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Now showing items 17 - 32 of 41

  • Effect of the particular temperature field on a National Ignition Facility deformable mirror

    Bian, Qi   Huang, Lei   Ma, Xingkun   Xue, Qiao   Gong, Mali  

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  • Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

    Wang, Shaofei   Li, Yubin   Fan, Jiajun   Zhang, Xuyao   Luan, Jingyun   Bian, Qi   Ding, Tao   Wang, Yichen   Wang, Ziyu   Song, Ping   Cui, Daxiang   Mei, Xiaobin   Ju, Dianwen  

    Diabetic nephropathy (DN) is one of the most lethal complications of diabetes mellitus with metabolic disorders and chronic inflammation. Although the cytokine IL-22 was initially implicated in the pathogenesis of chronic inflammatory diseases, recent studies suggested that IL-22 could suppress inflammatory responses and alleviate tissue injury. Herein, we examined the role of IL-22 in DN. We found that serum levels of IL-22 were significantly downregulated in both patients and mice with DN. The expression of IL-22 was further decreased with the progression of DN, whereas IL-22 gene therapy significantly ameliorated renal injury and mesangial matrix expansion in mice with established nephropathy. IL-22 could also markedly reduce high glucose-induced and TGF-beta 1-induced overexpression of fibronectin and collagen IV in mouse renal glomerular mesangial cells in a dose-dependent manner, suggesting the potential role of IL-22 to inhibit the overproduction of ECM in vitro. Simultaneously, IL-22 gene therapy drastically alleviated renal fibrosis and proteinuria excretion in DN. In addition, IL-22 gene therapy markedly attenuated hyperglycemia and metabolic disorders in streptozotocin-induced experimental diabetic mice. Notably, IL-22 drastically reversed renal activation of NLRP3, cleavage of caspase-1, and the maturation of IL-1 beta in DN, suggesting unexpected anti-inflammatory function of IL-22 via suppressing the activation of NLRP3 inflammasome in vivo. Moreover, IL-22 markedly downregulated high glucose-induced activation of NLRP3 inflammasome in renal mesangial cells in a dose-dependent manner, indicating that the effects of IL-22 on NLRP3 inflammasome activation was independent of improved glycemic control. These results suggested that nephroprotection by IL-22 in DN was most likely associated with reduced activation of NLRP3 inflammasome. In conclusion, our finding demonstrated that IL-22 could exert favorable effects on DN via simultaneously alleviating systemic metabolic syndrome and downregulating renal NLRP3/caspase-1/IL-1 beta pathway, suggesting that IL-22 might have therapeutic potential for the treatment of DN.
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  • Wavefront correction performed by a deformable mirror of arbitrary actuator pattern within a multireflection waveguide

    Ma, Xingkun   Huang, Lei   Bian, Qi   Gong, Mali  

    The wavefront correction ability of a deformable mirror with a multireflection waveguide was investigated and compared via simulations. By dividing a conventional actuator array into a multireflection waveguide that consisted of single-actuator units, an arbitrary actuator pattern could be achieved. A stochastic parallel perturbation algorithm was proposed to find the optimal actuator pattern for a particular aberration. Compared with conventional an actuator array, the multireflection waveguide showed significant advantages in correction of higher order aberrations. (C) 2014 Optical Society of America
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  • Markers for the progression of IgA nephropathy

    Maixnerova, Dita   Reily, Colin   Bian, Qi   Neprasova, Michaela   Novak, Jan   Tesar, Vladimir  

    We have summarized the latest findings on markers for progression of immunoglobulin A (IgA) nephropathy (IgAN), the most common primary glomerulonephritis with a high prevalence among end-stage renal disease (ESRD) patients. The clinical predictors of renal outcome in IgAN nephropathy, such as proteinuria, hypertension, and decreased estimated glomerular filtration rate (eGFR) at the time of the diagnosis, are well known. The Oxford classification of IgAN identified four types of histological lesions (known as the MEST score) associated with the development of ESRD and/or a 50 % reduction in eGFR. In addition, the role of genetic risk factors associated with IgAN is being elucidated by genome-wide association studies, with multiple risk alleles described. Recently, biomarkers in serum (galactose-deficient IgA1, IgA/IgG autoantibodies against galactose-deficient IgA1, and soluble CD 89-IgA complexes) and urine (soluble transferrin receptor, interleukin-6/epidermal growth factor ratio, fractalkine, laminin G-like 3 peptide, kappa light chains, and mannan-binding lectin) have been identified. Some of these biomarkers may represent candidates for the development of noninvasive diagnostic tests, that would be useful for detection of subclinical disease activity, monitoring disease progression, assessment of treatment, and at the same time circumventing the complications associated with renal biopsies. These advances, along with future disease-specific therapy, will be helpful in improving the treatment effectiveness, prognosis, and the quality of life in connection with IgAN.
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  • Sox2 function as a negative regulator to control HAMP expression.

