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Now showing items 81 - 96 of 6624

  • The Slow Philosophy of J. M. Coetzee. By \rJan Wilm. Pp. x, 251, London/NY, Bloomsbury, 2016, $60.00.

    Madigan   Patrick  

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  • Discourses of Poverty: Social Reform and the Picaresque in Early Modern Spainby Anne J. Cruz

    Review by: Peter N. Dunn  

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  • Discourses of Poverty: Social Reform and the Picaresque in Early Modern Spainby Anne J. Cruz

    Review by: Peter N. Dunn  

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  • A METHOD TO AVOID DIVERGING COMPONENTS IN THE CANDECOMP/PARAFAC MODEL FOR GENERIC I x J x 2 ARRAYS

    Stegeman, Alwin   De lathauwer, Lieven  

    Computing the Candecomp/Parafac (CP) solution of R components (i.e., the best rank-R approximation) for a generic I x J x 2 array may result in diverging components, also known as "degeneracy." In such a case, several components are highly correlated in all three modes, and their component weights become arbitrarily large. Evidence exists that this is caused by the nonexistence of an optimal CP solution. Instead of using CP, we propose to compute the best approximation by means of a generalized Schur decomposition (GSD), which always exists. The obtained GSD solution is the limit point of the sequence of CP updates (whether it features diverging components or not) and can be separated into a nondiverging CP part and a sparse Tucker3 part or into a nondiverging CP part and a smaller GSD part. We show how to obtain both representations and illustrate our results with numerical experiments.
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  • The group inverse of the transformation J(X) = AX ? XB

    Georg Heinig  

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  • Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J x SM/J Murine Model of Obesity

    Ehrich, T. H.   Hrbek, T.   Kenney-Hunt, J. P.   Pletscher, L. S.   Wang, B.   Semenkovich, C. F.   Cheverud, J. M.  

    Obesity is one of the most serious threats to human health today. Although there is general agreement that environmental factors such as diet have largely caused the current obesity pandemic, the environmental changes have not affected all individuals equally. To model gene-by-environment interactions in a mouse model system, our group has generated an F-16 advanced intercross line (AIL) from the SM/J and LG/J inbred strains. Half of our sample was fed a low-fat (15% energy from fat) diet while the other half was fed a high-fat (43% energy from fat) diet. The sample was assayed for a variety of obesity- and diabetes-related phenotypes such as growth rate, response to glucose challenge, organ and fat pad weights, and serum lipids and insulin. An examination in the F-16 sample of eight adiposity quantitative trait loci previously identified in an F-2 intercross of SM/J and LG/J mouse strains reveals locus-by-diet interactions for all previously mapped loci. Adip7, located on proximal chromosome 13, demonstrated the most interactions and therefore was selected for fine mapping with microsatellite markers. Three phenotypic traits, liver weight in male animals, serum insulin in male animals, and reproductive fat pad weight, show locus-by-diet interactions in the 127-kb region between markers D13Mit1 and D13Mit302. The phosphofructokinase (PFK) C (Pfkp) and the pitrilysin metalloprotease 1 (Pitrm1) genes are compelling positional candidate genes in this region that show coding sequence differences between the parental strains in functional domains.
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  • Inheritance Patterns of Noise Vulnerability and "Protectability" in (C57BL/6J x CBA/J) F1 Hybrid Mice

    Barden, Emily K.   Rellinger, Erin A.   Ortmann, Amanda J.   Ohlemiller, Kevin K.  

