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Now showing items 1 - 16 of 17

  • Acupuncture for symptoms in menopause transition:a randomized controlled trial

    Liu, Zhishun   Ai, Yanke   Wang, Weiming   Zhou, Kehua   He, Liyun   Dong, Guirong   Fang, Jianqiao   Fu, Wenbing   Su, Tongsheng   Wang, Jie   Wang, Rui   Yang, Jun   Yue, Zenghui   Zang, Zhiwei   Zhang, Wei   Zhou, Zhongyu   Xu, Huanfang   Wang, Yang   Liu, Yan   Zhou, Jing   Yang, Likun   Yan, Shiyan   Wu, Jiani   Liu, Jia   Liu, Baoyan  

    BACKGROUND: Acupuncture has been used for women during menopause transition, but evidence is limited. OBJECTIVE: We sought to evaluate the efficacy of electroacupuncture on relieving symptoms of women during menopause transition. STUDY DESIGN: We conducted a prospective, multicenter, randomized, participant-blinded trial in China mainland. Subjects were randomized to receive 24 treatment sessions of electroacupuncture at traditional acupoints or sham electroacupuncture at nonacupoints over 8 weeks with 24 weeks' follow-up. Primary outcome was the change from baseline in the total score of Menopause Rating Scale at week 8. Secondary outcomes included the changes from baseline in the average 24-hour hot flash score, the Menopause Rating Scale subscale scores, the total score of Menopause-Specific Quality of Life Questionnaire and its subscales, and serum female hormones. All analyses were performed with a 2-sided P value of <.05 considered significant based on the intention-to-treat principle. RESULTS: A total of 360 women (180 in each group) with menopause-related symptoms during menopause transition were enrolled from June 9, 2013, through Dec 28, 2015. At week 8, the reduction from baseline in the Menopause Rating Scale total score was 6.3 (95% confidence interval, 5.0-7.7) in the electroacupuncture group and 4.5 (95% confidence interval, 3.2-5.8) in the sham electroacupuncture group with a between-group difference of 1.8 (95% confidence interval, 0.9-2.8; P =3D.0002), less than the minimal clinically important difference of 5 points' reduction. For secondary outcomes, the between-group differences for the decrease in the mean 24-hour hot flash score were significant at weeks 8, 20, and 32, but all were less than the minimal clinically important difference in previous reports. Interestingly, the between-group differences for the Menopause-Specific Quality of Life Questionnaire total score reduction were 5.7 at week 8, 7.1 at week 20, and 8.4 at week 32, greater than the minimal clinically important difference of 4 points. Changes from baseline in follicle-stimulating hormone, luteinizing hormone, and estradiol levels at weeks 8 and 20 (P >.05 for all), with the exception of follicle-stimulating hormone/luteinizing hormone ratios (P =3D.0024 at week 8 and .0499 at week 20), did not differ between groups. CONCLUSION: Among women during menopause transition, 8 weeks' electroacupuncture treatment did not seem to relieve menopausal symptoms, even though it appeared to improve their quality of life. Generalizability of the trial results may be limited by mild baseline menopausal symptoms in the included participants.
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  • Acupuncture for Chronic Severe Functional Constipation: A Randomized Trial.

    Liu, Zhishun   Yan, Shiyan   Wu, Jiani   He, Liyun   Li, Ning   Dong, Guirong   Fang, Jianqiao   Fu, Wenbin   Fu, Lixin   Sun, Jianhua   Wang, Linpeng   Wang, Shun   Yang, Jun   Zhang, Hongxing   Zhang, Jianbin   Zhao, Jiping   Zhou, Wei   Zhou, Zhongyu   Ai, Yanke   Zhou, Kehua   Liu, Jia   Xu, Huanfang   Cai, Yuying   Liu, Baoyan  

