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Now showing items 1 - 16 of 439

  • Bisphenol a induces inflammation and proliferation in human endometrial cells

    Cho, Y.   Han, M.   Park, S.   Park, J.  

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  • HRD Educators\" Views on Teaching and Learning: An International Perspective

    Cho, Y.   Zachmeier, A.  

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  • Long-term outcomes and risk analyses of coronary bypass for left main disease

    Cho, Y.   Shimura, S.   Aki, A.   Furuya, H.   Ueda, T.  

    Background: We retrospectively analyzed the long-term outcomes and risk predictors of conventional coronary artery bypass grafting routinely employed for patients with left main disease. Methods: From January 2000 through December 2009, conventional coronary artery bypass grafting was routinely employed in 193 consecutive patients with left main disease. Long-term analyses were performed, looking at the primary endpoint of major adverse cardiac and cerebrovascular events which included all-cause death, stroke, myocardial infarction, and repeat revascularization. We also analyzed the effects of variables on major adverse cardiac and cerebrovascular events at 9 years after the operation. Results: The overall 9-year rates of combined outcomes (death, stroke, myocardial infarction), repeat revascularization, and major adverse cardiac and cerebrovascular events were 20.2%, 8.9%, 27.7%, respectively. The SYNTAX score was demonstrated to be the only significant predictor of combined outcomes at 9 years (hazard ratio 1.04, p = 0.033), repeat revascularization at 9 years (hazard ratio 1.11, p = 0.0030), and major adverse cardiac and cerebrovascular events at 9 years (hazard ratio 1.07, p = 0.0003). Conclusions: With our routine strategy of conventional coronary artery bypass for left main disease, patients revealed excellent long-term outcomes in terms of major adverse cardiac and cerebrovascular events. These results provide a suitable benchmark against which long-term outcomes of percutaneous coronary intervention for left main disease can be compared. The SYNTAX score, which was introduced to determine treatment for complex coronary disease, is indicative of long-term outcomes after coronary artery bypass for left main disease.
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  • Surface Cleaning Using CO2 Gas Cluster for Semiconductor Device

    Cho, Y.   Choi, H.   Kim, T.  

    The present semiconductor cleaning technology is based upon chemical cleaning, a high-temperature process that consumes vast amounts of chemicals and ultrapure water. Therefore, this technology gives rise to many environmental issues, and some alternatives are being evaluated. Herein we report, gas cluster cleaning method for cleaning semiconductor devices. Two types of particles such as Ceria (CeO 2) and Silica (SiO 2) were used to evaluate particle removal efficiency (PRE). It is observed from the field emission scanning electron microscopy (FE-SEM) images that most of particles were removed with PRE more than 90% under various experimental conditions. Further, the pattern damage evaluation is carried out for poly-Si patterns which have width of pattern in the range of 60 to 100 nm. It is observed that there is no pattern damage for various experimental conditions.
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  • Effects of pregabalin on patients with hypnotic dependent insomnia

    Cho, Y.   Moon, H.   Lee, Y.   Song, M.  

    IntroductionLong-term use of hypnotics runs the risk of dependency, and the patient usually experiences difficulties in withdrawal or discontinuing treatment. It has been reported that pregabalin has a positive effect on both sleep and withdrawing from hypnotics. The objective of this study was to investigate the efficacy of pregabalin on sleep in patients with hypnotic dependent insomnia.Materials and methodsThis is a prospective, open-label, single arm, and interventional study. We enrolled patients with hypnotic dependent insomnia who were 18 older. The starting dosage of Pregabalin was 75 mg/day and was increased up to as much as 300 mg/day, depending on the individual patients condition, while tapering off hypnotics. After four weeks of titration, the final dosage amount was maintained for at least another 4 weeks. Sleep and clinical variables were evaluated by using the Pittsburgh Sleep Quality Index (PSQI), Epworth sleepiness scale (ESS), Insomnia Severity Index (ISI), the hospital depression and anxiety scale (HADS), in addition to the polysomnography (PSG) at baseline and after treatment. A paired t-test was used for analyzing the effect of pregabalin using SPSS 18.0 program.ResultsWe enrolled 40 patients whose mean age was 52.33 ± 8.39, 28 were women (70.0%). Twenty-one (52.5%) were successful in withdrawing from hypnotics. The duration of withdrawing from hypnotics was 42.19 ± 16.08 days (range: 27.00-84.00). The mean pregabalin dose was 121.43 ± 69.05 mg/day (range: 75.00-300.00). The results using pregabalin showed a significant improvement with the total score of the PSQI (15.05 ± 2.11, 8.90 ± 3.08, p  0.001), insomnia severity index (20.95 ± 4.32, 9.62 ± 4.41, p  0.001), BDI-2 (7.95 ± 4.20, 5.67 ± 3.69, p = 0.013) and HAS (7.24 ± 4.90, 4.67 ± 3.92, p = 0.002). The main adverse effects of pregabalin were nausea and dizziness.ConclusionOur results showed pregabalin is effective in allowing patients with hypnotic dependent insomnia to withdraw from hypnotics, with a success rate of more than half, and the quality of sleep improved in the group as a whole.AcknowledgementsThis work was supported by a research promoting grant from Pfizer, Korea.
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  • Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition

