: Our results indicated that Curcumin-NP reversed oxidative stress, growth inhibition and cell apoptosis accompanied with down-regulation of apoptotic markers Caspase-3 and GRP-78 in vitro. In vivo studies revealed enhanced AKI treatment efficacy with Curcumin-NP as characterized by reduced serum creatine phosphokinase (CPK), creatinine (Cr) and urea and less severe histological damage in renal tubules. In addition, kidney tissues from Curcumin-NP-treated AKI rats exhibited reduced oxidative stress, apoptosis, and cleaved Capase-3 and GRP-78 expression. Conclusion: Our results suggest that nanoparticle-loaded curcumin enhances treatment efficacy for RM-induced AKI both in vitro and in vivo. (c) 2017 The Author(s) Published by S. Karger AG, Basel
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