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Now showing items 1 - 16 of 145

  • An investigation on the anti-tumor properties of FSH33-53-Lytic

    Liu, Ping   Yang, Runlin   Pan, Donghui   Xu, Yuping   Zhu, Chen   Xu, Qing   Wang, Lizhen   Yan, Junjie   Li, Xiaotian   Yang, Min  

    A new designed hybrid peptide FSH33-53-Lytic was synthesized and expected to combine the follicle stimulating hormone receptor (FSHR) targeting and tumor cell membranes disintegration. Through in vitro and vivo study, no significant enhancement on anti-tumor activity was shown compared with Lytic peptide only. We also prepared 18F-Al-NOTA-MAL-FSH33-53-Lytic and use microPET image to observe the FSHR targeting of FSH33-53-Lytic. No accumulation in the tumor may explain the failure of FSH33-53-Lytic on cancer therapy. In summary, microPET image can provide more accurate and visible information for screening new anti-tumor agents.
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  • Micro-mechanical properties of different sites on woodpecker’s skull

    Ni, Yikun   Wang, Lizhen   Liu, Xiaoyu   Zhang, Hongquan   Lin, Chia-Ying   Fan, Yubo  

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  • PET imaging of prostate cancer with18F-Al-NODA-MATBBN

    Chen, Fei   Zhu, Bao   Pan, Donghui   Xu, Yuping   Lin, Xiufeng   Yang, Runlin   Wang, Lizhen   Yang, Min  

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  • Pilot Study of a Novel18F-labeled FSHR Probe for Tumor Imaging

    Xu, Yuping   Pan, Donghui   Zhu, Chen   Xu, Qing   Wang, Lizhen   Chen, Fei   Yang, Runlin   Luo, Shineng   Yang, Min   Yan, Yongjun  

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  • A modular gene targeting system for sequential transgene stacking in plants

    Kumar, Sandeep   AlAbed, Diaa   Worden, Andrew   Novak, Stephen   Wu, Huixia   Ausmus, Carla   Beck, Margaret   Robinson, Heather   Minnicks, Tatyana   Hemingway, Daren   Lee, Ryan   Skaggs, Nicole   Wang, Lizhen   Marri, Pradeep   Gupta, Manju  

    Highlights • We have developed a modular and flexible gene targeting system for creating multigene stacks in plants. • The method exchanges fully functional genes with every cycle of targeting. • Up to 30% gene targeting obtained based on plants regenerated on selection medium. • Targeted transgene(s) inherited and co-segregated to the next generation. • Consistent and similar gene expression among four events containing independent targeted insertions was obtained. Abstract A modular, selection-based method was developed for site-specific integration of transgenes into a genomic locus to create multigene stacks. High-frequency gene targeting was obtained using zinc finger nuclease (ZFN)-mediated double-strand break (DSB) formation at a pre-defined target genomic location using a unique intron directly downstream of a promoter driving a selectable marker gene to facilitate homology between target and donor sequences. In this system, only insertion into the target locus leads to a functional selectable marker, and regeneration from random insertions of the promoterless donor construct are reduced on selection media. A new stack of transgenes can potentially be loaded with each successive cycle of gene targeting by exchanging the selectable marker gene using the intron homology. This system was tested in maize using the pat selectable marker gene, whereby up to 30% of the plants regenerated on Bialaphos-containing medium were observed to have the donor construct integrated into the target locus. Unlike previous gene targeting methods that utilize defective or partial genes for selecting targeted events, the present method exchanges fully functional genes with every cycle of targeting, thereby allowing the recycling of selectable marker genes, hypothetically for multiple generations of gene targeting.
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  • Adverse Events of Acupuncture: A Systematic Review of Case Reports

    Xu, Shifen   Wang, Lizhen   Cooper, Emily   Zhang, Ming   Manheimer, Eric   Berman, Brian   Shen, Xueyong   Lao, Lixing  

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  • A retrospective study of six???patients with mandibular metastatic carcinoma

    Cai, Zhen   Zhu, Chao   Wang, Lizhen   Zhu, Ling   Zhang, Zhiyuan   Zhu, Hanguang   Wang, Yan\"an  

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  • Prostate cancer imaging of FSHR antagonist modified with a hydrophilic linker

    Zhu, Chen   Xu, Qing   Pan, Donghui   Xu, Yuping   Liu, Ping   Yang, Runlin   Wang, Lizhen   Sun, Xinchen   Luo, Shineng   Yang, Min  

