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Now showing items 49 - 64 of 273

  • Interleaver address generation in turbo decoders for mobile multimedia multicast system communication systems

    Address generation for interleaving in a wireless communication system includes at least one input generation module to generate at least one input signal. A first address generator module and a second address generator module generate a first output address for interleaving and a second output address for interleaving. A selector module selects an address for interleaving from the first and the second output address based on predetermined criteria. At least one input translation module is receives an input signal and translate the received input signal to generate a nominal input signal based on a value of the received input signal. An address generation module generates an address for interleaving based on the nominal input signal.
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  • A new strategy for the preparation of an active Mn(0) and its use for radical cyclization reactions

    Jun Tang   Hiroshi Shinokubo   Koichiro Oshima  

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  • Pharmacokinetics and the active metabolite of enrofloxacin in Chinese mitten-handed crab (Eriocheir sinensis)

    Jun Tang   Xian-le Yang   Zong-lin Zheng   Wen-juan Yu   Kun Hu   Hui-juan Yu  

    The pharmacokinetics and active metabolite of enrofloxacin were estimated after single intramuscular administration (10.0 or 20.0 mg/kg body weight) to the Chinese mitten-handed crab (Eriocheir sinensis) in fresh water at 25.0 ± 1.0 °C. Levels of enrofloxacin and its metabolite ciprofloxacin in the main tissues (hemolymph, hepatopancreas, muscle, ovary and spermary) were simultaneously detected by HPLC. Enrofloxacin concentration–time profiles for the hemolymph in both tests were described by a two-compartment open model with first-order absorption. Distribution half-time (T1/2α), elimination half-time (T1/2β), body clearance (CL/F), mean residence time (MRT0–∞), area under the concentration–time curve from 0 to ∞ h (AUC0–∞) and apparent volume of distribution (Vd/F), which derived from the pharmacokinetic model, were 0.427 h, 21.3 h, 0.133 l/h/kg, 60.0 h, 96.9 μg/ml/h and 4.08 l/kg, respectively, at a dose of 10.0 mg/kg body weight, and 0.216 h, 12.3 h, 0.189 l/h/kg, 85.8 h, 187 μg/ml/h and 3.35 l/kg, respectively, at a dose of 20.0 mg/kg body weight. Similarities were found between the hemolymph concentration–time curves of the two tests; for example, instant absorption process followed by the distribution phrase, and a second absorption peak at 6 h post-treatment. After intramuscular administration of 10.0 mg/kg body weight, absorption of enrofloxacin was observed in the main edible tissues (hepatopancreas, muscle, ovary and spermary), and the drug residue was the highest in the hepatopancreas, where the ‘drug sink’ phenomenon occurred. Comparative pharmacokinetics showed fast absorption, broad distribution and fast elimination of enrofloxacin in E. sinensis after intramuscular dosing. Regarding ciprofloxacin, the main active metabolite of enrofloxacin, though relatively low levels were detected in all the main tissues of the crab, its kinetics in the hemolymph in the two tests were not described by a one- or two-compartment open model.
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  • Pharmacokinetics and the active metabolite of enrofloxacin in Chinese mitten-handed crab (Eriocheir sinensis)

    Jun Tang   Xian-le Yang   Zong-lin Zheng   Wen-juan Yu   Kun Hu and Hui-juan Yu  

    The pharmacokinetics and active metabolite of enrofloxacin were estimated after single intramuscular administration (10.0 or 20.0 mg/kg body weight) to the Chinese mitten-handed crab (Eriocheir sinensis) in fresh water at 25.0 ± 1.0 °C. Levels of enrofloxacin and its metabolite ciprofloxacin in the main tissues (hemolymph, hepatopancreas, muscle, ovary and spermary) were simultaneously detected by HPLC. Enrofloxacin concentration–time profiles for the hemolymph in both tests were described by a two-compartment open model with first-order absorption. Distribution half-time (T1/2α), elimination half-time (T1/2β), body clearance (CL/F), mean residence time (MRT0–∞), area under the concentration–time curve from 0 to ∞ h (AUC0–∞) and apparent volume of distribution (Vd/F), which derived from the pharmacokinetic model, were 0.427 h, 21.3 h, 0.133 l/h/kg, 60.0 h, 96.9 μg/ml/h and 4.08 l/kg, respectively, at a dose of 10.0 mg/kg body weight, and 0.216 h, 12.3 h, 0.189 l/h/kg, 85.8 h, 187 μg/ml/h and 3.35 l/kg, respectively, at a dose of 20.0 mg/kg body weight. Similarities were found between the hemolymph concentration–time curves of the two tests; for example, instant absorption process followed by the distribution phrase, and a second absorption peak at 6 h post-treatment. After intramuscular administration of 10.0 mg/kg body weight, absorption of enrofloxacin was observed in the main edible tissues (hepatopancreas, muscle, ovary and spermary), and the drug residue was the highest in the hepatopancreas, where the ‘drug sink’ phenomenon occurred. Comparative pharmacokinetics showed fast absorption, broad distribution and fast elimination of enrofloxacin in E. sinensis after intramuscular dosing. Regarding ciprofloxacin, the main active metabolite of enrofloxacin, though relatively low levels were detected in all the main tissues of the crab, its kinetics in the hemolymph in the two tests were not described by a one- or two-compartment open model.
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  • Nanomedical Theranostics in Cardiovascular Disease