    Cho, Y.   Hong, J.   Ryoo, H.   Kim, D.   Park, J.   Han, J.  

    Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb2O5) or tantalum oxide (Ta2O5) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.
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  • Development of Tissue Equivalent Gel Dosimeter for 3-dimensional Dose Evaluation

    Cho, Y.   Lee, D.   Lee, Y.   Park, J.   Kim, K.   Jung, H.   Ji, Y.   Rhee, C.   Kwon, S.  

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  • The State of the Art of Action Learning Research

    Cho, Y.   Egan, T. M.  

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  • The role of transcriptional activator GATA-1 at human ?-globin HS2

    Cho, Y.   Song, S.-H.   Lee, J. J.   Choi, N.   Kim, C. G.   Dean, A.   Kim, A.  

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  • Development of Tissue Equivalent Gel Dosimeter for Clinical Radiation Therapy System

    Cho, Y.   Lee, D.   Park, J.   Kim, K.   Jung, H.   Ji, Y.   Rhee, C.   Lee, Y.   Kwon, S.  

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  • Action Learning Research: A Systematic Review and Conceptual Framework

    Cho, Y.   Egan, T. M.  

    Despite considerable interest in action learning, no systematic investigation of action learning literature has been reported. Two purposes of this study are (a) to systematically access and examine recent empirical studies on action learning and related themes using Garrard’s Matrix Method for reviewing literature (the review of the literature covered an 8-year period from 2000 to 2007; 50 studies have been selected based on the search criteria) and (b) based on Revans’s proposition regarding the need for a conceptual and practical balance between action and learning, to categorize empirical studies into action-oriented, learning-oriented, and balanced action learning. Studies selected from the systematic literature review process are highlighted, and Revans’s balance issue and the quality of select studies are discussed. A conceptual framework for the future studies of action learning, key concluding themes, and the limitations of the study are also articulated.
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  • Peritoneal dialysis outcomes after temporary haemodialysis transfer for peritonitis

    Cho, Y.   Badve, S. V.   Hawley, C. M.   McDonald, S. P.   Brown, F. G.   Boudville, N.   Clayton, P.   Johnson, D. W.  

    Background. There has not been a comprehensive examination to date of peritoneal dialysis (PD) outcomes after temporary haemodialysis (HD) transfer for peritonitis. Methods. The study included all incident Australian patients who experienced peritonitis between 1 October 2003, and 31 December 2011, using Australia and New Zealand Dialysis and Transplant Registry data. Patients were grouped into three categories: Interim HD, Permanent HD and Never HD based on HD transfer status after the first peritonitis. The independent predictors of HD transfer and subsequent return to PD were determined by multivariable, multilevel mixed-effects logistic regression analysis. Matched case-control analyses were performed to compare clinical outcomes (e. g. patient survival) between groups. Results. Of the 3305 patients who experienced peritonitis during the study period, 553 episodes (16.7%) resulted in transfer to HD and 101 patients subsequently returned to PD. HD transfer was significantly and independently predicted by inpatient treatment of peritonitis [odds ratio (OR) 11.45, 95% confidence interval (CI) 7.14-18.36] and the recovered microbiologic profile of organisms recognized to be associated with moderate (20-40%) to high (>40%) rates of catheter removal (moderate: OR 2.45, 95% CI 1.89-3.17; high: OR 8.63, 95% CI 6.44-11.57). Matched case-control analyses yielded comparable results among Interim, Permanent and Never HD groups in terms of patient survival (P = 0.28), death-censored technique survival [hazard ratio (HR) 0.87, 95% CI 0.59-1.28; P = 0.48] and peritonitis-free survival (HR 0.84, 95% CI 0.50-1.39, P = 0.49). Conclusions. In an observational registry study of first peritonitis episodes, temporary HD transfer was not associated with inferior patient-level clinical outcomes when compared with others who either never required HD transfer or remained on HD permanently if all patient-level and peritonitis-related factors were considered equal. Therefore, return to PD after a temporary HD due to peritonitis should not be discouraged in appropriate PD patients.
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  • Nocardioides marinquilinus sp. nov., isolated from coastal seawater

