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  • Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation.

    Ye-ping Yu   Peng Lei   Jia Hu   Wei-hui Wu   Yufen Zhao   Yan-Mei Li  

    Copper enhances amyloid cytotoxicity and mediates human islet amyloid polypeptide (hIAPP) oligomerization; nickel, a redox inactive metal with similar protein binding affinity to copper, also mimics this effect, thereby demonstrating copper-mediated hIAPP cytotoxicity is due mainly to granular oligomer generation rather than ROS accumulation in type 2 diabetes.
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