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Now showing items 1 - 16 of 18

  • Trade credit contract in the presence of retailer investment opportunity

    Zha, Yong   Chen, Kehong   Yue, Xiaohang   Yu, Yugang   Mukhopadhyay, Samar  

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  • POWER FACTOR IMPROVEMENT METHOD AND DEVICE USED IN LED LIGHTING SYSTEM

    The present invention provides a power factor improvement method and device used in an LED lighting system. The device comprises: a rectifier bridge and a power factor improvement module. The rectifier bridge comprises two alternating current input ends and two direct current output ends. The power factor improvement module is connected between the two direct current input ends of the rectifier bridge. The power factor improvement module comprises: a resistor group formed of a first resistor (R1), a second resistor (R2), and a third resistor (R3) connected in series sequentially; a logic control circuit, a first input end thereof being connected between the first resistor (R1) and the second resistor (R2), and a second input end thereof being connected between the first resistor (R1) and the second resistor (R2); a drive circuit, an input end thereof being connected to the logic control circuit, and an output end thereof being connected to multiple switches and used for controlling on/off of the multiple switches; and a current control module, an input end thereof being connected to the logic control circuit, and an output end thereof being connected to multiple switches.
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  • Dynamic pricing in the presence of reference price effect and consumer strategic behaviour

    Chen, Kehong   Zha, Yong   Alwan, Layth C.   Zhang, Lu  

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  • Optimal pricing and availability strategy of a bike-sharing firm with time-sensitive customers

    Chen, Yujing   Wang, Dong   Chen, Kehong   Zha, Yong   Bi, Gongbing  

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  • ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

    Chen, Kehong   Zhang, Jianguo   Zhang, Weiwei   Zhang, Jinhua   Yang, Jurong   Li, Kailong   He, Yani  

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  • Functional significance of the Toll-like receptor 4 promoter gene polymorphisms in the Chinese Han population

    Chen, Kehong   Wang, Yong-tang   Gu, Wei   Zeng, Ling   Jiang, Dong-po   Du, Ding-yuan   Hu, Ping   Duan, Zhao-xia   Liu, Qing   Huang, S. N.   Jiang, Jian-xin  

    Objective: Toll-like receptor 4 is an important signaling receptor for lipopolysaccharide in mammals, and the variation of the promoter may affect the activity of toll-like receptor 4 expression. Although 12 single nucleotide polymorphisms have been identified in the toll-like receptor 4 promoter, little is known about the functional significance of these single nucleotide polymorphisms. Design: Genetic functional and association studies. Setting: National Key Laboratory of Trauma and Departments of Traumatic Surgery in two teaching hospitals. Subjects: Three hundred seventy-nine healthy volunteers and 303 patients with major trauma. Interventions: None. Measurements and Main Results: Five single nucleotide polymorphisms identified in the toll-like receptor 4 promoter in the Chinese Han population were selected. Three of them revealed a close relationship with transcription factor binding sites. Among the three single nucleotide polymorphisms, only the T-2242C polymorphism significantly increased transcriptional activities of the toll-like receptor 4 promoter, as shown by reporter gene assay. Results from flow cytometry and ex vivo responsiveness of peripheral blood leukocytes indicated that the T-2242C polymorphism was well-associated with increased expression of toll-like receptor 4 protein and production of tumor necrosis factor-alpha. The clinical relevance of these single nucleotide polymorphisms was then investigated in 303 patients with major trauma. The peripheral blood leukocytes of trauma patients with the variant C allele revealed greater capacity to produce tumor necrosis factor-alpha and interleukin-6 on the admission day. Furthermore, the toll-like receptor 4/-2242 polymorphism was significantly associated with higher sepsis morbidity rates and multiple organ dysfunction scores in patients with major trauma. Conclusions: The toll-like receptor 4/-2242 polymorphism is a functional variant and might be used as a relevant risk estimate for organ dysfunction and sepsis in trauma patients. (Crit Care Med 2010; 38:1292-1299)
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  • Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy

    Chen, Kehong   Feng, Lei   Hu, Wei   Chen, Jia   Wang, Xiaoyue   Wang, Liming   He, Yani  

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  • SuO029PARKIN INHIBITS ACCELERATING SENESCENCE OF RENAL TUBULAR CELLS BY PROMOTING GATA4 DEGRADATION IN DIABETIC NEPHROPATHY

    Chen, Kehong   He, Yani  

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  • Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

    Chen, Kehong   Dai, Huanzi   Yuan, Junjie   Chen, Jia   Lin, Lirong   Zhang, Weiwei   Wang, Limin   Zhang, Jianguo   Li, Kailong   He, Yani  

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  • Simultaneous determination of 16 alkaloids in blood by ultrahigh-performance liquid chromatography-tandem mass spectrometry coupled with supported liquid extraction.

