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Now showing items 129 - 144 of 383732

  • T CELL COMPOSITIONS FOR IMMUNOTHERAPY

    The invention relates to compositions comprising a heterogeneous population of T cells with reactivity to selected antigens that are useful for adoptive immunotherapy and methods for making the T cell compositions.
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  • Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis

    Catalan-Serra, Ignacio   Andreu-Ballester, Juan Carlos   Bruland, Torunn   Sandvik, Arne Kristian  

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  • MULTIVALENT REGULATORY T CELL MODULATORS

    This disclosure provides compounds that contain an IL-2 receptor-binding moiety and an ST2-binding moiety. The methods described in the present disclosure provide for a method for treating a condition by administering to a subject in need thereof a therapeutically-effective amount of a compound containing an IL-2 receptor-binding moiety and an ST2-binding moiety.
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  • METHODS OF ISOLATING NEOANTIGEN-SPECIFIC T CELL RECEPTOR SEQUENCES

    Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.
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  • TARGETED T CELLS WITH CYTOTOXICITY TOWARD IMMUNOSUPPRESSIVE CELLS

    Described herein are methods for producing and utilizing T cells comprising a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain specific for a target tumor antigen, and a polypeptide comprising an extracellular antigen binding domain specific for an extracellular polypeptide expressed on an immunosuppressive cell. The technology described herein is related to methods of treating cancer, specifically solid tumors, by targeting immunosuppressive cells found within the tumor microenvironment.
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  • Regulatory T and T helper 17 cells: Their roles in preeclampsia

    Hosseini, Arezoo   Dolati, Sanam   Hashemi, Vida   Abdollahpour-Alitappeh, Meghdad   Yousefi, Mehdi  

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  • MODIFIED T CELLS AND METHODS OF THEIR USE

    The technology described herein relates to modified T cells and their use in immunotherapeutic methods. In various examples, the T cells are modified so as to decrease or eliminate ΟD3ζ, TRAC, and/or TRBC expression.
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  • COMPOSITIONS AND METHODS FOR CAR T CELL THERAPY

    The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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  • MR1 RESTRICTED T CELL RECEPTORS FOR CANCER IMMUNOTHERAPY

    The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells. The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.
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  • T\r 2 mapping of cerebrospinal fluid: 3?T versus 7?T

    Spijkerman, Jolanda M.   Petersen, Esben T.   Hendrikse, Jeroen   Luijten, Peter   Zwanenburg, Jaco J. M.  

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  • T&T Clark Companion to Henri de Lubac. Edited by Jordan Hillebert

    McPartlan   Paul  

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  • Stillstand als T?uschung

    Ehrmann, Guido   Ehrmann, Andrea  

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  • Darmkrebsspezifische Mortalit?t geringer

    Leiner   Peter  

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  • Sweet T Cell Dysfunction

    Alegre   Maria-Luisa  

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  • T LYMPHOCYTE PRODUCTION METHODS AND T LYMPHOCYTES PRODUCED THEREBY

    Provided herein are methods of generating T cells, e.g., cytotoxic T lymphocytes starting from peripheral blood mononuclear cells without a separate step of generating and isolating antigen-presenting cells, and with a single round of antigen stimulation. Also provided herein are methods of using said cytotoxic T lymphocytes, for example, to treat cancer and/or viral infection.
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  • Knowledge representation with T

    Sunik, Boris  

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