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Now showing items 65 - 80 of 383

  • Embryonic stem cell-derived neural precursor cells improve memory dysfunction in Aβ(1–40) injured rats

    Jun Tang   Haiwei Xu   Xiaotang Fan   Dabing Li   Derrick Rancourt   Guangji Zhou   Zhifang Li   Li Yang  

    The versatility of neural precursor cells (NPCs) derived from mouse embryonic stem cells (ESCs) has recently rekindled interests in cell replacement strategies aimed at neurodegenerative diseases. We observed the survival, migration, differentiation and functional recovery of NPCs transplanted into the hippocampus of aggregated β-amyloid (Aβ) peptide injured rats. Congo Red plaques, Fluro-jade B positive degenerating neurons and neuronal loss were observed in the Aβ-injured hippocampus of rats, accompanied with significant increases in escape latency and decrease in the ratio of exploratory time in a Morris water maze test. EGFP-expressing mouse ES cells were induced into Nestin-positive NPCs before transplantation into the Aβ-injured hippocampus. A marked decrease in escape latency and exploratory time were observed at least 16 weeks after transplantation compared to Aβ-injured animals without grafts. Grafted EGFP-expressing NPCs spread away from the injection tract and about 12.01±0.67% and 9.41±0.78% of NPCs differentiated into, respectively, GFAP- and NF200-positive cells 4W after transplantation. These ratios gradually increased to 40.25±0.57% and 19.35±0.84% by 16W. The restoration of hippocampal function by ESCs suggests that cell transplantation may be the effective choice to improve the cognitive function caused by Aβ injured.
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  • Mounting apparatus for data storage devices

    A data storage device assembly includes a data storage device having two opposite sidewalls, a supporting bracket, a positioning member mounted on the supporting bracket, a pressing member movably attached to the positioning member, and a driving member movably connected with the pressing member. The sidewalls of the data storage device form a first and second positioning post. The supporting bracket has a sidewall defines two guiding slots for receiving the first and second positioning post in a first direction. The pressing member defines a first receiving portion for receiving and locating the first positioning post in a second direction. The driving member has a driving portion. When the pressing member is pressed, the pressing member urges the driving portion to resist against the second positioning post, thereby causing the first positioning post to disengage from the first receiving portion and the corresponding guiding slot.
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  • Mounting apparatus for data storage device

    A data storage device assembly includes a data storage device having two sidewalls, each sidewall having a first positioning post; a supporting bracket having two sidewalls, one of the sidewalls defining a guiding slot for locating the first positioning post; a driving member movably attached to the supporting bracket, the driving member having a sliding post; a pivoting member pivotally located between the driving member and the supporting bracket, the pivoting member defining a sliding slot for the sliding post to slide therein, and having a stopping block for locating the first positioning post; and a first elastic component for urging the driving member to move towards an original position. When the driving member is pushed, the sliding post of the driving member slides in the sliding slot to urge the pivoting member to rotate, thereby causing the first positioning post to disengage from the stopping block.
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  • Retaining device for assembling drive bracket

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  • The relationship between genetic variants ofXRCC1gene and lung cancer susceptibility in Chinese Han population

    Jun Tang   Jianzhu Zhao   Jungang Zhao  

    Previous evidence indicate that genetic variants of X-ray repair cross-complementing group 1 gene (XRCC1) are potentially associated with the development of lung cancer. This study aimed to detect the relationship between the XRCC1 genetic variants and lung cancer susceptibility. A total of 420 lung cancer patients and 425 cancer-free healthy controls were recruited in this case-control study. The genotypes of XRCC1 genetic variants were investigated by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The relationship between the XRCC1 genetic variants and lung cancer susceptibility was determined by the association analyses. We found that the distributions of allelic and genotypic in lung cancer patients were significantly different from those of cancer-free healthy controls. Our data indicated that the XRCC1 c.1161G>A and c.1779C>G genetic variants were significantly associated with the increased susceptibility to lung cancer [for c.1161G>A, AA versus (vs.) GG: odds ratio (OR) 2.59, 95 % confidence interval (95 % CI) 1.59-4.21, chi(2) = 15.17, P < 0.001; A vs. G: OR 1.39, 95 % CI 1.13-1.70, P = 0.002; for c.1779C>G, GG vs. CC: OR 2.51, 95 % CI 1.42-4.44, chi(2) = 10.60, P = 0.001; G vs. C: OR 1.24, 95 % CI 1.00-1.54, chi(2) = 3.98, P = 0.046]. The allele A and genotype AA of c.1161G>A and allele G and genotype GG of c.1779C>G genetic variants may enhance lung cancer susceptibility. Taken together, these findings show that the functional c.1161G>A and c.1779C>G genetic variants of XRCC1 are associated with lung cancer susceptibility in the Chinese Han populations and might be used as molecular markers for evaluating the risk of lung cancer.
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  • One-pot synthesis of 2-amino-3-cyanopyridine derivatives catalyzed by ytterbium perfluorooctanoate [Yb(PFO)3]

