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Now showing items 1 - 16 of 21

  • METHOD AND APPARATUS FOR DESIGN OF PIPELINE COMPONENTS

    Methods and apparatus for pipeline component design are described. Input parameters and output parameters for the component design are identified (210). An analytic model is constructed using a design of experiments technique to represent influence of the input parameters on the output parameters (220). Value sets for the input parameters which meet a selection criterion for at least one of the output parameters are then identified (230). Finite element analysis is conducted (240) on the identified value sets, and a pipeline component design choice is identified (250) from results of the finite element analysis. Pipeline components are then manufactured according to the identified design.
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  • Using Mimicry to Elicit Answers to Intimate Questions in Survey Research

    Gueguen, Nicolas   Martin, Angelique   Meineri, Sebastien   Simon, Julien  

    Mimicry is generally associated with a feeling of similarity that often results in a positive perception of the mimicker. We hypothesized that participants would become less reluctant to respond to highly intimate questions when these questions were administered by a mimicking interviewer. A female confederate approached female students for their participation in a survey on sexual behavior in which the questions became increasingly intimate. During the survey, confederates mimicked or did not mimic the participants. It was found that participants in the mimicry condition responded to more questions than did nonparticipants.
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  • Incorporation of CF3-Pseudoprolines into Peptides: A Methodological Study

    Simon, Julien   Caupene, Caroline   Lensen, Nathalie   Miclet, Emeric  

    The peptide coupling reactions allowing the incorporation of trifluoromethyl substituted oxazolidine-type pseudoprolines (CF3-Psi Pro) into peptide chains have been studied. While standard protocols can be used for the peptide coupling reaction at the C-terminal position of the CF3-Psi Pro, acid chloride activation has to be used for the peptide coupling reaction at the N-terminal position to overcome the decrease of nucleophilicity of the CF3-Psi Pro. We demonstrate that the N-amidification of a diastereomeric mixture of CF3-Psi Pro using Fmoc-protected amino acid chloride without base gave the corresponding dipeptides as a single diastereomer (6 examples). The ratio of the cis and trans amide bond conformers was determined by NMR study, highlighting the role of the Xaa side chains in the control of the peptide backbone conformation. Finally a tripeptide bearing a central CF3-Psi Pro has been successfully synthesized.
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  • DEVICE FOR PROVIDING A VEHICLE USER WITH INFORMATION

    The invention relates to a device for providing a vehicle user with information via various functional elements by means of a screen display system. Said device comprises an overview display for representing the functional elements, a rotating actuator, associated with the functional elements and arbitrarily rotatable about its axis in order to individually select the functional elements, and is capable of displaying additional information via the respective functional element when the actuator is axially displaced. The inventive device is characterized in that the functional elements are highlighted in the overview display. The functional elements can be individually selected by rotating the actuator. The information can be displayed as an enlarged section of the overview display which section comprises the respective functional element.
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  • DRIVER ASSISTANCE SYSTEM FOR A ROAD VEHICLE

    The invention relates to a driver assistance system provided with an auxiliary system (1 - 9, 15 - 19). The driver assistance system comprises detecting means (11) for detecting information about a vehicle and influencing means (11) for influencing a direction of movement and/or the speed of the vehicle according to information about said environment. The auxiliary system (1 - 9, 15 - 19) is used for issuing assistance information to the driver of the vehicle. Said auxiliary system comprises recognition means for recognising whether the driver assistance system can be operated in a reliable manner in a momentary environment state and/or in a future environment state and/or an operational state of the vehicle. The auxiliary system (1 - 9, 15 - 19) is connected to the recognition means (11) and is embodied in such a manner that information can be given to the driver during operation of the vehicle if the driver assistance system can not be operated in a reliable manner.
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  • Enantiopure α-Trifluoromethylated Aziridine-2-carboxylic Acid (α-TfmAzy): Synthesis and Peptide Coupling

    Ouerfelli, Oussema   Simon, Julien   Chelain, Evelyne   Pytkowicz, Julien   Besbes, Rafâa   Brigaud, Thierry  

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  • Using acoustic telemetry to estimate post-release survival of undulate ray Raja undulata (Rajidae) in northeast Altantic

    Morfin, Marie   Simon, Julien   Morandeau, Fabien   Baulier, Loïc   Méhault, Sonia   Kopp, Dorothée  

