Home to a culturally heterogeneous population, India is also a melting pot of genetic diversity. The population architecture characterized by multiple endogamous groups with specific marriage patterns, including the widely prevalent practice of consanguinity, not only makes the Indian population distinct from rest of the world but also provides a unique advantage and niche to understand genetic diseases. Centuries of genetic isolation of population groups have amplified the founder effects, contributing to high prevalence of recessive alleles, which translates into genetic diseases, including rare genetic diseases in India. Rare genetic diseases are becoming a public health concern in India because a large population size of close to a billion people would essentially translate to a huge disease burden for even the rarest of the rare diseases. Genomics-based approaches have been demonstrated to accelerate the diagnosis of rare genetic diseases and reduce the socio-economic burden. The Genomics for Understanding Rare Diseases: India Alliance Network (GUaRDIAN) stands for providing genomic solutions for rare diseases in India. The consortium aims to establish a unique collaborative framework in health care planning, implementation, and delivery in the specific area of rare genetic diseases. It is a nation-wide collaborative research initiative catering to rare diseases across multiple cohorts, with over 240 clinician/scientist collaborators across 70 major medical/research centers. Within the GUaRDIAN framework, clinicians refer rare disease patients, generate whole genome or exome datasets followed by computational analysis of the data for identifying the causal pathogenic variations. The outcomes of GUaRDIAN are being translated as community services through a suitable platform providing low-cost diagnostic assays in India. In addition to GUaRDIAN, several genomic investigations for diseased and healthy population are being undertaken in the country to solve the rare disease dilemma. In summary, rare diseases contribute to a significant disease burden in India. Genomics-based solutions can enable accelerated diagnosis and management of rare diseases. We discuss how a collaborative research initiative such as GUaRDIAN can provide a nation-wide framework to cater to the rare disease community of India.

This letter reports the design and development of a conductive bridging RF switch with simple fabrication steps without the use of any clean room technologies. The reported device is a fully passive shunt mode RF switch on a co-planar waveguide transmission line, which operates in the dc-3GHz range. This particular topology is chosen in contemplation to limitations imposed by the chosen realization process. The device is based on a metal-insulator (electrolyte)-metal structure, with copper-Nafion-aluminum switching layers. S-21 switching between -1 dB (RF-ON) and -16 dB (RF-OFF) is demonstrated till 3 GHz by the device. Dc pulses in the range between 18 V/0.5 mA and -20 V/0.1 A are used, respectively, to SET and RESET the switch, and the instantaneous power consumed for SET and RESET is, respectively, 1.7 mu W and 3 mW. The SET and RESET state dc resistances of the switch are observed as 2 Omega and 2 M Omega subsequently. The model is initially simulated using commercial finite element method-based electromagnetic modeling tool and validated experimentally.

In this paper, we define the homodyne q-deformed quadrature operator and find its eigenstates in terms of the deformed Fock states. We find the quadrature representation of q-deformed Fock states in the process. Furthermore, we calculate the explicit analytical expression for the optical tomogram of the q-deformed coherent states. (C) 2017 Elsevier Inc. All rights reserved.

The detailed experimental and simulation studies of the stacked dogbone metamaterial particles are presented in this article. Besides the conventional left handed propagation mode, it is observed that the structure supports Fabry-Perot resonant modes and the excitation of this mode can be identified from the right handed resonant tunnel band in the dispersion diagrams. It is shown that the coupling between the Fabry-Perot and left handed resonant modes gives flat tunnel band characteristics in the dispersion diagram and is associated with huge electromagnetic absorption. The spectral response can be tailored by varying the stacking thickness of the sample making it suitable for microwave absorption and left handed transmission applications. (c) 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1347-1353, 2016

The extraordinary optical transmission (EOT) through an array of holes in a metal plate has been a constant source of inspiration for researchers for over a decade (Ebbesen et al 1998 Nature 391 667-9). In this paper, an EOT analogue is proposed in the microwave frequency range for enhancing the radiation performance of a stacked dipole antenna. It is observed that the back radiated power of the antenna is considerably reduced and the reason behind transmission enhancement is the excitation of Fabry-Perot resonant modes on the slit loaded aperture. Computational analysis based on finite difference time domain is performed for identifying the true reason behind resonant transmission enhancement.

The quest for invisibility has inspired a deep ardour in the research community over the past decade. The invention of metamaterials has boosted the research on electromagnetic cloaking due to its unusual electromagnetic parameters under plane wave incidence. In this study, we propose a novel cloaking scheme, using dogbone metamaterials, for effectively routing the incident electromagnetic fields around a target metal cylinder under consideration. Notable reduction in the scattered power is observed from the target in comparison to an uncloaked target. Experiments and simulations validate an effective reduction in the scattering cross section of the target and effective guiding of the incident plane wave around the target.

