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Now showing items 33 - 48 of 80

  • Secreted Monocyte miR-27a, via Mesenteric Arterial Mas Receptor-eNOS Pathway, Causes Hypertension

    Zou, Xue   Wang, Jialiang   Chen, Caiyu   Tan, Xiaorong   Huang, Yu   Jose, Pedro A   Yang, Jian   Zeng, Chunyu  

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  • Targeting the IGF1R/PI3K/AKT pathway sensitizes Ewing sarcoma to BET bromodomain inhibitors

    Loganathan, Sudan N   Tang, Nan   Holler, Albert E   Wang, Nenghui   Wang, Jialiang  

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  • SYSTEM AND METHOD FOR CONTROLLING SLIDE OPERATION AUXILIARY INPUT IN PORTABLE TERMINAL DEVICES

    The present invention relates to a system for realizing slide operation auxiliary information input control function in a portable terminal device, the system comprising a communication function display control module, a slide input database module, a slide processing module and a slide operation customization module. The present invention also relates to a method for realizing slide operation auxiliary information input control function in the portable terminal device on the basis of the system. Application of the system and the method thereof for realizing slide operation auxiliary information input control function in the portable terminal device replaces the conventional complex operation processes, such as dialing, contact search and the like, by inputting a simple slide input on the basis of address book software, and enables the operations such as speed dialing, searching contacts and the like, and simplifies the common and fussy using steps in the address book software, and gives the users great convenience by using steps simplification. Application of the system and the method is simple with high efficiency and stable and reliable working performance and wide application range, and lays the solid foundation for large-scale popularization and application of the portable terminal devices.
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  • A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

    Wang, Jialiang   He, Xiaping   Luo, Ying   Yarbrough, Wendell?G.  

    The tumour suppressor ARF (alternative reading frame) is encoded by the INK4a (inhibitor of cyclin-dependent kinase 4)/ARF locus, which is frequently altered in human tumours. ARF binds MDM2 (murine double minute 2) and releases p53 from inhibition by MDM2, resulting in stabilization, accumulation and activation of p53. Recently, ARF has been found to associate with other proteins, but, to date, little is known about ARF-associated proteins that are implicated in post-translational regulation of ARF activity. Using a yeast two-hybrid screen, we have identified a novel protein, LZAP (LXXLL/leucine-zipper-containing ARF-binding protein), that interacts with endogenous ARF in mammalian cells. In the present study, we show that LZAP reversed the ability of ARF to inhibit HDM2's ubiquitin ligase activity towards p53, but simultaneously co-operated with ARF, maintaining p53 stability and increasing p53 transcriptional activity. Expression of LZAP, in addition to ARF, increased the percentage of cells in the G, phase of the cell cycle. Expression of LZAP also caused activation of p53 and a p53-dependent G, cell-cycle arrest in the absence of ARE Taken together, our data suggest that LZAP can regulate ARF biochemical and biological activity. Additionally, LZAP has p53-dependent cell-cycle effects that are independent of ARF.
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  • Self-assembly of graphene into three-dimensional structures promoted by natural phenolic acids

    Wang, Jialiang   Shi, Zixing   Fan, Jinchen   Ge, Yu   Yin, Jie   Hu, Guoxin  

    Three-dimensional (3D) structures of graphene have attracted extensive interest for their practical applications, such as supercapacitors and catalyst supports. Self-assembly is a typical technique to fabricate macroscopic graphene materials integrated with various superior properties. However, an efficient and environmentally-friendly strategy is still needed. In this paper, we report a green and mild method for the synthesis of 3D architectures of graphene. This proposed method is based on the chemical reduction of graphene oxide (GO) with the aid of a range of natural phenolic acids and in situ self-assembly of graphene sheets via pi-pi interactions. The obtained monolithic graphene exhibits low density, super hydrophobicity, high porosity, excellent mechanical strength and electrical conductivity. These multifunctional products can be used as adsorbents for removal of oils, organic solvents and dyes from contaminated water, as well as electrode materials for supercapacitors.
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  • Self-assembly of graphene into three-dimensional structures promoted by natural phenolic acids