    Chen, Rui   Ning, Ze   Zheng, Chao   Yang, Yongsheng   Zhang, Chengyu   Ou, Xuemei   Chen, Kehong   Yu, Hongyan   Wei, Xiaojuan   Zhao, Qingbiao   He, Jianguo  

    Alkaloids are widely present in food and medicine. However, many alkaloids have poisoning effect. Thus, a sensitive and rapid method for determination of alkaloids is highly desired. In this study, a convenient, reliable and accurate method is developed for the simultaneous determination of 16 poisonous alkaloids in human blood by ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) coupled with supported liquid extraction (SLE). The 16 alkaloids include colchicine, anisodamine, scopolamine, atropine, sinomenine, dicaine, thebaine, papaverine, strychnine, brucine, aconitine, hypaconitine, yunaconitine, deoxyaconitine, bullatine A and bullatine B. Low limits of detection (LODs) were obtained ranging in 0.002-0.03=E2=80=AFmug=E2=80=AFL-1. The linear ranges are 0.005-200=E2=80=AFmug=E2=80=AFL-1 for colchicine, papaverine, brucine, aconitine, hypaconitine, yunaconitine and deoxyaconitine, 0.01-200=E2=80=AFmug=E2=80=AFL-1 for anisodamine and scopolamine, 0.05-200=E2=80=AFmug=E2=80=AFL-1 for atropine, strychnine, bullatine A and bullatine B, 0. 1-200=E2=80=AFmug=E2=80=AFL-1 for other target analytes, all with correlation coefficients (R2) higher than 0.995. The recoveries range from 79.2% to 95.8%. The relative standard deviation (RSD) values are lower than 15% and the values of matrix effect (ME) range in 86.3%-118.2%. This method of UPLC-MS/MS coupled with SLE has high potential for analyzing multiple alkaloids in blood samples. Copyright =C2=A9 2019 Elsevier B.V. All rights reserved.
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  • DCR2,a Cellular Senescent Molecule,Is a Novel Marker for Assessing Tubulointerstitial Fibrosis in Patients with Immunoglobulin A Nephropathy

    Chen, Jia   Hu, Wei   Xiao, Fei   Lin, Lirong   Chen, Kehong   Wang, Liming   Wang, Xiaoyue  

    Background/Aims: Stress-induced cell senescence, which contributes to cell cycle arrest and is independent of age, plays an important role in chronic kidney disease (CKD) progression. DcR2, as a senescent marker, exclusively expressed in senescent tubular epithelia. The objective of this study was to examine whether urinary DcR2 (uDcR2) could be a potential biomarker for tubulointerstitial fibrosis (TIF) in patients with immunoglobulin A nephropathy (IgAN). Methods: This study included 210 IgAN patients and 80 healthy volunteers, with uDcR2 levels measured using enzyme-linked immunosorbent assay. We examined the relationship among uDcR2/Cr levels, renal function, and pathological parameters, using regression analysis to identify risk factors for TIF and the area under the curve (AUC) approach to predict TIF. Renal DcR2 expression was quantified by immunohistochemistry. Co-expression of DcR2 with fibrotic markers (alpha-smooth muscle actin [alpha-SMA], collagen III) was analyzed by confocal microscopy. Results: Levels of uDcR2/Cr were significantly higher in IgAN patients and in those with more severe TIF, compared with healthy controls. Serum DcR2 levels were similar across groups. The proportion of IgAN patients with stages 1-2 CKD and T0 was highest among those with uDcR2/Cr <130 ng/g. In contrast, the majority of those with uDcR2/Cr >201 ng/g had stages 4-5 CKD and T2. Levels of uDcR2/Cr were positively associated with urinary albumin to creatinine ratio (ACR), urinary N-acetyl-beta-D-glucosaminidase (uNAG)/Cr, and TIF scores and negatively associated with estimated glomerular filtration rate (eGFR). uDcR2/Cr, uNAG, ACR, and eGFR were independent predictors for TIF, with AUC of 0.907 for uDcR2/Cr. This AUC value was higher than that observed for eGFR, uNAG/Cr, or ACR. The sensitivity and specificity of uDcR2/Cr in predicting TIF were 87.0 and 80.5%, respectively. Moreover, uDcR2/Cr levels were positively associated with the percentage of renal DcR2 expression. Renal DcR2 co-localized with alpha-SMA and collagen III in the kidneys of IgAN patients. Conclusions: Levels of uDcR2/Cr were closely associated with the severity of TIF and renal function parameters. uDcR2/Cr represents a potential biomarker for predicting TIF in IgAN patients.
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  • Trade credit contract in the presence of retailer investment opportunity

