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Metabolic engineering for improving l-tryptophan production in Escherichia coli

Author:
Niu, Hao  Li, Ruirui  Liang, Quanfeng  Qi, Qingsheng  Li, Qiang  Gu, Pengfei  


Journal:
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY


Issue Date:
2019


Abstract(summary):

l-Tryptophan is an important aromatic amino acid that is used widely in the food, chemical, and pharmaceutical industries. Compared with the traditional synthetic methods, production of l-tryptophan by microbes is environmentally friendly and has low production costs, and feed stocks are renewable. With the development of metabolic engineering, highly efficient production of l-tryptophan in Escherichia coli has been achieved by eliminating negative regulation factors, improving the intracellular level of precursors, engineering of transport systems and overexpression of rate-limiting enzymes. However, challenges remain for l-tryptophan biosynthesis to be cost-competitive. In this review, successful and applicable strategies derived from metabolic engineering for increasing l-tryptophan accumulation in E. coli are summarized. In addition, perspectives for further efficient production of l-tryptophan are discussed.


Page:
55---65


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