The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
Methods and systems for image upscaling are disclosed. In one embodiment, a low frequency band image intermediate is obtained from an input image. The input image is upsampled by a scale factor to obtain an upsampled image intermediate. A result image is estimated based at least in part on the upsampled image intermediate, the low frequency band image intermediate, and the input image, wherein the input image is of a smaller scale than the result image.
A method for cleaning internal components of a fuel injector for a diesel engine. The method includes operating a fuel injected diesel engine on a fuel composition comprising a major amount of fuel and from about 10 to about 100 ppm by weight based on the total weight of the fuel composition of (A) a compound of the formula:
A system and method for using content on multiple devices includes a head end associating a first user device and a second user device with a user account and authorizing the first user device and the second user device to receive content. The first user device forms a selection signal corresponding to a first content. The head end communicates the first content to the first user device corresponding to the selection signal. The first user device displays the first content on a first display associated therewith. The second user device receives the first content and displays the first content on a second display associated with the second user device.
Systems and methods for providing multi-homed tandem access in a communication system are disclosed. The disclosure may include a private packet network backbone exchange (PPNBE) in connection with a set of access tandems and with a call destination such as an end-user or a communications service. A set of LRNs may be homed across the set of access tandems, with each of the set of LRNs mapped to one or more TNs corresponding to the call destination. An originating party may use any of the TNs to reach the call destination. A plurality of originating calls each including one of the TNs may be received at the PPNBE from any of the access tandems and routed to the call destination. Thus, the present disclosure provides greater call capacity than available access tandem architectures as well as optimizes a maximum number of call paths to a particular call destination.
GaN-based heterojunction field effect transistor (HFET) sensors are provided with engineered, functional surfaces that act as pseudo-gates, modifying the drain current upon analyte capture. In some embodiments, devices for sensing nitric oxide (NO) species in a NO-containing fluid are provided which comprise a semiconductor structure that includes a pair of separated GaN layers and an AlGaN layer interposed between and in contact with the GaN layers. Source and drain contact regions are formed on one of the GaN layers, and an exposed GaN gate region is formed between the source and drain contact regions for contact with the NO-containing fluid. The semiconductor structure most preferably is formed on a suitable substrate (e.g., SiC). An insulating layer may be provided so as to cover the semiconductor structure. The insulating layer will have a window formed therein so as to maintain exposure of the GaN gate region and thereby allow the gate region to contact the NO-containing fluid. Electrical contact pads are preferably provided in some embodiments so as to be in electrical contact with the source and drain contact regions, respectively. Electrical leads may thus be connected to the contact pads. According to other embodiments, the NO detection device will include a metalloporphyrin adsorbed on the GaN gate region.
Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.