A five-year-old girl admitted with scrub typhus developed multiple organ dysfunction associated with hyperferritinaemia, hypofibrinogenaemia and hyperlipidaemia. Bone marrow aspiration studies confirmed haemophagocytic lymphohistiocytosis (HLH). HLH is a syndrome characterized by the uncontrolled activation and proliferation of macrophages and T-cells and can occur together with infections, connective tissue disorders, malignancies and genetic disorders.

Aneurysm of the vein of Galen is a rare intracranial vascular malformation. It is known to have diverse manifestations and varying severity. Four cases with different modes of presentation and outcome are reported. A mortality of 50 per cent was encountered. Among the survivors, one had neurologic sequelae whereas the other had attained age-appropriate developmental milestones. The former was a rare case of spontaneous thrombosis of the aneurysm while the latter was a boy who underwent therapeutic embolization.

A single probe-fed novel V slit, stub and slot embedded circular microstrip antenna with resonances in the three bands of UMTS, worldwide interoperability for microwave access (WiMAX) and WLAN is presented. The polarisation is circular in the UMTS band and linear in the other two bands. Asymmetrical V slits in the patch boundary along with an embedded circular slot in the patch centre are employed to introduce the perturbation necessary for circular polarisation. Impedance bandwidths (BWs) of 4.2, 2 and 6.2%, respectively, in the three bands centred at 2, 3.5 and 5.6 GHz are obtained. The axial ratio BW is 2.3% in the UMTS band. Moderate gains of 4.4, 3.5 and 2.8 dBi are obtained in the three bands. There is a patch size reduction of about 48% when compared with the conventional circular patch antenna at a fixed operating frequency. The radiation pattern is directional in the WiMAX band and nearly omnidirectional in the WLAN band.

Let D be a bounded positive (m, p)-circle domain in C-2 The authors prove that if dim(Iso(D)(0)) =3D 2, then D is holomorphically equivalent to a Reinhardt domain; if dim(Iso(D)(0)) =3D 4, then D is holomorphically equivalent to the unit ball in C-2. Moreover, the authors prove the Thullen's classification on bounded Reinhardt domains in C-2 by the Lie group technique.

We define a new generalized class of harmonically preinvex functions named harmonically (p, h, m)-preinvex functions, which includes harmonic (p, h)-preinvex functions, harmonic. p-preinvex functions, harmonic h-preinvex functions, and m-convex functions as special cases. We also investigate the properties and characterizations of harmonically (p, h, m)-preinvex functions. Finally, we establish some integral inequalities to show the applications of harmonically (p, h, m)-preinvex functions.

Rather than searching for a universal optimal level of multinationality for all firms, we argue that firm-specific attributes should result in firm-specific optimal levels of multinationality. Specifically, we draw upon transaction cost and internalization theory to argue that there will be different optimal levels of multinationality for individual firms, and if firms internalize foreign operations to an extent less than or greater than their individual optimal levels, transaction costs will increase and performance will decrease. To test this idea, we use transaction cost models in the context of large US law firms during the time period from 1986 through 2008 to estimate firm-specific optimal multinationality. Next, we test relationships between alignment with, or deviations from, firm-specific optimal levels of multinationality and performance (MA P). Consistent with the MA P hypothesis, insufficient and excessive levels of multinationality are both negatively related to financial performance. In addition, excessive multinationality is positively associated with downside performance risk. One key implication is that an MA P approach may offer greater theoretical validity and clarity than traditional multinationality and performance (M P) approaches.

In this paper, we propose two new algorithms and their hardware implementations for the normal basis multiplication over GF(p(m)), where p is an element of {2, 3}. In this case, the proposed multipliers are designed using serial and digit-serial hardware architectures. The normal basis multipliers over GF(2(m)) and GF(3(m)) are based on two proposed algorithms to compute the multiplication matrices T-k in order to speed-up the execution time and to reduce the area resources. It can be seen that the new hardware architecture for the NB multiplier over GF(2(m)) has the best characteristics of area complexity presented by Reyhani [16] and time complexity presented by Azarderakhsh and Reyhani [31]. The proposed hardware architectures for the normal basis multipliers over GF(2(163)), GF(2(233)), GF(2(283)), GF(2(409)), GF(3(89)) and GF(3(233)) were described in VHDL, and simulated and synthesized using Modelsim and Quartus Prime v16, respectively.