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Now showing items 33 - 48 of 104

  • Erratum for “Formulation of Cross-Anisotropic Failure Criterion for Granular Material” by Yang Xiao, Hanlong Liu, and Gui Yang

    Xiao, Yang  

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  • Erratum for “Formulation of Cross-Anisotropic Failure Criterion for Granular Material” by Yang Xiao, Hanlong Liu, and Gui Yang

    Xiao   Yang  

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  • Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

    Limopasmanee, Wirin   Chansakaow, Sunee   Rojanasthien, Noppamas   Manorot, Maleeya   Sangdee, Chaichan   Teekachunhatean, Supanimit  

    A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed with beta-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentration (C-max), time to reach peak concentration (T-max), area under the plasma concentration-time curve (AUC), and half-life (t(1/2)). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens.
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  • Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers

    Chen, Y.   Ouyang, D.-S.   Kang, Z.   Yang, G.-P.   Tan, Z.-R.   Zhou, G.   Yan, J.  

    1. Liu Wei Di Huang Wan (LDW), a well-known traditional Chinese medicine, is widely used for the treatment of various diseases in China. This study was designed to investigate the potential herb-drug interactions of LDW in healthy volunteers and attempted to ascertain whether the interaction might be affected by genotypes. 2. We assessed the effect of LDW on the activities of CYP2C19, CYP2D6 and CYP3A4 in 12 Chinese healthy subjects in a single-center, controlled, non-blinded, two-way crossover clinical trial. The subject pool consisted of six extensive metabolizers with CYP2C19*1/*1 and six poor metabolizers with CYP2C19*2/*2. Placebo or 4.8 g LDW (12 pills, 0.2 g/pill, twice daily) was given to each participant for 14 continuous days with a wash-out period of 2 weeks after an oral administration of 30 mg omeprazole, 30 mg dextromethorphan hydrobromide and 7.5 mg midazolam. The activities of CYP2C19, CYP2D6 and CYP3A4 were ascertained by their respective plasma or urinary metabolic ratios on day 14 post-treatment. 3. There is no difference in the activities of the three tested enzymes before or after a 14-day administration of LDW. LDW had no effect on the pharmacokinetic parameters of the substrates and their metabolites. 4. A 14-day administration of LDW did not affect the activities of CYP2C19, CYP2D6 and CYP3A4. LDW is unlikely to cause pharmacokinetic interaction when it is combined with other medications predominantly metabolized by these enzymes.
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  • Impact of a Chinese Medicinal Formula, Xiao Liu Fang, on the “3A” Ability of Endometrial Stromal Cells in Patients with Endometriosis

    Zhou, Hua   Zhang, Qian   Qi, Cong  

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  • The proof of the sufficient descent condition of the Wei–Yao–Liu conjugate gradient method under the strong Wolfe–Powell line search

    Hai Huang   Zengxin Wei   Yao Shengwei  

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  • Píldora de 6 Sabores con Rehmanniae (Liu Wei Di Huang Wan) y derivadas (fórmulas que Nutren el Yin más una para Tonificar el Yang)

    Salgado, Fernando  

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  • The molecular mechanisms of Yang Wei Kang Liu powder on anticancer and reducing chemotherapy side-effect in combination with chemotherapy

    Guizhi Sun   Zhikui Wu   Jinyu Lu   Wenping Lu   Xun Wang  

    Objective We studied the molecular mechanisms of Yang Wei Kang Liu Power (YWKL, traditional Chinese medicine for nourishing stomach and anticancer) on anticancer and reducing chemotherapy side-effect in combination with chemotherapy. Methods 615 pre-cancer mouse model of YWKL for 10 days and CTX 1 time, semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) to detect bone marrow granulocyte-macrophage colony-stimulating factor (GM-CSF) gene and cancer proto-oncogene Bcl-2, c-myc expression. Results YWKL in combination with chemotherapy could obviously promoted the expression of GM-CSF gene and inhibited the expression of Bcl-2 and c-myc oncogenes of FC 615 mice. Conclusion The molecular mechanisms of anticancer and reducing chemotherapy side-effect of YWKL in combination with chemotherapy are to promote the expression of GM-CSF gene and inhibit the expression of Bcl-2 and c-myc oncogenes.
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  • Closure to “Transitional Behaviors in Well-Graded Coarse Granular Soils” by Yang Xiao, M. R. Coop, Hong Liu, Hanlong Liu, and Jingshan Jiang

    Xiao, Yang   Coop, M. R.   Liu, Hong   Liu, Hanlong   Jiang, Jingshan  

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  • An in vitro study of the antioxidant activities and effect on human DNA of the Chinese herbal decoction 'Liu Wei Di Huang' RID G-1074-2011

    Szeto, Yim-Tong   Lei, Pui-Cheong   Ngai, Kam-Leong   Yiu, Andy Tak-Wah   Chan, Catarina Sin-Pek   Kok, Edith Wun-Fong   Leong, Chi-Wa  

    A Chinese medicinal formulation, 'Liu Wei Di Huang', and its individual components have been tested for the genoprotective effect on human DNA by the comet assay. Results showed no DNA protection contributed by this prescription. However, the aqueous extracts of individual herbs, namely Cortex Moutan and Rhizoma Dioscoreae, were able to decrease by 10-15% the DNA stand break from hydrogen peroxide-mediated oxidative stress. This provides insight to further evaluate the interaction among herbs and the search for the active ingredient responsible for the DNA protective effect.
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  • "Does Competition Drive up Corporate Demand for Insurance? Evidence from Chinese Manufacturing Industrial Firms" By Wei Huang and Zhiyond Liu

    Shinichi Kamiya  

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  • Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS

    Ping Wang   Hui Sun   Haitao Lv   Wenjun Sun   Ye Yuan   Ying Han   Dongwu Wang   Aihua Zhang   Xijun Wang  

    The promise of metabonomics, a new “omics” technique, to validate Chinese medicines and the compatibility of Chinese formulas has been appreciated. The present study was undertaken to explore the excretion pattern of low molecular mass metabolites in the male Wistar-derived rat model of kidney yin deficiency induced with thyroxine and reserpine as well as the therapeutic effect of Liu Wei Di Huang Wan (LW) and its separated prescriptions, a classic traditional Chinese medicine formula for treating kidney yin deficiency in China. The study utilized ultra-performance liquid chromatography/electrospray ionization synapt high definition mass spectrometry (UPLC/ESI-SYNAPT-HDMS) in both negative and positive electrospray ionization (ESI). At the same time, blood biochemistry was examined to identify specific changes in the kidney yin deficiency. Distinct changes in the pattern of metabolites, as a result of daily administration of thyroxine and reserpine, were observed by UPLC-HDMS combined with a principal component analysis (PCA). The changes in metabolic profiling were restored to their baseline values after treatment with LW according to the PCA score plots. Altogether, the current metabonomic approach based on UPLC-HDMS and orthogonal projection to latent structures discriminate analysis (OPLS-DA) indicated 20 ions (14 in the negative mode, 8 in the positive mode, and 2 in both) as “differentiating metabolites”.
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  • Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS

    Wang, Ping   Sun, Hui   Lv, Haitao   Sun, Wenjun   Yuan, Ye   Han, Ying   Wang, Dongwu   Zhang, Aihua   Wang, Xijun  

    The promise of metabonomics. a new "omics" technique, to validate Chinese medicines and the compatibility of Chinese formulas has been appreciated. The present study was undertaken to explore the excretion pattern of low molecular mass metabolites in the male Wistar-derived rat model of kidney yin deficiency induced with thyroxine and reserpine as well as the therapeutic effect of Liu Wei Di Huang Wan (LW) and its separated prescriptions, a classic traditional Chinese medicine formula for treating kidney yin deficiency in China The study utilized ultra-performance liquid chromatography/electrospray ionization synapt high definition mass spectrometry (UPLC/ESI-SYNAPT-HDMS) in both negative and positive electrospray ionization (ESI) At the same time, blood biochemistry was examined to identify specific changes in the kidney yin deficiency Distinct changes in the pattern of metabolites, as a result of daily administration of thyroxine and reserpine, were observed by UPLC-HDMS combined with a principal component analysis (PCA). The changes in metabolic profiling were restored to their baseline values after treatment with LW according to the PCA score plots Altogether, the current metabonomic approach based on UPLC-HDMS and orthogonal projection to latent structures discriminate analysis (OPLS-DA) indicated 20 ions (14 in the negative mode, 8 in the positive mode, and 2 in both) as "differentiating metabolites" Crown Copyright (C) 2010 Published by Elsevier B V All rights reserved
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  • The miscarriages of justice in late Qing Dynasty—analysis focused on the original trial judge Liu Xitong in the case of Yang Naiwu and Xiao Baicai

    Ding Zheng   Ang Yang  

    Abstract  This article introduces the case of Yang Naiwu and Xiao Baicai, a famous case in late imperial China, and its important value for the study of legal history of the Qing Dynasty. Based on the analysis of this case, this article focuses on the issue of the responsibility of the magistrate Liu xitong, the judge of this case, who analyzed the mentation of his miscarriage under the pressure of the rules about judges responsibilities in their judgment through which reveal the stimulation and passive infection of the judgment of the judges.
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  • The miscarriages of justice in late Qing Dynasty—analysis focused on the original trial judge Liu Xitong in the case of Yang Naiwu and Xiao Baicai

    Ding Zheng; Ang Yang  

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  • Liu Wei Di Huang Wan, a well-known traditional Chinese medicine, induces CYP1A2 while suppressing CYP2A6 and N-acetyltransferase 2 activities in man

    Yao Chen   Zhen Kang   Jin Yan   Guo-Ping Yang   Zhi-Rong Tan   Gan Zhou   Dong-Sheng Ouyang  

    Ethnopharmacological relevanceLiu Wei Di Huang Wan (LDW), a well-known traditional Chinese medicine, is frequently combined with other prescription or non-prescription drugs in China.Aim of the studyThis study was designed to investigate the effects of LDW on the activities of CYP1A2, CYP2A6, N-acetyltransferase 2 (NAT2) and xanthine oxidase (XO) in healthy subjects, using caffeine as a probe drug.Materials and methodsTwelve unrelated healthy males were enrolled in a single-blind, randomized, placebo-controlled, two-phase crossover study. Placebo or LDW (12 pills, 0.2 g/pill, twice daily) was given to each participant for 14 continuous days with a wash-out period of 2 weeks. A dose of 100 mg caffeine was given afterwards to test the activities of drug-metabolizing enzymes of interest.ResultsCompared to placebo, LDW significantly induced the CYP1A2 activity, as determined by an increase in the ratio of (AFMU + 1U + 1X)/17U and the formation of 17X and 1X after taking caffeine. Interestingly, LDW significantly decreased the ratio of 17U/(17U + 17X + 1X + 1U + AFMU) and the formation of 17U (CYP2A6-mediated) (by 39.2%; 95%CI: 23.1–55.3%; P = 0.026), and decreased the ratio of AFMU/(AFMU + 1U + 1X) and the formation of AFMU (NAT2-catalized) (by 26.2%; 95%CI: 9.2–61.6%; P = 0.038), suggesting a marked inhibition of CYP2A6 and NAT2, respectively.ConclusionsLDW can induce CYP1A2 and suppress CYP2A6 and NAT2 activities, and affect caffeine metabolism in vivo.
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