    Wang, Jialiang   Shi, Zixing   Fan, Jinchen   Ge, Yu   Yin, Jie   Hu, Guoxin  

    Three-dimensional (3D) structures of graphene have attracted extensive interest for their practical applications, such as supercapacitors and catalyst supports. Self-assembly is a typical technique to fabricate macroscopic graphene materials integrated with various superior properties. However, an efficient and environmentally-friendly strategy is still needed. In this paper, we report a green and mild method for the synthesis of 3D architectures of graphene. This proposed method is based on the chemical reduction of graphene oxide (GO) with the aid of a range of natural phenolic acids and in situ self-assembly of graphene sheets via pi-pi interactions. The obtained monolithic graphene exhibits low density, super hydrophobicity, high porosity, excellent mechanical strength and electrical conductivity. These multifunctional products can be used as adsorbents for removal of oils, organic solvents and dyes from contaminated water, as well as electrode materials for supercapacitors.
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  • Intratumoral Delivery of M-CSF by Calcium Crosslinked Polymer Micelles Enhances Cancer Immunotherapy

    Mao, Kuirong   Cong, Xiuxiu   Feng, Liangzhu   Chen, Hongmei   Wang, Jialiang   Wu, Chenxi   Liu, Kun   Xiao, Chunsheng   Yang, Yong-guang   Sun, Tianmeng  

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  • Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation

    Gong, Yuanying   Ma, Yufang   Sinyuk, Maksim   Loganathan, Sudan   Thompson, Reid C.   Sarkaria, Jann N.   Chen, Wenbiao   Lathia, Justin D.   Mobley, Bret C.   Clark, Stephen W.   Wang, Jialiang  

    Metabolic complications such as obesity, hyperglycemia, and type 2 diabetes are associated with poor outcomes in patients with glioblastoma. To control peritumoral edema, use of chronic high-dose steroids in glioblastoma patients is common, which can result in de novo diabetic symptoms. These metabolic complications may affect tumors via profound mechanisms, including activation of insulin receptor (InsR) and the related insulin-like growth factor 1 receptor (IGF1R) in malignant cells. In the present study, we assessed expression of InsR in glioblastoma surgical specimens and glioblastoma response to insulin at physiologically relevant concentrations. We further determined whether genetic or pharmacological targeting of InsR affected oncogenic functions of glioblastoma in vitro and in vivo. We showed that InsR was commonly expressed in glioblastoma surgical specimens and xenograft tumor lines, with mitogenic isoform-A predominating. Insulin at physiologically relevant concentrations promoted glioblastoma cell growth and survival, potentially via Akt activation. Depletion of InsR impaired cellular functions and repressed orthotopic tumor growth. The absence of InsR compromised downstream Akt activity, but yet stimulated IGF1R expression. Targeting both InsR and IGF1R with dual kinase inhibitors resulted in effective blockade of downstream signaling, loss of cell viability, and repression of xenograft tumor growth. Taken together, our work suggests that glioblastoma is sensitive to the mitogenic functions of insulin, thus significant insulin exposure imposes risks to glioblastoma patients. Additionally, dual inhibition of InsR and IGF1R exhibits promise for treating glioblastoma.
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  • Nrf2 suppresses the function of dendritic cells to facilitate the immune escape of glioma cells

    Wang, Jialiang   Liu, Peng   Xin, Shaoyan   Wang, Zongbao   Li, Jun  

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  • Identification on Mantle Cell Lymphoma Using CD20 and CD5 Coupled Upconversion Fluorescent Nanoprobes

    Zhang, Mingkai   Gao, Yang   Wang, Jialiang   Liu, Zhanbo   Jin, Zaishun   Yu, Jianbo   Feng, Yukuan   Lu, Qiang  

