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Now showing items 33 - 42 of 42

  • Polymeric nanocapsules embedded with ultra-small silver nanoclusters for synergistic pharmacology and improved oral delivery of Docetaxel.

    Sohail, Muhammad Farhan   Hussain, Syed Zajif   Saeed, Hamid   Javed, Ibrahim   Sarwar, Hafiz Shoaib   Nadhman, Akhtar   Huma, Zil-E-   Rehman, Mubashar   Jahan, Sarwat   Hussain, Irshad   Shahnaz, Gul  

    Despite of the remarkable cytotoxic and imaging potential of ultra-small metal nanoclusters, their toxicity-free and targeted delivery to cancerous cells remains a substantial challenge that hinders their clinical applications. In this study, a polymeric scaffold was first synthesized by grafting folic acid and thiol groups to chitosan (CS) for cancer cell targeting and improved gastric permeation. Furthermore, silver nanocluster (Ag NCs) were synthesized in situ, within CS scaffold by microwave irradiation and core-shell nanocapsules (NCPs) were prepared with hydrophobic docetaxel (DTX) in the core and Ag NCs embedded CS in the shell. A significant cytotoxicity synergism (~300 folds) was observed for DTX with co-delivery of Ag NCs against breast cancer MDA-MB-231 cells. Following oral administration, the DTX-Ag-NCPs increased bioavailability due to enhanced drug transport across gut (9 times), circulation half-life (~6.8 times) and mean residence time (~6.7 times), as compared to the control DTX suspension. Moreover, 14 days acute oral toxicity of the DTX-Ag-NCPs was performed in mice and evaluated for changes in blood biochemistry parameters, organ to body weight index and histopathology of liver and kidney tissues that revealed no significant evidence of toxicity suggesting the safety and efficiency of the DTX-Ag-NCPs as hybrid nanocarrier for biocompatible delivery of metal nanoclusters.=20
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  • Fabrication of Emulsion-Templated Poly(vinylsulfonic acid)−Ag Nanocomposite Beads with Hierarchical Multimodal Porosity for Water Cleanup

    Mudassir, Muhammad Ahmad   Hussain, Syed Zajif   Asma, Syeda Tasmia   Zhang, Haifei   Ansari, Tariq Mahmood   Hussain, Irshad  

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  • Facile preparation of size-controlled gold nanoparticles using versatile and end-functionalized thioether polymer ligands RID E-3166-2010

    Huang, Xin   Li, Buyi   Zhang, Hui   Hussain, Irshad   Liang, Liyun   Tan, Bien  

    At present, thiol ligands are generally used whenever the classical Brust-Schiffrin two-phase method is employed to prepare metal nanoparticles. In general, the previous research was mainly focused on utilizing small molecular thiol compounds or thiol polymers as the stabilizers in organic phase to obtain small sized and uniform gold nanoparticles (Au NPs). Such preparations are usually associated with the problems of ligand exchange on the nanoparticle's surface due to strong Au-thiol interaction. Herein, we report an approach to produce fairly uniform Au NPs with diameters about 2-6 nm using thioether end-functional polymer ligands (DDT-PVAc and PTMP-PVAc) as the capping agents. These nanoparticles are thoroughly characterized using DLS, TEM, UV-Vis spectroscopy and other complementary techniques. The results indicate that multidentate thioether polymeric ligands (PTMP-PVAc) lead to formation of smaller but special 'multimer' morphology in organic phase; whereas fairly uniform nanoparticles are produced using monodentate thioether functionalized ligands (DDT-PVAc). Further modification of such polymer ligands to introduce the hydrophilic functionalities realizes the phase transfer of Au NPs from organic to aqueous media.
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  • Synthesis and use of self-assembled rhamnolipid microtubules as templates for gold nanoparticles assembly to form gold microstructures

    Rehman, Asma   Raza, Zulfiqar Ali   Saif-ur-Rehman   Khalid, Zafar M.   Subramani, Chandramouleeswaran   Rotello, Vincent M.   Hussain, Irshad  

    Natural unmodified rhamnolipids are thermally self-assembled into soft microtubules, which can produce gold nanoparticles onto themselves due to the presence of rhamnose sugar moieties at their surface. The loading of gold nanoparticles on composite microtubules can be controlled by varying the concentration of gold salt to rhamnolipid and the reaction temperature. The composite rhamnolipid-gold nanopartide microtubules are then heat treated to produce porous gold microwire-like structures with fairly controlled nanostructured features, which may have interesting applications in catalysis, biosensing and electronics. (C) 2010 Elsevier Inc. All rights reserved.
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  • Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

    Lodhi, Bilal Ahmad   Hussain, Muhammad Ajaz   Sher, Muhammad   Haseeb, Muhammad Tahir   Ashraf, Muhammad Umer   Hussain, Syed Zajif   Hussain, Irshad   Bukhari, Syed Nasir Abbas  

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  • Emulsions-directed assembly of gold nanoparticles to molecularly-linked and size-controlled spherical aggregates RID F-3868-2011 RID D-9662-2011

    Hussain, Irshad   Zhang, Haifei   Brust, Mathias   Barauskas, Justas   Cooper, Andrew I.  