    Background: Acupuncture has been used for chronic constipation, but evidence for its effectiveness remains scarce.; Objective: To determine the efficacy of electroacupuncture (EA) for chronic severe functional constipation (CSFC).; Design: Randomized, parallel, sham-controlled trial. ( NCT01726504).; Setting: 15 hospitals in China.; Participants: Patients with CSFC and no serious underlying pathologic cause for constipation.; Intervention: 28 sessions of EA at traditional acupoints or sham EA (SA) at nonacupoints over 8 weeks.; Measurements: The primary outcome was the change from baseline in mean weekly complete spontaneous bowel movements (CSBMs) during weeks 1 to 8. Participants were followed until week 20.; Results: 1075 patients (536 and 539 in the EA and SA groups, respectively) were enrolled. The increase from baseline in mean weekly CSBMs during weeks 1 to 8 was 1.76 (95% CI, 1.61 to 1.89) in the EA group and 0.87 (CI, 0.73 to 0.97) in the SA group (between-group difference, 0.90 [CI, 0.74 to 1.10]; P< 0.001). The change from baseline in mean weekly CSBMs during weeks 9 to 20 was 1.96 (CI, 1.78 to 2.11) in the EA group and 0.89 (CI, 0.69 to 0.95) in the SA group (between-group difference, 1.09 [CI, 0.94 to 1.31]; P< 0.001). The proportion of patients having 3 or more mean weekly CSBMs in the EA group was 31.3% and 37.7% over the treatment and follow-up periods, respectively, compared with 12.1% and 14.1% in the SA group (P< 0.001). Acupuncture-related adverse events during treatment were infrequent in both groups, and all were mild or transient.; Limitations: Longer-term follow-up was not assessed. Acupuncturists could not be blinded.; Conclusion: Eight weeks of EA increases CSBMs and is safe for the treatment of CSFC. Additional study is warranted to evaluate a longer-term treatment and follow-up.; Primary Funding Source: Ministry of Science and Technology of the People's Republic of China through the Twelfth Five-Year National Science and Technology Pillar Program.=20
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  • Effects of Current Frequency on Electromagnetic Sheet Metal Forming Process

    Cao, Quanliang   Han, Xiaotao   Lai, Zhipeng   Zhang, Bo   Zhou, Zhongyu   Qiu, Li   Li, Liang  

    In the paper, the effects of current frequency on the electromagnetic sheet metal forming process are investigated using an efficient finite element model, which couples analysis of circuit, electromagnetic, and mechanical equations. Based on the initial electrical and structural parameters of the system, the model calculates the pulsed current flowing through the coil, the consequent magnetic force acting on the metal sheet, and finally the generated sheet deformation. The effects of current frequency on the maximum displacement in axial direction of the sheet are analyzed for two sheets by changing the capacitance of capacitor bank, while keeping the stored energy constant. The results show that there exist two optimum frequencies that produce relatively large sheet deformation and the optimum frequencies are related with the thickness of the sheet.
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  • Electromagnetic cold-expansion process for circular holes in aluminum alloy sheets

    Zhou, Zhongyu   Fu, Jiekai   Cao, Quanliang   Lai, Zhipeng   Xiong, Qi   Han, Xiaotao   Li, Liang  

    Although the mechanical cold-expansion process may improve the fatigue life of holes in workpieces to some extent, various inherent limitations of this process restrict further improvement of the fatigue life of holes. To overconie the limitations of the mechanical cold-expansion process, a new electromagnetic cold expansion process with a dual-stage coil system, which expands holes by a radial pulsed electromagnetic force, is presented in this paper. The basic principle and implementation of the process are analyzed in detail. Then a series of experiments for cold expansion of holes in sheets made of 2Al2-T4 aluminum alloy, is carried out to validate the proposed method. Results show that it can significantly improve fatigue life and increase the fatigue limit of specimens from 60 MPa to about 127 MPa. Compared with the mechanical cold expansion processes, the fatigue life has doubled in high maximum nominal stress, which is mainly attributed to non-contact processing and more uniform residual stress distribution. Moreover, it can be concluded that the new process can strengthen different types of holes (i.e. special-shaped, small) that are difficult to be processed by conventional cold expansion processes.
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  • Design and Experiments of a High Field Electromagnetic Forming System

    Qiu, Li   Han, Xiaotao   Peng, Tao   Ding, Hongfa   Xiong, Qi   Zhou, Zhongyu   Jiang, Chengxi   Lv, Yiliang   Li, Liang  

