A primer, probe and kit used for detecting C-KIT gene mutation. The primer is shown in SEQ ID NO: 1-2, 4-5, 7-8 or 10-11, and the probe is shown in SEQ ID NO: 3, 6, 9 and 12. The kit is used for real-time fluorescent polymerase chain reaction (PCR) and may detect mutation of a C-KIT gene.
Primers, probes and a kit for use in detecting c-kit gene mutations. The primers are shown in SEQ ID No. 1-2, 4-5, 7-8 or 10-11, and the probes are shown in SEQ ID No. 3, 6, 9, 12. The kit can be used to perform real-time fluorescent PCR which is capable of detecting c-kit gene mutations.
Disclosed are an installation cartridge of an electric component and an electric motor for same. The installation cartridge comprises a cartridge body (1), a first empty cavity (11) arranged inside the cartridge body for containing an electric component and a first flanging (12) arranged outside the bottom of the cartridge body, wherein the bottom of the cartridge body has an opening (13) in communication with the first empty cavity, and the first flanging is provided with a first lug (121); the installation cartridge of an electric component is mounted on an electric motor housing (2), a second lug (122) is set on the electric motor housing, the first lug is mounted on one side of the second lug by means of a screw, a bolt or nut mechanism or welding, and the first flanging on the bottom of the cartridge body is closely adhered to a surface of the electric motor housing. The installation cartridge is simple in structure, has a high efficiency in assembly with the electric motor housing, reduces the use of screws, and the face-to-face connection between the second lug and the first lug is convenient to assemble.
Disclosed are a primer, probe, and reagent kit used for detecting C-KIT gene mutation. The primer is as shown in SEQ ID No. 1 - SEQ ID No. 2, or as shown in SEQ ID No. 4 - SEQ ID No. 5; the probe is as shown in SEQ ID No. 3 or as shown in SEQ ID No. 6. In the present invention, the reagent kit is used to perform real-time fluorescent PCR, thus absences or mutations at the 1672-1713 positions of the C-KIT gene or the 1700-1733 positions of the C-KIT gene being replaced by a T mutation may be detected.
Disclosed are a primer, a probe, and a reagent kit for use in detecting a mutation in C-KIT gene. The primer is either as represented by SEQ ID No. 1-SEQ ID No. 2 or as represented by SEQ ID No. 4-SEQ ID No. 5. The probe is either as represented by SEQ ID No. 3 or as represented by SEQ ID No. 6. Utilization of the reagent kit of the present invention for real-time fluorescent PCR allows detection of a deletion mutation at loci 1723-1728 of C-KIT gene or detection of a deletion mutation at loci 1670-1690 of C-KIT gene.
Chen, Zhao
Song, Xiaokang
Duan, Gaoyan
Wang, Lulu
Yu, Li
We theoretically demonstrate a plasmonic waveguide that allows easy control of the fano profile. The proposed structure is analyzed by the coupled-mode theory and demonstrated by the finite-element method. Due to the interaction of the local discrete state and the continuous spectrum caused by the side-coupled cavity and the baffle, respectively, the transmission spectrum exhibits a sharp and asymmetric profile. The profile can be easily tuned by changing the parameters of the structure. Moreover, the compact structure can easily be extended to several complex structures to achieve multiple fano resonances. These characteristics offer flexibility in the design of the device. This nanosensor yields a sensitivity of 1280 nm/RIU and switches with an on/off contrast ratio of about 30 dB. Our structures may have potential applications for nanoscale optical switching, nanosensors, and slow-light devices in highly integrated circuits.
Two-terminal electronic devices, such as photodetectors, photovoltaic devices and electroluminescent devices, are provided. The devices include a first electrode residing on a substrate, wherein the first electrode comprises a layer of metal; an I-layer comprising an inorganic insulating or broad band semiconducting material residing on top of the first electrode, and aligned with the first electrode, wherein the inorganic insulating or broad band semiconducting material is a compound of the metal of the first electrode; a semiconductor layer, preferably comprising a p-type semiconductor, residing over the I-layer; and a second electrode residing over the semiconductor layer, the electrode comprising a layer of a conductive material. The band gap of the material of the semiconductor layer, is preferably smaller than the band gap of the I-layer material. The band gap of the material of the I-layer is preferably greater than 2.5 eV.
Chen, Zhao
Fillmore, Christine M.
Hammerman, Peter S.
Kim, Carla F.
Wong, Kwok-Kin
Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have diverse pathological features. During the past decade, in-depth analyses of lung cancer genomes and signalling pathways have further defined NSCLCs as a group of distinct diseases with genetic and cellular heterogeneity. Consequently, an impressive list of potential therapeutic targets was unveiled, drastically altering the clinical evaluation and treatment of patients. Many targeted therapies have been developed with compelling clinical proofs of concept; however, treatment responses are typically short-lived. Further studies of the tumour microenvironment have uncovered new possible avenues to control this deadly disease, including immunotherapy.
Chen, Zhao
Cao, Xueyan
Song, Xiaokang
Wang, Lulu
Yu, Li
A compact structure based on plasmonic metal-insulator-metal (MIM) side-coupled cavities for nanosensor is proposed and numerically simulated. Simulation results show that a typical Lorentzian and Fano-like response emerge in the transmission spectrum, and they can be easily tuned by changing the length of the side cavity and the material imbedded in the resonator. Based on above analysis, our structures offer flexibility to design nanosensor with a sensitivity of ~1820 nm/RIU and a figure of merit about 4.5 × 104. By adding another side-coupled cavity, multiple Fano resonances are achieved and the sensing properties are also investigated. Our structures may have important potential applications in highly integrated optical circuits and networks, especially for nanosensor, spectral splitter, and nonlinear devices.
Creat membership
Sweep WeChat yards
