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Now showing items 1 - 16 of 2900

  • HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF

    The present disclosure provides an immunogenic composition comprising: a) a hepatitis C virus (HCV) heterodimeric polypeptide that includes HCV E1 and E2 polypeptides; b) a T-cell epitope polypeptide comprising a T-cell epitope present in an HCV protein other than E1 and E2; and c) a pharmaceutically acceptable excipient. The present disclosure provides a method of inducing an immune response, in an individual, to an HCV polypeptide. The present disclosure provides an immunogenic composition comprising: a) a polypeptide that comprises one or more T-cell epitopes present in an HCV protein other than E1 and E2; and b) a pharmaceutically acceptable excipient.
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  • SURFACE CTS ANTI-CORROSION TREATMENT METHOD FOR STAINLESS STEEL PART

    Disclosed is a surface anti-corrosion treatment method for stainless steel. The method comprises the following steps: (1) performing chemical de-oiling and alkaline corrosion treatments on the surface of stainless steel by using a sodium hydroxide solution and a solution containing an alkaline corrosion active agent, and then washing with water; (2) performing, by using an oxidation solution, an oxidation treatment on the surface of the stainless steel treated in step (1), and then washing with water; (3) using the surface of the stainless steel treated in step (2) as a cathode and soaking same in an electrolyte for electrolysis, and then washing with water; and (4) placing the surface of the stainless steel treated in step (3) at a temperature of 50ºC - 60ºC under a humidity of 60% - 70%, and performing a hardening treatment. Also disclosed are the use of the treatment method in the treatment of a stainless steel part and a stainless steel part obtained after the treatment by means of the treatment method.
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  • DUAL-TARGET FUSION PROTEINS COMPRISING THE FC PORTION OF AN IMMUNOGLOBULIN

    Provided is a fusion protein containing GLP-1 and FGF21 linked through an immunoglobulin Fc portion. Each of the GLP-1 and FGF21 can be substituted with its analogues or variants and, the Fc portion, which can be derived from IgG4, can include substitutions that further enhance the fusion protein's stability and activity. These fragments can be linked together through peptide linkers. The fusion protein can be used clinically to reduce glucose and lipid levels and body weight.
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  • HIGH-PRECISION FREQUENCY CALIBRATION CIRCUIT USED FOR GM-C FILTER

    Provided is a Gm-C filter frequency-calibration circuit having low power consumption and high calibration precision; the frequency calibration circuit comprises four modules: a clock generation circuit, a sample-and-hold circuit, a master transconductance amplifier (Gm), and an error amplifier (OTA2). The master transconductance amplifier (Gm) in the master-slave structure control calibration circuit matches the slave transconductance amplifier in the Gm-C filter, and is controlled by the same bias voltage. The error of the frequency characteristics of the Gm-C filter is influenced primarily by such factors as the transconductance value of the transconductance amplifier, the process variation of the capacitance, and temperature; the consideration of the frequency characteristics of the Gm-C filter is determined primarily by the time constant Gm/C thereof; by means of converting the transconductance value Gm of the transconductance amplifier into a variable having an accurate directly proportional relationship with the capacitance C, the influence of the process variation of the capacitance on the time constant Gm/C is eliminated, allowing for very high calibration accuracy; the invention has the features of a simple structure, low power consumption, and a small chip area, and is also highly stable.
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  • HEPATITIS C VIRUS E1/E2 HETERODIMERS AND METHODS OF PRODUCING SAME

    The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis C virus (HCV) El polypeptide and an HCV E2 polypeptide, where one or both of the El and E2 polypeptides comprises an affinity tag. The present disclosure provides a method of producing an affinity tagged E1/E2 heterodimer of the present disclosure. The present disclosure provides methods of producing untagged HCV E1/E2 heterodimers. The present disclosure provides HCV E1/E2 heterodimers, compositions comprising same, and methods of inducing an immune response to HCV.
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  • WASHING MACHINE DOOR BODY WITH ASYMMETRIC GLASS WINDOW AND WASHING MACHINE

    Disclosed are a washing machine door body with an asymmetric glass window and a washing machine. The washing machine door body comprises a front plate component, a viewing window assembly (1) and a laundry feeding port, wherein the viewing window assembly (1) comprises a frame component (2), an asymmetric glass window (3), and an inner frame N (4); the frame component (2) is assembled into a whole from an outer frame (2-1), a window screen (2-2), a middle frame (2-3), an inner frame W (2-4), a hinge (9) and a door hook (10); the asymmetric glass window (3) is attached to the frame component (2), the inner frame N (4) is attached to the asymmetric glass window (3), and the inner frame N (4) is connected to the inner frame W (2-4) so that the asymmetric glass window (3) is clamped therebetween; and a mounting area for the front plate component is provided with at least two sets of hinge holes and door hook holes. The washing machine door body with the asymmetric glass window can conveniently achieve assembly and disassembly as well as inversion of the asymmetric glass window, such that the washing machine door body can be opened both leftwards and rightwards.
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  • BAND-GAP REFERENCE VOLTAGE SOURCE WITH HIGH POWER SUPPLY REJECTION RATIO