    Jun Tang   Limin Wang   Yinfang Yao   Liang Zhang   Wenbo Wang  

    A family of 2-amino-3-cyanopyridine derivatives are synthesized from aldehydes, ketones, malononitrile, and ammonium acetate via one-pot reaction catalyzed by ytterbium perfluorooctanoate [Yb(PFO)(3)]. This procedure tolerates most of substrates and has the advantages of short routine, high yields, and environmentally friendly. Furthermore, the possible mechanism is also proposed. (C) 2010 Elsevier Ltd. All rights reserved.
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  • A new strategy for the preparation of an active Mn(0) and its use for radical cyclization reactions

    Jun Tang   Hiroshi Shinokubo   Koichiro Oshima  

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  • Interleaver address generation in turbo decoders for mobile multimedia multicast system communication systems

    Address generation for interleaving in a wireless communication system includes at least one input generation module to generate at least one input signal. A first address generator module and a second address generator module generate a first output address for interleaving and a second output address for interleaving. A selector module selects an address for interleaving from the first and the second output address based on predetermined criteria. At least one input translation module is receives an input signal and translate the received input signal to generate a nominal input signal based on a value of the received input signal. An address generation module generates an address for interleaving based on the nominal input signal.
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  • Pharmacokinetics and the active metabolite of enrofloxacin in Chinese mitten-handed crab (Eriocheir sinensis)

    Jun Tang   Xian-le Yang   Zong-lin Zheng   Wen-juan Yu   Kun Hu   Hui-juan Yu  

    The pharmacokinetics and active metabolite of enrofloxacin were estimated after single intramuscular administration (10.0 or 20.0 mg/kg body weight) to the Chinese mitten-handed crab (Eriocheir sinensis) in fresh water at 25.0 ± 1.0 °C. Levels of enrofloxacin and its metabolite ciprofloxacin in the main tissues (hemolymph, hepatopancreas, muscle, ovary and spermary) were simultaneously detected by HPLC. Enrofloxacin concentration–time profiles for the hemolymph in both tests were described by a two-compartment open model with first-order absorption. Distribution half-time (T1/2α), elimination half-time (T1/2β), body clearance (CL/F), mean residence time (MRT0–∞), area under the concentration–time curve from 0 to ∞ h (AUC0–∞) and apparent volume of distribution (Vd/F), which derived from the pharmacokinetic model, were 0.427 h, 21.3 h, 0.133 l/h/kg, 60.0 h, 96.9 μg/ml/h and 4.08 l/kg, respectively, at a dose of 10.0 mg/kg body weight, and 0.216 h, 12.3 h, 0.189 l/h/kg, 85.8 h, 187 μg/ml/h and 3.35 l/kg, respectively, at a dose of 20.0 mg/kg body weight. Similarities were found between the hemolymph concentration–time curves of the two tests; for example, instant absorption process followed by the distribution phrase, and a second absorption peak at 6 h post-treatment. After intramuscular administration of 10.0 mg/kg body weight, absorption of enrofloxacin was observed in the main edible tissues (hepatopancreas, muscle, ovary and spermary), and the drug residue was the highest in the hepatopancreas, where the ‘drug sink’ phenomenon occurred. Comparative pharmacokinetics showed fast absorption, broad distribution and fast elimination of enrofloxacin in E. sinensis after intramuscular dosing. Regarding ciprofloxacin, the main active metabolite of enrofloxacin, though relatively low levels were detected in all the main tissues of the crab, its kinetics in the hemolymph in the two tests were not described by a one- or two-compartment open model.
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  • Pharmacokinetics and the active metabolite of enrofloxacin in Chinese mitten-handed crab (Eriocheir sinensis)

