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Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents:A randomized,double-blind,placebo-controlled,dose-response study

Author:
Meng, Ge  Wang, Honglei  Pei, Yinghua  Li, Yanmei  Wu, Hongmei  Song, Yanqi  Guo, Qi  Guo, Hui  Fukushima, Shinobu  Tatefuji, Tomoki  Wang, Jiazhong  Du, Huanmin  Su, Qian  Zhang, Wen  Shen, Suxing  Wang, Xiuyang  Dong, Renwei  Han, Peipei  Okazaki, Tatsuma  Nagatomi, Ryoichi  Wang, Jianhua  Huang, Guowei  Sun, Zhong  Song, Kun  Niu, Kaijun  


Journal:
SCIENTIFIC REPORTS


Issue Date:
2017


Abstract(summary):

Although we have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strength in elderly nursing home residents. One hundred and ninety-four subjects enrolled into this multicenter, randomized, double-blind, placebo-controlled study. Subjects received either placebo(Group 1), pRJ 1.2 g/d(Group 2), or 4.8 g/d(Group 3). Data through 1 year are reported for 163 subjects. The primary outcome measure is handgrip strength. Secondary outcomes include several physical performance tests (six-minute walk test, timed up and go test, and standing on one leg with eyes closed). The dropout rate was 16.0%. The means (95% confidence interval) of change in handgrip strength for placebo, low-dose, and high-dose groups are -0.98(-2.04,0.08), 0.50(-0.65,1.65) and 1.03(-0.37,2.44) kg (P =3D 0.06, P for trend =3D 0.02), respectively. No significant effects of the interventions were observed for physical performances. These findings suggest that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people. In addition, we have not found that pRJ intervention can achieve improvement or attenuating the decrease in physical performance.


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