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Now showing items 33 - 48 of 1227

  • CAPS criteria fail to identify most severely-ill thrombotic antiphospholipid syndrome patients requiring intensive care unit admission

    Pineton de Chambrun, Marc   Larcher, Romaric   Pène, Frédéric   Argaud, Laurent   Demoule, Alexandre   Jamme, Matthieu   Coudroy, Remi   Mathian, Alexis   Gibelin, Aude   Azoulay, Elie   Tandjaoui-Lambiotte, Yacine   Dargent, Auguste   Beloncle, François-Michel   Raphalen, Jean-Herlé   Couteau-Chardon, Amélie   de Prost, Nicolas   Devaquet, Jérôme   Contou, Damien   Gaugain, Samuel   Trouiller, Pierre   Grangé, Steven   Ledochowski, Stanislas   Lemarie, Jérémie   Faguer, Stanislas   Degos, Vincent   Combes, Alain   Luyt, Charles-Edouard   Amoura, Zahir  

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  • Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: Proportion and determinants of underreporting to pharmacovigilance

    Chaby, Guillaume   Lebrun-Vignes, Bénédicte   Haddad, Cynthia   Hemery, Francois   Ingen-Housz-Oro, Saskia   de Prost, Nicolas   Wolkenstein, Pierre   Chosidow, Olivier   Fardet, Laurence  

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  • Outcomes after extracorporeal membrane oxygenation for the treatment of high-risk pulmonary embolism:a multicentre series of 52 cases

    Meneveau, Nicolas   Guillon, Benoit   Planquette, Benjamin   Piton, Gael   Kimmoun, Antoine   Gaide-Chevronnay, Lucie   Aissaoui, Nadia   Neuschwander, Arthur   Zogheib, Elie   Dupont, Herve   Pili-Floury, Sebastien   Ecarnot, Fiona   Schiele, Francois   Deye, Nicolas   de Prost, Nicolas   Favory, Raphael   Girard, Philippe   Cristinar, Mircea   Ferre, Alexis   Meyer, Guy   Capellier, Gilles   Sanchez, Olivier  

    Aims The role of extracorporeal membrane oxygenation (ECMO) remains ill defined in pulmonary embolism (PE). We investigated outcomes in patients with high-risk PE undergoing ECMO according to initial therapeutic strategy. Methods and results From 01 January 2014 to 31 December 2015, 180 patients from 13 Departments in nine centres with high-risk PE were retrospectively included. Among those undergoing ECMO, we compared characteristics and outcomes according to adjunctive treatment strategy (systemic thrombolysis, surgical embolectomy, or no reperfusion therapy). Primary outcome was all-cause 30-day mortality. Secondary outcome was 90-day major bleeding. One hundred and twenty-eight patients were treated without ECMO; 52 (mean age 47.6 years) underwent ECMO. Overall 30-day mortality was 48.3% [95% confidence interval (CI) 41-56] (87/180); 43% (95% CI 34-52) (55/128) in those treated without ECMO vs. 61.5% (95% CI 52-78) (32/52) in those with ECMO (P =3D 0.008). In patients undergoing ECMO, 30-day mortality was 76.5% (95% CI 57-97) (13/17) for ECMO+fibrinolysis, 29.4% (95% CI 51-89) (5/17) for ECMO+surgical embolectomy, and 77.7% (95% CI 59-97) (14/18) for ECMO alone (P =3D 0.004). Among patients with ECMO, 20 (38.5%, 95% CI 25-52) had a major bleeding event in-hospital; without significant difference across groups. Conclusion In patients with high-risk PE, those with ECMO have a more severe presentation and worse prognosis. Extracorporeal membrane oxygenation in patients with failed fibrinolysis and in those with no reperfusion seems to be associated with particularly unfavourable prognosis compared with ECMO performed in addition to surgical embolectomy. Our findings suggest that ECMO does not appear justified as a stand-alone treatment strategy in PE patients, but shows promise as a complement to surgical embolectomy.
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  • A multiplex analysis of sepsis mediators during human septic shock: a preliminary study on myocardial depression and organ failures

    Razazi, Keyvan   Boissier, Florence   Surenaud, Mathieu   Bedet, Alexandre   Seemann, Aurélien   Carteaux, Guillaume   de Prost, Nicolas   Brun-Buisson, Christian   Hue, Sophie   Mekontso Dessap, Armand  

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  • Removal of totally implanted venous access ports for suspected infection in the intensive care unit:a multicenter observational study

    Lecronier, Marie   Valade, Sandrine   Bige, Naike   de Prost, Nicolas   Roux, Damien   Lebeaux, David   Maury, Eric   Azoulay, Elie   Demoule, Alexandre   Dres, Martin  

