Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 113 - 128 of 203

  • Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia.

    Huang, Congwu   Cen, Chuan   Wang, ChengXu   Zhan, Haiyong   Ding, Xin  

    BACKGROUND: Inflammation and endothelial dysfunction is implicated in the atherosclerosis initiation and progression in the setting of hyperlipidemia. Colchicine is a potent anti-inflammatory agent and whether colchicine combined with atorvastatin has synergistic effects on inflammation amelioration and endothelial function improvement is unknown.; METHODS: Hyperlipidemic rat model was produced by high-fat and high-cholesterol diet for 6weeks. Rats with normal diet were served as shame group. In hyperlipidemic group, normal saline, atorvastatin (10mg/kg body weight/day), colchicines (0.5mg/kg body weight/day), or atorvastatin combined with colchicines (same dosages) were prescribed for 2weeks. Serum levels of lipid profile, C-reactive protein (CRP), liver enzyme, lipoprotein associated phospholipase A2 (Lp-PLA2) and nitric oxide (NO) production were serially assessed.; RESULTS: Before the beginning of the study, all laboratory variables were comparable among each group. After 6weeks of hyperlipidemic model production, serum levels of cholesterols, CRP and Lp-PLA2 were significantly increased when compared to sham group, whereas NO production was reduced. With 2weeks of colchicine therapy, serum levels of CRP and Lp-PLA2 were decreased and NO production was enhanced in the colchicine group in a lipid-lowering independent manner. Added colchicine into atorvastatin therapy further improved NO production and decreased CRP and Lp-PLA2 levels, indicating a potential synergism of colchicine and atorvastatin.; CONCLUSION: Colchicine combined with atorvastatin may have stronger protective effects on improving endothelial function and ameliorating inflammation in rats with hyperlipidemia.=20
    Download Collect
  • Os, Nd, O and S isotope constraints on country rock contamination in the conduit-related Eagle Cu-Ni-(PGE) deposit, Midcontinent Rift System, Upper Michigan

    Ding, Xin   Ripley, Edward M.   Shirey, Steven B.   Li, Chusi  

    The Eagle Cu-Ni-(PGE) deposit is hosted by mafic to ultramafic intrusive rocks associated with the Marquette-Baraga dike swarm in northern Michigan. Sulfide mineralization formed in a conduit system during early stages in the development of the similar to 1.1 Ga Midcontinent Rift System. The conduit environment represents a prime location for melt-rock interaction. In order to better assess the extent of country rock contamination in the Eagle system, a combined trace element, Nd, Os, O and S isotope study of country rocks, sulfide-bearing igneous rocks and massive sulfide was undertaken. Both the Eagle and the weakly mineralized East Eagle intrusion show trace element patterns that are similar to those of picritic basalts that formed during early stages of rift development. The trace element, Os, Nd, and O isotopic values of the igneous rocks are consistent with <5% of bulk contamination by Paleoproterozoic and Archean country rocks. Both the Re-Os and Sm-Nd system provide isochrons that are in agreement with the 1107 Ma U-Pb baddeleyite age of the intrusive rocks. Calculated gamma(Os)(1100) and epsilon(Nd)(1100) values for the magmas are +34 and -2. delta O-18 values of pyroxene in feldspathic pyroxenite range from 6.5 parts per thousand to 6.6 parts per thousand and provide the only indication that bulk contamination may locally have exceeded 20%. Sulfur isotopic values of disseminated and massive sulfide in the Eagle intrusion range from 0.3 parts per thousand to 4.6 parts per thousand. The delta S-34 values are much lower than those that characterize most of the country rocks, but could still be indicative of a contribution of S from country rocks of up to similar to 50%. Delta S-33 values of the disseminated and massive sulfides range from -0.10 parts per thousand to 0.09 parts per thousand indicating a source in Paleoproterozoic country rocks. Semi-massive sulfide in the Eagle deposit has delta S-34 values between 2.2 parts per thousand and 5.3 parts per thousand, and Delta S-33 values show a broad range between -0.86 parts per thousand and 0.86 parts per thousand indicating a major contribution from an Archean source. Isotopic data from the Eagle deposit strongly indicate that multiple sources of sulfur were involved in the generation of the Ni-Cu-(PGE) mineralization, and magmas which traversed variable paths through the mantle and crust were focused and utilized the same conduit at the level of the Eagle deposit. Our results emphasize the fact that the sulfur isotopic values of immediate country rocks may not be appropriate as end-member values for mixing calculations; sulfur derivation from deeper in the conduit system may have involved rocks with very different sulfur isotope ratios. In addition, sulfur isotopic exchange reactions between passing magma and accumulated crystals or sulfide liquid in the conduit may have led to decreased sulfur isotope variability and delta S-34 values near those of mantle sulfur. (C) 2012 Elsevier Ltd. All rights reserved.
    Download Collect
  • Enhancing Electrochemical Performance of Graphene Fiber-Based Supercapacitors by Plasma Treatment