    Jun Tang   Mark E. Lobatto   Joanna C. Read   Aneta J. Mieszawska   Zahi A. Fayad   Willem J. M. Mulder  

    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. New diagnostic and therapeutic strategies are needed to mitigate this public health issue. Advances in nanotechnology have generated innovative strategies for diagnosis and therapy in a variety of diseases, foremost in cancer. Based on these studies, a novel concept referred to as nanomedical theranostics, or the combinatory application of nanoparticulate agents to allow diagnostic therapy, is being explored to enable image-guided, personalized, or targeted treatment. Preclinically, theranostics have been gradually applied to CVD with several interesting and encouraging findings. This article summarizes studies and challenges of nanotheranostic strategies in CVD. It also evaluates nanotheranostic strategies that may potentially be utilized to benefit patients.
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  • Azaindole inhibitors of aurora kinases

    The present invention relates to a compound represented by Formula (I):
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  • Mounting apparatus for power supply

    A mounting assembly includes a chassis having a bottom wall forming a plurality of securing members, a blocking piece attached to the bottom wall of the chassis and deflectable downwards, a power supply, and an actuating member movably mounted on the power supply. The power supply includes a bottom wall defining a plurality of securing opening for the securing members of the chassis engaging therein and a blocking step abutting against the elastic blocking piece for limiting a horizontal movement of the power supply. The actuating member forms a pressing portion corresponding to the blocking piece. When the actuating member is pushed, the pressing portion of the actuating member depresses the blocking member to free the power supply.
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  • Computer enclosure with drive bracket

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  • Erratum to ‘p- and n-Type Ba8Ga16Ge30 studied by X-ray photoelectron spectroscopy’ [Chem. Phys. Lett. 472 (2009) 60]

    Jun Tang   Ryotaro Kumashiro   Jing Ju   Zhaofei Li   Marcos A. Avila   Kouichirou Suekuni   Toshiro Takabatake   Fangzhun Guo   Keisuke Kobayashi   Katsumi Tanigaki  

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  • Reactor head with integral nozzles

    A reactor closure head assembly has guide tube nozzles which are integral with the reactor closure head. A dome-shaped forging having a concave surface is prepared with extra thickness equal to or greater than the desired nozzle height. Nozzles having bores therethrough are machined opposite the concave surface. Weld buttering is applied to the ends of the nozzles, the concave surface is clad with a corrosion resistant layer, and the forging is then heat treated. A guide tube flange is attached to the ends of the nozzles. The surfaces of the nozzle bores are covered with a protective layer which is preferably applied without heating, for example by electrochemical deposition, thereby avoiding the need for subsequent post weld heat treatment.
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  • Propenoate derivatives of betulin

    The present invention relates to a compound characterized by the following Formula I: or a pharmaceutically acceptable salt thereof, wherein X, Y, and Z are as described herein. Compounds of the present invention are useful for the treatment of HIV.
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  • Generation of allylic manganates from trimethylmanganate and allylic stannanes and their reactions with epoxides

    Jun Tang   Hideki Yorimitsu   Hirotada Kakiya   Rie Inoue   Hiroshi Shinokubo   Koichiro Oshima  

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  • Zircon U–Pb age and geochemical constraints on the tectonic affinity of the Jiaodong terrane in the Sulu orogen, China

    Jun Tang   Yong-Fei Zheng   Yuan-Bao Wu   Bing Gong   Xiangping Zha   Xiaoming Liu  

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  • miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer

    Jin Wang   Cailu Song   Hailin Tang   Chao Zhang   Jun Tang   Xing Li…  

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  • Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APPswe/PS1ΔE9 transgenic mouse model of Alzheimer’s disease

    Jun Tang   Min Song   Yanyan Wang   Xiaotang Fan   Haiwei Xu   Yun Bai  

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  • Computer front bezel

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