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Now showing items 129 - 144 of 22467

  • Sushan, G. (2018). Near-Death Experience in Indigenous Religions

    Doka, Kenneth J.  

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  • Heronamides G–L, polyene macrolactams from\r Streptomyces niveus

    Ding, Nan   Han, Li   Jiang, Yi   Li, Guiding   Zheng, Zehui   Cao, Bixuan   Guan, Peipei   Mu, Yu   Lin, Bin   Huang, Xueshi  

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  • Global Environmental Historyby I. G. Simmons

    Review by: J. Donald Hughes  

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  • Ya. G. Sinai: Selecta, Volumes I and II

    Domokos Szász  

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  • Units, Jargon, g -forces, and Squirting Blood

    Milanick, Mark  

    Two of the most frustrating things for me as a teacher are the way units and jargon can get in the way of understanding concepts. When I teach pre-nursing and medical students about blood pressure, they end up memorizing a lot of information that would be obvious if they had remembered some of their basic physics - particularly the ability to change units. Of course, the other solution would be to use units that make sense to the students. Some non-majors taking physics classes are thinking about careers in the medical field, but often don't see the connection between physics and their interest in medicine. However, there are a number of ways instructors can build on students' interests to help them explore real-world applications of physics and medicine. This laboratory exercise provides an example of one such connection, by engaging students in considering why large g-forces may cause individuals to ldquoblack out.rdquo We have used this activity with success in a pre-nursing physiology class and believe it could be easily adapted for teachers of high school physics.
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  • On holomorphic curves in a complex Grassmann manifold G(2, n)

    Let s : S 2 → G(2, n) be a linearly full totally unramified non-degenerate holomorphic curve in a complex Grassmann manifold G(2, n), and let K(s) be its Gaussian curvature. It is proved that K(s) = \frac4n-2{K(s) = \frac{4}{n-2}} if K(s) satisfies K(s) 鲁 \frac4n-2{K(s) \geq \frac{4}{n-2}} or K(s) 拢 \frac4n-2 {K(s) \leq \frac{4}{n-2} } everywhere on S 2. In particular, K(s) = \frac4n-2{K(s) = \frac{4}{n-2}} if K(s) is constant.
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  • Protein kinase G type I in cardiac myocytes: unmasked at last?

    Balligand, Jean-Luc   Hammond, Joanna  

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  • Forskolin-free cAMP assay for G<sub>i</sub>-coupled receptors

    Julie Gilissen   Pierre Geubelle   Nadine Dupuis   Céline Laschet   Bernard Pirotte   Julien Hanson  

    Graphical abstract Abstract G protein-coupled receptors (GPCRs) represent the most successful receptor family for treating human diseases. Many are poorly characterized with few ligands reported or remain completely orphans. Therefore, there is a growing need for screening-compatible and sensitive assays. Measurement of intracellular cyclic AMP (cAMP) levels is a validated strategy for measuring GPCRs activation. However, agonist ligands for G i -coupled receptors are difficult to track because inducers such as forskolin (FSK) must be used and are sources of variations and errors. We developed a method based on the GloSensor system, a kinetic assay that consists in a luciferase fused with cAMP binding domain. As a proof of concept, we selected the succinate receptor 1 (SUCNR1 or GPR91) which could be an attractive drug target. It has never been validated as such because very few ligands have been described. Following analyses of SUCNR1 signaling pathways, we show that the GloSensor system allows real time, FSK-free detection of an agonist effect. This FSK-free agonist signal was confirmed on other G i -coupled receptors such as CXCR4. In a test screening on SUCNR1, we compared the results obtained with a FSK vs FSK-free protocol and were able to identify agonists with both methods but with fewer false positives when measuring the basal levels. In this report, we validate a cAMP-inducer free method for the detection of G i -coupled receptors agonists compatible with high-throughput screening. This method will facilitate the study and screening of G i -coupled receptors for active ligands.
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  • G x E interaction and neurodevelopment I. Focus on maltreatment

    Bellani, M.   Nobile, M.   Bianchi, V.   van Os, J.   Brambilla, P.  

    In a short series of articles, we will review the evidence for genotype by environment interaction (G x E) in developmental psychopathology. We will focus specifically on the characteristics of types of exposure assessed with respect to both their methods and findings. This article aims to review the studies exploring the effects of child maltreatment on children, adolescents and young adults closer in time to maltreatment experience, in a G x E perspective.
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  • Existentially closed fields with\r G\r -derivations

    Hoffmann, Daniel   Kowalski, Piotr  

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  • R. G. Tallboys, Encounters of a Diplomatic Kind

    Berridge, G. R.  

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  • Duke Ellington’s America by Harvey G. Cohen (review)

    Whitehead, Kevin  

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  • Review of Jeremy G. Butler,\r Television Style

    Salt   Barry  

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  • New\r g\r ? 2 experiment at J-PARC

    Mibe   Tsutomu  

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  • Beyond the Tether\r , by Bruno G. Botti

    Uzych   Leo  

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  • G-compactness and groups

    Jakub Gismatullin and Ludomir Newelski  

    Lascar described E KP as a composition of E L and the topological closure of E L (Casanovas et al. in J Math Log 1(2):305–319). We generalize this result to some other pairs of equivalence relations. Motivated by an attempt to construct a new example of a non-G-compact theory, we consider the following example. Assume G is a group definable in a structure M. We define a structure M′ consisting of M and X as two sorts, where X is an affine copy of G and in M′ we have the structure of M and the action of G on X. We prove that the Lascar group of M′ is a semi-direct product of the Lascar group of M and G/G L . We discuss the relationship between G-compactness of M and M′. This example may yield new examples of non-G-compact theories.
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