Abstract Four new sulfonated serinol derivatives, siladenoserinols M–P ( 1 – 4 ), were isolated from a tunicate of the family Didemnidae collected in Indonesia. Their chemical structures were elucidated by the interpretation of NMR and mass spectroscopic data. Two of them ( 2 and 4 ) were revealed to be disulfonate serinol derivatives, and the others were monosulfonates. Siladenoserinols A ( 5 ) and B ( 6 ), which we previously isolated from the same tunicate, inhibited the p53–Hdm2 interaction with an IC 50 value of 2.0 μM. However, 1 – 4 did not inhibit the activity. The result suggested that the acetyl group in the bicyclic ketal unit and/or the glycerophospholipid moiety in 5 and 6 were responsible for the inhibition of the p53–Hdm2 interaction. Graphical abstract Image 1
For a positive integer m, a bounded linear operator T on a Hilbert space H is called an (A, m)-isometry, if Theta((m))(A) (T) =3D Sigma(m)(k=3D0)(-1)(m-k) (k(m)) T*(k) AT(k) =3D 0, where A is a positive (semi-definite) operator. In this paper we give a characterization of (A, m)-isometric and strict (A, m)-isometric unilateral weighted shifts in terms of their weight sequences, respectively. Moreover, we characterize (A, 2)-expansive unilateral weighted shifts (i.e. operators satisfying Theta((2))(A) (T) <=3D 0).
We examine the M&A exit behavior of new, young businesses and the way the exit is shaped by their innovative capabilities and their growth in employment. Using a large sample of startups founded in 2004, we find that businesses organized as corporations had very different acquisition outcomes than those organized as sole proprietorships. These different acquisition outcomes could be explained by differences in innovation and growth potential in the startup year as well throughout the business' lifetime. Our results suggest that higher innovation and employment growth explain the likelihood of M&A exit for new, young corporations but not for sole proprietorships. These results indicate that acquirers value the growth potential signaled by corporations through intellectual property rights and growth in employment and, therefore, businesses with high quality innovations are the most attractive targets for acquisitions. Young corporations with external equity investors are more likely to become M&A targets, as angels or venture capitalists have the first opportunity to liquidate some or all their equity holdings when the business becomes an acquisition target. Our results also show that young corporations owned by serial entrepreneurs are more likely to become M&A targets. From an acquirer's perspective, entrepreneurs with startup experience are typically favored due to their proven ability to realize the growth potential of a venture as well as their willingness and ability to harvest value for themselves and their investors.
A new class of high-entropy M3B4 borides of the Ta_(3)B_(4)-prototyped orthorhombic structure has been synthesized in the bulk form for the first time.Specimens with compositions of(V0.2Cr0.2Nb0.2Mo0.2Ta0.2)3B4 and(V0.2Cr0.2Nb0.2Ta0.2W0.2)_(3)B_(4) were fabricated via reactive spark plasma sintering of high-energy-ball-milled elemental boron and metal precursors.The sintered specimens were〜98.7%in relative densities with virtually no oxide contamination,albeit the presence of minor(4-5 vol%)secondary high-entropy M5B6 phases.Despite that Mo_(3)B_(4) or W_(3)B_(4) are not stable phase,20%of M03B4 and W3B4 can be stabilized into the high-entropy M3B4 borides.Vickers hardness was measured to be 18.6 and 19.8 GPa at a standard load of 9.8 N.This work has further expanded the family of different structures of high-entropy ceramics reported to date.
ABSTRACT abstract =E2=80=93 The article recovers the history of the Brazilian record label Chantecler, founded in 1958 and based in S=C3=A3o Paulo, which played a crucial role in the production of Brazilian regional music, especially Brazilian sertaneja music. Until the 1990s, regional music genres were mostly disregarded by major international record companies operating in Brazil. From that perspective, this work discusses the stratification of popular music consumption in Brazil after the 1960s, noting the role of domestic vis-=C3=A0-vis international record labels, and thus contextualizes the presence of Chantecler in the broader scenario of the national record industry.=09
A U-m-subnormal subgroup of a finite group is introduced, some new characterizations of the hypercyclically embedded subgroups of a finite group are obtained and a series of known results is generalized.