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Now showing items 1 - 16 of 123

  • miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer.

    Yan, Ting-Ting   Ren, Lin-Lin   Shen, Chao-Qin   Wang, Zhen-Hua   Yu, Ya-Nan   Liang, Qian   Tang, Jia-Yin   Chen, Ying-Xuan   Sun, Dan-Feng   Zgodzinski, Witold   Majewski, Marek   Radwan, Piotr   Kryczek, Ilona   Zhong, Ming   Chen, Jinxian   Liu, Qiang   Zou, Weiping   Chen, Hao-Yan   Hong, Jie   Fang, Jing-Yuan  

    Colorectal cancer includes an invasive stem-like/mesenchymal subtype, but its genetic drivers, functional, and clinical relevance are uncharacterized. Here we report the definition of an altered miRNA signature defining this subtype that includes a major genomic loss of miR-508. Mechanistic investigations showed that this miRNA affected the expression of cadherin CDH1 and the transcription factors ZEB1, SALL4, and BMI1. Loss of miR-508 in colorectal cancer was associated with upregulation of the novel hypoxia-induced long noncoding RNA AK000053. Ectopic expression of miR-508 in colorectal cancer cells blunted epithelial-to-mesenchymal transition (EMT), stemness, migration, and invasive capacity in vitro and in vivo In clinical colorectal cancer specimens, expression of miR-508 negatively correlated with stemness and EMT-associated gene expression and positively correlated with patient survival. Overall, our results showed that miR-508 is a key functional determinant of the stem-like/mesenchymal colorectal cancer subtype and a candidate therapeutic target for its treatment.Significance: These results define a key functional determinant of a stem-like/mesenchymal subtype of colorectal cancers and a candidate therapeutic target for its treatment. Cancer Res; 78(7); 1751-65. =C2=A92018 AACR. =C2=A92018 American Association for Cancer Research.
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  • Strain manipulation of Majorana fermions in graphene armchair nanoribbons

    Wang, Zhen-Hua   Castro, Eduardo V.   Lin, Hai-Qing  

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  • Macromol. Biosci. 3/2018

    Wang, Zhen-Hua   Chang, Yen-Yu   Wu, Jhih-Guang   Lin, Chia-Yu   An, Hsiao-Lung   Luo, Shyh-Chyang   Tang, Tang K.   Su, Wei-Fang  

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  • A Neber approach for the synthesis of spiro-fused 2H-azirine-pyrazolone

    Yue, Deng-Feng   Zhao, Jian-Qiang   Wang, Zhen-Hua   Zhang, Xiao-Mei   Xu, Xiao-Ying   Yuan, Wei-Cheng  

    A base-mediated Neber reaction of enaminopyrazolones, which are the tautomers of 4-acyloxime-2-pyrazolin-5-ones, with sulfonyl chlorides was achieved. With this developed approach, a range of spiro-fused 2H-azirine-pyrazolones were obtained in good yields under mild conditions. A preliminary trial of a catalytic asymmetric version of the Neber reaction was conducted and gave promising enantioselectivity.
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  • Two new flavonoid glycosides from the halophyte Limonium franchetii.

    Kong, Na-Na   Fang, Sheng-Tao   Wang, Jian-Hua   Wang, Zhen-Hua   Xia, Chuan-Hai  

    Two new flavonoid glycosides, named quercetin-3-O-(2-O-tigloyl)-alpha-L-rhamnopyranoside (1) and quercetin-3-O-(3-O-tigloyl)-alpha-L-rhamnopyranoside (2), together with 10 known flavonoids (3-12), were isolated from the whole plant of the halophyte Limonium franchetii. Their structures were elucidated on the basis of extensive spectroscopic analysis including 2D NMR and HR-EI-MS. In addition, primary bioassays showed that compound 1 had moderate cytotoxic activity against rat C6 glioma cell lines.=20
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  • Strategies for hypoxia adaptation in fish species: a review

    Zhu, Chang-Dong   Wang, Zhen-Hua   Yan, Biao  

    Aquatic environments exhibit wide temporal and spatial variations in oxygen levels compared to terrestrial environments. Fish are an excellent model for elucidating the underlying mechanisms of hypoxia adaptation. Over the past decade, several hypoxia-related proteins have been reported to act in concert to convey oxygen change information to downstream signaling effectors. Some signaling pathways, such as redox status, AMPK, MAPK and IGF/PI3K/Akt, are known to play a central role in hypoxia adaptation. These networks regulate oxygen-sensitive transcription factors which, in turn, affect the expression of hypoxia adaptation-related genes. This review summarizes current insights into hypoxia adaptation-related proteins and signaling pathways in fish.
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  • FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.

