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Fragmentation reactions of a(n) (n=3D4-8) ions containing only alanine residues

Author:
Harrison, Alex G.  


Journal:
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY


Issue Date:
2015


Abstract(summary):

A detailed study of the fragmentation reactions of an (n=3D4-8) ions containing only Ala residues has been carried out using collisional activation on an electrospray/QqToF instrument. Two distinct fragmentation pathways are observed. One, which we have called the "imine" pathway, involves initial elimination of an imine (a(n) -> b(n-1)) followed by elimination of Ala residues (b(n-1) -> b(n-2), etc.). This pathway most likely involves the protonated substituted imine R2C(=3D O)NH+=3D CHR1. The second pathway, which we have called the "amide" pathway, involves initial elimination of NH3 to form an a(n)* ion followed by elimination of Ala residues to form a series of a* ions (a(n)* a(n-2)*, etc.). This latter reaction sequence begins from a protonated C-terminal amide which has been identified by IRMPD studies as the major species present for the A-A-A-A a(4) ion (Bythell et al., 2010). The present results strongly indicate that the larger an ions fragment in a manner similar to that elucidated for the all-Ala a(4) ion and that the "amide" pathway is the dominant fragmentation channel for all the an ions studied in the present work. (C) 2015 Elsevier B.V. All rights reserved.


Page:
26---33


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