    Meng, Jie   Nie, Wenqi   Zhang, Kun   Xu, Fujun   Ding, Xin   Wang, Shiren   Qiu, Yiping  

    Graphene fiber-based supercapacitors (GFSCs) hold high power density, fast charge discharge rate, ultralong cycling life, exceptional mechanical/electrical properties, and safe operation conditions, making them very promising to power small wearable electronics. However, the electrochemical performance is still limited by the severe stacking of graphene sheets, hydrophobicity of graphene fibers, and complex preparation process. In this work, we develop a facile but robust strategy to easily enhance electrochemical properties of all-solid-state GFSCs by simple plasma treatment. We find that 1 min plasma treatment under an ambient condition results in 33.1% enhancement of areal specific capacitance (36.25 mF/cm(2)) in comparison to the as-prepared GFSC. The energy density reaches 0.80 mu W h/cm(2) in polyvinyl alcohol/H2SO4 gel electrolyte and 18.12 mu W h/cm(2) in poly(vinylidene difluoride)/ethyl-3-methylimidazolium tetrafluoroborate electrolyte, which are 22 times of that of as-prepared ones. The plasma treated GFSCs also exhibit ultrahigh rate capability (69.13% for 40 s plasma-treated ones) and superior cycle stability (96.14% capacitance retention after 20 000 cycles for 1 min plasma-treated ones). This plasma strategy can be extended to mass manufacture high-performance carbonaceous fiber-based supercapacitors, such as graphene and carbon nanotube-based ones.
    Download Collect
  • Biomechanical mechanism of fabric softness discrimination

    Hu, Jiyong   Ding, Xin   Wang, Rubin  

    "Softness" is one of the primitive terms describing the physical and sensory attributes of fabric, however, the information for its physiological mechanism compared to statistical physical factors of fabric softness is scarce. To explain the biomechanical and the potential neurophysiological phenomenon for exploring fabric softness, a finger-fabric finite element model is used to conduct an active contact simulation analysis. The effects of surface friction index and compression modulus of fabric on softness discrimination are investigated. The interests of the study are in the contributions of these fabric variables to the changing contact area, interfacial friction shear stress and contact pressure distributions, which are significant cognitive variables or stimulus parameters in peripheral neural levels documented by prior observations. The mechanistic data for fingerpad-fabric interaction indicate that the basis for the perception of softness of flexible and bulk fabric is likely on the spatial variation of the pressure and shear stress on the skin resulting from the surface friction index and compression property of fabric. These conclusions suggest that devices for the haptic rendering of fabric softness, based on vibration result from surface roughness, is not sufficient to perceive the soft-touch feel of fabric as a result of the cues with lack information for the changing contact area by touch.
    Download Collect
  • Supercritical CO2 source for underground seismic exploration

    Wang, Bo   Qiu, Wanyong   Liu, Shengdong   Sun, Huachao   Ding, Xin   Jin, Biao   Zhang, Zhendong  

    Download Collect
  • Structure, luminescence property and abnormal energy transfer behavior of color-adjustable Ca\r 3\r Hf\r 2\r SiAl\r 2\r O\r 12\r :Ce\r 3+\r ,Mn\r 2+\r phosphors

    Ding, Xin   Geng, Wanying   Wang, Qian   Wang, Yuhua  

    Download Collect
  • Segregated double network enabled effective electromagnetic shielding composites with extraordinary electrical insulation and thermal conductivity

    Zhang, Ping   Ding, Xin   Wang, Yanyan   Gong, Yi   Zheng, Kang   Chen, Lin   Tian, Xingyou   Zhang, Xian  

    Download Collect
  • Prevalence and risk factor for MDR-GNB infection in liver transplantation

    Men, Tong-Yi   Li, Hao   Gu, Yan   Ding, Xin   Xing, Tong-Hai   Fan, Jun-Wei   Peng, Zhi-Hai  

