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Now showing items 1 - 16 of 28

  • Storage of aerobic granular sludge embedded in agar and its reactivation by real wastewater

    Cheng, Yuanyuan   Xuan, Xinpeng   Zhang, Linan   Zhao, Jue   Long, Bei  

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  • Evidence of repurposing drugs and identifying contraindications from real world study in Parkinson’s disease

    Tang, Yilin   Yang, Ke   Zhao, Jue   Liang, Xiaoniu   Wang, Jian  

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  • Zwitterionic stealth peptide-protected gold nanoparticles enable long circulation without accelerated blood clearance phenomenon

    Zhao, Jue   Qin, Zhihui   Wu, Jina   Li, Lijie   Jin, Qiao   Ji, Jian  

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  • Seminole County Markham Regional Water Treatment Plant Ozone Regulatory Compliance Considerations – Treatment Challenges and Solutions

    Zhao, Jue   Roberto, Gonzalez   Cliburn, Mike   Brodeur, Tim   Lovins, Will   Sipes, Hugh  

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    Disclosed herein is a pond for cultivating a non-vascular photosynthetic organism in a liquid medium, comprising a sump comprising an inflow slope with an angle of about 20 to about 70 degrees, and optionally an outflow slope of with an angle of about 5 to about 40 degrees. The novel sump design results in good overall carbonation efficiency and does not result in a large loss of biomass of a cultivated organism.
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  • [IEEE 2010 International Conference on E-Product E-Service and E-Entertainment (ICEEE 2010) - Henan, China (2010.11.7-2010.11.9)] 2010 International Conference on E-Product E-Service and E-Entertainment - E-Learning Systems Adoption across Cultures: A Comparison Study

    Zhao, Jue   Tan, Weiwei  

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  • [IEEE 2010 International Conference on Parallel and Distributed Computing, Applications and Technologies (PDCAT) - Wuhan, Hubei, China (2010.12.8-2010.12.11)] 2010 International Conference on Parallel and Distributed Computing, Applications and Technologies - Cognition and Culture in ICT Experience

    Zhao, Jue   Zhang, Sheng   Tan, Weiwei  

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  • Effect of UVA irradiance on photocatalytic and UVA inactivation of Bacillus cereus spores RID D-5238-2009

    Zhao, Jue   Krishna, Vijay   Hua, Bin   Moudgil, Brij   Koopman, Ben  

    The current study is the first to delineate the contribution of photocatalysis to inactivation of Bacillus cereus endospores on dry surfaces over a broad range (0-153W/m(2)) of UVA irradiance. Inactivation of spores at low UVA irradiance (30W/m(2)) was primarily due to photocatalysis, whereas at higher UVA irradiance inactivation was primarily due to UV alone. A linear relationship between UVA irradiance and the rate of spore inactivation was observed in the absence of photocatalyst. The rate of photocatalytic inactivation was non-linear with respect to UVA irradiance, exhibiting a maximum at 30W/m(2). (C) 2008 Elsevier B.V. All rights reserved.
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  • Preserved caudate function in young-onset patients with Parkinson's disease:a dual-tracer PET imaging study

    Yang, Yu-jie   Ge, Jing-jie   Liu, Feng-tao   Liu, Zhen-yang   Zhao, Jue   Wu, Jian-jun   Ma, Yilong   Zuo, Chuan-tao   Wang, Jian  

    Parkinson's disease (PD) is a highly heterogeneous clinical entity. Patients with young-onset PD (YOPD) show some characteristic manifestations to late-onset PD (LOPD). The current study aimed to investigate the cerebral dopaminergic and metabolic characteristics in YOPD with positron emission tomography (PET) imaging. In our study, 103 subjects (42 YOPD and 61 LOPD patients) accepted both C-11-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (C-11-CFT) and F-18-fluorodeoxyglucose (F-18-FDG) cerebral PET imaging. Sixty-two patients out of 103 patients in our study completed the cognition tests. In this limited subsection, YOPD patients performed better in cognitive functioning than LOPD patients of similar disease duration. In C-11-CFT imaging, dopamine transporter binding in caudate was relatively spared in YOPD compared with lesions in putamen. In F-18-FDG PET, YOPD patients showed increased metabolism in basal ganglia relative to the healthy controls. When compared with LOPD patients, YOPD patients exhibited hypermetabolism in caudate and hypometabolism in putamen. Furthermore, the regional metabolic values in caudate correlated positively and moderately with the dopaminergic binding deficiency in caudate. The findings of this imaging study might offer new perspectives in understanding the characteristic manifestations in YOPD in light of better-preserved cognition function.
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  • Associations between cognitive impairment and motor dysfunction in Parkinson's disease

