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Now showing items 1 - 13 of 13

  • RAPID COLORIMETRIC DETECTION OF BACTERIA IN WATER

    The invention provides a nanoparticle (NP)-based detection system for bacteria that is both rapid and sensitive for bacterial analytes in water. The system reports its results colorimetrically, in the form of an easily observable color change, allowing analysis to be done visually by non-scientifically trained personnel.
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  • Detection of bacteria using inkjet-printed enzymatic test strips.

    Creran, Brian   Li, Xiaoning   Duncan, Bradley   Kim, Chang Soo   Moyano, Daniel F   Rotello, Vincent M  

    Low-cost diagnostics for drinking water contamination have the potential to save millions of lives. We report a method that uses inkjet printing to copattern an enzyme-nanoparticle sensor and substrate on a paper-based test strip for rapid detection of bacteria. A colorimetric response is generated on the paper substrate that allows visual detection of contamination without the need for expensive instrumentation. These strips demonstrate a viable nanomanufacturing strategy for low-cost bacterial detection. =20
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  • Detection of Bacteria Using Inkjet-Printed Enzymatic Test Strips

    Creran, Brian   Li, Xiaoning   Duncan, Bradley   Kim, Chang Soo   Moyano, Daniel F.   Rotello, Vincent M.  

    Low-cost diagnostics for drinking water contamination have the potential to save millions of lives. We report a method that uses inkjet printing to copattern an enzymenanoparticle sensor and substrate on a paper-based test strip for rapid detection of bacteria. A colorimetric response is generated on the paper substrate that allows visual detection of contamination without the need for expensive instrumentation. These strips demonstrate a viable nanomanufacturing strategy for low-cost bacterial detection.
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  • Tunable elastic modulus of nanoparticle monolayer films by host-guest chemistry.

    Jeong, Youngdo   Chen, Yu-Cheng   Turksoy, Merve K   Rana, Subinoy   Tonga, Gulen Yesilbag   Creran, Brian   Sanyal, Amitav   Crosby, Alfred J   Rotello, Vincent M  

    The elastic modulus of an ultrathin nanoparticle (NP) monolayer film is tuned by modulating the binding strength between the NPs on a molecular level. NP monolayer films constructed by crosslinking NPs of different binding affinities are fabricated at oil/water interfaces. By inducing buckling patterns on these films, the correlation between the binding affinity of the NPs and the elastic modulus is investigated. =C2=A9 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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  • Flavin-Functionalized Amphiphilic Block Copolymer Gels

    Fitzpatrick, Brian   Creran, Brian   Cooke, Graeme   Rotello, Vincent M.  

    The synthesis of flavin-containing amphiphilic block copolymers using atom transfer radical polymerisation (ATRP) is described. In these systems, a flavin moiety is engineered into the ATRP initiator unit as an environmental probe and is subsequently used to produce three block copolymers featuring a hydrophobic methacrylate block and a DMAEM block. The dimethylamino unit of the latter is converted to a trimethylammonium unit to afford three amphiphilic block copolymers. Rheological measurements show that these materials form gels in dilute aqueous solution that can be disrupted upon irradiation with ultrasound. The disruption of the gel can be conveniently monitored by exploiting the solvatochromic nature of the S0S2 absorption in the UV-vis spectrum in response to its changing environment.
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  • Colorimetric Protein Sensing Using Catalytically Amplified Sensor Arrays

    Li, Xiaoning   Wen, Fang   Creran, Brian   Jeong, Youngdo   Zhang, Xinrong   Rotello, Vincent M.  

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  • Direct Patterning of Engineered Ionic Gold Nanoparticles via Nanoimprint Lithography

    Yu, Xi   Pham, Jonathan T.   Subramani, Chandramouleeswaran   Creran, Brian   Yeh, Yi-Cheun   Du, Kan   Patra, Debabrata   Miranda, Oscar R.   Crosby, Alfred J.   Rotello, Vincent M.  