    Song, Bin   Bian, Qi   Shao, Cheng-Hao   Liu, An-An   Jing, Wei   Liu, Rui   Zhang, Yi-Jie   Zhou, Ying-Qi   Li, Gang   Jin, Gang  

    BACKGROUND: Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores. Abnormal levels of HAMP expression alter plasma iron parameters and lead to iron metabolism disorders. Therefore, it is an important goal to understand the mechanisms controlling HAMP gene expression.; RESULTS: Overexpression of Sox2 decrease basal expression of HAMP or induced by IL-6 or BMP-2, whereas, knockdown of Sox2 can increase HAMP expression, furthermore, two potential Sox2-binding sites were identified within the human HAMP promoter. Indeed, luciferase experiments demonstrated that deletion of any Sox2-binding site impaired the negative regulation of Sox2 on HAMP promoter transcriptional activity in basal conditions. ChIP experiments showed that Sox2 could directly bind to these sites. Finally, we verified the role of Sox2 to negatively regulate HAMP expression in human primary hepatocytes.; CONCLUSION: We found that Sox2 as a novel factor to bind with HAMP promoter to negatively regulate HAMP expression, which may be further implicated as a therapeutic option for the amelioration of HAMP-overexpression-related diseases, including iron deficiency anemia.=20
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  • A sodium laser guide star coupling efficiency measurement method

    Feng, Lu   Shen, Zhi-Xia   Xue, Suijian   Li, Yang-Peng   Jin, Kai   Otarola, Angel   Bo, Yong   Zuo, Jun-Wei   Bian, Qi   Wei, Kai   Hu, Jing-Yao  

    A large telescope's adaptive optics (AO) system requires one or more bright artificial laser guide stars to improve its sky coverage. The recent advent of a high power sodium laser is perfect for such application. However, besides the output power, other parameters of the laser also have a significant impact on the brightness of the generated sodium laser guide star, mostly in non-linear relationships. When tuning and optimizing these parameters it is necessary to tune based on a laser guide star generation performance metric. Although return photon fluxis widely used, variability of the atmosphere and sodium layer makes it difficult to compare results from different sites or even within a short time period for the same site. A new metric, coupling efficiency, is adopted in our field tests. In this paper, we will introduce our method for measuring the coupling efficiency of a 20W class pulse sodium laser for AO application during field tests that were conducted during 2013-2015.
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  • Low molecular weight heparin (LMWH) improves peritoneal function and inhibits peritoneal fibrosis possibly through suppression of HIF-1alpha, VEGF and TGF-beta1.

    Li, Juan   Guo, Zhi Yong   Gao, Xian Hua   Bian, Qi   Jia, Meng   Lai, Xue Li   Wang, Tie Yun   Bian, Xiao Lu   Wang, Hai Yan  

