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Now showing items 97 - 112 of 24606

  • Estimating the strength of the M–H–B interaction: a kinetic approach

    Sohail, Muhammad   Moncho, Salvador   Brothers, Edward N.   Darensbourg, Donald J.   Bengali, Ashfaq A.  

    Photolysis of BzCr(CO)(3) and TpMn(CO)(3) in the presence of H3B-NEt3 yields a metal-borane sigma complex. Displacement of the weakly coordinated borane by P(OEt)(3) proceeds by a dissociative mechanism and an Eyring analysis yields the first estimate of 20 kcal mol(-1) for the strength of this novel interaction.
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  • Connor H. G. Patros: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). The 2015 recipient is Connor H. G Patros. Patros was chosen for "an excellent research paper that examines the complex relationship between working memory, choice-impulsivity, and the attention-deficit/hyperactivity disorder (ADHD) phenotype." Patros's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).
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  • Hepcidine, bêta-thalassémie, hémochromatose

    Jean-Marie Manus  

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  • K. H. B. Wood

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  • B/N co-doped carbon derived from the sustainable chitin for C H bond oxidation

    Zhang Yunrui   Zhang Hong   Zhao Yinuo   Han Xingyan   Wang Haijun   Gao Yongjun  

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  • On Catalysis. Edited by Wladimir Reschetilowski and Wolfgang H?nle

    Prof. Wolfgang Grünert  

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  • About B. H. Fairchild

    Rebecca Morgan Frank  

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  • Defekt auf X-Chromosom - Gentherapie zeigt Erfolg bei H?mophilie B

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  • Machine learning techniques in searches for th in the h → b decay channel

    R. Santos   M. Nguyen   J. Webster   S. Ryu   J. Adelman   S. Chekanov   J. Zhou  

    Study of the production of pairs of top quarks in association with a Higgs boson is one of the primary goals of the Large Hadron Collider over the next decade, as measurements of this process may help us to understand whether the uniquely large mass of the top quark plays a special role in electroweak symmetry breaking. Higgs bosons decay predominantly to b, yielding signatures for the signal that are similar to t + jets with heavy flavor. Though particularly challenging to study due to the similar kinematics between signal and background events, such final states (t b) are an important channel for studying the top quark Yukawa coupling. This paper presents a systematic study of machine learning (ML) methods for detecting th in the h → b decay channel. Among the eight ML methods tested, we show that two models, extreme gradient boosted trees and neural network models, outperform alternative methods. We further study the effectiveness of ML algorithms by investigating the impact of feature set and data size, as well as the structure of the models. While extended feature set and larger training sets expectedly lead to improvement of performance, shallow models deliver comparable or better performance than their deeper counterparts. Our study suggests that ensembles of trees and neurons, not necessarily deep, work effectively for the problem of th detection.
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  • Nonlinear preserver problems on B(H)

    Jian Lian Cui  

    Let H be a complex Hilbert space of dimension greater than 2, and B(H) denote the Banach algebra of all bounded linear operators on H. For A, B ∈ B(H), define the binary relation A ≤* B by A*A = A*B and AA* = AB*. Then (B(H), “≤*”) is a partially ordered set and the relation “≤*” is called the star order on B(H). Denote by Bs(H) the set of all self-adjoint operators in B(H). In this paper, we first characterize nonlinear continuous bijective maps on B s (H) which preserve the star order in both directions. We characterize also additive maps (or linear maps) on B(H) (or nest algebras) which are multiplicative at some invertible operator.
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  • Iridium-catalysed regioselective borylation of carboranes via direct B–H activation

    Cheng, Ruofei   Qiu, Zaozao   Xie, Zuowei  

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  • H/KDEL receptors mediate host cell intoxication by a viral A/B toxin in yeast

    Becker, Bj?rn   Blum, Andrea   Gie?elmann, Esther   Dausend, Julia   Rammo, Domenik   Müller, Nina C.   Tschacksch, Emilia   Steimer, Miriam   Spindler, Jenny   Becherer, Ute   Rettig, Jens   Breinig, Frank   Schmitt, Manfred J.  

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  • Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L

    Neera Raghav   Ravinder Kaur  

    Highlights • Three bio macromolecules cathepsins B, H and L of physiological and pathological significance have been selected for the study. • The molecules have been designed by combining two important pharmacophores their cyclized analogues and were studied for their inhibitory effects on selected enzymes. • Two isomeric forms of chalconesemicarbazones are reported for the first time. • The synthesized compounds showed a competitive inhibition towards cathepsins B, H and L. • Docking experiments were run along with to relate with in vitro studies. Abstract Cathepsin B [EC 3.4.22.1], cathepsin H [EC 3.4.22.16] and cathepsin L [EC 3.4.22.15] are the most versatile lysosomal cysteine proteases and are responsible for intracellular protein degradation. These are involved in a number of pathological conditions including tissue degenerative processes. In the present work, we report the synthesis and systematic evaluation of differently substituted chalcones, chalconesemicarbazones, and diarylpyrazolines on cathepsins B, H and L activity. It was found that after a preliminary screening as cysteine protease inhibitors, chalconesemicarbazones were better inhibitors to these cysteine proteases than diarylpyrazolines followed by chalcones. All the synthesized compounds were identified as the best inhibitors to cathepsin L followed by cathepsin B and then cathepsin H. The results are compared with docking studies and it was found that all the compounds resulted in decrease in energy while interacting with the active site of the enzyme.
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  • Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L

    Raghav, Neera   Kaur, Ravinder  

    Highlights • Three bio macromolecules cathepsins B, H and L of physiological and pathological significance have been selected for the study. • The molecules have been designed by combining two important pharmacophores their cyclized analogues and were studied for their inhibitory effects on selected enzymes. • Two isomeric forms of chalconesemicarbazones are reported for the first time. • The synthesized compounds showed a competitive inhibition towards cathepsins B, H and L. • Docking experiments were run along with to relate with in vitro studies. Abstract Cathepsin B [EC 3.4.22.1], cathepsin H [EC 3.4.22.16] and cathepsin L [EC 3.4.22.15] are the most versatile lysosomal cysteine proteases and are responsible for intracellular protein degradation. These are involved in a number of pathological conditions including tissue degenerative processes. In the present work, we report the synthesis and systematic evaluation of differently substituted chalcones, chalconesemicarbazones, and diarylpyrazolines on cathepsins B, H and L activity. It was found that after a preliminary screening as cysteine protease inhibitors, chalconesemicarbazones were better inhibitors to these cysteine proteases than diarylpyrazolines followed by chalcones. All the synthesized compounds were identified as the best inhibitors to cathepsin L followed by cathepsin B and then cathepsin H. The results are compared with docking studies and it was found that all the compounds resulted in decrease in energy while interacting with the active site of the enzyme.
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  • Gloryland: Christian Suburbia, Christian Nation – By H. B. Cavalcanti

    Diane J. Chandler  

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  • Detlef B. Linke, Lebenskunst und Neuropsychologie. H?lderlin als Hirnforscher

    Gonther   Uwe  

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