    The concept of capacity coefficient is introduced to evaluate the processing capacity of electromagnetic forming (EMF). An EMF system design method, including capacity coefficient design, inductance design and strength design, is developed by a finite element method. The geometry and size of the driving coil are optimized by the capacity coefficient design. The inductance design is aimed at obtaining a reasonable pulse width of EMF. Finally, the strength design of the driving coil is presented with respect to the reinforcement. With this design method, a high strength driving coil is designed and wound. The height, inner radius, and outer radius of the driving coil are 25 mm, 5 mm, and 50 mm respectively. The number of turns is 40, resulting in reasonable pulse width of 380 mu s. Experiments with different driving coils and pulse width were carried out. The results show that the processing capability of EMF is improved due to the high strength driving coil.
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  • Evaluation Indexes of Reinforcement for Optimizing Pulsed Magnet Design

    Zhou, Zhongyu   Song, Yunxing   Xiao, Houxiu   Peng, Tao   Li, Liang  

    To evaluate the efficiency of reinforcing layers in pulsed magnets with different reinforcing materials, reinforcement methods, and sizes by the same standard, evaluation indexes of reinforcement, Reinforcement Ratio (RR) and material Utilization Ratio (UR), are introduced. The RR is used to evaluate the reinforcing ability of a reinforcing layer, and the UR is used to indicate the material utilization ratio of a reinforcing layer. The approximate analytical formulas of RR and UR are derived in the approximation of zero axial stress. Both the approximate formulas can reflect the effects of the radius, thickness of reinforcing layer, and the anisotropy of the reinforcing materials. Two examples about optimizing the magnet design using the indexes are discussed. One is about poly-layer reinforcement scheme for pulsed magnets, which can utilize reinforcement material effectively. The indexes are used to determine the thickness of each layer with different reinforcing materials in this scheme. The other is about dividing conductor layer into thinner layers, which is an effective method for reducing the peak stress in the reinforcing layer, the indexes are applied to optimize the number of layer division.
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  • Jasmonate-Elicited Stress Induces Metabolic Change in the Leaves of Leucaena leucocephala

    Xu, Yingchao   Tao, Zhenru   Jin, Yu   Chen, Shuangyan   Zhou, Zhongyu   Gong, Amy G. W.   Yuan, Yunfei   Dong, Tina T. X.   Tsim, Karl W. K.  

    The plant Leucaena leucocephala was exposed to four jasmonate elicitors, i.e., jasmonic acid (JA), methyl jasmonic acid (MeJA), jasmonoyl-L-isoleucine (JA-Ile) and 6-ethyl indanoyl glycine conjugate (2-[(6-ethyl-1-oxo-indane-4-carbonyl)-amino]-acetic acid methyl ester) (CGM). The treatment was to mimic the herbivores and wounding stresses. By using NMR spectroscopy along with chemometric analysis, including principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), the changes of metabolites in the leaves of L. leucocephala were determined under the stress as induced by the four elicitors. The challenge of JA-Ile caused an accumulation of lactic acid (6), beta-glucose (10), alanine (12), threonine (13), steroids (18), 3,4-dihydroxypyridine (19) and an unidentified compound 20. The chemometric analysis of the PCA and PLS-DA models indicated that the alternation of metabolites triggered by JA, MeJA, and CGM treatments were very minimum. In contrast, the treatment by JA-Ile could induce the most significant metabolic changes in the leaves. Moreover, there was very minimal new metabolite being detected in responding to the jasmonate-induced stresses. The results showed some metabolite concentrations changed after application of the elicitors, which may be related to a high level of tolerance to stress conditions as well as the strong ecological suitability of L. leucocephala.
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  • Dynamic analysis of electromagnetic sheet metal forming process using finite element method

    Cao, Quanliang   Li, Liang   Lai, Zhipeng   Zhou, Zhongyu   Xiong, Qi   Zhang, Xiao   Han, Xiaotao  