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  • Controlled and Sustained Release of Drugs from Dendrimer-Nanoparticle Composite Films

    Park, Myoung-Hwan   Agasti, Sarit S.   Creran, Brian   Kim, Chaekyu   Rotello, Vincent M.  

    A dendrimer-nanoparticle hybrid scaffold based on robust dithiocarbamate formation provides a controlled drug delivery system. These composite films are nontoxic and can incorporate a variety of guests, providing sustained drug release over multiple uses. The system is highly modular: the release process can be easily tuned by altering the dendrimer generation and the size of the AuNPs, generating a versatile delivery system.
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  • Dopamine coated Fe3O4 nanoparticles as enzyme mimics for the sensitive detection of bacteria.

    Mumtaz, Shazia   Wang, Li-Sheng   Hussain, Syed Zajif   Abdullah, Muhammad   Huma, Zille   Iqbal, Zafar   Creran, Brian   Rotello, Vincent M   Hussain, Irshad  

    We report a simple and economical colorimetric bacterial sensing strategy with catalytic amplification using dopamine-capped iron oxide (Dop-Fe3O4) nanoparticles. These nanoparticles catalyse the oxidation of a chromogenic substrate in the presence of H2O2 into a green colored product. The catalytic activity of the nanoparticles is inhibited in the presence of bacteria, providing naked eye detection of bacteria at 104 cfu mL-1 and by spectrophotometric detection down to 102 cfu mL-1.=20
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  • Array-based sensing with nanoparticles: 'Chemical noses' for sensing biomolecules and cell surfaces

    Miranda, Oscar R.   Creran, Brian   Rotello, Vincent M.  

    Nanoparticle-based arrays have been used to distinguish a wide range of biomolecular targets through pattern recognition. In this report, we highlight new 'chemical nose' methodologies that use nanoparticle systems to provide high sensitivity sensing of biomolecular targets, including fluorescent polymer/gold nanoparticle complexes that can discriminate between different bioanalytes including proteins, bacteria, and mammalian cells as well as dye-based micellar systems for the detection of clinically important metalloproteins and nonmetalloproteins.
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  • Laser desorption ionization mass spectrometric imaging of mass barcoded gold nanoparticles for security applications

    Creran, Brian   Yan, Bo   Moyano, Daniel F.   Gilbert, Michael M.   Vachet, Richard W.   Rotello, Vincent M.  

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  • Laser desorption ionization mass spectrometric imaging of mass barcoded gold nanoparticles for security applications

    Creran, Brian   Yan, Bo   Moyano, Daniel F.   Gilbert, Michael M.   Vachet, Richard W.   Rotello, Vincent M.  

    Patterns created by the inkjet printing of functionalized gold nanoparticles (NPs) can be selectively detected by laser desorption/ionization imaging mass spectrometry (LDI-IMS). These patterns can only be visualized by mass, providing a robust yet tunable system for potential anti-counterfeiting applications.
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  • Inkjet-printed gold nanoparticle surfaces for the detection of low molecular weight biomolecules by laser desorption/ionization mass spectrometry.

    Marsico, Alyssa L M   Creran, Brian   Duncan, Bradley   Elci, S Gokhan   Jiang, Ying   Onasch, Timothy B   Wormhoudt, Joda   Rotello, Vincent M   Vachet, Richard W  

    Effective detection of low molecular weight compounds in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is often hindered by matrix interferences in the low m/z region of the mass spectrum. Here, we show that monolayer-protected gold nanoparticles (AuNPs) can serve as alternate matrices for the very sensitive detection of low molecular weight compounds such as amino acids. Amino acids can be detected at low fmol levels with minimal interferences by properly choosing the AuNP deposition method, density, size, and monolayer surface chemistry. By inkjet-printing AuNPs at various densities, we find that AuNP clusters are essential for obtaining the greatest sensitivity. Graphical Abstract =E1=85=9F. =20
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