    BACKGROUND: Peritoneal fibrosis is the major cause of ultrafiltration failure, and intraperitoneal administration of Low Molecular Weight Heparin (LMWH) was reported to protect peritoneal function. But the exact mechanism of its influence on peritoneal structure and function is still unknown.; METHODS: A fibrosis model of rat was established by intraperitoneal (IP) administration of PD fluid and Erythromycin Lactobionate. Fifty-two rats were randomly divided into 6 groups: (1) normal control group (CON, n =3D 6); (2) normal saline group (NS, n =3D 10); (3) high-glucose group (GLU, n =3D 10); (4) heparin group (HEP, n =3D 6); (5) low dose LMWH group (LLMWH, n =3D 10); (6) high dose LMWH group (HLMWH, n =3D 10). Two hour peritoneal equilibration test was performed after 28 days of intervention. The peritoneum, mesentery and omentum were harvested, and evaluated by Hematoxylin-Eosin and Masson Trichrome staining. The expressions of HIF-1alpha, VEGF and TGF-beta1 in parietal peritoneum were detected by IHC and RT-PCR (Reverse Transcriptase Polymerase Chain Reaction).; RESULTS: Compared with group CON and NS, ultrafiltration volume and D2/D0 glucose in group GLU decreased significantly, D/Purea (Dialysate-Plasma ratio of urea), D/Palb (Dialysate-Plasma ratio of albumin), peritoneal thickness, neoangiogenesis and inflammatory reaction increased significantly (all P<0.05). Administration of heparin and LMWH markedly alleviated these above pathological changes. The protein and mRNA levels of HIF-1alpha, VEGF and TGF-beta1 increased significantly in group GLU, and decreased significantly after administration of LMWH in a dose-dependent manner.; CONCLUSIONS: LMWH ameliorates peritoneal function and inhibits peritoneal fibrosis, possibly through suppression of HIF-1alpha, VEGF and TGF-beta1.=20
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  • Investigating Policy Instrument Adoption in Low-Carbon City Development: A Case Study from China

    Mao, Qingduo   Ma, Ben   Wang, Hongshuai   Bian, Qi  

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  • Wavelength switchable high-power diode-side-pumped rod Tm:YAG Laser around 2 mu m

    Wang, Caili   Du, Shifeng   Niu, Yanxiong   Wang, Zhichao   Zhang, Chao   Bian, Qi   Guo, Chuan   Xu, Jialin   Bo, Yong   Peng, Qinjun   Cui, Dafu   Zhang, Jingyuan   Lei, Wenqiang   Xu, Zuyan  

    We report a high-power diode-side-pumped rod Tm:YAG laser operated at either 2.07 or 2.02 mu m depending on the transmission of pumped output coupler. The laser yields 115W of continuous-wave output power at 2.07 mu m with 5% output coupling, which is the highest output power for all solid-state 2.07 mu m cw rod Tm: YAG laser reported so far. With an output coupler of 10% transmission, the center wavelength of the laser is switched to 2.02 mu m with an output power of 77.1 W. This is the first observation of high-power wavelength switchable diode-side-pumped rod Tm: YAG laser around 2 mu m. (C) 2013 Optical Society of America
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  • First light for the sodium laser guide star adaptive optics system on the Lijiang 1.8 m telescope

    Wei, Kai   Li, Min   Chen, Shan-Qiu   Bo, Yong   Chen, Feng   Zuo, Jun-Wei   Bian, Qi   Yao, Ji   Zhou, Lu-Chun   Wei, Lin   Chen', Dong-Hong   Gao, Yang   Jin, Kai   Dai, Xiao-Lin   Fu, Han-Chu   Xu, Chang   Wang, Zhi-Chao   Xue, Xiang -Hui   Chen, Xue-Wu   Qian, Xian-Mei   Zhou, Yu   Xian, Hao   Peng, Qin-Jun   Rao, Chang-Hui   Xu, Zu-Yan   Zhang, Yu-Dong  

    A first generation sodium Laser Guide Star Adaptive Optics System (LGS-AOS) was developed and integrated into the Lijiang 1.8 m telescope in 2013. The LGS-AOS has three sub-systems: (1) a 20 W long pulsed sodium laser, (2) a 300-millimeter-diameter laser launch telescope, and (3) a 37-element compact adaptive optics system. On 2014 January 25, we obtained high resolution images of an my 8.18 star, HIP 43963, during the first light of the LGS-AOS. In this paper, the sodium laser, the laser launch telescope, the compact adaptive optics system and the first light results will be presented.
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  • Raman detection of hidden phonons assisted by atomic point defects in a two-dimensional semimetal

    Yuan, Hui   Zhou, Xieyu   Cao, Yan   Bian, Qi   Zhang, Zongyuan   Sun, Haigen   Li, Shaojian   Shao, Zhibin   Hu, Jin   Zhu, Yanglin   Mao, Zhiqiang   Ji, Wei   Pan, Minghu  