    Hu, Hong-Jun   Zhang, Li-Guo   Wang, Zhen-Hua   Guo, Xi-Xi  

    Emerging evidence has suggested that misregulation of oncogenes and/or tumor suppressors has a crucial role in the development of lung carcinoma. The present study demonstrated that the expression levels of forkhead box O6 (FOXO6) were downregulated in lung cancer tissue samples, as compared with those in adjacent normal tissue. Overexpression of FOXO6 inhibited the proliferation of A549 human lung cancer cells, whereas knockdown of endogenous FOXO6 expression enhanced cell proliferation. Furthermore, ectopic FOXO6 expression induced the expression of ubiquitin-specific-processing protease 7 (USP7). As a result of this regulation, FOXO6 overexpression led to an elevation of p53 protein expression levels in A549 cells. In conclusion, the results of the present study indicated that the FOXO6/USP7 molecular network has an important role in the regulation of lung cancer development.=20
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  • The research strategies for probing the function of long noncoding RNAs

    Yan, Biao   Wang, Zhen-Hua   Guo, Jin-Tao  

    Long noncoding RNAs (IncRNAs) represent a new frontier in molecular genetics and molecular biology. They have a tremendous potential for advancing our comprehensive understanding of biological processes in huma n health and disease. The transcripts of IncRNAs are easy to find, but sorting out what they do remains the biggest challenge in IncRNAs' research field. In the paper, we highlight recent progress regarding the methods to explore the roles of IncRNAs. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
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  • Sensor Fault Estimation Filter Design for Discrete-time Linear Time-varying Systems

    WANG, Zhen-Hua   RODRIGUES, Mickael   THEILLIOL, Didier   SHEN, Yi  

    Abstract This paper proposes a sensor fault diagnosis method for a class of discrete-time linear time-varying (LTV) systems. In this paper, the considered system is firstly formulated as a descriptor system representation by considering the sensor faults as auxiliary state variables. Based on the descriptor system model, a fault estimation filter which can simultaneously estimate the state and the sensor fault magnitudes is designed via a minimum-variance principle. Then, a fault diagnosis scheme is presented by using a bank of the proposed fault estimation filters. The novelty of this paper lies in developing a sensor fault diagnosis method for discrete LTV systems without any assumption on the dynamic of fault. Another advantage of the proposed method is its ability to detect, isolate and estimate sensor faults in the presence of process noise and measurement noise. Simulation results are given to illustrate the effectiveness of the proposed method.
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  • Synthesis,Crystal Structure and Catalytic Property of a New Cadmium Coordination Polymer

    Liu, Shu-Hua   Zhang, Jian-Wei   Wang, Xiao   Wang, Li-Hong   Wang, Zhen-Hua   Wei, Yun-Bo  

    A new cadmium coordination polymer [Cd(L)(Cl)(H2O)](n) (1) (L =3D 5-(imidazol-1-yl)-2-pyridine carboxylic anion) constructed from dinuclear cadmium clusters has been synthesized under hydrothermal condition and structurally characterized by single-crystal X-ray diffraction analysis. The compound crystallizes in triclinic system, space group P-1, with a =3D 6.8747(6), b =3D 9.7434(8), c =3D 9.9119(7) , alpha =3D 118.615(8)A degrees, beta =3D 104.445(7)A degrees, gamma =3D 94.815(7)A degrees, V =3D 548.01(9) (3), Z =3D 2. Compound 1 is a one-dimensional (1D) double chain structure based on dinuclear [Cd-2(Cl)(2)] clusters, and is further extended to a 3D supramolecular framework by hydrogen bonds. As a Lewis acid catalyst, compound 1 exhibits excellent catalytic performance for the acetalization reaction under mild conditions and can be reused several times without a significant decrease of the catalytic activity.
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  • Tirucallane-Type Triterpenoids from Dysoxylum lenticellatum

    Huang, Hong-Li   Wang, Chun-Ming   Wang, Zhen-Hua   Yao, Ming-Jun   Han, Guang-Tian   Yuan, Ji-Cheng   Gao, Kun   Yuan, Cheng-Shan  