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  • Cauchy problems for Keller–Segel type time–space fractional diffusion equation

    Li, Lei   Liu, Jian-Guo   Wang, Lizhen  

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  • Energy Reduction Effect of the South-to-North Water Diversion Project in China

    Zhao, Yong   Zhu, Yongnan   Lin, Zhaohui   Wang, Jianhua   He, Guohua   Li, Haihong   Li, Lei   Wang, Hao   Jiang, Shan   He, Fan   Zhai, Jiaqi   Wang, Lizhen   Wang, Qingming  

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  • Prediction of globe rupture caused by primary blast: a finite element analysis

    Liu, Xiaoyu   Wang, Lizhen   Wang, Chao   Fan, Jie   Liu, Songyang   Fan, Yubo  

    Although a human eye comprises less than 0.1% of the frontal body surface area, injuries to the eye are found to be disproportionally common in survivors of explosions. This study aimed to introduce a Lagrangian-Eulerian coupling model to predict globe rupture resulting from primary blast effect. A finite element model of a human eye was created using Lagrangian mesh. An explosive and its surrounding air domain were modelled using Eulerian mesh. Coupling the two models allowed simulating the blast wave generation, propagation and interaction with the eye. The results showed that the peak overpressures caused by blast wave on the corneal apex are 2080, 932.1 and 487.3kPa for the victim distances of 0.75, 1.0 and 1.25m, respectively. Higher stress occurred at the limbus, where the peaks for the three victim distances are 25.5, 14.1 and 6.4MPa. The overpressure threshold of globe rupture was determined as 2000kPa in a small-scale explosion. The findings would provide insights into the mechanism of primary blast-induced ocular injuries.
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  • Robust Macroscopic 3D Sponges of Manganese Oxide Molecular Sieve

    Liu, Zhenxin   Wu, Depeng   Guo, Xuehui   Fang, Shaoming   Wang, Lizhen   Xing, Yu   Suib, Steven L.  

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  • Robust Macroscopic 3D Sponges of Manganese Oxide Molecular Sieves

    Liu, Zhenxin   Wu, Depeng   Guo, Xuehui   Fang, Shaoming   Wang, Lizhen   Xing, Yu   Suib, Steven L.  

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  • Robust Macroscopic 3D Sponges of Manganese Oxide Molecular Sieve

    Liu, Zhenxin   Wu, Depeng   Guo, Xuehui   Fang, Shaoming   Wang, Lizhen   Xing, Yu   Suib, Steven L.  

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  • Methanol tolerant core-shell RuFeSe@Pt/C catalyst for oxygen reduction reaction

    Gao, Haili   Liao, Shijun   Zhang, Yong   Wang, Lizhen   Zhang, Linsen  

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  • Effect ofGSTM1null genotype on risk of childhood acute leukemia: a meta-analysis

    Ma, Yan   Sui, Yun   Wang, Lizhen   Li, Huirong  

    Glutathione S-transferases are important enzymes in the detoxification of a wide range of reactive oxygen species. Recently, there have been a number of studies on the association between Glutathione S-transferase M1 (GSTM1) null genotype and childhood acute leukemia in Chinese, but the results of previous reports are inconsistent. Thus, we performed a meta-analysis to clarify the effect of GSTM1 null genotype on childhood acute leukemia risk. PubMed, Embase, and Wanfang databases were searched to identify case-control studies investigating the association between GSTM1 null genotype and risk of childhood acute leukemia. Between-study heterogeneity was assessed using the I (2) statistic method. Odds ratios (OR) with corresponding 95 % confidence intervals (95 % CI) were pooled to assess the association. Seven case-control studies were finally included in the meta-analysis. There was no between-study heterogeneity among those seven studies (I (2) = 0 %). Overall, the GSTM1 null genotype was significantly associated with increased risk of childhood acute leukemia in Chinese (fixed effect OR = 2.49; 95 % CI, 1.84-3.37; P < 0.001). The cumulative meta-analyses showed a trend of more obvious association between GSTM1 null genotype and risk of childhood acute leukemia in Chinese as data accumulated by year. Sensitivity analysis by omitting single study in turns also did not materially alter the pooled ORs. Therefore, the GSTM1 null genotype is significantly associated with increased risk of childhood acute leukemia in Chinese.
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