    In order to determine a particular tumor cell via nanomaterials, we introduce the preparation of CD20 and CD5 coupled nanoprobes (denoted as CD20 and CD5 nanoprobes for convenience) and an application in identification of mantle cell lymphoma (MCL) from B-cell lymphoma. In this work, CD20 and CD5 nanoprobes were prepared by selectively oxidizing the carbon-carbon double bonds of oleate ligands on the surfaces of NaYF4:Yb-3(+), Tm3+ and NaYF4:Yb-3(+), Er-3(+) nanoparticles and, respectively, coupling carboxyl groups on the particles' surfaces with CD20 and CD5 monoclonal antibodies through EDC/NHS crosslinking agents. After in situ hybridized Jeko-1 cells and Raji cells as a reference with CD20 and CD5 nanoprobes, in vitro double-color upconversion fluorescence imaging of Jeko-1 cells was demonstrated through visualization of blue and green fluorescence under a 980 nm laser excitation. Moreover, in vivo upconversion fluorescence imaging of the transplanted cancer model was also measured. These experimental results indicate that Jeko-1 cells have been specifically labeled by CD20 and CD5 nanoprobes. It is therefore concluded that CD20 and CD5 nanoprobes could be used to specially differentiate mantle cell lymphoma (MCI.) from B-cell lymphoma.
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  • Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma

    Hover, Laura D.   Owens, Philip   Munden, Alexander L.   Wang, Jialiang   Chambless, Lola B.   Hopkins, Corey R.   Hong, Charles C.   Moses, Harold L.   Abel, Ty W.  

    Background. Improved therapies for high-grade glioma (HGG) are urgently needed as the median survival for grade IV gliomas is only 15 months. Bone morphogenetic protein (BMP) signaling plays critical and complex roles in many types of cancer, including glioma, with most of the recently published work focusing on BMP-mediated regulation of glioma stem cells (GSCs). We hypothesized that BMP signaling may be an important modulator of tumorigenic properties in glioma cells outside of the GSC compartment. Methods. We used a human HGG tissue microarray and performed immunohistochemistry for phospho-Smads1,5,8. To examine the role of BMP signaling in tumorigenic astrocytes, transgenic mice were used to delete the BMP type IA receptor (Bmpr1 alpha) and generate astrocytes transformed with oncogenic Ras and homozygous deletion of p53. The cells were transplanted orthotopically into immunocompetent adult host mice. Results. First we established that BMP signaling is active within the vast majority of HGG tumor cells. Mice implanted with BMPR1 alpha-knockout transformed astrocytes showed an increase in median survival compared with mice that received BMPR1 alpha-intact transformed astrocytes (52.5 vs 16 days). In vitro analysis showed that deletion of BMPR1 alpha in oncogenic astrocytes resulted in decreased proliferation, decreased invasion, decreased migration, and increased expression of stemness markers. In addition, inhibition of BMP signaling in murine cells and astrocytoma cells with a small molecule BMP receptor kinase inhibitor resulted in similar tumor suppressive effects in vitro. Conclusion. BMP inhibition may represent a viable therapeutic approach in adult HGG.
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  • A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase eta

    Ai, Yongxing   Wang, Jialiang   Johnson, Robert E.   Haracska, Lajos   Prakash, Louise  

    The ubiquitin binding zinc finger (UBZ) domain in the C-terminal portion of Pol eta has been found to interact with ubiquitin. However, the affinity between the Pol eta UBZ and ubiquitin was shown to be low with a previously reported K-d of 73-81 mu M. This low-affinity binding between Pol eta UBZ and ubiquitin has been difficult to reconcile with its presumed role in translesion synthesis as suggested by genetic and cell biology studies. In this work, we constructed a minimal S. cerevisiae Pol eta UBZ domain and probed the Pol eta UBZ-ubiquitin interaction using a surface plasmon resonance (SPR) technique. Our quantitative binding data between the wild-type or mutant Pol eta UBZ and ubiquitin revealed an interesting divergence between the Pol eta UBZ from S. cerevisiae and humans. Moreover, we found that the C-terminal portion of yeast Pol eta (amino acid 515-632) binds ubiquitin with a much higher affinity than the minimal UBZ domain. Further, distinct ubiquitin-binding kinetics were observed for the C-terminal portion of Pol eta and the isolated UBZ domain. This observation raised the interesting possibility that the Pol eta C-terminal portion binds ubiquitin in a novel mode that affords higher affinity. Our findings have broader implication in understanding the generally weak interaction between the known ubiquitin-binding domains and ubiquitin.
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  • Synthesis of sugar-lysine chimera with integrated gluco-configured 1,3-hydroxyamine motif

