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Now showing items 1 - 16 of 18

  • A blow-up criterion for 3D compressible viscoelastic flow with large initial data

    Liu, Shengquan   Zhao, Junning  

    In this paper, we consider a Cauchy problem for the three-dimensional compressible viscoelastic flow with large initial data. We establish a blow-up criterion for the strong solutions in terms of the gradient of velocity only, which is similar to the Beale-Kato-Majda criterion for ideal incompressible flow (cf. Beale et al. (1984) [20]) and the blow-up criterion for the compressible Navier-Stokes equations (cf. Huang et al. (2011) [21]). (C) 2011 Elsevier Ltd. All rights reserved.
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  • An evaluation of the wound healing potential of tetrahydrocurcumin-loaded MPEG-PLA nanoparticles

    He, Peng   Yan, Hong   Zhao, Junning   Gou, Maling   Li, Xiaolu  

    Wound healing refers to the healing process of skin and other tissues appear to be broken or defective after one body suffers external force. Accelerating wound healing through the use of natural products isolated from plants and microbes is a hot research topic. Tetrahydrocurcumin is one of the major in vivo colorless hydrogenated metabolites of curcumin with superior wound healing and anti-inflammatory properties. The poor bioavailability of these curcuminoids limits their clinical applications. Preparation of curcuminoids-loaded nanoparticles is one appropriate method of addressing this issue. In this study, tetrahydrocurcumin nanoparticles were firstly used for wound healing. In vitro experiments revealed that tetrahydrocurcumin-loaded MPEG-PLA nanoparticles (THC-NPs) could stimulate the closure of defect by enhancing directional migration of human fibroblasts in tetrahydrocurcumin dose-dependent manner. In addition, we also evaluated the effect of sodium alginate/chitosan dressings featuring THC-NPs on wound healing. We found that the nanometer dressings (sodium alginate/chitosan dressings featuring THC-NPs) could accelerate wound healing by improving collagen deposition, increasing vascular density in a rat model of wound repair. These results demonstrated that THC-NPs could promote cutaneous healing by increasing the synthesis of collagen I and III, revascularization and improving the migration of fibroblasts. Thus, THC-NPs have the potential for enhancing wound healing progress.
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  • Global classical solutions to the 3D isentropic compressible Navier-Stokes equations in a bounded domain

    Yu, Haibo   Zhao, Junning  

    In this paper, we study the global existence for classical solutions to the 3D isentropic compressible Navier-Stokes equations in a cuboid domain. Compared to the Cauchy problem studied in Hoff (1995 J. Differ. Equ. 120 215-54), Hoff (2005 J. Math. Fluid Mech. 7 315-38), Huang et al (2012 Commun. Pure Appl. Math. 65 549-85), some new thoughts are applied to obtain upper bounds for density. Precisely, through piecewise estimation and some time-depending a priori estimates, we establish time-uniform upper bounds for density under the assumption that the initial energy is small. The initial vacuum is allowed.
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  • On the cauchy problem of evolution p-Laplacian equation with nonlinear gradient term RID G-3431-2010

    Chen, Mingyu   Zhao, Junning  

    The authors study the existence of solution to p-Laplacian equation with nonlinear forcing term under optimal assumptions on the initial data, which are assumed to be measures. The existence of local solution is obtained.
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  • Localization for the evolution p-Laplacian equation with strongly nonlinear source term RID G-3431-2010

    Liang, Zhilei   Zhao, Junning  

    In this paper we study the strict localization for the p-Laplacian equation with strongly nonlinear source term. Let u := u(x, t) be a solution of the Cauchy problem u(t) = div(vertical bar del u vertical bar(p-2)del u) + u(q), u(x,0) = u(0)(x). where (x,t) is an element of R(N) x ((0, T), N >= 1 and p >= 2. When q >= p - 1, we prove that if the initial data u(0)(x) has a compact Support, then the Solution u(., t) has also compactly support. Moreover, when 1 < q < p - 1, we show that the solution of the Cauchy problem blows up at any point of R(N) to arbitrary Compactly Supported initial data. (C) 2008 Elsevier Inc. All rights reserved.
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  • THE PROCESS FOR PREPARATION OF TOTAL COUMARINS FROM CORTEX FRAXINI AND THEIR USE IN MEDICINE

