Iqbal, Zafar | onAcademic

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iqbal, zafar(414)

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Now showing items 49 - 64 of 428

Geriatric Diabetic Nephropathy: An Analysis of Renal Referral in Patients Age 60 or Older

Iqbal, Zafar Meguira, Simon Friedman, Eli A.

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Spatial distribution of the trends in precipitation and precipitation extremes in the sub-Himalayan region of Pakistan

Iqbal, Zafar Shahid, Shamsuddin Ahmed, Kamal Ismail, Termizi Nawaz, Nadeem

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Missense variants in AIMP1 gene are implicated in autosomal recessive intellectual disability without neurodegeneration

Iqbal, Zafar Püttmann, Lucia Musante, Luciana Razzaq, Attia Zahoor, Muhammad Yasir Hu, Hao Wienker, Thomas F Garshasbi, Masoud Fattahi, Zohreh Gilissen, Christian Vissers, Lisenka ELM de Brouwer, Arjan PM Veltman, Joris A Pfundt, Rolph Najmabadi, Hossein Ropers, Hans-Hilger Riazuddin, Sheikh Kahrizi, Kimia van Bokhoven, Hans

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Case study of primary imatinib resistance and correlation of BCR-ABL multiple mutations in chronic myeloid leukemia

Iqbal, Zafar Siddiqui, Rubina T Qureshi, Javed A Khalid, Ahmad M

Background: The kinase inhibitor, imatinib (Gleevec™, Novartis) has proven to be an effective treatment for chronic myeloid leukemia, providing proof-of-principle for a molecularly targeted approach in oncology. Despite its success in BCR-ABL-positive chronic myeloid leukemia patients, primary imatinib resistance has emerged, resulting in disease relapse. Little is known about the underlying genetic causes of resistance, however, with emerging pharmacogenomic approaches, a more comprehensive picture is developing. In imatinib-resistant patients, point mutations have been detected in an ATP-binding domain of the ABL gene, which disturbs the binding of imatinib to this target leading to resistance. However, it remains to be determined whether these mutations confer primary imatinib resistance. Methods: Primary imatinib resistance was observed in a chronic myeloid leukemia patient with no hematological, cytogenetic and molecular response to 9 months treatment with 400 mg imatinib/day. A highly sensitive allele-specific oligonucleotide polymerase chain reaction was established to detect point mutations in BCR-ABL adenosine triphosphate-binding domain. Results: C944T and T1052C mutations were detected which cause complete and partial imatinib resistance, respectively. Conclusions: This is a case study of multiple point mutations conferring primary imatinib resistance in one patient at the same time. Elucidating the biological mechanisms of primary imatinib resistance will improve the ability to predict patient responsiveness and provide effective clinical management. Furthermore, the allele-specific oligonucleotide-polymerase chain reaction assay is very effective in detecting mutations related to imatinib resistance.

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CORROSION RESISTANT COATED FUEL CELL BIPOLAR PLATE WITH GRAPHITE PROTECTIVE BARRIER AND METHOD OF MAKING THE SAME

A corrosion resistant coated fuel cell plate and method of making the same are embodied in a metal plate (400) provided with a graphite emulsion coating (402) and then a layer (406) of graphite foil which is pressed over the coating (402). The graphite emulsion (402) bonds the graphite foil (406) to the metal plate (400) and seals fine scale porosities (410) in the graphite foil (406). Flow fields (414) are formed by stamping the coated fuel cell plate.

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Automated external defibrillators in public places: position statement from the Faculty of Sport and Exercise Medicine UK

Iqbal, Zafar Somauroo, John

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Comparative Study of Alterations in Tri-iodothyronine (T3) and Thyroxine (T4) Hormone Levels in Breast and Ovarian Cancer

Naseer, Muhammad Imran Rasool, Mahmood Zaigham, Kalsoom Malik, Arif Riaz, Naila Alam, Rabail Manan, Abdul Arooj, Mahwish Asif, Muhammad Qazi, Mahmood Husain Iqbal, Zafar Sheikh, Ishfaq Ahmed

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Unusual Pseudomyiasis with Musca Domestica (Housefly) Larvae in a Tracheostomy Wound: A Case Report and Literature Review

Shakeel, Mohammad Khan, Iram Ahmad, Imteyaz Iqbal, Zafar Hasan, Syed Abrar

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IMPROVED PIEZOELECTRIC CERAMIC-POLYMER COMPOSITES

This invention relates to compositions and processes for the fabrication of piezoelectric composites having improved figures of merit for both sensor and non-sensor applications. These composites comprise piezoelectric particles embedded in a polymer matrix. The improvements of this invention result from discoveries of the effects of polymer bulk compliance, polymer anisotropy, polymer melt index, and polymer/ceramic wettability on performance. The loss corrected figure of merit (g¿h?d¿h?/tan$g(d)) obtained for the 0-3 composites is as high as 10.5 x 10?-10¿ m?2¿/N, which is about four times higher than previously published for 0-3 composites of the prior art. Methods are described for the introduction of anisotropy into ceramic particle/polymer composites, so that cancellation effects that degrade the piezoelectric properties of composites can be reduced.