    Background: While no data support this practice, international guidelines recommend the removal of totally implanted venous access ports (TIVAPs) in patients with suspicion of TIVAP-related bloodstream infection admitted in the intensive care unit (ICU) for a life-threatening sepsis. Methods: During this multicenter, retrospective and observational study, we included all patients admitted in five ICU for a life-threatening sepsis in whom a TIVAP was removed between January 2012 and December 2014. We aimed (1) at determining the proportion of confirmed TIVAP-related infections and (2) at assessing short- and long-term survival of patients with and without TIVAP-related infections. Results: One hundred and fifty-one patients (58 +/- 14 years, 62% males) were included between 2012 and 2014. TIVAP-related infections were confirmed in 68 patients (45%). Demographic characteristics were similar between patients with and without TIVAP-related infections. SOFA score on admission per point increase [odd ratio (OR), 0.86 interval confidence (IC) 95% (0.8-0.9), p < 0.01] and local signs of infection [OR 4.0, IC 95% (1.1-15.6), p =3D 0.04] were significantly associated with TIVAP-related infection. Patients with TIVAP-related infection had lower ICU and 6-month mortality as compared to their counterparts (9 vs. 40%, respectively, p < 0.01; and 50 vs. 66%, respectively, p =3D 0.04). TIVAP-related infection was significantly associated with ICU survival [OR 0.2, IC 95% (0.05-0.5), p < 0.01]. Conclusions: TIVAP-related infection was confirmed in nearly one out of two cases of life-threatening sepsis in patients in whom it has been removed. TIVAP-related infection was associated with a good prognosis, as compared to patients with other causes of infection.
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  • Risk of cross transmission with point-of-care ultrasound system: effect of a glass-sealed control panel on microbial contamination.

    Mekontso Dessap, Armand   Jansen, Chloe   Boissier, Florence   Razazi, Keyvan   de Prost, Nicolas   Michaud, Gael   Cizeau, Florence   Ducellier, David   Abid, Shariq   Decousser, Jean-Winoc   Brun-Buisson, Christian  

    Contamination of a point-of-care ultrasound system (POCUS) mainly involved electrocardiography accessories and included pathogenic microorganisms. The use of a glass-sealed control panel significantly facilitated its cleaning and reduced its bacterial contamination compared with a standard control panel. Overall hand hygiene compliance during examinations with POCUS was poor. =20
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  • Brève biographie de Pierre-Antoine Prost

    Caire, Michel  

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  • Lymphogranulome vénérien (maladie de Nicolas Favre)

    E. Caumesa   N. Dupinb   M. Janierc   C. Chartierd   R. Virabene   I. Maatoukf   et la section MST de la SFD  

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  • Lymphogranulome vénérien (maladie de Nicolas Favre)

    Caumes, E.   Dupin, N.   Janier, M.   Chartier, C.   Viraben, R.   Maatouk, I.  

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  • Pierre-Antoine Prost a-t-il découvert l’origine intestinale de la folie ?

    Luauté, Jean-Pierre  

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  • Actualité de Nicolas de Cues. Publications francophones récentes

    Sfez   Jocelyne  

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  • A democracia no Governo de Nicolás Maduro

    Oliveira, Aline   Barcellos, Bruna Leal  

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  • Hervé Pasqua (ed.): Nicolas de Cues et l’Islam

    José González Ríos   Héctor  

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  • The Party Paradox:a Comment Nicolas van de Walle (Cornell) February 20,2018

    van de Walle, Nicolas  

    This article analyzes several stylized facts and implications concerning intra-party violence developed in the other articles of this special issue on intra-party violence in African electoral systems. It then turns more specifically to the implications of intra-party violence for democratic consolidation in the region, and argues that paradoxically, though parties are centrally important to democratic politics, the degree to which they are internally inclusive and participatory may not have much importance, or may indeed undermine democracy. Though they are perhaps the key actor on the path to a consolidated democracy, they tend to work best when they themselves are not internally democratic.
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  • Nicolas de Beguelin and the foundations of natural philosophy

    Duchesneau, Francois  

    Nicolas de Beguelin, philosopher and scientist and a member of the Berlin Academy, undertook to conciliate such conflicting views concerning the foundations of natural philosophy as seemed to suggest an irreducible antinomy between the Leibnizian-Wolffian and the Newtonian principles. In a series of memoirs, he argued that experimental philosophy would remain unsettled about the validity of its hypotheses as long as it failed to check them against requisites arising from architectonic principles and their source in sufficient reason. At the heart of his argument, one finds an analysis of the relationship that holds between laws of nature and contingent truths. Case studies were provided relative to the "deduction" of the fundamental laws of mechanics : these should be in no way equated with abstract statements featuring geometrical necessity. Relying on the requisites of universal harmony, Beguelin framed up hypotheses concerning the integration of motive forces underpinning inertia, as well as concerning space as an order of coexistent bodies that would depend on the interrelation between monadic elements.
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  • Nicolas Beauzée précurseur de la phonétique

    Christophe   Rey  

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