    The present invention discloses a process for preparing total coumarins from Cortex Fraxini, which comprises: a. extracting Cortex Fraxini by the method of water-extracting and alcohol-depositing (50 %-90%) or alcohol-extracting and alcohol-depositing (50 %-90%) or alcohol-extracting (70 %-95%) to obtain a extract; b. subjecting the extract to the temperature between 4-12 °C for 8-24 hours to form a deposit; c. filtering the resulting deposit and drying, resulting the total coumarins from Cortex Fraxini . The invention also relates to the use of total coumarins in Cortex Fraxini in manufacturing medicines for treating acute or chronic gout diseases. The present invention also discloses a process for extracting esculin from total coumarins from Cortex Fraxini, and the use of esculin in manufacturing medicines for treating acute or chronic gout diseases.
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  • Super-kdrmutationM918Land multiple cytochrome P450s associated with the resistance ofRhopalosiphum padito pyrethroid

    Wang, Kang   Bai, Jiaoyang   Zhao, Junning   Su, Sha   Liu, Lang   Han, Zhaojun   Chen, Maohua  

    BACKGROUND Rhopalosiphum padiis an important pest affecting cereal crops worldwide. Pyrethroid, including lambda-cyhalothrin, has been widely used to controlR. padiin the field. This work investigated the resistance levels ofR. padifield populations to lambda-cyhalothrin, and analysed biochemical and molecular mechanisms of aphid resistance to the insecticide pyrethroid. RESULTS A lambda-cyhalothrin-resistant field population (JY) was sampled, and a super-kdrmutation, M918L, in the voltage-gated sodium channel (VGSC) was identified in the population. The lambda-cyhalothrin-resistant strain (LC-R) was subsequently established by selecting the field population with lambda-cyhalothrin. All individuals of theR. padiLC-R strain showed the M918L heterozygous mutation in the VGSC IIS4-IIS6 region. Cross-resistance profiles of the LC-R strain to nine insecticides were detected. Both synergistic and enzyme activity studies indicated that cytochrome P450 monooxygenase played an important role in this resistance. Further gene expression analysis showed that seven P450 genes were significantly upregulated in the LC-R strain compared with the susceptible strain. CONCLUSION Field-evolved resistance to pyrethroid insecticides has been found inR. padi. The M918L (super-kdr) mutation in the VGSC was documented for the first time in field samples obtained from an important wheat-growing area. The super-kdrmutation, as well as metabolic resistance mediated by P450 genes, was determined to contribute to the lambda-cyhalothrin resistance inR. padi. (c) 2020 Society of Chemical Industry
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  • Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo

    Zeng, Anqi   Hua, Hua   Liu, Li   Zhao, Junning  

    Betulinic acid (BA) is a pentacyclic triterpenoids extracted from birch with a wide range of biological properties. Recent studies have shown that BA has significant cytotoxicity to various types of human cancer cells, and shows potential in cancer treatment. However, the efficacy of BA on human colorectal cancer tumor cells is still unclear. The purpose of our study was to evaluate the anti-cancer activity of BA in human colorectal cancer cells in vitro and in vivo to investigate the possible mechanism. In this experiment, we found that BA inhibited colorectal cancer cell lines in vitro with a time-dependent and dose-dependent manner. Moreover, BA could induce cell apoptosis by upregulating expression of Bax and cleaved caspase-3 and downregulating protein of Bcl-2. BA could increase the production of reactive oxygen species and reduce mitochondrial membrane potential of cancer cell, suggesting that BA induced cancer cells apoptosis by mitochondrial mediated pathways. Furthermore, BA significantly inhibited the migration and invasion of colorectal cancer cells, reduced the expression of matrix metalloproteinase (MMPs) and increased the expression of MMPs inhibitor (TIMP-2). In addition, the growth of tumor was significantly suppressed by intraperitoneal administration of 20 mg/kg/day of BA in a xenograft tumor mouse model of HCT-116. Histopathological and immunohistochemical analysis showed that MMP-2+ cells and Ki-67+ cells were reduced and cleaved caspase-3+ cells were increased in tumor tissues of mice after BA administration. The results showed that BA not only promoted the apoptosis of colorectal cancer cells, but also inhibited the metastasis of cancer cells. Our results suggest that BA can be a potential natural drug to inhibit the growth and metastasis of colorectal cancer.
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  • Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo

    Zeng, Anqi   Hua, Hua   Liu, Li   Zhao, Junning  

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  • SINGULAR SOLUTIONS FOR A CONVECTION DIFFUSION EQUATION WITH ABSORPTION

    Zhao, Junning  

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  • Asymptotic stability of viscous contact discontinuity to an inflow problem for compressible Navier-Stokes equations

    Zheng, Tingting   Zhang, Jianwen   Zhao, Junning  

    This paper is concerned with an initial-boundary value problem for one-dimensional full compressible Navier-Stokes equations with inflow boundary conditions in the half space R(+) = (0,+infinity). The asymptotic stability of viscous contact discontinuity is established under the conditions that the initial perturbations and the strength of contact discontinuity are suitably small. Compared with the free-boundary and the initial value problems, the inflow problem is more complicated due to the additional boundary effects and the different structure of viscous contact discontinuity. The proofs are given by the elementary energy method. (C) 2011 Elsevier Ltd. All rights reserved.
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  • Editorial comment on the paper Huashui Zhan, Junning Zhao: Some remarks on Prandtl system

    Pavel Krejčí  

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  • Editorial comment on the paper Huashui Zhan, Junning Zhao: Some remarks on Prandtl system

    Pavel Krej?í  

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  • Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo (vol 27,pg 2546,2019)

    Zeng, Anqi   Hua, Hua   Liu, Li   Zhao, Junning  

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  • Simultaneous determination of six bioactive compounds in Evodiae Fructus by high-performance liquid chromatography with diode array detection.

    Tang, Xiaolong   Huang, Zhifang   Chen, Yan   Liu, Yunhua   Liu, Yuhong   Zhao, Junning   Yi, Jinhai  

    A simple and reliable high-performance liquid chromatography method with diode array detection (HPLC-DAD) was developed and validated for the simultaneous determination of six bioactive components, rutaevine, limonin, evodiamine, rutaecarpine, N-formyldihydrorutaecarpine and dihydroevocarpine, in the traditional Chinese medicine Evodiae Fructus (Wuzhuyu in Chinese). HPLC separation was conducted on an Agilent Eclipse C18 column (4.6 * 150 mm, 5 m) at 35=C2=B0C with a mixture of mobile phase A [tetrahydrofuran-0.02% phosphoric acid (16 : 35)] and mobile phase B (acetonitrile) (gradient elution as follows: 0 min, 22% B; 23 min, 22% B; 24 min, 75% B) at a flow rate of 1 mL/min, and the DAD detection wavelength was set at 220 nm. A linear relationship within the range of investigated concentrations was observed for the six compounds, with correlation coefficients greater than 0.999. The average recovery yields of the six compounds ranged from 98.39 to 104.96%. The HPLC-DAD method was validated by its repeatability [relative standard deviation (RSD) < 2.0%] and intra-day and inter-day precision (RSD < 2.0%). The method was successfully applied to the simultaneous determination of the six previously mentioned components in Evodiae Fructus. It is the first report of a simultaneous qualitative and quantitative analysis for three classes of bioactive components in Wuzhuyu, including the indolequinazoline alkaloids, quinolone alkaloid and limonoids. Based on these results, it is suggested, for possible future revision of the Chinese Pharmacopoeia, that the total contents of evodiamine and rutaecarpine are not less than 0.15% and the total contents of rutaevine and limonin are not less than 0.50%. =20
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  • Boundary-layer effects for the 2-D Boussinesq equations with vanishing diffusivity limit in the half plane RID G-3488-2010 RID G-3431-2010

    Jiang, Song   Zhang, Jianwen   Zhao, Junning  

    The main purpose of this paper is to justify the Stokes-Blasius law of boundary-layer thickness for the 2-D Boussinesq equations with vanishing diffusivity limit in the half plane, i.e., we shall prove that the boundary-layer thickness is of the value delta(epsilon) = epsilon(alpha) with any alpha is an element of (0.1/2) for small diffusivity coefficient epsilon > 0. Moreover, the convergence rates of the vanishing diffusivity limit are also obtained. (C) 2011 Elsevier Inc. All rights reserved.
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