    Aggregation of gold nanoparticles into soluble spherical assemblies using bi-functional ligands i.e., dithiols has recently been demonstrated but with limited control over the size of such assemblies. Herein, we report a new approach to further control the size of water dispersible spherical assemblies by confining gold nanoparticles in tiny oil droplets in water (oil-in-water emulsions) followed by their cross-linking with alkanedithiols. By controlling the size of the oil droplets and the concentration of nanoparticles, the size of spherical aggregates can be controlled from 20 to 400 nm. Cryo-TEM micrographs confirm the formation of covalently-linked soluble spherical nanoparticle assemblies within the oil emulsions in water. Such size-controlled nanoparticle assemblies may have several potential applications including those in gas sensors, controlled delivery, and optical coatings. (C) 2010 Elsevier Inc. All rights reserved.
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  • In situ growth of gold nanoparticles on latent fingerprints-from forensic applications to inkjet printed nanoparticle patterns RID D-9662-2011

    Hussain, Irshad   Hussain, Syed Zajif   Habib-ur-Rehman   Ihsan, Ayesha   Rehman, Asma   Khalid, Zafar M.   Brust, Mathias   Cooper, Andrew I.  

    Latent fingerprints are made visible in a single step by in situ growth of gold nanoparticles on ridge patterns. The chemicals, among the essential components of human sweat, found responsible for the formation and assembly of gold nanoparticles are screened and used as ink to write invisible patterns, using common ball pen and inkjet printer, which are then developed by selectively growing gold nanoparticles by soaking them in gold salt solution.
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  • Controlled Step Growth of Molecularly Linked Gold Nanoparticles: From Metallic Monomers to Dimers to Polymeric Nanoparticle Chains RID D-9662-2011

    Hussain, Irshad   Brust, Mathias   Barauskas, Justas   Cooper, Andrew I.  

    The solution-phase assembly of 15 nm gold particles into relatively linear chains of fairly controllable length of up to 1 mu m is achieved by molecularly linking nanoparticles with alkanedithiols. This step-growth process can be controlled to prepare dimers, oligomers, and polymer-like gold nanoparticle chains by varying the ratio of alkanedithiols to nanoparticles. These size-controlled, relatively linear aggregates remain suspended in ethanol solution without precipitation for several weeks to months depending on the chain length. The resulting soluble nanoparticle assemblies were characterized by a variety of techniques including cryogenic transmission electron microscopy. The surface plasmon coupling of regularly spaced gold nanoparticles in these chains could be of interest in the fabrication of optical waveguide and nanoelectronic systems.
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  • Design,characterization and evaluation of hydroxyethylcellulose based novel regenerable supersorbent for heavy metal ions uptake and competitive adsorption

    Abbas, Azhar   Hussain, Muhammad Ajaz   Sher, Muhammad   Irfan, Muhammad Imran   Tahir, Muhammad Nawaz   Tremel, Wolfgang   Hussain, Syed Zajif   Hussain, Irshad  

    Hydroxyethylcellulose succinate-Na (HEC-Suc-Na) was designed and evaluated for removal of some heavy metal ions from aqueous solution. Pristine sorbent HEC-Suc-Na was thoroughly characterized by FTIR and solid-state CP/MAS C-13 NMR spectroscopy, SEM-EDS and zero point charge analyses. Langmuir isotherm, pseudo second order kinetic and ion exchange models provided best fit to the experimental data of sorption of metal ions. Maximum sorption capacities of supersorbent HEC-Suc-Na for sorption of heavy metal ions from aqueous solution as calculated by Langmuir isotherm model were found to be 1000, 909.09, 666.6, 588 and 500 mg g-(1) for Pb(II), Cr(VI), Co(II), Cu(II) and Ni(II), respectively. Competitive sorption of these heavy metal ions was carried out from galvanic and nuclear waste water simulated environment. The negative values of Delta G degrees and Delta H degrees indicated spontaneity and exothermic nature of sorption. The sorbent was efficiently regenerated with no significant decrease in sorption capacity after five cycles. (C) 2017 Elsevier B.V. All rights reserved.
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  • Citric acid crosslinking of mucilage from Cydonia oblonga engenders a superabsorbent, pH-sensitive and biocompatible polysaccharide offering on-off swelling and zero-order drug release

    Hussain, Muhammad Ajaz   Kiran, Laraib   Haseeb, Muhammad Tahir   Hussain, Irshad   Hussain, Syed Zajif  

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