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In situ film forming fibroin gel intended for cutaneous administration

Author:
Gennari, Chiara G. M.  Selmin, Francesca  Ortenzi, Marco A.  Franze, Silvia  Musazzi, Umberto M.  Casiraghi, Antonella  Minghetti, Paola  Cilurzo, Francesco  


Journal:
INTERNATIONAL JOURNAL OF PHARMACEUTICS


Issue Date:
2016


Abstract(summary):

The possible use of regenerated silk fibroin gels as in situ film forming formulations for cutaneous administration of drugs was studied. Ethanol was selected as volatile and skin tolerant solvent to favor the sol-gel transition of silk fibroin solutions. Glycerin was chosen to ameliorate the gel texture profile. Eighteen placebo formulations were prepared to individuate the optimal component ratios as a function of the texture analysis, spreadability and drying time. The in vitro biopharmaceutical performance was investigated by in vitro permeation test through human epidermis on formulations loading caffeine as a model drug. The data evidenced that the optimal technological performances were achieved using gels containing 70% ethanol and silk fibroin/glycerin ratio from 0.18 to 0.36. The caffeine flux (J) through the skin was significantly improved due to an increase of the drug thermodynamic activity (hydro-alcoholic solution: J similar to 0.8 mu g/cm(2)/h; in situ formed film: J similar to 1.4-1.7 mu g/cm(2)/h). In conclusion, silk fibroin can be advantageously proposed as a novel film forming material to develop dosage forms to be topically applied. (C) 2016 Published by Elsevier B.V.


Page:
296---302


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