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Now showing items 1 - 6 of 6

  • Axis I comorbidity and psychopathologic correlates of autodestructive syndromes

    Fliege, Herbert   Lee, Jeong-Ran   Grimm, Anne   Fydrich, Thomas   Klapp, Burghard F.  

    Objective: Nonsuicidal deliberate self-harm and factitious disorders have been proposed as subtypes within the autodestructive behavior spectrum, basically differing in the issue of concealment. Aims are to determine Axis I diagnoses and psychopathologic correlates of open self-banners and patients diagnosed with factitious disorders. Methods: One hundred ninety-four psychosomatic medicine inpatients participated. Assessment included the structured World Health Organization Composite International Diagnostic Interview (computerized version) and self-report questionnaires for anxiety, depression. perceived stress, and personal coping resources. Results: Thirty-seven patients identified with self-destructive behavior were matched with 37 patients without such behavior. Overt self-harmers (n = 18) were more frequently diagnosed with anxiety, depressive, substance abuse/dependence, or eating disorders rind reported more stress than factitious disorder patients (n = 19) or those without self-destructive behavior. Patients with factitious disorder exhibited lower Axis I comorbidity and less psychopathology than patients without self-harm behavior. Conclusions: Regarding psychopathologic assessment, contrary to open self-harmers, factitious disorder patients appear strikingly inconspicuous. (C) 2009 Elsevier Inc. All rights reserved.
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  • Risk factors and correlates of deliberate self-harm behavior: A systematic review

    Fliege, Herbert   Lee, Jeong-Ran   Grimm, Anne   Klapp, Burghard F.  

    Objective: Deliberate self-harm behavior-without suicidal intent-is a serious health problem and may be studied as a clinical phenomenon in its own right. Empirical studies of sociodemographic and psychological correlates and risk factors are systematically reviewed. Methods: We searched Medline, PsycINFO, PSYNDEX (German psychological literature), and reference lists. We targeted self-induced bodily harm without conscious suicidal intent. Studies on suicidal behavior or self-poisoning were only included if they also assessed nonsuicidal self-harm. Results: Fifty-nine original studies met the criteria. Deliberate self-harm may occur at all ages, yet adolescents and young adults are at a higher risk. Evidence on gender is complex. Only 5 studies realize a prospective design (6 months to 10 years) and test predictors. The majority use cross-sectional and retrospective methods. No longitudinal study (separately) examines new incidence. Evidence of correlates encompasses distal/proximal, person/environment, and state/trait factors. Many studies report associations between current self-harm behavior and a history of childhood sexual abuse. Adolescent and adult self-harmers experience more frequent and more negative emotions, such as anxiety, depression, and aggressiveness, than persons who do not self-harm. Two studies yield specific interactions between childhood trauma and current traits and states such as low emotional expressivity, low self-esteem, and dissociation with respect to a vulnerability to self-harm. Conclusion: Evidence of distal, biographical stressors is fairly strong. Proximal stressors have rarely been investigated; protective factors, hardly at all. Despite many findings of correlates, the data do not yet justify terming them risk factors. Longitudinal studies are needed. (C) 2009 Elsevier Inc. All rights reserved.
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  • Effects of chronic alcohol and excessive iron intake on mitochondrial DNA damage in the rat liver

    Park, Jung-Eun   Lee, Jeong-Ran   Chung, Jayong  

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  • The Effects of Meridian Massage on Menopausal Symptoms and Shin-Hur in Middle-aged Menopausal Women

    Yang, Kyung-Hee   Park, Kum-Sook   Lee, Jeong-Ran  

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  • Principal components analysis applied to genetic evaluation of racing performance of Thoroughbred race horses in Korea

    Park, Jong-Eun   Lee, Jeong-Ran   Oh, Seungyoon   Lee, Jin Woo   Oh, Hee-Seok   Kim, Heebal  

    Selection of proper phenotypic trait among various traits related with interesting performance plays an important role in genetic evaluation. In this study, principal components analysis (PCA) was adapted to generate a new index as a measure of racing performance of 12,279 horses. This method allows us to reduce the number of variables considered in the evaluation of the horses' racing performance, which may facilitate modeling genetic programs. The resulted racing time, earning prize and rank were selected for generating new indices as the representation of racing performance of the horses. Three indices used in this study were: 1) PCA1 generated from the modified values of racing time, earning prize and rank, 2) PCA2 generated from the modified racing time and rank, and 3) the adjusted racing time. The first principal components (Ks), elements in the eigenvector corresponding to the largest eigenvalue of PCA, of PCA1 and PCA2 explained the variance of the selected variables about 75.6% and 75.4% respectively. Linear combinations of the first Ks and adjusted variables were used as new performance indices. Those animal models were composed of significant explanatory variables selected by Akaike information criterion (AIC). Heritability and repeatability were 0.324 (+/- 0.026) and 0.334 (+/- 0.034) for adjusted racing time, 0.319 (+/- 0.014) and 0.326 (+/- 0.018) for PCA1, and 0.324 (+/- 0.010) and 0.332 (+/- 0.012) for PCA2 respectively. Estimated heritabilities and repeatabilities for three indices showed similar values for domestic racing records. However, models using PCA showed better fitting for data than model using racing time as a performance index. The proposed methodology is efficient to evaluate the total variance in this group of correlated traits, allowing reduction in the number of variables for genetic evaluation and construction of better fitting model. (c) 2010 Elsevier B.V. All rights reserved.
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  • Enhancement of solubility and dissolution rate of poorly water-soluble naproxen by complexation with 2-hydroxypropyl-beta-cyclodextrin

    Lee, Beom-Jin   Lee, Jeong-Ran  

    The solubility and dissolution rate of naproxen (NPX) complexed with 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) using coprecipitation, evaporation, freeze-drying and kneading method were investigated. Solubility of NPX linearly increased (correlation coefficient, 0.995) as 2-HP-beta-CD concentration increased, resulting in AL type phase solubility curve. Inclusion complexes prepared by four different methods were compared by differential scanning calorimetry (DSC). The NPX showed sharp endothermic peak around 156 degree C but inclusion complexes by evaporation, freeze-drying and kneading method showed very broad peak without distinct phase transition temperature. In contrast, inclusion complex prepared by coprecipitation method resulted in detectable peak around 156 degree C which is similar to NPX, suggesting incomplete formation of inclusion complex. Dissolution rate of inclusion complexes prepared by evaporation, freeze-drying and kneading except coprecipitation method was largely enhanced in the simulated gastric and intestinal fluid when compared to NPX powder and commercial NAXEN tablet However, about 65% of NPX in gastric fluid still remained unreleased but most of NPX dissolved within 5 min in intestinal fluid. In case of inclusion complex prepared by coprecipitation method, formation of inclusion complex appeared to be incomplete, resulting in no marked enhancement of dissolution rate. From these findings, inclusion complexes of poorly water-soluble NPX with 2-HP-beta-CD were useful to increase solubility and dissolution rate, resulting in enhancement of bioavailability and minimization of gastrointestinal toxicity of drug upon oral administration of inclusion complex.
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