    Zha, Yong   Chen, Kehong   Yue, Xiaohang   Yu, Yugang   Mukhopadhyay, Samar  

    This paper presents a model for designing a trade credit contract between a supplier and a retailer that would coordinate a supply chain in the presence of investment opportunity for the retailer. Specifically, we study a newsvendor model where the supplier offers a trade credit contract to the retailer who, by delaying the payment, can invest the accounts payable amount and earn returns. We find that when the channel partners have symmetric information about the retailer's investment return, a conditionally concessional trade credit (CTC) contract, which includes a wholesale price, an interest-free period, and a minimum order requirement, can achieve channel coordination. We then extend the model to the information asymmetry setting in which the retailer's investment return is unobservable by the supplier. We show that, although the CTC contract cannot achieve the coordination in this setting, it can effectively improve channel efficiency as well as profitability for individual partners.
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  • Trps1 Promotes Tubular Cell Proliferation After Renal Ischemia-Reperfusion Injury Through Transactivation of Notch2

    Chen, Kehong   Yang, Jurong   He, Yani  

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  • Optimal pricing and availability strategy of a bike-sharing firm with time-sensitive customers

    Chen, Yujing   Wang, Dong   Chen, Kehong   Zha, Yong   Bi, Gongbing  

    In the context of bike-sharing, availability is a critical factor that impacts customers' travel behavior as well as the bike-sharing firm's profit. In this paper, we investigate how the bike-sharing firm should develop its pricing and availability strategy when its customers have heterogeneous time-sensitive preferences. Specifically, we propose a model in which a monopolistic bike-sharing firm leases bikes to customers and find that a high availability rate makes potential customers more likely to use the bike sharing service. We then analyze the bike-sharing firm's decision to increase availability by raising the availability cost to optimize profits. We also discuss the effects of a subsidy policy on improving availability, the firm's profit, the consumer surplus and social welfare. We analyze the optimal decisions of the firm and the social welfare-maximizing subsidy policy. We then compare the social welfare achievable under different subsidy levels and different levels of the availability cost. Some of our results are notable. First, a low availability cost yields high social welfare regardless of the subsidy policy. Second, when the availability cost is relatively high, further increasing the subsidy to mitigate the availability risk may not necessarily improve the social welfare of bike-sharing. (C) 2019 Published by Elsevier Ltd.
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  • Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

    Fu, Biqiong   Yang, Jie   Chen, Jia   Lin, Lirong   Chen, Kehong   Zhang, Weiwei   Zhang, Jianguo   He, Yani  

    Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose; (2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol; (3) HG medium (HG group) containing 30 mmol/L glucose; (4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG + SKI group); or (5) 200 mg/L SKI treatment in control medium (control + SKI group) for 72 h. HG-induced senescent cells showed the emergence of senescence associated heterochromatin foci, up-regulation of P16(INK4) and cyclin D1, increased senescence-associated -galactosidase activity, and elevated expression of membrane decoy receptor 2. SKI treatment potently prevented these changes in a dose-independent manner. SKI treatment prevented HG-induced up-regulation of pro-senescence molecule mammalian target of rapamycin and p66Shc and down-regulation of anti-senescence molecules klotho, sirt1, and peroxisome proliferator-activated receptor-g in renal tubular epithelial cells. SKI may be a novel strategy for protecting against HG-induced renal tubular cell senescence in treatment of diabetic nephropathy.
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  • Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

    Chen, Kehong   Dai, Huanzi   Yuan, Junjie   Chen, Jia   Lin, Lirong   Zhang, Weiwei   Wang, Limin   Zhang, Jianguo   Li, Kailong   He, Yani  

    Premature senescence is a key process in the progression of diabetic nephropathy (DN). Premature senescence of renal tubular epithelial cells (RTEC) in DN may result from the accumulation of damaged mitochondria. Mitophagy is the principal process that eliminates damaged mitochondria through PTEN-induced putative kinase 1 (PINK1)-mediated recruitment of optineurin (OPTN) to mitochondria. We aimed to examine the involvement of OPTN in mitophagy regulation of cellular senescence in RTEC in the context of DN. In vitro, the expression of senescence markers P16, P21, DcR2, SA-beta-gal, SAHF, and insufficient mitophagic degradation marker (mitochondrial P62) in mouse RTECs increased after culture in 30mM high-glucose (HG) conditions for 48 h. Mitochondrial fission/mitophagy inhibitor Mdivi-1 significantly enhanced RTEC senescence under HG conditions, whereas autophagy/mitophagy agonist Torin1 inhibited cell senescence. MitoTempo inhibited HG-induced mitochondrial reactive oxygen species and cell senescence with or without Mdivi-1. The expression of PINK1 and OPTN, two regulatory factors for mitophagosome formation, decreased significantly after HG stimulation. Overexpression of PINK1 did not enhance mitophagosome formation under HG conditions. OPTN silencing significantly inhibited HG-induced mitophagosome formation, and overexpression of OPTN relieved cellular senescence through promoting mitophagy. In clinical specimens, renal OPTN expression was gradually decreased with increased tubulointerstitial injury scores. OPTNpositive renal tubular cells did not express senescence marker P16. OPTN expression also negatively correlated with serum creatinine levels, and positively correlated with eGFR. Thus, OPTN-mediated mitophagy plays a crucial regulatory role in HG-induced RTEC senescence in DN. OPTN may, therefore, be a potential antisenescence factor in DN.
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