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  • Long‐Term Gynecological Cancer Survivors in Côte d'Or: Health‐Related Quality of Life and Living Conditions

    Mamguem Kamga, Ariane   Dumas, Agnès   Joly, Florence   Billa, Oumar   Simon, Julien   Poillot, Marie‐Laure   Darut‐Jouve, Ariane   Coutant, Charles   Fumoleau, Pierre   Arveux, Patrick   Dabakuyo‐Yonli, Tienhan Sandrine  

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  • Highly Diastereoselective Synthesis of Enantiopure β-Trifluoromethyl β-Amino Alcohols from Chiral Trifluoromethyl Oxazolidines (Fox)

    Simon, Julien   Chelain, Evelyne   Brigaud, Thierry  

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  • The Economics of Population: Classic Writings. 1998.by Julien L. Simon

    Review by: Heather Joshi  

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  • The Economics of Population: Classic Writings. 1998.by Julien L. Simon

    Review by: Heather Joshi  

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  • Highly Diastereoselective Synthesis of Enantiopure beta-Trifluoromethyl beta-Amino Alcohols from Chiral Trifluoromethyl Oxazolidines (Fox)

    Simon, Julien  

    The organolithium species addition to 2-hydroxymethyl fluorinated oxazolidines (Fox) provides a highly diastereoselective and straightforward route for the synthesis of enantiopure trifluoromethyl beta-amino alcohols quaternarized at the beta-position.
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  • Homochiral versus Heterochiral Trifluoromethylated Pseudoproline Containing Dipeptides:A Powerful Tool to Switch the Prolyl-Amide Bond Conformation

    Chaume, Gregory   Simon, Julien   Lensen, Nathalie   Pytkowicz, Julien   Brigaud, Thierry   Miclet, Emeric  

    The design of constrained peptides is of prime importance in the development of bioactive compounds and for applications in supramolecular chemistry. Due to its nature, the peptide bond undergoes a spontaneous cis-trans isomerism, and the cis isomers are much more difficult to stabilize than the trans forms. By using oxazolidine-based pseudoprolines (psi Pro) substituted by a trifluoromethyl group, we show that the cis peptide bond can be readily switched from 0% to 100% in Xaa-psi Pro dipeptides. Our results prove that changing the configuration of the C-alpha in Xaa or in psi Pro is sufficient to invert the cis:trans populations while changing the nature of the Xaa side chain finely tuned the conformers ratio. Moreover, a strong correlation is found between the puckering of the oxazolidine ring and the peptide bond conformation. This finding highlights the role of the trifluoromethyl group in the stabilization of the peptide bond geometry. We anticipate that such templates will be very useful to constrain the backbone geometry of longer peptides.
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  • Using automated video analysis to study fish escapement through escape panels in active fishing gears: Application to the effect of net colour

    Simon, Julien   Kopp, Dorothée   Larnaud, Pascal   Vacherot, Jean-Philippe   Morandeau, Fabien   Lavialle, Gaël   Morfin, Marie  

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  • Incorporation of Trifluoromethylated Proline and Surrogates into Peptides:Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide

    Simon, Julien   Pytkowicz, Julien   Lensen, Nathalie   Chaume, Gregory   Brigaud, Thierry  

    The incorporation into a peptide chain of highly hindered and weakly nucleophilic trifluoromethylated prolines, pseudoprolines and oxazolidines has been achieved. As an application, the synthesis of a new class of fluorinated analogues of the neuroprotective tripeptide glycine-proline-glutamate (GPE) is reported. These analogues have been elaborated from a panel of five-membered ring trifluoromethylated amino acids (Tfm-AAs) through the coupling reaction with a glutamate residue at the C-terminus and a glycine at the N-terminus. Although the peptide coupling reaction at the C-terminal position of the fluorinated amino acid was conveniently performed under standard conditions, the very challenging coupling reaction at the highly deactivated N-terminal position proved to be much more problematic. A methodological study was needed to identify suitable reaction conditions for this difficult peptide coupling.
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  • Incorporation of Trifluoromethylated Proline and Surrogates into Peptides: Application to the Synthesis of Fluorinated Analogues of the Neuroprotective Glycine-Proline-Glutamate (GPE) Tripeptide

    Simon, Julien   Pytkowicz, Julien   Lensen, Nathalie   Chaume, Grégory   Brigaud, Thierry  

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