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  • Narrow-Linewidth 100-W-Level Microsecond TEM00 Nd:YAG Twisted-Mode Laser

    Bian, Qi   Zong, Qing-Shuang   Chang, Jin-Quan   Feng, Lu   Bo, Yong   Zuo, Jun-Wei   Shen, Yu   Zong, Nan   Zhang, Shen-Jin   Peng, Qin-Jun   Chen, Hong-Bin   Cui, Da-Fu   Xu, Zu-Yan  

    We demonstrated a compact high-efficiency 100-W-level, narrow-linewidth, quasi-continuous-wave (QCW) diode-side-pumped Nd:YAG laser with a linearly polarized TEM00 mode. Spatial hole-burning elimination and narrow-linewidth laser output were realized by a twisted-mode cavity and an etalon, respectively. The resonator was based on a thermally near-unstable cavity design with dual-rod birefringence compensation convex-convex structure. A 100.4-W linear polarized 1064-nm laser was achieved with a 340-W pump power, corresponding to an optical-to-optical conversion efficiency of 29.5%. The wavelength of the laser was tunable from 1064.22634 to 1064.68071 nm while stably maintaining a beam quality of M-2 =3D 1.22 and a linewidth of similar to 240 MHz. The laser was operated at a repetition rate of 500 Hz with 160-mu s pulse duration. To the best of our knowledge, this represents the highest average-power and the highest brightness for narrow-linewidth QCW microsecond pulse 1064-nm lasers.
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  • Layer-stacking, defects and robust superconductivity on Mo-terminated surface of ultrathin Mo2C flakes grown by CVD

    Zhang, Zongyuan   Gedeon, Habakubaho   Cheng, Zhengwang   Xu, Chuan   Shao, Zhibin   Sun, Haigeng   Li, Shaojian   Cao, Yan   Zhang, Xin   Bian, Qi   Liu, Lijun   Liu, Zhibo   Cheng, Hui-Ming   Ren, Wencai   Pan, Minghu  

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  • Directed co-evolution of β-carotene ketolase and hydroxylase and its application in temperature-regulated biosynthesis of astaxanthin

    Zhou, Pingping   Li, Min   Shen, Bin   Yao, Zhen   Bian, Qi   Ye, Lidan   Yu, Hongwei  

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  • Strongly-compressed Few-layered SnSe2 films grown on SrTiO3 substrate: the coexistence of charge order and enhanced interfacial superconductivity

    shao, zhibin   Fu, Zhen-Guo   Li, Shaojian   Cao, Yan   Bian, Qi   Sun, Haigen   Zhang, Zongyuan   Gedeon, Habakubaho   Zhang, Xin   Liu, Lijun   Cheng, Zhengwang   Zheng, Fawei   Zhang, Ping   Pan, Minghu  

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  • Spiking suppression of high power QCW pulse 1319 nm Nd:YAG laser with different intracavity doublers

    Bian, Qi   Zuo, Jun-Wei   Guo, Chuan   Xu, Chang   Shen, Yu   Zong, Nan   Bo, Yong   Peng, Qin-Jun   Chen, Hong-Bin   Cui, Da-Fu   Xu, Zu-Yan  

    We describe the results of our efforts in suppressing spiking of a high power, high beam quality 1319 nm Nd: YAG microsecond-pulse laser with three different intracavity frequency doublers. The 1319 nm laser is generated by a quasi-continuous-wave diode-pumped Nd: YAG ring laser system. One potassium titanyl phosphate (KTP), two KTPs and one lithium triborate (LBO) as frequency doublers are installed in the ring resonator and tested, respectively. At 800 Hz repetition rate, with a pulse width of 100 mu s, performances of spiking suppression for each case are observed. The average output power are 23.6 W, 22.7 W and 23.4 W with beam quality factors of M-2 = 2.21, 1.28 and 1.25 for one KTP, two KTPs and one LBO, respectively. The corresponding brightness are 270 MW/(cm(2) . sr), 780 MW/(cm(2) . sr) and 860 MW/(cm(2) . sr). With better beam quality, higher brightness, and easier maintainability, the LBO is the best option of the three. A laser rate equation model including the insertion loss of the doubler is applied for theoretical analysis of the output temporal pulse shape and power, and the simulated results agree well with the experimental data.
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