    Wang, Yi-Xuan   Zhao, Jue   Li, Da-Ke   Peng, Fang   Wang, Ying   Yang, Ke   Liu, Zhen-Yang   Liu, Feng-Tao   Wu, Jian-Jun   Wang, Jian  

    Introduction: Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease (PD). The aim of our study was to investigate the association between cognitive performance and motor dysfunction in Chinese patients with PD. Methods: Data from 96 patients with PD were obtained from the Parkinson's disease patient cohort database of Huashan Hospital. All participants underwent a comprehensive neuropsychological evaluation to assess cognitive status, that included scoring on the Mini-mental state examination (MMSE), followed by more detailed cognitive assessment on five main cognitive domains (verbal memory, nonverbal memory, visuospatial function, language and attention/executive function). Correlations between cognitive and motor scores were investigated after controlling for age, disease duration, education, and gender. Results: We report a significant correlation between subdomains of cognitive impairment and motor dysfunction using analyses of the multiple linear regression. Notably, executive function and attention was significantly associated with bradykinesia and rigidity, while visuospatial function was associated with bradykinesia and tremor. Conclusions: The association between motor dysfunction and cognitive decline in PD might highlight deficits represented by a shared neurochemical pathway.
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  • Protective Effects of Salvianolic Acid B on Schwann Cells Apoptosis Induced by High Glucose

    Sun, Lian-Qing   Zhao, Jue   Zhang, Ting-Ting   Qu, Ling   Wang, Xuan   Xue, Bing   Li, Xiao-Jin   Mu, Yi-Ming  

    Diabetic peripheral neuropathy (DPN) is one of the most common and debilitating microvascular complications of diabetes, and there is no effective therapy for the prevention or treatment of DPN. Oxidative stress triggers several pathways of injury and may be the unifying factor of hyperglycemia. The aim of this study was to investigate protective effect of Salvianolic acid B (Sal B) on the high glucose (HG)-induced oxidative stress-induced mitochondrial pathway activation and Schwann cells (SCs) apoptosis in vitro. We found that Sal B inhibited the HG-induced oxidative stress by reducing ROS and 8-hydroxy-2-deoxy Guanosine (8-OHdG) production, and mitochondrial depolarization and apoptosis in SCs in a dose-dependent manner. Furthermore, Sal B down-regulated the HG-mediated Bax expression and AIF nuclear translocation and the release of cytochrome c, but up-regulated the HG-induced BcL-2 expression in SCs. In addition, Sal B attenuated the HG-induced activation of caspase 3 and 9 and minimized the cleavage of PARP in SCs. Our results indicated that Sal B antagonized the HG-induced oxidative stress, activation of the mitochondrial pathway and apoptosis in SCs.
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  • Clinical characteristics of cognitive impairment in patients with Parkinson's disease and its related pattern in 18 F-FDG PET imaging.

    Wu, Lei   Liu, Feng-Tao   Ge, Jing-Jie   Zhao, Jue   Tang, Yi-Lin   Yu, Wen-Bo   Yu, Huan   Anderson, Tim   Zuo, Chuan-Tao   Chen, Ling   Wang, Jian  

    This study aimed to characterize the clinical features and the related cerebral glucose metabolism pattern of cognitive impairments in Parkinson's disease (PD) with positron emission tomography (PET) imaging. We recruited 168 PD patients and 100 age-matched healthy controls of similar education and gender distribution. All of those enrolled underwent clinical assessment including the unified Parkinson's disease rating scale motor score, Hoehn and Yahr scale, and comprehensive neuropsychological tests including domains of executive function, attention, memory, visuospatial function, and language. Demographics and the results of cognitive measures were compared between patients and healthy controls. Cognition status was classified as PD patients with dementia (PD-D), PD patients with mild cognitive impairment (PD-MCI), or PD patients with normal cognition (PD-NC). In 53 PD patients who underwent 18 F-fluorodeoxyglucose (18 F-FDG) PET imaging, correlations between Z-score values of the different cognitive domains and cerebral 18 F-FDG uptake were assessed using statistical parametric mapping (SPM8) corrected for age and motor severity. A total of 23.2% of PD patients were PD-MCI and 8.9% were PD-D. In the group of PD-MCI, 96.3% showed multiple-domain deficits, with executive function and attention impairment most predominantly involved. All the cognitive domain scores with the exception of language correlated with 18 F-FDG metabolisms, primarily in posterior temporo-parieto-occipital association cortical areas. This study found that cognitive impairment in PD particularly encompasses frontal/executive deficits. Posterior cortical areas, containing multiple neurotransmitters and neural circuits, may play an important role in the pathogenesis of cognitive impairment in PD. =C2=A9 2018 Wiley Periodicals, Inc.
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  • Storage of aerobic granular sludge embedded in agar and its reactivation by real wastewater