    This paper presents a simple and efficient method for the analysis of dynamic behavior of the workpiece in the electromagnetic forming process. A two-dimensional (2D) axisymmetric finite element model with the equations of electrical equivalent circuit, electromagnetic field, and mechanical field has been developed for calculating the discharge currents through the forming coil, the magnetic forces acting on the workpiece, and the plastic deformation of the workpiece. By considering the effects of the sheet geometry and velocity on the above parameters, the method realizes the full coupling between the electromagnetic fields and the workpiece deformation, which should be more accurate than the existing loose coupling and sequential coupling simulation methods.
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  • Effect of Electromagnetic Ring Expansion on the Mechanical Property of A5083 Aluminum Alloy

    Huang, Lantao   Han, Xiaotao   Chen, Qi   Niu, Yuanhang   Lai, Zhipeng   Cao, Quanliang   Zhou, Zhongyu   Li, Liang  

    Electromagnetic forming (END) is a promising metal-forming process for complex geometrical shape and lightweight construction. Ring expansion is one of the basic EMFs wherein the workpiece is under nearly uniform tensile stress. The final strains of the rings at different discharge voltages are measured. It is found that the strain increases with the voltage. The strain can exceed the maximum strain in the ASTM standard tension test when the voltage is higher than 8 kV, and it has the largest improvement of 53% at 9 kV. The Vickers hardness is also measured at each voltage. Also, a rising trend is observed as the voltage increases. The highest hardness is found at 9 kV with a value of 110.1. It has an increase of 46% compared to the ring without expansion. Finally, the microstructure of the expanded ring is observed with the electron backscatter diffraction technique.
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  • [Prescription analysis of electroacupuncture for simple obesity based on complex network technique].

    Chen, Xia   Huang, Wei   Jin, Yiting   Hu, Feng   Cheng, Xiaoling   Hong, Zhehao   Zhou, Zhongyu  

    OBJECTIVE: To analyze the core acupoints and compatibility of electroacupuncture (EA) for simple obesity based on complex network technique, and to explore the usage of EA waveform.; METHODS: The clinical research literature regarding EA for simple obesity published from January of 1980 to June of 2016 were searched in PubMed, CNKI, WanFang, VIP, CBM and TCM online database to establish a prescription database of EA for simple obesity. The Matlab2014a software was used to perform the center analysis and cluster analysis, and the analysis of core points and compatibility were conducted. Gephi 9.1 software was used to demonstrate the complex network diagram to further analyze the usage of EA waveform.; RESULTS: Totally 238 prescriptions were obtained. The selection of acupoints at yang-meridians were equally important with acupoints at yin-meridians. The meridians with highest core degree were stomach meridian, conception vessel and spleen meridian. The acupoints with highest core degree were Sanyinjiao (SP 6), Tianshu (ST 25) and Zusanli (ST 36). The cluster analysis indicated three acupoint clusters, including the key-acupoint cluster, syndrome-acupoint cluster, and ashi-point cluster; it was revealed Tianshu (ST 25) and Zhongwan (CV 12) had the highest intensity of compatibility. The sparse-dense wave was mostly used in EA for simple obesity, followed by continuous wave, indicating both sparse-dense wave and continuous wave had high clinical application value.; CONCLUSION: The acupoints of EA for simple obesity are mainly in stomach meridian, conception vessel and spleen meridian; sparse-dense wave is mostly used, followed by continuous wave.=20
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  • A Compact Explosive-Driven Flux Compression Generator for Reproducibly Generating Multimegagauss Fields

    Zhou, Zhongyu   Gu, Zhuowei   Luo, Hao   Tong, Yanjin   Tang, Xiaosong   Tan, Fuli   Zhao, Jianheng   Sun, Chengwei  

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  • Association between UBE2E2 variant rs7612463 and type 2 diabetes mellitus in a Chinese Han population.