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Comparative study on floristic diversity of protected and unprotected Forests of Sathan Gali, District Mansehra, KP, Pakistan

Khan, Khalid Rasheed Iqbal, Zafar Alam, Jan Farooq, Muhammad Shah, Abbas Hussain Hussain, Manzoor Shah, Ghulam Mujaba Ali, Danish

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The quantification of endogenous steroids in bovine aqueous humour and vitreous humour using isotope dilution GC-NCI-MS

Iqbal, Zafar Midgely, John M. Watson, David G.

Pentafluorobenzyloxime-trimethylsilyl derivatives of androgens, progestogens and corticosteroids were prepared and used for the analysis of these steroids in bovine aqueous humour and vitreous humour by GC-MS method. Appropriate deuteriated isotopomers of the parent steroids were labelled with deuterium via simple synthetic procedure and used as internal standards. The concentration (ng ml−1, ±S.E.M.) of these steroids in bovine aqueous humour and vitreous humour were found to be as follow: (1) aqueous humour (n

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A review of the genus\r Hyperaspis\r Chevrolat, 1837 (Coleoptera: Coccinellidae) from Pakistan

Iqbal, Zafar Nasir, Muhammad Farooq Bodlah, Imran Szawaryn, Karol Khormizi, Mehdi Zare Hassan, Muhammad Asghar

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Vasorelaxant activities and the underlying pharmacological mechanisms of Gynura procumbens Merr. leaf extracts on rat thoracic aorta

Iqbal, Zafar Bello, Idris Asmawi, Mohd Zaini Al-Mansoub, Majed Ahmed Ahmad, Ashfaq Jabeen, Qaiser Fei, Yam Mun

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Investigation of Spatio-temporal Satellite Thermal IR Anomalies Associated with the Awaran Earthquake (Sep 24, 2013; M 7.7), Pakistan

Ahamd, Nabeel Barkat, Adnan Ali, Aamir Sultan, Mahmood Rasul, Khurram Iqbal, Zafar Iqbal, Talat

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Vegetation composition and ecological gradients of subtropical-moist temperate Ecotonal forests of Nandiar Khuwar Catchment, Pakistan

Haq, Faizul Ahmad, Habib Iqbal, Zafar

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Infrared absorption and reflection studies of organic radical salt: K+TCNQ?

Iqbal, Zafar Christoe, C. W. Dawson, D. K.

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Geriatric Diabetic Nephropathy: An Analysis of Renal Referral in Patients Age 60 or Older

Spatial distribution of the trends in precipitation and precipitation extremes in the sub-Himalayan region of Pakistan

Missense variants in AIMP1 gene are implicated in autosomal recessive intellectual disability without neurodegeneration

Case study of primary imatinib resistance and correlation of BCR-ABL multiple mutations in chronic myeloid leukemia

CORROSION RESISTANT COATED FUEL CELL BIPOLAR PLATE WITH GRAPHITE PROTECTIVE BARRIER AND METHOD OF MAKING THE SAME

Automated external defibrillators in public places: position statement from the Faculty of Sport and Exercise Medicine UK

Comparative Study of Alterations in Tri-iodothyronine (T3) and Thyroxine (T4) Hormone Levels in Breast and Ovarian Cancer

Unusual Pseudomyiasis with Musca Domestica (Housefly) Larvae in a Tracheostomy Wound: A Case Report and Literature Review

IMPROVED PIEZOELECTRIC CERAMIC-POLYMER COMPOSITES

Comparative study on floristic diversity of protected and unprotected Forests of Sathan Gali, District Mansehra, KP, Pakistan

The quantification of endogenous steroids in bovine aqueous humour and vitreous humour using isotope dilution GC-NCI-MS

A review of the genus\r Hyperaspis\r Chevrolat, 1837 (Coleoptera: Coccinellidae) from Pakistan

Vasorelaxant activities and the underlying pharmacological mechanisms of Gynura procumbens Merr. leaf extracts on rat thoracic aorta

Investigation of Spatio-temporal Satellite Thermal IR Anomalies Associated with the Awaran Earthquake (Sep 24, 2013; M 7.7), Pakistan

Vegetation composition and ecological gradients of subtropical-moist temperate Ecotonal forests of Nandiar Khuwar Catchment, Pakistan

Infrared absorption and reflection studies of organic radical salt: K+TCNQ?

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