    Cheng, Yuanyuan   Xuan, Xinpeng   Zhang, Linan   Zhao, Jue   Long, Bei  

    Aerobic granular sludge (AGS) was preserved using an agar embedding method to maintain its stability. No obvious damage was imposed on the granular appearance during 30 days of cold and dry storage, but the granular microstructure had an uneven surface with a large number of holes. The results were consistent with the extinction of microbial communities and the monitored consumption of extracellular polymeric substances, in which granular specific oxygen utilization rate and mixed liquor volatile suspended solids/mixed liquor suspended solids ratio, respectively, decreased by 72.4% and 62.5% during storage. A mass conversation calculation indicated that the loss of granular mass was 1.6393 g. An offensive odour was smelled during storage, and the results indicated that a material transformation and mitigation were involved between AGS and the gas phase. Although the granular structure was destroyed to a certain extent, no obvious damage was imposed on the granular skeleton during storage. After it was aerated again after a feeding with real wastewater, the residual skeleton served as a carrier for the rapid proliferation of microorganisms, and good granular properties were obtained after 11 days of reactivation.
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  • Dissecting the differentiation process of the preplacodal ectoderm in zebrafish.

    Yao, Di   Zhao, Feng   Wu, Ying   Wang, Jialiang   Dong, Wei   Zhao, Jue   Zhu, Zuoyan   Liu, Dong  

    BACKGROUND: The preplacodal region (PPR) is a region of specialized ectoderm at the border of neural and nonneural ectoderm (NNE). Coordinated Bmp, Fgf, and Wnt signals are known to drive PPR development; however, the underlying mechanism is unknown.; RESULTS: We identified key components involved in PPR differentiation. The mesoderm/marginal Wnts at the early gastrula stage trigger differentiation by allowing the adjacent NNE border cells to start adopting caudal PPR fates; otherwise, the development of caudal PPR identity is hindered due to the persistent presence of gata3 mRNA. The caudal PPR fate dominates when foxi1 expression is enhanced at the late gastrula stage, and depleting Foxi1 after 6 hours postfertilization (hpf) reduces the otic-epibranchial placodal domain. When the Gata3 level is manipulated at the fertilized egg stage or near 6 hpf, the lens is always affected. In establishing PPR polarity, both Gata3 and Foxi1 inhibit Bmp signaling, whereas Foxi1 inhibits, but Gata3 enhances, Fgf sensitivity of the PPR cells.; CONCLUSIONS: Our study reveals that in zebrafish, (1) the PPR at the shield stage may enter a developmental state when the PPR cells preferentially adopt a particular placodal fate and (2) a network of genetically linked factors, including Wnt/beta-catenin, Fgfr, Bmp, Gata3, and Foxi1, direct the process of PPR differentiation. Copyright =C2=A9 2014 Wiley Periodicals, Inc.
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  • Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose (vol 90, pg 99, 2012)

    Sun, Lian-Qing   Xue, Bing   Li, Xiao-Jin   Wang, Xuan   Qu, Ling   Zhang, Ting-Ting   Zhao, Jue   Wang, Bao-An   Zou, Xiao-Man   Mu, Yi-Ming  

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  • Trehalose alleviates PC12 neuronal death mediated by lipopolysaccharide-stimulated BV-2 cells via inhibiting nuclear transcription factor NF-kappaB and AP-1 activation.

    He, Qing   Wang, Ying   Lin, Wei   Zhang, Qiong   Zhao, Jue   Liu, Feng-Tao   Tang, Yi-Lin   Xiao, Bao-Guo   Wang, Jian  

    Inflammation is implicated in the pathogenesis of Parkinson's disease (PD). Trehalose is a disaccharide which exhibits a variety of effects like anti-aggregation, autophagy enhancement in PD. It has also been known to suppress inflammation in many experimental models, involving endotoxin shock, murine dry eye and subarachnoid hemorrhage. However, whether trehalose has an anti-inflammation effect on PD is largely unknown. In the present study, we found trehalose inhibited generation of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and nitric oxide in the conditioned medium released from lipopolysaccharide (LPS)-stimulated BV-2 cells. LPS-induced nuclear transcription factors of NF-kappaB and AP-1 activation were also inhibited by trehalose. Then the conditioned medium of BV-2 cells was applied to PC12 neurons. As a result, both MTT and LDH indicated that trehalose decreased PC12 neuronal death. TUNEL assay showed that trehalose suppressed apoptosis of PC12 neurons. These results implied that trehalose exerted a protective effect on PC12 neurons against the neurotoxic effect triggered by BV-2 microglial activation through inhibiting NF-kappaB and AP-1 activation and inflammatory mediators and cytokines production in BV-2 cells. =20
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