    Kazakova, Elena V   Wu, Yanhui   Zhou, Zhongyu   Chen, Meijun   Wang, Tongtong   Tong, Huixin   Zhuang, Tianwei   Sun, Lulu   Qiao, Hong  

    UBE2E2 encodes ubiquitin-conjugating enzyme E2E2, which plays an important role in the synthesis and secretion of insulin. Two previous studies indicated that SNPs in UBE2E2 were associated with risk for type 2 diabetes mellitus (T2DM) in the Japanese and Korean populations, respectively. We examined the association of one SNP in this gene, rs7612463, with the risk of T2DM in 1957 Han participants in northeastern China, using an SNPscan(TM) Kit. rs7612463 genotype was significantly associated with risk for T2DM under various genetic models, including an additive model (P =3D 0.004), a dominant model (P =3D 0.024), and a recessive model (P =3D 0.008). The AA genotype was associated with a significantly decreased risk for T2DM (P =3D 0.004, OR =3D 0.513, 95% CI =3D 0.325-0.810) after adjustment for age, gender, and BMI. The heterozygous genotype, AC, was associated with increased risk for total cholesterol (mmol l-1; P =3D 0.031) and triglycerides (mmol l-1; P =3D 0.039) in control individuals. Our results show that rs7612463 is associated with T2DM, with homozygotes of the AA genotype at decreased risk for T2DM in the Chinese population. Additionally, heterozygotes may have decreased risk of T2DM due to insulin resistance. =20
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  • Comparative Study of Different Acorus Species in Potentiating Neuronal Differentiation in Cultured PC12 Cells

    Lam, Kelly Y. C.   Huang, Yun   Yao, Ping   Wang, Huaiyou   Dong, Tina T. X.   Zhou, Zhongyu   Tsim, Karl W. K.  

    Acori Tatarinowii Rhizoma (ATR), the rhizome of Acorus tatarinowii Schott, is a common traditional Chinese medicine being used clinically for mental disorder. However, other Acorus species herbs are all having the same Chinese name Chang Pu', making the confusion in herbal market. Acori Graminei Rhizoma (AGR) and Acori Calami Rhizoma (ACR) are common adulterants of ATR. Here, we aim to provide a comparative analysis between ATR, AGR, and ACR in potentiating neuronal differentiation. Volatile oil, derived from Acorus species, was applied onto cultured PC12 cells, and various parameters were determined: (i) transcriptional activation of neurofilament promoters was determined by the promoter-driven luciferase activity assay; (ii) the neurite outgrowth of PC12 cells was captured and measured; and (iii) the neurofilament expression and its underlying mechanism were analyzed by western blotting. The co-treatment of ATR, AGR, or ACR volatile oil with low concentration of nerve growth factor (NGF) could potentiate the NGF-induced neuronal differentiation in cultured PC12 cells. In addition, application of protein kinase A inhibitor H89 in cultures blocked the induction of neurofilament. Among these three Acorus species, ATR volatile oil showed the highest NGF-induced induction in neurite outgrowth and neurofilament expression, as compared with that of AGR and ACR. Copyright (c) 2017 John Wiley & Sons, Ltd.
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  • Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura:multicentre,randomised clinical trial

    Xu, Shabei   Yu, Lingling   Luo, Xiang   Wang, Minghuan   Chen, Guohua   Zhang, Qing   Liu, Wenhua   Zhou, Zhongyu   Song, Jinhui   Jing, Huitao   Huang, Guangying   Liang, Fengxia   Wang, Hua   Wang, Wei  