    Zhang, Kaidong   Wang, Jialiang   Sun, Zhizhi   Nguyen, Dung-Huang   Schweizer, Frank  

    The paper describes the synthesis of glucose-configured sugar-lysine chimeras in which the side chain of lysine is conformationally constrained via incorporation into a D-glucose scaffold. Key step in the synthesis is a high-yielding, reductive ring opening of an exocyclic glucose-derived epoxide to form an alpha-hydroxyester that can be converted into chimeric sugar-lysine analogues. To demonstrate the use of these novel chimeric sugar-lysine building blocks in peptide coupling, we replaced D-lysine in the antimicrobial dipeptide sequence kW by a D-glucose-D-lysine chimera.
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  • [Effects of subcutaneous embedding of thumb-tack needle on tear film in patients with dry eye].

    Ma, Hongjie   Feng, Lei   Wang, Jialiang   Yang, Zhimin  

    OBJECTIVE: To observe the effects of subcutaneous embedding of thumb-tack needle combined with mytear and simple mytear on tear film in patients with dry eye.; METHODS: Eighty patients of dry eye (160 eyes) were randomly divided into an observation group and a control group, 40 cases in each group. The 0.1% sodium hyaluronate eye drop (alice) was applied in the control group, four times per day for two weeks. On the basis of the control group, the subcutaneous embedding of thumb-tack needle was used at =E2=91=A0 Cuanzhu (BL 2), Sizhukong (SJ 23), Sibai (ST 2), =E2=91=A1 Yintang (EX-HN 3), Yuyao (EX-HN 4), Taiyang (EX-HN 5). The two groups of acupoints were used alternately. The thumb-tack needle was placed for 2 to 3 days, once a week for two weeks. The subjective symptom score, Schirmer =E2=85=A0 test (S=E2=85=A0T), tear break-up time (BUT) and corneal fluorescein staining (CFS) were compared before treatment, after treatment and during 2-week follow-up visit in the two groups. The effects of the two groups were compared.; RESULTS: Compared before treatment, the subjective symptom score and CFS were reduced but S=E2=85=A0T and BUT were increased after treatment and during follow-up visit in the two groups (all P<0.05), which in the observation group were superior to those in the control group (all P<0.05). The total effective rate was 90.0% (36/40) in the observation group, which was superior to 85.0% (34/40) in the control group (P<0.05).; CONCLUSION: The subcutaneous embedding of thumb-tack needle could increase the amount of SIT, prolong BUT and repair pathological damage of cornea, which could relieve the symptoms of dry eye and improve visual quality.=20
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  • Prenatal Cold Exposure Causes Hypertension in Offspring by Hyperactivity of the Sympathetic Nervous System

    Chen, Ken   Sun, Dongdong   Qu, Shuang   Chen, Yue   Wang, Jialiang   Zhou, Lin   Jose, Pedro A.   Yang, Yongjian   Zeng, Chunyu  

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  • Regio- and stereospecific synthesis of polysubstituted alkenes by carbozincation of acetylenic sulfones

    Gu, Xiaoxia   Wang, Jialiang   Zhang, Jinhua   Lin, Gaofeng   Wang, Shaowu  

    Tri- or tetrasubstituted alkenes with various substituents can be constructed regio- and stereospecifically by treatment of acetylenic sulfones with organozinc reagents in tetrahydrofuran followed by hydrolysis or coupling with halohydrocarbon. Copyright (C) 2009 John Wiley & Sons, Ltd.
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