    A band-gap reference voltage source with a high power supply rejection ratio comprises a voltage self-regulating circuit (1), a starting circuit (2), a first-order temperature compensation reference voltage generating circuit (3), an error amplifier (4), a bias voltage generating circuit (5), and a reference starting circuit (6). According to the band-gap reference voltage source, power supply noise is suppressed to a certain extent by using the voltage self-regulating circuit (1), and then power is supplied to a back-stage band-gap reference circuit, so that the band-gap reference circuit further suppress the noise, and the entire power source thus has a high power supply rejection ratio. In addition, the self-regulating circuit (1) further comprises a feedback loop, the magnitude of an output current can be automatically regulated, and the problem of instability of the entire circuit due to the fact that the current required by the back-stage circuit increases suddenly is solved; meanwhile, the power supply rejection ratio of the band-gap reference voltage source can further be improved; compared with a conventional band-gap reference voltage source, the present invention has better stability, a higher power supply rejection ratio, and can meet high-accuracy operating requirements.
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  • E-TSPC STRUCTURE-BASED LOW-POWER-CONSUMPTION 2/3 FREQUENCY DIVIDER CIRCUIT

    An E-TSPC structure-based low-power-consumption 2/3 frequency divider circuit comprises a first-stage D trigger DFF1, a second-stage D trigger DFF2, and an inter-stage embedded gate circuit. A clock signal Clk serves as a clock signal to be subjected to frequency division, a positive clock signal Q and a negative clock signal QN serve as clock signals after the frequency division. A 2-frequency-division mode or a 3-frequency-division mode is selected by means of a mode control signal Mc: when the mode control signal Mc is at a low level, the frequency divider circuit works at the 3-frequency-division mode, and when the mode control signal input end Mc is at a high level, the frequency divider circuit works at the 2-frequency-division mode. Compared with a conventional frequency divider having a TSPC structure, the frequency division circuit has a higher working efficiency; and compared with a conventional 2/3 frequency division circuit having an E-TSPC structure, the frequency division circuit has lower power consumption, so that a very-low-power consumption 2/3 frequency division circuit capable of working at a gigahertz frequency is achieved.
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  • 7.5% n-i-p Sb2Se3 solar cells with CuSCN as hole-transport layer

    Li, Kanghua   Wang, Siyu   Chen, Chao   Kondrotas, Rokas   Hu, Manchen   Lu, Shuaicheng   Wang, Chong   Chen, Wei   Tang, Jiang  

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  • Organic Anion Facilitates In-situ Synthesis of Mesoporous LTA Zeolites

    Chen, Chao   Zhai, Dong   Dong, Lei   Wang, Yanding   Zhang, Jian   Liu, Yi   Chen, Zhuwen   Wang, Ya   Qian, Wei   Hong, Mei  

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  • Effect of Dimension Parameters on the Torsion Property of A C/SiC Pipe

    Chen, Chao   Mei, Hui   Li, Jun   Xu, Zhenye   Cheng, Laifei  

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  • Water Flow Velocity over Frozen and Non-frozen Black Soil Slopes

    Chen, Chao   Ban, Yunyun   Lei, Tingwu   Feng, Ren   Gao, Yuan  

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  • ALUMINIUM SUBSTRATE AND DRIVE POWER SUPPLY BOX MOUNTING STRUCTURE FOR LED LAMP

    An aluminium substrate and a drive power supply box (2) mounting structure for an LED lamp, relating to the technical field of LED lamps; the mounting structure comprises an aluminium substrate (1), a mounting through hole (1a) being disposed in the middle of the aluminium substrate (1), a drive power supply box (2) being inserted into the mounting through hole (1a), and the drive power supply box (2) being fixedly connected to the aluminium substrate (1) by means of screws; the drive power supply box (2) is composed of a lamp cap assembly (3) and a drive sleeve (4) fitting and connecting to one another; the lamp cap assembly (3) and the drive sleeve (4) fit together to form a hollow drive mounting cavity; a plurality of LED lamps are distributed on the aluminium substrate (1) surrounding the mounting through hole (1a), wiring holes (2a) being disposed on the drive power supply box (2), and driver output wires penetrating through the wiring holes (2a) and having a circuit connection to the LED lamps; the mounting structure has a compact structure, convenient use, and good effects.
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  • Qubit Neural Tree Network With Applications in Nonlinear System Modeling

    Qi, Feng   Chen, Chao  

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  • Ratiometric co-delivery of multiple chemodrugs in a single nanocarrier

    Chen, Chao   Tao, Ran   Ding, Dan   Kong, Deling   Fan, Aiping   Wang, Zheng   Zhao, Yanjun  

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  • The Impact of Sampling Medium and Environment on Particle Morphology

    Chen, Chao   Enekwizu, Ogochukwu   Ma, Yan   Zakharov, Dmitry   Khalizov, Alexei  

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