    Objective - To assess the efficacy of manual acupuncture as prophylactic treatment for acupuncture naive patients with episodic migraine without aura. Design - Multicentre, randomised, controlled clinical trial with blinded participants, outcome assessment, and statistician. Setting - Seven hospitals in China, 5 June 2016 to 15 November 2018. Participants - 150 acupuncture naive patients with episodic migraine without aura. Interventions - 20 sessions of manual acupuncture at true acupuncture points plus usual care, 20 sessions of non-penetrating sham acupuncture at heterosegmental non-acupuncture points plus usual care, or usual care alone over 8 weeks. Main outcome measures - Change in migraine days and migraine attacks per four weeks during weeks 1-20 after randomisation compared with baseline (four weeks before randomisation). Results - Among 150 randomised patients (mean age 36.5 (SD 11.4) years; 123 (82%) women), 147 were included in the full analysis set. Compared with sham acupuncture, manual acupuncture resulted in a significantly greater reduction in migraine days at weeks 13 to 20 and a significantly greater reduction in migraine attacks at weeks 17 to 20. The reduction in mean number of migraine days was 3.5 (SD 2.5) for manual versus 2.4 (3.4) for sham (adjusted difference -1.4, 95% confidence interval -2.4 to -0.3; P=3D0.005) at weeks 13 to 16 and 3.9 (3.0) for manual versus 2.2 (3.2) for sham (adjusted difference -2.1, -2.9 to -1.2; P<0.001) at weeks 17 to 20. At weeks 17 to 20, the reduction in mean number of attacks was 2.3 (1.7) for manual versus 1.6 (2.5) for sham (adjusted difference -1.0, -1.5 to -0.5; P<0.001). No severe adverse events were reported. No significant difference was seen in the proportion of patients perceiving needle penetration between manual acupuncture and sham acupuncture (79% v 75%; P=3D0.891). Conclusions - Twenty sessions of manual acupuncture was superior to sham acupuncture and usual care for the prophylaxis of episodic migraine without aura. These results support the use of manual acupuncture in patients who are reluctant to use prophylactic drugs or when prophylactic drugs are ineffective, and it should be considered in future guidelines.
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  • Electroacupuncture Versus Pelvic Floor Muscle Training Plus Solifenacin for Women With Mixed Urinary Incontinence: A Randomized Noninferiority Trial

    Liu, Baoyan   Liu, Yan   Qin, Zongshi   Zhou, Kehua   Xu, Huangfang   He, Liyun   Li, Ning   Su, Tongsheng   Sun, Jianhua   Yue, Zenghui   Zang, Zhiwei   Zhang, Wei   Zhao, Jiping   Zhou, Zhongyu   Liu, Lian   Wu, Dongning   Wu, Jiani   Zhou, Jing   Pang, Ran   Wang, Yang   Liu, Jia   Yu, Jinna   Liu, Zhishun  

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  • Electroacupuncture Versus Pelvic Floor Muscle Training Plus Solifenacin for Women With Mixed Urinary Incontinence: A Randomized Noninferiority Trial.

    Liu, Baoyan   Liu, Yan   Qin, Zongshi   Zhou, Kehua   Xu, Huangfang   He, Liyun   Li, Ning   Su, Tongsheng   Sun, Jianhua   Yue, Zenghui   Zang, Zhiwei   Zhang, Wei   Zhao, Jiping   Zhou, Zhongyu   Liu, Lian   Wu, Dongning   Wu, Jiani   Zhou, Jing   Pang, Ran   Wang, Yang   Liu, Jia   Yu, Jinna   Liu, Zhishun  

    OBJECTIVE: To evaluate the efficacy and safety of electroacupuncture vs pelvic floor muscle training (PFMT) plus solifenacin for women with mixed urinary incontinence (MUI).; PATIENTS AND METHODS: This randomized controlled noninferiority trial was conducted at 10 hospitals in China between March 1, 2014, and October 10, 2016. Participants were randomized 1:1 to receive electroacupuncture (36 sessions) over 12 weeks with 24 weeks of follow-up or PFMT-solifenacin (5 mg/d) over 36 weeks. The primary outcome was percentage change from baseline to week 12 in mean 72-hour incontinence episode frequency (IEF) measured by the 72-hour bladder diary. It was analyzed in the per-protocol set with a prespecified noninferiority margin of 15%.; RESULTS: Of 500 women with MUI who were randomized, 467 (239 in the electroacupuncture group and 228 in the PFMT-solifenacin group) completed treatment per protocol and were included in the primary outcome analysis. At weeks 1 through 12, the percentage of reduction from baseline in mean 72-hour IEF was 37.83% in the electroacupuncture group and 36.49% in the PFMT-solifenacin group (between-group difference,-1.34% [95% CI,-9.78% to 7.10%]; P<.001 for noninferiority), which demonstrates noninferiority; the treatment effect persisted throughout follow-up. Statistically significant improvements were found for secondary outcomes in both groups, with no meaningful difference between treatments.; CONCLUSION: In women with moderate to severe MUI, electroacupuncture was not inferior to PFMT-solifenacin in decreasing the 72-hour IEF and shows promise as an effective alternative for the treatment of MUI.; TRIAL REGISTRATION: Identifier: NCT02047032. Copyright =C2=A9 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
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