Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Collection
For ¥0.57 per day, unlimited downloads CREATE MEMBERSHIP Download

toTop

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

home > search >

Preserved caudate function in young-onset patients with Parkinson's disease:a dual-tracer PET imaging study

Author:
Yang, Yu-jie  Ge, Jing-jie  Liu, Feng-tao  Liu, Zhen-yang  Zhao, Jue  Wu, Jian-jun  Ma, Yilong  Zuo, Chuan-tao  Wang, Jian  


Journal:
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS


Issue Date:
2019


Abstract(summary):

Parkinson's disease (PD) is a highly heterogeneous clinical entity. Patients with young-onset PD (YOPD) show some characteristic manifestations to late-onset PD (LOPD). The current study aimed to investigate the cerebral dopaminergic and metabolic characteristics in YOPD with positron emission tomography (PET) imaging. In our study, 103 subjects (42 YOPD and 61 LOPD patients) accepted both C-11-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (C-11-CFT) and F-18-fluorodeoxyglucose (F-18-FDG) cerebral PET imaging. Sixty-two patients out of 103 patients in our study completed the cognition tests. In this limited subsection, YOPD patients performed better in cognitive functioning than LOPD patients of similar disease duration. In C-11-CFT imaging, dopamine transporter binding in caudate was relatively spared in YOPD compared with lesions in putamen. In F-18-FDG PET, YOPD patients showed increased metabolism in basal ganglia relative to the healthy controls. When compared with LOPD patients, YOPD patients exhibited hypermetabolism in caudate and hypometabolism in putamen. Furthermore, the regional metabolic values in caudate correlated positively and moderately with the dopaminergic binding deficiency in caudate. The findings of this imaging study might offer new perspectives in understanding the characteristic manifestations in YOPD in light of better-preserved cognition function.


VIEW PDF

The preview is over

If you wish to continue, please create your membership or download this.

Create Membership

Similar Literature

Submit Feedback

This function is a member function, members do not limit the number of downloads