    Ten new tirucallane-type triterpenoids, represented by a rearranged skeleton dysolenticin A (1), dysolenticin B (2), a rare trinortriterpenoid dysolenticin C (3), three tirucallane triterpenoid derivatives with a hemiketal moiety dysolenticins D-F (4-6), dysolenticins G-I (7, 9, 10), and the new alkaloid dysolenticin J (12), together with seven known analogues were isolated from the twigs and leaves of Dysoxylum lenticellatum. Their structures were elucidated by extensive spectroscopic methods, and those of compounds 1, 3, 4, 6, and 10 were confirmed by single-crystal X-ray diffraction experiments. Dysolenticin J (12) showed significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 mu g/mL.
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  • In Response

    Wang, Zhen-Hua   Gao, Qin-Yan   Fang, Jing-Yuan  

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  • Alcohol consumption and the risk of Barrett's esophagus: a comprehensive meta-analysis.

    Ren, Lin-Lin   Yan, Ting-Ting   Wang, Zhen-Hua   Bian, Zhao-Lian   Yang, Fan   Hong, Jie   Chen, Hao-Yan   Fang, Jing-Yuan  

    Several studies have been proposed to investigate the association between alcohol consumption and risk of Barrett's esophagus (BE), but as of yet, no quantitative summary of the literature to clarify the relationship between them. In our study, twenty eligible cohort studies involving 42925 participants were identified. Combined relative risk (RR) ratios for the highest versus lowest alcohol consumption levels were calculated. The alcohol dose-response analysis was performed to investigate the association between the increment consumption of 10 g/d alcohol and the risk of developing BE. Subgroup analyses were used to examine heterogeneity across the studies. A combined RR of 0.98 (0.62-1.34) was found when comparing highest vs. lowest alcohol consumption levels for BE. An inverse association between alcohol and incidence of BE (RR 0.51; 95% CI: 0.055-0.96) was demonstrated in women. Moreover, Asian drinkers had a relative higher risk of BE (RR 1.34; 95% CI: 1.11-1.56) compared with Western drinkers. In conclusion, our results showed that overall alcohol consumption was not associated with increased BE incidence. The limited data available on alcohol consumption supports a tentative inversion of alcohol consumption with BE risk in women, while Asian drinkers tend to have a higher risk of BE.=20
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  • Novel 3D Neuron Regeneration Scaffolds Based on Synthetic Polypeptide Containing Neuron Cue

    Wang, Zhen-Hua   Chang, Yen-Yu   Wu, Jhih-Guang   Lin, Chia-Yu   An, Hsiao-Lung   Luo, Shyh-Chyang   Tang, Tang K.   Su, Wei-Fang  

    Neural tissue engineering has become a potential technology to restore the functionality of damaged neural tissue with the hope to cure the patients with neural disorder and to improve their quality of life. This paper reports the design and synthesis of polypeptides containing neuron stimulate, glutamic acid, for the fabrication of biomimetic 3D scaffold in neural tissue engineering application. The polypeptides are synthesized by efficient chemical reactions. Monomer -benzyl glutamate-N-carboxyanhydride undergoes ring-opening polymerization to form poly(-benzyl-l-glutamate), then hydrolyzes into poly(-benzyl-l-glutamate)-r-poly(glutamic acid) random copolymer. The glutamic acid amount is controlled by hydrolysis time. The obtained polymer molecular weight is in the range of 200 kDa for good quality of fibers. The fibrous 3D scaffolds of polypeptides are fabricated using electrospinning techniques. The scaffolds are biodegradable and biocompatible. The biocompatibility and length of neurite growth are improved with increasing amount of glutamic acid in scaffold. The 3D scaffold fabricated from aligned fibers can guide anisotropic growth of neurite along the fiber and into 3D domain. Furthermore, the length of neurite outgrowth is longer for scaffold made from aligned fibers as compared with that of isotropic fibers. This new polypeptide has potential for the application in the tissue engineering for neural regeneration.
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  • Observer-based Controller Design for A T-S Fuzzy System with Unknown Premise Variables

    Xie, Wen-Bo   Li, He   Wang, Zhen-Hua   Zhang, Jian  

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  • Novel 3D Neuron Regeneration Scaffolds Based on Synthetic Polypeptide Containing Neuron Cue

    Wang, Zhen-Hua   Chang, Yen-Yu   Wu, Jhih-Guang   Lin, Chia-Yu   An, Hsiao-Lung   Luo, Shyh-Chyang   Tang, Tang K.   Su, Wei-Fang  

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