    Cho, Y.   Jang, G. I.   Cho, B. C.  

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  • Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

    Cho, Y.   Crichlow, G. V.   Vermeire, J. J.   Leng, L.   Du, X.   Hodsdon, M. E.   Bucala, R.   Cappello, M.   Gross, M.   Gaeta, F.   Johnson, K.   Lolis, E. J.  

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  • The surface composition of asteroid 162173 Ryugu from Hayabusa2 near-infrared spectroscopy

    Kitazato, K.   Milliken, R. E.   Iwata, T.   Abe, M.   Ohtake, M.   Matsuura, S.   Arai, T.   Nakauchi, Y.   Nakamura, T.   Matsuoka, M.   Senshu, H.   Hirata, N.   Hiroi, T.   Pilorget, C.   Brunetto, R.   Poulet, F.   Riu, L.   Bibring, J.-P.   Takir, D.   Domingue, D. L.   Vilas, F.   Barucci, M. A.   Perna, D.   Palomba, E.   Galiano, A.   Tsumura, K.   Osawa, T.   Komatsu, M.   Nakato, A.   Arai, T.   Takato, N.   Matsunaga, T.   Takagi, Y.   Matsumoto, K.   Kouyama, T.   Yokota, Y.   Tatsumi, E.   Sakatani, N.   Yamamoto, Y.   Okada, T.   Sugita, S.   Honda, R.   Morota, T.   Kameda, S.   Sawada, H.   Honda, C.   Yamada, M.   Suzuki, H.   Yoshioka, K.   Hayakawa, M.   Ogawa, K.   Cho, Y.   Shirai, K.   Shimaki, Y.   Hirata, N.   Yamaguchi, A.   Ogawa, N.   Terui, F.   Yamaguchi, T.   Takei, Y.   Saiki, T.   Nakazawa, S.   Tanaka, S.   Yoshikawa, M.   Watanabe, S.   Tsuda, Y.  

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  • Individual Pattern Making Using Computerized Draping Method for Clothing

    Cho, Y.   Komatsu, T.   Inui, S.   Takatera, M.   Shimizu, Y.   Park, H.  

    The consumer is demanding more variety and personalization in apparel products. Personalization includes creating clothing that not only takes into account of variations in size, but also variations of the body itself. The traditional grading method is the current standard sizing system in the apparel industry. it starts with a base size which is then proportionally graded to create a multiple set of sizes. Although it caters for a limited number of sizes, this method does not include variations in body shape. In our research, we have developed a method of individual pattern making by modifying a traditional draping system so that it can be used in conjunction with modern three-dimensional modeling techniques. Individualized pattern making means customized pattern making for individuals. This method uses a five-step draping process. The steps are: (1) defining the surface shape; (2) setting grainlines; (3) fitting the fabric to the surface shape; (4) cutting of the three-dimensionally fitted fabric into a two-dimensional pattern. Our fitting process prevents or controls buckling when the limit angle of a fabric's ability to conform to a surface is exceeded. We do this entire process using computed geometrical models, rather than physically. Therefore we believe it has the potential to be more efficient and simple than other techniques. When we used this method to make a pattern for a tight skirt, we easily created complex curved lines automatically using this development method. When test subjects compared our skirt with a traditionally designed skirt, approximately 80% of the subjects indicated a preference for our skirt. Although this paper focuses on patterns made for dummies, our future research will focus on fitting to real human body shapes
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