    Liver transplantation (LT) has emerged as a viable therapy for various end-stage liver diseases. Multi-drug resistant Gram-negative bacilli (MDR-GNB) have emerged as predominant pathogens. The prevalence of MDR-GNB infection has been increasing in LT recipients, especially in early post-LT stages. MDR-GNB infection has become a main cause of death following LT. Since key elements of MDR-GNB infection after LT mainly include the pre-LT severity of underlying disease, technical problems, acute rejection, and so on, appropriate measures, such as improvement of LT technology and management, restriction of antibiotic use and immunosuppressive therapy advancement, should be commenced to prevent and control the occurrence of MDR-GNB infection. A better understanding of the prevalence of and risk factors for MDR-GNB infection complications is needed to improve quality of life and survival rate after LT.
    Download Collect
  • Multidrug-resistant gram-negative bacterial infections after liver transplantation - Spectrum and risk factors

    Zhong, Lin   Men, Tong-Yi   Li, Hao   Peng, Zhi-Hai   Gu, Yan   Ding, Xin   Xing, Tong-Hai   Fan, Jun-Wei  

    Objectives: Gram-negative bacilli infections, especially multidrug-resistant gram-negative bacilli infections, are the leading cause of high mortality after liver transplantation. This study sought to investigate the type of infection, infection rate, pathogenic spectrum, antibiotic-resistance profile, risk factors, and epidemiology of multidrug-resistant gram-negative bacterial infection. Methods: A retrospective cohort study was conducted and data of 217 liver transplant patients receiving cadaveric livers between January 2007 and April 2010 were analyzed. Antibiotic susceptibility was determined by minimum inhibitory concentration test. Extended-spectrum and metallo-beta-lactamase assays were used to analyze beta-lactamase-produced isolates, and repetitive-sequence polymerase chain reaction was used to differentiate bacterium subspecies. Results: Sixty-seven isolates of multidrug-resistant gram-negative bacteria were isolated from 66 infected liver transplant patients. Stenotrophomonas maltophilia (100%, 8/8), Klebsiella pneumoniae (61.5%, 8/13), Enterobacter cloacae (75%, 3/4) and Escherichia coli (81.3%, 13/16) were the most common extended-spectrum beta-lactamase-producing bacilli. Metallo-beta-lactamase expressing isolates were identified as S. maltophilia (100%, 8/8), Pseudomonas aeruginosa (83.3%, 5/6), Acinetobacter baumannii (95%, 19/20). Significant independent risk factors for multidrug-resistant gram-negative infection were extended use of pre-transplant broad-spectrum antibiotics (OR 9.027, P = 0.001) and prolonged (>= 72 h) endotracheal intubation (OR 3.537, P = 0.033). Conclusions: To reduce the risk of acquiring MDR gram-negative bacillus infections after liver transplant, control measures are required to limit the use of prophylactic antibiotic in preventing infection during liver transplant and to shorten endotracheal intubation time. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
    Download Collect
  • Structure and photoluminescence properties of a novel apatite green phosphor Ba-5(PO4)(2)SiO4:Eu2+ excited by NUV light

    Ding, Xin   Wang, Yuhua  

    A novel apatite mineral of Ba-5(PO4)(2)SiO4 was synthesized successfully using a traditional high temperature solid-state reaction. Its structure was determined by high-resolution transmission electron microscopy, fast Fourier transform, energy dispersive X-ray spectroscopy, and X-ray powder diffraction Rietveld refinement, and this was found to be a hexagonal crystal system with the space group attributed to P63/m (176). Moreover, a series of Eu2+ doped Ba-5(PO4)(2)SiO4 phosphors were investigated. The photoluminescence (PL) properties of Ba-5(PO4)(2)SiO4:Eu2+ were investigated in detail by density functional theory calculations, diffuse reflection spectra, emission-excitation spectra, decay curves, and temperature dependence spectra. It can emit green light peaking at similar to 515 nm under 405 nm NUV excitation with quantum efficiency 31.89%. According to structure and photoluminescence (PL) property analysis, Eu2+ can occupy two kinds of Ba2+ site. The concentration quenching mechanism of Eu2+ could be a d-d interaction luminescence center. It has poor temperature stability properties because of too much temperature-dependent electron-phonon interaction at high temperature. Fabricated white-LEDs using a 405 nm GaN NUV chip combined with a blend of RGB phosphors: CaAlSiN3:Eu2+, Ba-5(PO4)(2)SiO4:1% Eu2+ and BAM:Eu2+, driven by 30 mA current can get warm-white light with chromaticity coordinates (0.355, 0.342) and correlated color temperature (CCT) 4561 K. This demonstrates that Ba-5(PO4)(2)SiO4:Eu2+ is a potential green phosphor matching NUV LED chips to get white light.
    Download Collect
  • In Situ Probing the Localized Optoelectronic Properties of Defective Monolayer WS 2