    Background: Interindividual variation in cochlear vulnerability to noise and ototoxins must in part reflect allelic variation in genes that largely remain unknown. Work in our laboratory has shown that young adult CBA/J mice are more vulnerable to cochlear noise injury than are similar-aged mice of other well-studied strains such as C57BU6J (B6). Conversely, young CBA/J mice are dramatically protected against noise exposure by low-dose kanamycin (KM) treatment, while B6 mice are not. Genetic differences that distinguish these two strains may include genes that help establish the early "sensitive period" in mammals, as well as genes that shape innate protective responses to stress. These genes may have human homologs that exert similar influences and thereby partly govern individual risk of acquired hearing loss. Purpose: We hypothesize that young CBA/J and B6 mice carry different alleles at unknown loci that mediate their characteristic sensitivities to noise and responses to kanamycin. The first step in any experimental genetic analysis of two divergent populations is to examine F1 hybrids formed from these. Accordingly, we evaluated both noise vulnerability and the extent of protection from noise by low-dose KM in 6-wk-old F1 hybrids derived from a B6 x CBA/J cross. Study Sample: The study included 52 CBA/J, 59 C57BU6J (B6), and 45 (B6 x CBA/J) F1 hybrid mice, aged 6 wk at time of noise exposure. Both genders were included. Intervention: For experiments aimed at noise vulnerability, B6 and F1 mice were exposed to loud broad-band noise (4-45 kHz, 110 dB SPL) for varying durations, and the resulting noise-induced permanent threshold shifts (NIPTSs, measured 2 wk postnoise) were compared with previous data from CBA/J mice. For experiments aimed at KM-based "protectability," CBA/J, B6, and F1 mice received either kanamycin (300 mg/kg, sc) or saline twice daily for 10 days and then were noise exposed for 30 min, followed by measurement of NIPTS at 2 wk postnoise. Data Collection and Analysis: Data comprised auditory brainstem response (ABR) thresholds examined by two-way ANOVA (threshold x frequency, group) and derived metrics for NIPTS, plotted versus noise duration. Results: The "threshold" noise exposure duration for NIPTS in F1 hybrid mice was similar to that in CBA/J. Like CBA/J mice, F1 mice were also significantly protected from noise by KM although the protection appeared less robust than in the CBA/J parent strain. B6 mice appeared harmed by KM alone, even without noise exposure. None of the experimental groups provided any evidence for synergistic interactions between noise and KM. Conclusions: Our data support the hypothesis that young CBA/J and B6 mice carry different alleles that underlie their divergent responses to KM and sensitivities to noise exposure. While the number and type of genes remain unknown, they are worth pursuing because they establish completely novel hearing phenotypes with potential relevance to humans. Our results lay the foundation for mapping of the underlying genes, and ultimately gene identification.
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  • Geographical Notes on Xuanzang's Account--Northeast India and Orissa: Xiyu Ji J X

    Ray, H.  

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  • State-to-state energy transfer of NH(X (3)Sigma(-),v=0,J,N) in collisions with He and N-2

    Rinnenthal, JL   Gericke, KH  

    State-to-state rotational energy transfer of ground state NH(X (3)Sigma(-),v=0,J,N) in collisions with He and N-2 is studied. A complete inversion between the metastable NH(a (1)Delta) state and the NH(X (3)Sigma(-)) state is generated via the photodissociation of hydrazoic acid at a wavelength of 266 nm. Single state NH(X (3)Sigma(-),v=0,J,N) is generated by applying the stimulated emission pumping technique using the strongly forbidden NH(a (1)Delta-->X (3)Sigma(-)) intercombination transition around 794 nm. The ground state NH(X (3)Sigma(-),v=0,J,N) distribution is probed with respect to all quantum states using laser induced fluorescence varying delay times and pressures. The collision induced energy transfer between the different rotational and spin levels is extensively studied and two comprehensive sets of rate constants for vibrationally elastic and rotationally inelastic collisions with He and N-2 as collision partners are given which include the effect of multiple collisions. We find propensities for (DeltaN=0,Deltai=+/-1) and (DeltaN=+/-1,Deltai=0) transitions where N represents the quantum state for nuclear rotation and i represents the index of the spin component F-i. The rotational relaxation for N-2 as a collision partner occurs on the average three times faster than the rotational relaxation with He as a collision partner. The energy dependence of the transition efficiency for only the nuclear rotational quantum number N obeys an energy-gap law for both He and N-2. (C) 2002 American Institute of Physics.
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  • Single state NH(X?[sup 3]Σ[sup ?],v=0,J,N) preparation for state-to-state studies

    Rinnenthal, Jan Leo   Gericke, Karl-Heinz  

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  • Contribution of colour-singlet process Upsilon -> J/Psi+c(c)over-bar-g to Upsilon -> J/Psi+X

    Li, SY   Xie, QB   Wang, Q  

    We show that the colour-singlet process Y --> J/Psi + c(c) over bar g F significantly contributes to the inclusive process Y --> J/Psi + X. We calculate the partial width and the momentum distribution of the produced J/Psi in this channel. The obtained width is comparable to the experimental data. The momentum distribution is fairly soft, which is in contrast to the results from the colour-octet processes discussed earlier in literature but is consistent with the CLEO measurements. Further experiments to check this contribution are suggested. (C) 2000 Elsevier Science B.V. All rights reserved.
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  • Steven J. Sutcliffe, Children of the New Age (London: Routledge, 2003), pp. x + 267. £12.99 (pb)

    Drane   John  

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  • Discourses of Poverty: Social Reform and the Picaresque Novel in Early Modern Spainby Anne J. Cruz

    Review by: Hilaire Kallendore  

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  • Branching fractions of B\r (c)\r decays involving J/ψ and X(3872)

    Hsiao, Y. K.   Geng, Chao-Qiang  

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  • Cylindrical symmetry-like solutions of Laplace equation 2V(xj) = 0

    Yang   Z.J.  

    The cylindrical symmetry-like solutions of Laplace equation 2V({xj}) = 0 are presented for three- and higher-dimensional systems.
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  • W. J. Waluchow, Inclusive Legal Positivism, Oxford, Clarendon Press, 1994, pp. x + 290.

    Shiner, Roger A.  

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