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Now showing items 1 - 16 of 577

  • A Conversation with Sang Yup Lee

    Lee, Sang Yup  

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  • A Conversation with Sang Yup Lee

    Lee, Sang Yup  

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  • METHOD FOR PRODUCING LACTAM

    The present invention relates to a recombinant microorganism having a lactam production capacity from omega-amino acid, into which a gene for coating a beta-alanine coenzyme A transferase on a microorganism having an omega-amino acid biosynthetic metabolic pathway from amino acid is introduced, and a method for producing a variety of lactams and omega-aminoacyl-CoAs using the same. The recombinant microorganism and the method for producing lactam according to the present invention are useful in producing a variety of lactams such as propiolactam, 2-pyrrolidone, valerolactam, carprolactam, heptanolactam, etc. from a variety of omega-amino acids.
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  • CRISPR/CAS9 BASED ENGINEERING OF ACTINOMYCETAL GENOMES

    The present invention relates to CRISPR/Cas-based methods for generating random-sized deletions around at least one target nucleic acid sequence, or for generating precise indels around at least one target nucleic acid sequence, or for modulating transcription of at least one target nucleic acid sequence. Also disclosed is a clonal library comprising clones with random-sized deletions, as well as polynucleotides, polypeptides, cells and kits useful for performing the present methods. The present methods can be performed in organisms where gene editing is typically considered as difficult, such as actinomycetes, in particular streptomycetes.
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  • MEMOTE for standardized genome-scale metabolic model testing

    Lieven, Christian   Beber, Moritz E.   Olivier, Brett G.   Bergmann, Frank T.   Ataman, Meric   Babaei, Parizad   Bartell, Jennifer A.   Blank, Lars M.   Chauhan, Siddharth   Correia, Kevin   Diener, Christian   Dräger, Andreas   Ebert, Birgitta E.   Edirisinghe, Janaka N.   Faria, José P.   Feist, Adam M.   Fengos, Georgios   Fleming, Ronan M. T.   García-Jiménez, Beatriz   Hatzimanikatis, Vassily   van Helvoirt, Wout   Henry, Christopher S.   Hermjakob, Henning   HerrgÃ¥rd, Markus J.   Kaafarani, Ali   Kim, Hyun Uk   King, Zachary   Klamt, Steffen   Klipp, Edda   Koehorst, Jasper J.   König, Matthias   Lakshmanan, Meiyappan   Lee, Dong-Yup   Lee, Sang Yup   Lee, Sunjae   Lewis, Nathan E.   Liu, Filipe   Ma, Hongwu   Machado, Daniel   Mahadevan, Radhakrishnan   Maia, Paulo   Mardinoglu, Adil   Medlock, Gregory L.   Monk, Jonathan M.   Nielsen, Jens   Nielsen, Lars Keld   Nogales, Juan   Nookaew, Intawat   Palsson, Bernhard O.   Papin, Jason A.   Patil, Kiran R.   Poolman, Mark   Price, Nathan D.   Resendis-Antonio, Osbaldo   Richelle, Anne   Rocha, Isabel   Sánchez, Benjamín J.   Schaap, Peter J.   Malik Sheriff, Rahuman S.   Shoaie, Saeed   Sonnenschein, Nikolaus   Teusink, Bas   Vilaça, Paulo   Vik, Jon Olav   Wodke, Judith A. H.   Xavier, Joana C.   Yuan, Qianqian   Zakhartsev, Maksim   Zhang, Cheng  

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  • Current status of pan-genome analysis for pathogenic bacteria

    Kim, Yeji   Gu, Changdai   Kim, Hyun Uk   Lee, Sang Yup  

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  • Advances in CRISPR-Cas systems for RNA targeting, tracking and editing

    Wang, Fei   Wang, Lianrong   Zou, Xuan   Duan, Suling   Li, Zhiqiang   Deng, Zixin   Luo, Jie   Lee, Sang Yup   Chen, Shi  

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  • A comprehensive metabolic map for production of bio-based chemicals

    Lee, Sang Yup   Kim, Hyun Uk   Chae, Tong Un   Cho, Jae Sung   Kim, Je Woong   Shin, Jae Ho   Kim, Dong In   Ko, Yoo-Sung   Jang, Woo Dae   Jang, Yu-Sin  

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  • The urgent need for microbiology literacy in society

    Timmis, Kenneth   Cavicchioli, Ricardo   Garcia, José Luis   Nogales, Balbina   Chavarría, Max   Stein, Lisa   McGenity, Terry J.   Webster, Nicole   Singh, Brajesh   Handelsman, Jo   Lorenzo, Victor   Pruzzo, Carla   Timmis, James   Martín, Juan Luis Ramos   Verstraete, Willy   Jetten, Mike   Danchin, Antoine   Huang, Wei   Gilbert, Jack   Lal, Rup   Santos, Helena   Lee, Sang Yup   Sessitsch, Angela   Bonfante, Paola   Gram, Lone   Lin, Raymond T. P.   Ron, Eliora   Karahan, Ceren   Meer, Jan Roelof   Artunkal, Seza   Jahn, Dieter   Harper, Lucy  

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  • Document vectorization method using network information of words

    Lee, Sang Yup   Amancio, Diego Raphael  

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  • Microbial production of 2,3-butanediol for industrial applications

    Song, Chan Woo   Park, Jong Myoung   Chung, Sang Chul   Lee, Sang Yup   Song, Hyohak  

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  • CRISPR/Cas-based genome engineering in natural product discovery

    Tong, Yaojun   Weber, Tilmann   Lee, Sang Yup  

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  • Current status and applications of genome-scale metabolic models

    Gu, Changdai   Kim, Gi Bae   Kim, Won Jun   Kim, Hyun Uk   Lee, Sang Yup  

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  • Microbial production of methyl anthranilate, a grape flavor compound

    Luo, Zi Wei   Cho, Jae Sung   Lee, Sang Yup  

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  • Microbial production of butyl butyrate, a flavor and fragrance compound

    Noh, Hyeon Ji   Lee, Sang Yup   Jang, Yu-Sin  

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  • Metabolomics for industrial fermentation

    Choi, Kyeong Rok   Kim, Won Jun   Lee, Sang Yup  

    Metabolomics is essential to understand the metabolism and identify engineering targets to improve the performances of strains and bioprocesses. Although numerous metabolomics techniques have been developed and applied to various organisms, the metabolome of Saccharopolyspora erythraea, a native producer of erythromycin, had never been studied. The 2017 best paper of Bioprocess and Biosystems Engineering reports examination of three methods for quenching and extraction to analyze the intracellular metabolome of S. erythraea, and identified the most reliable methods for studying different groups of the metabolites. Subsequent studies on the dynamics of the intracellular metabolome of S. erythraea during the fed-batch fermentation identified a positive correlation between the specific erythromycin production rate and the pool size of intracellular propionyl-CoA and other precursors of erythromycin. A series of follow-up studies, such as demonstrating the applicability of the quenching/extraction methods in other related antibiotic producers, demonstrating the generality of the best matches between the quenching/extraction methods and the metabolite groups, and combining metabolomics approaches with the fluxomics and systems metabolic engineering approaches, will facilitate the metabolomics studies on important antibiotic producers, enable standardization of the quenching/extraction protocols, and improve the performance of the antibiotic production with deeper insight into their metabolism.
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