    Yao, Yi   Chen, Fei   Fu, Li   Ding, Su   Zhao, Shichao   Zhang, Qi   Su, Weitao   Ding, Xin   Song, Kaixin  

    Download Collect
  • The Blue, Green and Grey Water Consumption for Crop Production in Heilongjiang

    Ding, Xin   Wang, Saige   Chen, Bin  

    Download Collect
  • Effects of tributyltin, benzo[a]pyrene, and their mixture on antioxidant defense systems in Sebastiscus marmoratus RID G-4583-2010 RID G-4632-2010 RID G-4615-2010 RID G-3937-2010

    Wang, Chonggang   Zhao, Yang   Zheng, Ronghui   Ding, Xin   Wei, Wei   Zuo, Zhenghong   Chen, Yixin  

    It has been reported that there is a metabolic interaction between tributyltin (TBT), an organometal used as an antifouling biocide, and benzo[a]pyrene (BaP), a widespread carcinogenic polycyclic aromatic hydrocarbon. This study was therefore designed to examine the potential in vivo influence of TBT, BaP, and their mixture on hepatic antioxidant defense systems of Sebastiscus marmoratus, which were given a single ip injection of TBT (0.5, 1, 5, and 10mg/kg), BaP (0.5, 1, 5, and 10mg/kg), or both in combination (0.5, 1, 5, and 10mg/kg); control fish received olive oil vehicle only. Samples were collected for biochemical analysis after injection for 7 days. Cotreatment with BaP caused a significant inhibition of TBT-mediated malondialdehyde contents elevation. Cotreatment with TBT decreased BaP-mediated glutathione peroxidase activity induction. Cotreatment with TBT and BaP did not significantly alter the reduced glutathione levels, which were significantly induced by TBT or BaP alone. TBT-induced suppression of BaP bioactivation or BaP-induced stimulation of the phase 11 metabolism of TBT and its biliary excretion, both of which have been reported previously, could explain the observed antagonism. The results suggest that combined exposure of TBT and BaP increases the vulnerability of the fish to oxidative stress. BaP cotreatment decreased the induction of glutathione S-transferase (GST) activity by the lower dose of TBT, while cotreatment with TBT and BaP at the highest dose (10mg/kg) resulted in inhibition of the GST activity by 4.8-fold. The results suggest that these biomarkers should be interpreted with caution in biomonitoring studies. Combined effects of TBT and BaP exposure at environmental levels on these biomarkers should be further researched. (c) 2005 Elsevier Inc. All rights reserved.
    Download Collect
  • Symmetric Electron Vortices of Hydrogen Ionized by Orthogonal Elliptical Fields

    Li, Meng   Zhang, Guizhong   Ding, Xin   Yao, Jianquan  

    In this paper, we report our numerical investigation on the photoionization of hydrogen by two orthogonal elliptically polarized and time-delayed attosecond pulses; we found that the momentum distributions exhibit a helical structure. The spectral patterns were obtained by making the use of the strong field approximation theory, and analyzed in terms of the irregularity of the overlapped fields. Some morphological characteristics of the generated vortex arms were found to be sensitive to the ellipticity and time delay of the two attosecond pulses. These phenomena could be used to investigate the intrinsic features of the photoionizaiton and complex polarized ultrashort pulses.
    Download Collect
  • Mechanical Properties of Bump-Prone Coal with Different Porosities and Its Acoustic Emission-Charge Induction Characteristics under Uniaxial Compression

    Ding, Xin   Xiao, Xiaochun   Lv, Xiangfeng   Wu, Di   Xu, Jun  

    Download Collect
  • A wearable fiber-shaped supercapacitor based on a poly(lactic acid) filament and high loading polypyrrole

    Nie, Wenqi   Liu, Lianmei   Li, Qiao   Zhang, Suyi   Hu, Jiyong   Yang, Xudong   Ding, Xin  

    Download Collect
3 4 5 6 7 8 9 10 11 12

Contact

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback