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Now showing items 1 - 16 of 166

  • GARBAGE TREATMENT METHOD AND SYSTEM BASED ON SET TOP BOX

    A garbage treatment method and system based on a set top box. When a user is required to classify garbage, the set top box classifies the garbage according to information about the garbage, notices the user, and locates garbage cans or stations being able to collect the garbage in the category, and convenience is provided for the user to throw the garbage, thereby making people know how to classify and throw the garbage, preventing the garbage from being mixed together, greatly reducing the opportunity and the cost of garbage classification, bringing great convenience for garbage treatment, effectively reducing the cost for garbage treatment, and aiding in saving and recycling resources.
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  • Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma

    Yu, Qin   Liu, Zhao-Yu   Chen, Qiong   Lin, Ju-sheng  

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  • Stromal cell-derived factor-1 alpha alleviates hypoxic-ischemic brain damage in mice

    Yu, Qin   Zhou, Liping   Liu, Lizhen   Cong, Li   Wang, Yan   Ge, Tingting   Lin, Deju  

    Highlights • SDF-1α treatment contributed to an improved functional recovery after HIBD. • SDF-1α treatment induced a reduction of apoptosis and mobilization of MSCs. • The regulatory mechanism was associated with up-regulating level of SDF-1α/CXCR4. Abstract Hypoxic-ischemic brain damage (HIBD) is a major cause of acute deaths and chronic nervous system damage. There is good evidence that stromal cell-derived factor-1 alpha (SDF-1α) has been receiving much interest in its role in the treatment of ischemic diseases. Here we aim to investigate the effect of intraperitoneal delivery of SDF-1α after experimental hypoxia-ischemia (HI) and the potentially involved mechanisms. A total of 129 mice were subjected to unilateral carotid artery ligation followed by 2.5 h of hypoxia, randomly assigned to three groups: sham, HI + vehicle and HI + SDF-1α. Mice treated with SDF-1α showed recovery of spatial learning abilities and pathological conditions, decreased number of apoptotic cells, and elevated expression of SDF-1α and its cognate receptor, CXC chemokine receptor-4 (CXCR4). Meanwhile, the increased number of mesenchymal stem cells (MSCs) was found in peripheral blood after SDF-1α treatment. Taken together, the treatment of SDF-1α after HIBD contributed to an improved functional recovery, and this behavioral restoration was paralleled by a reduction of apoptosis and mobilization of MSCs via SDF-1α/CXCR4.
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  • METHODS OF USING CD44 FUSION PROTEINS TO TREAT CANCER

    Pharmaceutical compositions and methods for treating cancer using CD44 antagonists are disclosed. In certain aspects, these pharmaceutical compositions and methods include treating a mammal having a cancer, such as glioma, colon cancer, breast cancer, prostate cancer, ovarian cancer, lung cancer, renal cell carcinoma, gastric cancer, esophageal cancer, head cancer, neck cancer, pancreatic cancer, or melanoma, with a CD44 fusion protein. These CD44 fusion proteins include CD44-Fc fusions and can be used to detect hyaluronan.
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  • Accelerating Dissolution of Polyacrylamide in Offshore Oil Field

    Yu, Qin   Lu, Xiangguo   Zhang, Defu   Xie, Kun  

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  • Co-zone {1ˉ012} Twin Interaction in Magnesium Single Crystal

    Yu, Qin   Wang, Jian   Jiang, Yanyao   McCabe, Rodney J.   Tomé, Carlos N.  

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  • Wnt/β-catenin signaling regulates neuronal differentiation of mesenchymal stem cells

    Yu, Qin   Liu, Lizhen   Duan, Yanping   Wang, Yan   Xuan, Xiaobo   Zhou, Liping   Liu, Wei  

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  • A NEW REFERENCE MANAGEMENT METHOD FOR VIDEO CODING

    Methods of reference picture management for video coding are disclosed. It is proposed to transmit the Coding Order Index (COI) for each picture in slice or picture header. Moreover, the Playing Order Index (POI) can be calculated by COI and a difference delta_poi between COI and POI of the current picture. Reference Configuration Set (RCS) which can be transmitted in slice or picture header or sequence header is used to define the reference picture parameters. The decoder can construct the reference picture list in a direct way and determine which decoded pictures in DPB can be removed based on RCS.
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  • METHOD FOR MANUFACTURING OPTICAL CABLE WITH WRAPPING YARN AUTOMATICALLY UNWINDING UNDER HEAT

    Disclosed is a method for manufacturing an optical cable with wrapping yarn (6) automatically unwinding under heat, which relates to the technical field of optical communications and comprises the following steps: S1, selecting a composite material which automatically unwinds at a temperature of 120-140ºC and preparing same into wrapping yarn (6); S2, extrusion moulding loose tubes (5) outside a plurality of coloured optical fibres by means of an extruder; S3, twisting a plurality of loose tubes (5) around a central reinforcement member (4), winding wrapping yarn (6) which automatically unwinds under heat on the periphery of all the loose tubes (5) to form a cable core (1); S4, coating an armour layer (2) on an outer layer of the cable core (1); and S5, extrusion moulding an outer sheath layer (3) outside the armour layer (2), and the wrapping yarn (6) of the cable core (1) automatically unwinding under heat, thus forming an optical cable with wrapping yarn (6) automatically unwinding under heat. Since the wrapping yarn (6) unwinds while extrusion moulding the outer sheath layer (3), a tube which is slightly flattened by the wrapping yarn (6) can automatically return to its original shape, thus improving the defect of excessive attenuation of optical cables in the prior art caused by wrapping yarn flattening loose tubes.
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  • Lipids-based nanostructured lipid carriers (NLCs) for improved oral bioavailability of sirolimus

    Yu, Qin   Hu, Xiongwei   Ma, Yuhua   Xie, Yunchang   Lu, Yi   Qi, Jianping   Xiang, Li   Li, Fengqian   Wu, Wei  

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  • Resistance to AHAS inhibitor herbicides: current understanding

    Yu, Qin   Powles, Stephen B  

    Acetohydroxyacid synthase (AHAS) inhibitor herbicides currently comprise the largest site-of-action group (with 54 active ingredients across five chemical groups) and have been widely used in world agriculture since they were first introduced in 1982. Resistance evolution in weeds to AHAS inhibitors has been rapid and identified in populations of many weed species. Often, evolved resistance is associated with point mutations in the target AHAS gene; however non-target-site enhanced herbicide metabolism occurs as well. Many AHAS gene resistance mutations can occur and be rapidly enriched owing to a high initial resistance gene frequency, simple and dominant genetic inheritance and lack of major fitness cost of the resistance alleles. Major advances in the elucidation of the crystal structure of the AHAS (Arabidopsis thaliana) catalytic subunit in complex with various AHAS inhibitor herbicides have greatly improved current understanding of the detailed molecular interactions between AHAS, cofactors and herbicides. Compared with target-site resistance, non-target-site resistance to AHAS inhibitor herbicides is less studied and hence less understood. In a few well-studied cases, non-target-site resistance is due to enhanced rates of herbicide metabolism (metabolic resistance), mimicking that occurring in tolerant crop species and often involving cytochrome P450 monooxygenases. However, the specific herbicide-metabolising, resistance-endowing genes are yet to be identified in resistant weed species. The current state of mechanistic understanding of AHAS inhibitor herbicide resistance is reviewed, and outstanding research issues are outlined. (C) 2013 Society of Chemical Industry
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  • Clinical value of prenatal echocardiographic examination in the diagnosis of fetal cardiac tumors

    Yu, Qin   Zeng, Wenhua   Zhou, Aiyun   Zhu, Wan   Liu, Juan  

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  • Effect of reduction temperature on Ru–Ir/ZnO catalyst for selective hydrogenation of crotonaldehyde

    Yu, Qin   Zhang, Xuanyu   Li, Bo   Lu, Jiqing   Hu, Gengshen   Jia, Aiping   Luo, Ceqi   Hong, Qinghong   Song, Yupeng   Luo, Mengfei  

    A Ru-Ir/ZnO catalyst with metal loadings of 3% Ru and 3% Ir was reduced at different temperatures (150 to 400 degrees C) and tested for vapor-phase selective hydrogenation of crotonaldehyde at 80 degrees C. It was found that with increasing reduction temperature, the crotonaldehyde conversion over the catalysts first increased and then decreased. A conversion of 93.5% and the selectivity to crotyl alcohol of 86.6% was observed after 10 h reaction on a Ru-Ir/ZnO catalyst reduced at 200 degrees C. Various characterizations such as X-ray photon spectroscopy (XPS) and ammonia temperature-programmed desorption (NH3-TPD) results demonstrated that moderate interaction between the C=O bond and the M-0 (M = Ru, Ir or Ru-Ir alloy) due to the proper charge density of M-0, and surface acidity of the catalysts played decisive roles in the enhanced activity and selectivity obtained on the catalyst. In addition, the deactivation of the catalyst was due to the carbon deposit (including organic compounds) on the catalyst surface, as evidenced by Raman spectroscopy and temperature-programmed oxidation over the spent catalyst. Also, the strong adsorption of CO on the catalyst surface generated by a decarbonylation reaction could be another reason for catalyst deactivation, as evidenced by a CO poisoning experiment. (C) 2014 Elsevier B.V. All rights reserved.
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  • Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

    Yu, Qin   K?nig, Renate   Pillai, Satish   Chiles, Kristopher   Kearney, Mary   Palmer, Sarah   Richman, Douglas   Coffin, John M   Landau, Nathaniel R  

    HIV-1 deleted for the vif accessory gene encapsidates the cellular cytidine deaminase APOBEC3G. Upon infection, the encapsidated APOBEC3G induces GfwdarwA mutations in the viral reverse transcripts. The GfwdarwA mutations result either from CfwdarwU deamination of the minus strand or deamination of both strands followed by repair of the plus strand. We report here that minus-strand deamination occurred over the length of the virus genome, preferentially at CCCA sequences, with a graded frequency in the 5'fwdarw3' direction. APOBEC3G induced previously undetected CfwdarwT mutations in the 5' U3 and the primer-binding site, both of which become transiently single-stranded during reverse transcription. In vitro, APOBEC3G bound and deaminated single-stranded DNA (ssDNA) but not double-stranded DNA (dsDNA) or DNA-RNA hybrids. We propose that the requirement for ssDNA accounts for the minus-strand mutations, the 5'fwdarw3' graded frequency of deamination and the rare CfwdarwT mutations.
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  • Enhanced transdermal delivery of meloxicam by nanocrystals: preparation, in vitro and in vivo evaluation

    Yu, Qin   Wu, Xiying   Zhu, Quangang   Wu, Wei   Chen, Zhongjian   Li, Ye   Lu, Yi  

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  • Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP

    Yu, Qin   Hu, Liyan   Yao, Qing   Zhu, Yongqun   Dong, Na   Wang, Da-Cheng   Shao, Feng  

    Rab GTPases are emerging targets of diverse bacterial pathogens. Here, we perform biochemical and structural analyses of LepB, a Rab GTPase-activating protein (GAP) effector from Legionella pneumophila. We map LepB GAP domain to residues 313-618 and show that the GAP domain is Rab1 specific with a catalytic activity higher than the canonical eukaryotic TBC GAP and the newly identified VirA/EspG family of bacterial RabGAP effectors. Exhaustive mutation analyses identify Arg444 as the arginine finger, but no catalytically essential glutamine residues. Crystal structures of LepB(313-618) alone and the GAP domain of Legionella drancourtii LepB in complex with Rab1-GDP-AlF3 support the catalytic role of Arg444, and also further reveal a 3D architecture and a GTPase-binding mode distinct from all known GAPs. Glu449, structurally equivalent to TBC RabGAP glutamine finger in apo-LepB, undergoes a drastic movement upon Rab1 binding, which induces Rab1 Gln70 side-chain flipping towards GDP-AlF3 through a strong ionic interaction. This conformationally rearranged Gln70 acts as the catalytic cis-glutamine, therefore uncovering an unexpected RasGAP-like catalytic mechanism for LepB. Our studies highlight an extraordinary structural and catalytic diversity of RabGAPs, particularly those from bacterial pathogens.
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