    Jun Tang   Xian-le Yang   Zong-lin Zheng   Wen-juan Yu   Kun Hu and Hui-juan Yu  

    The pharmacokinetics and active metabolite of enrofloxacin were estimated after single intramuscular administration (10.0 or 20.0 mg/kg body weight) to the Chinese mitten-handed crab (Eriocheir sinensis) in fresh water at 25.0 ± 1.0 °C. Levels of enrofloxacin and its metabolite ciprofloxacin in the main tissues (hemolymph, hepatopancreas, muscle, ovary and spermary) were simultaneously detected by HPLC. Enrofloxacin concentration–time profiles for the hemolymph in both tests were described by a two-compartment open model with first-order absorption. Distribution half-time (T1/2α), elimination half-time (T1/2β), body clearance (CL/F), mean residence time (MRT0–∞), area under the concentration–time curve from 0 to ∞ h (AUC0–∞) and apparent volume of distribution (Vd/F), which derived from the pharmacokinetic model, were 0.427 h, 21.3 h, 0.133 l/h/kg, 60.0 h, 96.9 μg/ml/h and 4.08 l/kg, respectively, at a dose of 10.0 mg/kg body weight, and 0.216 h, 12.3 h, 0.189 l/h/kg, 85.8 h, 187 μg/ml/h and 3.35 l/kg, respectively, at a dose of 20.0 mg/kg body weight. Similarities were found between the hemolymph concentration–time curves of the two tests; for example, instant absorption process followed by the distribution phrase, and a second absorption peak at 6 h post-treatment. After intramuscular administration of 10.0 mg/kg body weight, absorption of enrofloxacin was observed in the main edible tissues (hepatopancreas, muscle, ovary and spermary), and the drug residue was the highest in the hepatopancreas, where the ‘drug sink’ phenomenon occurred. Comparative pharmacokinetics showed fast absorption, broad distribution and fast elimination of enrofloxacin in E. sinensis after intramuscular dosing. Regarding ciprofloxacin, the main active metabolite of enrofloxacin, though relatively low levels were detected in all the main tissues of the crab, its kinetics in the hemolymph in the two tests were not described by a one- or two-compartment open model.
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  • 5p Electronic properties of Gd in Gd@C82(OH)x studied by synchrotron radiation XPS

    Jun Tang   Gengmei Xing   Hui Yuan   Xingfa Gao   Long Jing   Shukuan Wang   Yue Cheng and Yuliang Zhao  

    The electronic properties of the metal atoms encaged in a fullerence cage were investigated using synchrotron X-ray photoelectron spectroscopy. Systematic variations in photoemission of valence band of Gd@C82, Gd@C82(OH)12, and Gd@C82(OH)22 were observed in Gd 5p levels. The results suggest that the electronic properties of the inner metal atom can be efficiently modulated by surface chemistry of the fullerene cage.
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  • Nanomedical Theranostics in Cardiovascular Disease

    Jun Tang   Mark E. Lobatto   Joanna C. Read   Aneta J. Mieszawska   Zahi A. Fayad   Willem J. M. Mulder  

    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. New diagnostic and therapeutic strategies are needed to mitigate this public health issue. Advances in nanotechnology have generated innovative strategies for diagnosis and therapy in a variety of diseases, foremost in cancer. Based on these studies, a novel concept referred to as nanomedical theranostics, or the combinatory application of nanoparticulate agents to allow diagnostic therapy, is being explored to enable image-guided, personalized, or targeted treatment. Preclinically, theranostics have been gradually applied to CVD with several interesting and encouraging findings. This article summarizes studies and challenges of nanotheranostic strategies in CVD. It also evaluates nanotheranostic strategies that may potentially be utilized to benefit patients.
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  • Special Issue No. 52. Surface Water Modeling || Modeling Near-Shore Currents Induced by Irregular Breaking Wave

    Jun Tang   Yong-Ming Shen and Lei Cui  

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  • Azaindole inhibitors of aurora kinases

    The present invention relates to a compound represented by Formula (I):
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  • Mounting apparatus for power supply

    A mounting assembly includes a chassis having a bottom wall forming a plurality of securing members, a blocking piece attached to the bottom wall of the chassis and deflectable downwards, a power supply, and an actuating member movably mounted on the power supply. The power supply includes a bottom wall defining a plurality of securing opening for the securing members of the chassis engaging therein and a blocking step abutting against the elastic blocking piece for limiting a horizontal movement of the power supply. The actuating member forms a pressing portion corresponding to the blocking piece. When the actuating member is pushed, the pressing portion of the actuating member depresses the blocking member to free the power supply.
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  • Computer enclosure with drive bracket

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